LOCUS       NM_181535               1692 bp    mRNA    linear   PRI 02-JUN-2024
DEFINITION  Homo sapiens keratin 28 (KRT28), mRNA.
ACCESSION   NM_181535
VERSION     NM_181535.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1692)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1692)
  AUTHORS   Schweizer,J., Bowden,P.E., Coulombe,P.A., Langbein,L., Lane,E.B.,
            Magin,T.M., Maltais,L., Omary,M.B., Parry,D.A., Rogers,M.A. and
            Wright,M.W.
  TITLE     New consensus nomenclature for mammalian keratins
  JOURNAL   J Cell Biol 174 (2), 169-174 (2006)
   PUBMED   16831889
REFERENCE   3  (bases 1 to 1692)
  AUTHORS   Rogers,M.A., Winter,H., Langbein,L., Bleiler,R. and Schweizer,J.
  TITLE     The human type I keratin gene family: characterization of new hair
            follicle specific members and evaluation of the chromosome 17q21.2
            gene domain
  JOURNAL   Differentiation 72 (9-10), 527-540 (2004)
   PUBMED   15617563
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK129827.1 and AC090283.7.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Sep 15, 2006 this sequence version replaced NM_181535.2.
            
            Summary: This gene encodes a member of the type I (acidic) keratin
            family, which belongs to the superfamily of intermediate filament
            (IF) proteins. Keratins are heteropolymeric structural proteins
            which form the intermediate filament. These filaments, along with
            actin microfilaments and microtubules, compose the cytoskeleton of
            epithelial cells. The type I keratin genes are clustered in a
            region of chromosome 17q12-q21. [provided by RefSeq, Jul 2009].
            
            Sequence Note: This RefSeq contains an in-frame start site 22
            codons upstream from the currently annotated site but is not being
            annotated as a start site since it is in a weak Kozak sequence
            context and no support was found for use of the upstream AUG.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK129827.1, AJ564207.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA1968968,
                                           SAMEA2148093 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: lack of evidence for use of
                                                upstream AUG
            MANE Ensembl match               :: ENST00000306658.8/
                                                ENSP00000305263.7
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1685              AK129827.1         1-1685
            1686-1692           AC090283.7         58531-58537
FEATURES             Location/Qualifiers
     source          1..1692
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.2"
     gene            1..1692
                     /gene="KRT28"
                     /gene_synonym="K25IRS4; KRT25D"
                     /note="keratin 28"
                     /db_xref="GeneID:162605"
                     /db_xref="HGNC:HGNC:30842"
                     /db_xref="MIM:616677"
     exon            1..516
                     /gene="KRT28"
                     /gene_synonym="K25IRS4; KRT25D"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..1461
                     /gene="KRT28"
                     /gene_synonym="K25IRS4; KRT25D"
                     /note="type I inner root sheath specific keratin 25 irs4;
                     K28; K25D; CK-28; keratin-25D; cytokeratin-28; type I
                     inner root sheath-specific keratin-K25irs4; keratin 28,
                     type I"
                     /codon_start=1
                     /product="keratin, type I cytoskeletal 28"
                     /protein_id="NP_853513.2"
                     /db_xref="CCDS:CCDS11376.1"
                     /db_xref="GeneID:162605"
                     /db_xref="HGNC:HGNC:30842"
                     /db_xref="MIM:616677"
                     /translation="MSLQFSNGSRHVCLRSGAGSVRPLNGGAGFAGSSACGGSVAGSE
                     FSCALGGGLGSVPGGSHAGGALGNAACIGFAGSEGGLLSGNEKVTMQNLNDRLASYLD
                     NVRALEEANAELERKIKGWYEKYGPGSCRGLDHDYSRYHLTIEDLKNKIISSTTTNAN
                     VILQIDNARLAADDFRLKYENELTLHQNVEADINGLRRVLDELTLCRTDQELQYESLS
                     EEMTYLKKNHEEEMKALQCAAGGNVNVEMNAAPGVDLAVLLNNMRAEYEALAEQNRKD
                     AEAWFNEKSASLQQQISHDSGAATFARSQLTEMRRTLQTLEIQLQSLMATKHSLECSL
                     TETESNYCTQLAQIQAQIGALEEQLHQVRTETEGQKLEYEHLLDVKVHLEKEIETYCR
                     LIDGDGNSCSKSKGFGSGSPGNSSKDLSKTTLVKTVVEELDQRGKVLSSRIHSIEEKT
                     SKMTNGKTEQRVPF"
     exon            517..599
                     /gene="KRT28"
                     /gene_synonym="K25IRS4; KRT25D"
                     /inference="alignment:Splign:2.1.0"
     exon            600..756
                     /gene="KRT28"
                     /gene_synonym="K25IRS4; KRT25D"
                     /inference="alignment:Splign:2.1.0"
     exon            757..918
                     /gene="KRT28"
                     /gene_synonym="K25IRS4; KRT25D"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1044
                     /gene="KRT28"
                     /gene_synonym="K25IRS4; KRT25D"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1262
                     /gene="KRT28"
                     /gene_synonym="K25IRS4; KRT25D"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..1318
                     /gene="KRT28"
                     /gene_synonym="K25IRS4; KRT25D"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..1692
                     /gene="KRT28"
                     /gene_synonym="K25IRS4; KRT25D"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1668..1673
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KRT28"
                     /gene_synonym="K25IRS4; KRT25D"
     polyA_site      1692
                     /gene="KRT28"
                     /gene_synonym="K25IRS4; KRT25D"
ORIGIN      
        1 atgatattct gttctcttgg gacattacag ttttgcatag acaaggtgaa catttctcaa
       61 aacaccatgt ctctccaatt ttctaatgga tccaggcatg tttgcttaag gtctggagct
      121 ggatctgtca gacccctcaa tggaggtgca ggctttgcag gcagcagtgc atgtggtggc
      181 tctgttgctg gaagtgaatt ttcctgtgcc ttgggagggg gcttgggcag tgttcctggt
      241 gggagccatg ctggtggtgc ccttggaaat gctgcttgta ttggctttgc tggaagcgaa
      301 gggggactcc tctctggaaa tgagaaggtg accatgcaaa atcttaatga ccgcttggca
      361 tcctacctgg ataatgtgcg agctctggag gaggcaaatg ctgaattaga gagaaaaatc
      421 aagggttggt atgaaaaata cggacctgga tcttgccgtg gacttgatca tgactatagc
      481 agatatcacc taacaattga ggatcttaag aataagatta tctcctccac tactactaat
      541 gctaatgtca ttctgcagat tgataatgcc agactggctg ctgatgattt caggctaaag
      601 tatgaaaatg agctcaccct tcaccaaaac gtagaggccg acatcaacgg attacggcga
      661 gtcctggacg agctgacgct ctgcaggacc gaccaggagc tgcaatatga gtctctgagt
      721 gaggagatga catatctcaa aaagaaccac gaagaggaga tgaaggctct gcagtgcgcg
      781 gctgggggca acgtgaacgt ggagatgaac gcggccccgg gggtagacct cgcggttttg
      841 ttgaacaaca tgcgagcgga gtacgaagcc cttgcagagc agaaccgcaa ggacgcggag
      901 gcctggttca atgagaagag cgcctcgctg cagcaacaga tctcccacga ctcaggcgca
      961 gccactttcg cccggagcca gctcaccgag atgaggcgca ccctgcagac cctggagatc
     1021 cagctgcagt ccctgatggc cacgaaacac tccctggagt gctccttgac agagaccgag
     1081 agcaactact gtacgcagct ggcgcagatc caggctcaga tcggggccct ggaggagcag
     1141 ctgcaccagg tcagaaccga gaccgagggc cagaagctgg agtatgagca tctcctcgat
     1201 gtcaaggtcc acttggaaaa agaaattgag acctactgcc gcctgataga tggagatgga
     1261 aattcatgct ccaaatcaaa gggctttgga tcaggaagcc ctgggaattc atctaaagat
     1321 ttatccaaaa ccacactggt aaagacagtg gttgaagagc tagatcaacg tggtaaagtt
     1381 ctttcatcaa ggattcactc cattgaagaa aagacatcta aaatgaccaa cggcaagaca
     1441 gaacaaaggg ttcctttcta gctgtcattt tagagaaaag aataatttgg gaaaggatcc
     1501 tgtacaattg cattattcta aatatcagag agaatataca cactttttac ttttaaagat
     1561 acattactta gcaaaaatac ctgttttctt agttttacag gatattgagt gtttgtttcc
     1621 aataaataaa aaagttgatg tgcattcatt tccattcact gatgactaat aaataactat
     1681 ttgtgatttt tt
//
