LOCUS       NM_181537               1628 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens keratin 27 (KRT27), mRNA.
ACCESSION   NM_181537
VERSION     NM_181537.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1628)
  AUTHORS   Kim,D.K., Weller,B., Lin,C.W., Sheykhkarimli,D., Knapp,J.J.,
            Dugied,G., Zanzoni,A., Pons,C., Tofaute,M.J., Maseko,S.B.,
            Spirohn,K., Laval,F., Lambourne,L., Kishore,N., Rayhan,A.,
            Sauer,M., Young,V., Halder,H., la Rosa,N.M., Pogoutse,O.,
            Strobel,A., Schwehn,P., Li,R., Rothballer,S.T., Altmann,M.,
            Cassonnet,P., Cote,A.G., Vergara,L.E., Hazelwood,I., Liu,B.B.,
            Nguyen,M., Pandiarajan,R., Dohai,B., Coloma,P.A.R., Poirson,J.,
            Giuliana,P., Willems,L., Taipale,M., Jacob,Y., Hao,T., Hill,D.E.,
            Brun,C., Twizere,J.C., Krappmann,D., Heinig,M., Falter,C., Aloy,P.,
            Demeret,C., Vidal,M., Calderwood,M.A., Roth,F.P. and
            Falter-Braun,P.
  TITLE     A proteome-scale map of the SARS-CoV-2-human contactome
  JOURNAL   Nat Biotechnol 41 (1), 140-149 (2023)
   PUBMED   36217029
REFERENCE   2  (bases 1 to 1628)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1628)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1628)
  AUTHORS   Schweizer,J., Bowden,P.E., Coulombe,P.A., Langbein,L., Lane,E.B.,
            Magin,T.M., Maltais,L., Omary,M.B., Parry,D.A., Rogers,M.A. and
            Wright,M.W.
  TITLE     New consensus nomenclature for mammalian keratins
  JOURNAL   J Cell Biol 174 (2), 169-174 (2006)
   PUBMED   16831889
REFERENCE   5  (bases 1 to 1628)
  AUTHORS   Klammt,J., Garten,A., Barnikol-Oettler,A., Beck-Sickinger,A.G. and
            Kiess,W.
  TITLE     Comparative analysis of the signaling capabilities of the insulin
            receptor-related receptor
  JOURNAL   Biochem Biophys Res Commun 327 (2), 557-564 (2005)
   PUBMED   15629149
REFERENCE   6  (bases 1 to 1628)
  AUTHORS   Rogers,M.A., Winter,H., Langbein,L., Bleiler,R. and Schweizer,J.
  TITLE     The human type I keratin gene family: characterization of new hair
            follicle specific members and evaluation of the chromosome 17q21.2
            gene domain
  JOURNAL   Differentiation 72 (9-10), 527-540 (2004)
   PUBMED   15617563
REFERENCE   7  (bases 1 to 1628)
  AUTHORS   Suzuki,H., Fukunishi,Y., Kagawa,I., Saito,R., Oda,H., Endo,T.,
            Kondo,S., Bono,H., Okazaki,Y. and Hayashizaki,Y.
  TITLE     Protein-protein interaction panel using mouse full-length cDNAs
  JOURNAL   Genome Res 11 (10), 1758-1765 (2001)
   PUBMED   11591653
REFERENCE   8  (bases 1 to 1628)
  AUTHORS   Xu,P., Jacobs,A.R. and Taylor,S.I.
  TITLE     Interaction of insulin receptor substrate 3 with insulin receptor,
            insulin receptor-related receptor, insulin-like growth factor-1
            receptor, and downstream signaling proteins
  JOURNAL   J Biol Chem 274 (21), 15262-15270 (1999)
   PUBMED   10329736
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC090283.7.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_181537.3.
            
            Summary: This gene encodes a member of the type I (acidic) keratin
            family, which belongs to the superfamily of intermediate filament
            (IF) proteins. Keratins are heteropolymeric structural proteins
            which form the intermediate filament. These filaments, along with
            actin microfilaments and microtubules, compose the cytoskeleton of
            epithelial cells. The type I keratin genes are clustered in a
            region of chromosome 17q12-q21. [provided by RefSeq, Jul 2009].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ564206.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968540,
                                           SAMEA1968968 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000301656.4/ ENSP00000301656.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                AC090283.7         68183-68198
            17-501              AC090283.7         68199-68683
            502-584             AC090283.7         69463-69545
            585-741             AC090283.7         70277-70433
            742-903             AC090283.7         70872-71033
            904-1029            AC090283.7         71106-71231
            1030-1247           AC090283.7         73001-73218
            1248-1297           AC090283.7         73431-73480
            1298-1628           AC090283.7         73595-73925
FEATURES             Location/Qualifiers
     source          1..1628
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.2"
     gene            1..1628
                     /gene="KRT27"
                     /gene_synonym="K25IRS3; KRT25C"
                     /note="keratin 27"
                     /db_xref="GeneID:342574"
                     /db_xref="HGNC:HGNC:30841"
                     /db_xref="MIM:616676"
     exon            1..501
                     /gene="KRT27"
                     /gene_synonym="K25IRS3; KRT25C"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..1437
                     /gene="KRT27"
                     /gene_synonym="K25IRS3; KRT25C"
                     /note="type I inner root sheath specific keratin 25 irs3;
                     K27; K25C; CK-27; keratin-25C; cytokeratin-27; type I
                     inner root sheath-specific keratin-K25irs3; keratin 27,
                     type I"
                     /codon_start=1
                     /product="keratin, type I cytoskeletal 27"
                     /protein_id="NP_853515.2"
                     /db_xref="CCDS:CCDS11375.1"
                     /db_xref="GeneID:342574"
                     /db_xref="HGNC:HGNC:30841"
                     /db_xref="MIM:616676"
                     /translation="MSVRFSSTSRRLGSCGGTGSVRLSSGGAGFGAGNTCGVPGIGSG
                     FSCAFGGSSSAGGYGGGLGGGSASCAAFTGNEHGLLSGNEKVTMQNLNDRLASYLENV
                     RALEEANADLEQKIKGWYEKFGPGSCRGLDHDYSRYFPIIDELKNQIISATTSNAHVV
                     LQNDNARLTADDFRLKFENELALHQSVEADINGLRRVLDELTLCRTDLEIQLETLSEE
                     LAYLKKNHEEEMKALQCAAGGNVNVEMNAAPGVDLTVLLNNMRAEYEALAEQNRRDAE
                     AWFNEKSASLQQQISDDAGATTSARNELIEMKRTLQTLEIELQSLLATKHSLECSLTE
                     TESNYCAQLAQIQAQIGALEEQLHQVRTETEGQKLEYEQLLDIKVHLEKEIETYCLLI
                     DGEDGSCSKSKGYGGPGNQTKDSSKTTIVKTVVEEIDPRGKVLSSRVHTVEEKSTKVN
                     NKNEQRVSS"
     exon            502..584
                     /gene="KRT27"
                     /gene_synonym="K25IRS3; KRT25C"
                     /inference="alignment:Splign:2.1.0"
     exon            585..741
                     /gene="KRT27"
                     /gene_synonym="K25IRS3; KRT25C"
                     /inference="alignment:Splign:2.1.0"
     exon            742..903
                     /gene="KRT27"
                     /gene_synonym="K25IRS3; KRT25C"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1029
                     /gene="KRT27"
                     /gene_synonym="K25IRS3; KRT25C"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1247
                     /gene="KRT27"
                     /gene_synonym="K25IRS3; KRT25C"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1297
                     /gene="KRT27"
                     /gene_synonym="K25IRS3; KRT25C"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1628
                     /gene="KRT27"
                     /gene_synonym="K25IRS3; KRT25C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1602..1607
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KRT27"
                     /gene_synonym="K25IRS3; KRT25C"
                     /note="hexamer: AATAAA"
     polyA_site      1628
                     /gene="KRT27"
                     /gene_synonym="K25IRS3; KRT25C"
                     /note="major polyA site"
ORIGIN      
        1 aggccgttca ccatcagagc atcaccgcag aaacaaaggc tccagcctcc ggacaccatg
       61 tctgtgcgct tttcttctac ctccaggaga cttggctctt gcgggggcac tggctctgtg
      121 aggctctcta gtgggggagc aggctttggg gctggaaaca catgcggtgt gccaggcatt
      181 ggaagtggct tctcttgtgc ttttgggggc agctcatctg caggaggcta tggcggaggt
      241 ctgggcgggg gaagtgcttc ctgtgctgcc ttcacaggga atgagcacgg cctcctctct
      301 ggcaatgaga aggtgaccat gcagaacctc aacgaccgct tggcctccta cctggagaat
      361 gttcgagccc tagaggaggc caacgctgac ttggagcaga agatcaaggg gtggtatgag
      421 aaatttggac ctggttcttg ccgtggcctt gatcatgatt acagcagata tttcccaatt
      481 attgacgaac ttaagaacca gataatttct gcaactacca gtaatgccca tgttgtcctg
      541 caaaatgata atgcaagact aacagctgat gacttcagac taaagtttga aaacgagcta
      601 gcgcttcacc agagcgtgga ggcggacatc aatggtttgc gaagagtcct ggatgagctg
      661 accttgtgca gaacggacct ggagatccag ctggaaactc tcagtgagga gctcgcttac
      721 ctcaagaaga atcatgagga ggaaatgaaa gctcttcagt gcgcggctgg aggcaacgtg
      781 aacgtggaga tgaacgcggc ccccggggta gacctcacgg ttctgctgaa caatatgcga
      841 gctgagtacg aagccctcgc agagcagaac cgcagggacg cggaggcctg gttcaacgaa
      901 aagagcgcct cgctgcagca gcagatctct gacgacgctg gcgccaccac ctcagcccgg
      961 aatgagctta tcgagatgaa acgcactctt caaacccttg agattgaact tcagtccctc
     1021 ttagcaacga aacactccct ggagtgctcc ttgacagaga ccgagagtaa ctactgtgca
     1081 cagctggcac agatccaggc tcagatcggg gccctggagg agcagctgca ccaggtcaga
     1141 accgagaccg agggccagaa gctcgagtat gagcagctcc ttgacatcaa ggtccacctg
     1201 gaaaaagaaa ttgagaccta ctgcctcctg atagatggag aagatggctc ctgttctaaa
     1261 tcaaaaggct atggaggccc aggaaatcaa acaaaagatt catctaaaac caccattgtc
     1321 aaaacagttg ttgaagagat agatcctcgt ggcaaagttc tctcatccag agttcacact
     1381 gtggaagaga aatccaccaa agtcaacaac aagaatgaac agagggtgtc ttcctgaact
     1441 ccagcctctg agacagaatg gcccccaaat taaaatacca aaatgaagct agtttcctaa
     1501 ataagggtcc ccttattttt ctgcttttct tccaatgaat taagacaagt tatttttaga
     1561 atagtaccat ttctttggct ttttctctat ggtggtgttt caataaaagt tcttcctgtt
     1621 gcaagtca
//
