LOCUS       NM_002277               1615 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens keratin 31 (KRT31), mRNA.
ACCESSION   NM_002277
VERSION     NM_002277.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1615)
  AUTHORS   Kim,D.K., Weller,B., Lin,C.W., Sheykhkarimli,D., Knapp,J.J.,
            Dugied,G., Zanzoni,A., Pons,C., Tofaute,M.J., Maseko,S.B.,
            Spirohn,K., Laval,F., Lambourne,L., Kishore,N., Rayhan,A.,
            Sauer,M., Young,V., Halder,H., la Rosa,N.M., Pogoutse,O.,
            Strobel,A., Schwehn,P., Li,R., Rothballer,S.T., Altmann,M.,
            Cassonnet,P., Cote,A.G., Vergara,L.E., Hazelwood,I., Liu,B.B.,
            Nguyen,M., Pandiarajan,R., Dohai,B., Coloma,P.A.R., Poirson,J.,
            Giuliana,P., Willems,L., Taipale,M., Jacob,Y., Hao,T., Hill,D.E.,
            Brun,C., Twizere,J.C., Krappmann,D., Heinig,M., Falter,C., Aloy,P.,
            Demeret,C., Vidal,M., Calderwood,M.A., Roth,F.P. and
            Falter-Braun,P.
  TITLE     A proteome-scale map of the SARS-CoV-2-human contactome
  JOURNAL   Nat Biotechnol 41 (1), 140-149 (2023)
   PUBMED   36217029
REFERENCE   2  (bases 1 to 1615)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1615)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1615)
  AUTHORS   Du,L., Zhang,X., Chen,L., Zhang,L. and Li,H.
  TITLE     K31 as a novel marker for clear secretory cells in human eccrine
            sweat glands
  JOURNAL   J Mol Histol 51 (1), 47-53 (2020)
   PUBMED   31975318
  REMARK    GeneRIF: K31 as a novel marker for clear secretory cells in human
            eccrine sweat glands.
REFERENCE   5  (bases 1 to 1615)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1615)
  AUTHORS   Winter,H., Hofmann,I., Langbein,L., Rogers,M.A. and Schweizer,J.
  TITLE     A splice site mutation in the gene of the human type I hair keratin
            hHa1 results in the expression of a tailless keratin isoform
  JOURNAL   J Biol Chem 272 (51), 32345-32352 (1997)
   PUBMED   9405442
REFERENCE   7  (bases 1 to 1615)
  AUTHORS   Fink,P., Rogers,M.A., Korge,B., Winter,H. and Schweizer,J.
  TITLE     A cDNA encoding the human type I hair keratin hHal
  JOURNAL   Biochim Biophys Acta 1264 (1), 12-14 (1995)
   PUBMED   7578244
REFERENCE   8  (bases 1 to 1615)
  AUTHORS   Bowden,P.E., Hainey,S., Parker,G. and Hodgins,M.B.
  TITLE     Sequence and expression of human hair keratin genes
  JOURNAL   J Dermatol Sci 7 Suppl, S152-S163 (1994)
   PUBMED   7528047
REFERENCE   9  (bases 1 to 1615)
  AUTHORS   Yu,J., Yu,D.W., Checkla,D.M., Freedberg,I.M. and Bertolino,A.P.
  TITLE     Human hair keratins
  JOURNAL   J Invest Dermatol 101 (1 Suppl), 56S-59S (1993)
   PUBMED   7686952
  REMARK    Review article
REFERENCE   10 (bases 1 to 1615)
  AUTHORS   Dhouailly,D., Xu,C., Manabe,M., Schermer,A. and Sun,T.T.
  TITLE     Expression of hair-related keratins in a soft epithelium:
            subpopulations of human and mouse dorsal tongue keratinocytes
            express keratin markers for hair-, skin- and esophageal-types of
            differentiation
  JOURNAL   Exp Cell Res 181 (1), 141-158 (1989)
   PUBMED   2465162
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Michael Rogers. The reference sequence was
            derived from AC003958.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 25, 2018 this sequence version replaced NM_002277.2.
            
            Summary: The protein encoded by this gene is a member of the
            keratin gene family. As a type I hair keratin, it is an acidic
            protein which heterodimerizes with type II keratins to form hair
            and nails. The type I hair keratins are clustered in a region of
            chromosome 17q12-q21 and have the same direction of transcription.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1002028.1, X86570.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968968,
                                           SAMEA1970526 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000251645.3/ ENSP00000251645.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-417               AC003958.3         35328-35744
            418-500             AC003958.3         35941-36023
            501-657             AC003958.3         36360-36516
            658-819             AC003958.3         37313-37474
            820-945             AC003958.3         37566-37691
            946-1166            AC003958.3         37868-38088
            1167-1615           AC003958.3         38767-39215
FEATURES             Location/Qualifiers
     source          1..1615
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.2"
     gene            1..1615
                     /gene="KRT31"
                     /gene_synonym="Ha-1; HA1; hHa1; KRTHA1"
                     /note="keratin 31"
                     /db_xref="GeneID:3881"
                     /db_xref="HGNC:HGNC:6448"
                     /db_xref="MIM:601077"
     exon            1..417
                     /gene="KRT31"
                     /gene_synonym="Ha-1; HA1; hHa1; KRTHA1"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..1320
                     /gene="KRT31"
                     /gene_synonym="Ha-1; HA1; hHa1; KRTHA1"
                     /note="keratin, hair, acidic,1; hard keratin, type I, 1;
                     K31; hair keratin, type I Ha1; keratin 31, type I"
                     /codon_start=1
                     /product="keratin, type I cuticular Ha1"
                     /protein_id="NP_002268.2"
                     /db_xref="CCDS:CCDS11391.1"
                     /db_xref="GeneID:3881"
                     /db_xref="HGNC:HGNC:6448"
                     /db_xref="MIM:601077"
                     /translation="MPYNFCLPSLSCRTSCSSRPCVPPSCHSCTLPGACNIPANVSNC
                     NWFCEGSFNGSEKETMQFLNDRLASYLEKVRQLERDNAELENLIRERSQQQEPLLCPS
                     YQSYFKTIEELQQKILCTKSENARLVVQIDNAKLAADDFRTKYQTELSLRQLVESDIN
                     GLRRILDELTLCKSDLEAQVESLKEELLCLKSNHEQEVNTLRCQLGDRLNVEVDAAPT
                     VDLNRVLNETRSQYEALVETNRREVEQWFTTQTEELNKQVVSSSEQLQSYQAEIIELR
                     RTVNALEIELQAQHNLRDSLENTLTESEARYSSQLSQVQSLITNVESQLAEIRSDLER
                     QNQEYQVLLDVRARLECEINTYRSLLESEDCNLPSNPCATTNACSKPIGPCLSNPCTS
                     CVPPAPCTPCAPRPRCGPCNSFVR"
     exon            418..500
                     /gene="KRT31"
                     /gene_synonym="Ha-1; HA1; hHa1; KRTHA1"
                     /inference="alignment:Splign:2.1.0"
     exon            501..657
                     /gene="KRT31"
                     /gene_synonym="Ha-1; HA1; hHa1; KRTHA1"
                     /inference="alignment:Splign:2.1.0"
     exon            658..819
                     /gene="KRT31"
                     /gene_synonym="Ha-1; HA1; hHa1; KRTHA1"
                     /inference="alignment:Splign:2.1.0"
     exon            820..945
                     /gene="KRT31"
                     /gene_synonym="Ha-1; HA1; hHa1; KRTHA1"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1166
                     /gene="KRT31"
                     /gene_synonym="Ha-1; HA1; hHa1; KRTHA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1615
                     /gene="KRT31"
                     /gene_synonym="Ha-1; HA1; hHa1; KRTHA1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1589..1594
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KRT31"
                     /gene_synonym="Ha-1; HA1; hHa1; KRTHA1"
                     /note="hexamer: AATAAA"
     polyA_site      1615
                     /gene="KRT31"
                     /gene_synonym="Ha-1; HA1; hHa1; KRTHA1"
                     /note="major polyA site"
ORIGIN      
        1 acagctctgt ggcttggaga atttagactc tgtcttcagc caggcactcc ctccctccct
       61 cccagcacta tgccctacaa cttctgcctg cccagcctga gctgccgcac cagctgctcc
      121 tcccggccct gcgtgccccc cagctgccac agctgcaccc tgcccggggc ctgcaacatc
      181 cccgccaatg tgagcaactg caactggttc tgcgagggct ccttcaatgg tagcgagaag
      241 gagactatgc agttcctgaa cgaccgcctg gccagctacc tggagaaagt gcgtcagctg
      301 gagcgggaca acgcggagct ggagaacctc atccgggagc ggtctcagca gcaggagccc
      361 ttgctgtgcc ccagttacca gtcctatttt aagaccattg aggagctcca gcagaagatc
      421 ctgtgtacca agtctgagaa tgccaggctt gtggtgcaga tcgacaacgc caagctggct
      481 gcggatgatt tcagaaccaa gtaccagacc gagctgtccc tgcggcagct ggtggagtcg
      541 gacatcaacg gtctgcgcag gatcctggat gagctgaccc tgtgcaagtc cgacctggag
      601 gcccaggtgg agtccctgaa ggaggagctg ctctgcctca agagcaacca tgagcaggag
      661 gtcaataccc tgcgctgcca gcttggagac cgcctcaatg tggaggtgga tgctgctccc
      721 actgtggacc tgaatcgggt gctgaacgag accaggagtc agtatgaggc cctggtggaa
      781 accaaccgca gggaagtgga gcaatggttc accacgcaga ccgaggagct gaacaagcag
      841 gtggtatcca gctcagagca gctgcagtcc taccaggcgg agatcatcga gctgagacgc
      901 acagtcaacg ccctggagat cgagctgcag gcccagcaca acctgcgaga ctctctggaa
      961 aacacgctga cagagagtga ggcccgctac agctcccagc tgtcccaggt gcagagcctg
     1021 atcaccaacg tggagtccca gctggcggag atccgcagtg acctggagcg gcagaaccag
     1081 gagtaccagg tgctgctgga tgtgcgtgcc cggctggagt gtgagatcaa cacataccgg
     1141 agcctgctgg agagcgagga ctgcaatctg cccagcaatc cctgtgccac gaccaacgcg
     1201 tgcagcaagc ccatcggacc ctgtctctcc aatccctgta cctcttgtgt ccctcctgcc
     1261 ccctgcacac cctgtgcccc acgcccccgc tgtgggccct gcaattcctt cgtgcgctag
     1321 aacctaggga atgccagagg agcaaggatg cagggcccag gactccagag ctgtgacctg
     1381 gctctggttc aacaaaaggg gcctgaaaac atcatttgca tggctggagt tgcccgcgta
     1441 aggcagccaa gaaactcacc caaagcctgt agcctcccca actactccag actgtcctgc
     1501 tcaccctttc cttcctgggg gtctgttcct tcctatgctc acccagagaa ctctctgatg
     1561 tgccagtggg cctccctttt aacctcctaa taaatatcat ttccttggca aagca
//
