LOCUS       NM_181539               1772 bp    mRNA    linear   PRI 12-JUN-2024
DEFINITION  Homo sapiens keratin 26 (KRT26), mRNA.
ACCESSION   NM_181539
VERSION     NM_181539.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1772)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1772)
  AUTHORS   Langbein,L., Rogers,M.A., Praetzel-Wunder,S., Helmke,B.,
            Schirmacher,P. and Schweizer,J.
  TITLE     K25 (K25irs1), K26 (K25irs2), K27 (K25irs3), and K28 (K25irs4)
            represent the type I inner root sheath keratins of the human hair
            follicle
  JOURNAL   J Invest Dermatol 126 (11), 2377-2386 (2006)
   PUBMED   16874310
REFERENCE   3  (bases 1 to 1772)
  AUTHORS   Schweizer,J., Bowden,P.E., Coulombe,P.A., Langbein,L., Lane,E.B.,
            Magin,T.M., Maltais,L., Omary,M.B., Parry,D.A., Rogers,M.A. and
            Wright,M.W.
  TITLE     New consensus nomenclature for mammalian keratins
  JOURNAL   J Cell Biol 174 (2), 169-174 (2006)
   PUBMED   16831889
REFERENCE   4  (bases 1 to 1772)
  AUTHORS   Rogers,M.A., Winter,H., Langbein,L., Bleiler,R. and Schweizer,J.
  TITLE     The human type I keratin gene family: characterization of new hair
            follicle specific members and evaluation of the chromosome 17q21.2
            gene domain
  JOURNAL   Differentiation 72 (9-10), 527-540 (2004)
   PUBMED   15617563
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC090283.7.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 7, 2021 this sequence version replaced NM_181539.4.
            
            Summary: The protein encoded by this gene is a member of the
            keratin superfamily. This keratin protein is a type I keratin that
            is specific for the inner root sheath of the hair follicle. This
            gene exists in a cluster with other keratin genes on chromosome
            17q21. [provided by RefSeq, Jul 2009].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ564205.2, BC136896.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148874, SAMEA2151119
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000335552.5/ ENSP00000334798.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-529               AC090283.7         78532-79060
            530-612             AC090283.7         79497-79579
            613-769             AC090283.7         80324-80480
            770-931             AC090283.7         80611-80772
            932-1057            AC090283.7         80854-80979
            1058-1275           AC090283.7         81637-81854
            1276-1343           AC090283.7         83080-83147
            1344-1772           AC090283.7         84067-84495
FEATURES             Location/Qualifiers
     source          1..1772
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.2"
     gene            1..1772
                     /gene="KRT26"
                     /gene_synonym="CK26; K25B; K25IRS2; K26; KRT25B"
                     /note="keratin 26"
                     /db_xref="GeneID:353288"
                     /db_xref="HGNC:HGNC:30840"
                     /db_xref="MIM:616675"
     exon            1..529
                     /gene="KRT26"
                     /gene_synonym="CK26; K25B; K25IRS2; K26; KRT25B"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..1495
                     /gene="KRT26"
                     /gene_synonym="CK26; K25B; K25IRS2; K26; KRT25B"
                     /note="type I inner root sheath specific keratin 25 irs2;
                     cytokeratin-26; keratin-25B; type I inner root
                     sheath-specific keratin-K25irs2; keratin 26, type I"
                     /codon_start=1
                     /product="keratin, type I cytoskeletal 26"
                     /protein_id="NP_853517.2"
                     /db_xref="CCDS:CCDS11374.1"
                     /db_xref="GeneID:353288"
                     /db_xref="HGNC:HGNC:30840"
                     /db_xref="MIM:616675"
                     /translation="MSFRLSGGSRRICSRTGSGRLSGGGTGFVAGNVCVGSGARSSFS
                     CTLEGISSGGSFCNSGGGLGSGACAGFLGNEHSLLSGNEKVTMQNLNDRLASYLDHVH
                     ALEEANADLEQKIKGWYEKCEPGSSREHDHDYSRYFSVIEDLKRQIISATICNASIVL
                     QNDNARLTADDFRLKYENELALHHSVEADTSGLRRVLDELTLCTTDLEIQCETLSEEL
                     TYLKKSHEEEMEVLQYTAGGNVNVEMNATPGVDLTVLLNNMRAEYEDLAEQNRKDAEA
                     WFNERSATLQQQISDHEGAATAARNELTELKRNLQTLEIELQSLMAVKHSYECSLAET
                     EGNYCNQLQQIQDQIGVMEEQLQQIRTETEGQKLEYEQLLDVKIFLEKEIDIYCNLLD
                     GEERKSKSTCYKSKGYRPVNSGNQAKDSTEETIVKTVVEELDQIGNLLSLRVHSVEEK
                     SSKISNITVEQRVPSKAP"
     exon            530..612
                     /gene="KRT26"
                     /gene_synonym="CK26; K25B; K25IRS2; K26; KRT25B"
                     /inference="alignment:Splign:2.1.0"
     exon            613..769
                     /gene="KRT26"
                     /gene_synonym="CK26; K25B; K25IRS2; K26; KRT25B"
                     /inference="alignment:Splign:2.1.0"
     exon            770..931
                     /gene="KRT26"
                     /gene_synonym="CK26; K25B; K25IRS2; K26; KRT25B"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1057
                     /gene="KRT26"
                     /gene_synonym="CK26; K25B; K25IRS2; K26; KRT25B"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1275
                     /gene="KRT26"
                     /gene_synonym="CK26; K25B; K25IRS2; K26; KRT25B"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1343
                     /gene="KRT26"
                     /gene_synonym="CK26; K25B; K25IRS2; K26; KRT25B"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1772
                     /gene="KRT26"
                     /gene_synonym="CK26; K25B; K25IRS2; K26; KRT25B"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaaaggccaa gggagctaac aagtgtggaa ggtgaaccct ggctttgctc ctctttctgg
       61 gaaggggttg cccggctgtg ctgccaccat gtcttttcga ctttctggtg gatccaggag
      121 gatctgctcg cgaactgggt ctggtaggct gtccggtgga ggaacaggct tcgtggctgg
      181 gaatgtgtgt gttggatcgg gagcaagaag cagcttttct tgtactcttg agggcatctc
      241 ttctggagga agcttctgca atagcggtgg agggttggga agtggtgcct gtgctggttt
      301 tcttggcaat gagcacagcc tcctctctgg gaatgaaaag gtgaccatgc agaatctcaa
      361 cgaccgcctg gcatcctacc tggaccatgt gcatgctcta gaggaggcca acgcagacct
      421 ggagcagaag atcaagggct ggtacgagaa atgtgagcct ggctcttccc gggaacacga
      481 tcatgactat agcagatact tctcagtcat agaagatctt aaaaggcaga ttatttctgc
      541 gaccatctgc aatgccagca ttgttctaca aaatgacaat gccagactga ccgctgatga
      601 cttcaggctg aagtatgaaa atgagctggc tctgcaccac agtgttgagg ccgacaccag
      661 tggtcttcgc agagtgttgg atgaactgac cctttgtaca accgacctgg agatacagtg
      721 tgagaccctc agtgaggaat tgacctacct caaaaaaagt catgaggagg aaatggaagt
      781 cttgcaatat acagctgggg ggaacgtgaa cgtggagatg aatgcaaccc caggagtgga
      841 cctaactgtc ctgttgaaca acatgagggc tgagtatgag gacttggctg agcagaaccg
      901 caaagatgct gaagcctggt tcaacgagag gagtgcaacg ctgcaacaac agatttccga
      961 tcatgaggga gcagccacag cagccagaaa tgagctgacc gaattaaaac gcaatctgca
     1021 aaccctggaa atagaacttc agtccctcat ggctgtgaaa cattcctatg aatgctcctt
     1081 ggctgagact gaaggaaatt actgcaatca actccagcaa attcaggatc agataggggt
     1141 gatggaggaa caactgcaac agattcgaac agaaacagaa ggccagaagc tggagtatga
     1201 acagcttctt gatgtaaaaa tatttttaga aaaagaaatt gacatttatt gcaacttact
     1261 agatggagaa gaaagaaaaa gcaaatccac atgttacaaa tcaaaaggat acaggcctgt
     1321 gaattctgga aatcaagcca aagactcaac agaagaaact attgttaaaa cagtggttga
     1381 ggaactggat caaattggca atctcctttc actgagagtc cactcagttg aagaaaagtc
     1441 ctctaaaata agcaacatta cagtagagca acgagtacct tctaaagcac cataatgagg
     1501 aaaaagttat ttggaaagaa agaaagaaag agagagagag agaaagaaag aaagaaaggc
     1561 tgcctttgca aaaatcctac tggtcaaata acctaaggaa attattcatt tctgttctta
     1621 aaagggctag aatttgttct ccttctcttc cttttctcat gttctatgca tgtaatcctt
     1681 ttccagagta gaaaaatcct gctctgtccc taatttttgt ttttattttg ggggcctttt
     1741 ttgacatttc attaaaaatt cttctattgc aa
//
