LOCUS       NM_019016               1883 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens keratin 24 (KRT24), transcript variant 1, coding,
            mRNA.
ACCESSION   NM_019016
VERSION     NM_019016.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1883)
  AUTHORS   Gul,D., Habtemichael,N., Dietrich,D., Dietrich,J., Gosswein,D.,
            Khamis,A., Deuss,E., Kunzel,J., Schneider,G., Strieth,S. and
            Stauber,R.H.
  TITLE     Identification of cytokeratin24 as a tumor suppressor for the
            management of head and neck cancer
  JOURNAL   Biol Chem 403 (8-9), 869-890 (2021)
   PUBMED   34450690
  REMARK    GeneRIF: Identification of cytokeratin24 as a tumor suppressor for
            the management of head and neck cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1883)
  AUTHORS   Shibata,N., Ishida,H., Kiyokawa,E., Singh,D.P., Sasaki,H. and
            Kubo,E.
  TITLE     Relative gene expression analysis of human pterygium tissues and UV
            radiation-evoked gene expression patterns in corneal and
            conjunctival cells
  JOURNAL   Exp Eye Res 199, 108194 (2020)
   PUBMED   32822701
  REMARK    GeneRIF: Relative gene expression analysis of human pterygium
            tissues and UV radiation-evoked gene expression patterns in corneal
            and conjunctival cells.
REFERENCE   3  (bases 1 to 1883)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1883)
  AUTHORS   Klar,A.S., Michalak,K., Bottcher-Haberzeth,S., Reichmann,E.,
            Meuli,M. and Biedermann,T.
  TITLE     The expression pattern of keratin 24 in tissue-engineered
            dermo-epidermal human skin substitutes in an in vivo model
  JOURNAL   Pediatr Surg Int 34 (2), 237-244 (2018)
   PUBMED   29039047
  REMARK    GeneRIF: the keratinocyte differentiation marker Keratin 24 is
            expressed in our dermo-epidermal skin substitutes in a normal
            pattern. This highlights that our bio-engineered skin analogs
            mature and reach homeostasis in an in vivo assay.
REFERENCE   5  (bases 1 to 1883)
  AUTHORS   Min,M., Chen,X.B., Wang,P., Landeck,L., Chen,J.Q., Li,W., Cai,S.Q.,
            Zheng,M. and Man,X.Y.
  TITLE     Role of keratin 24 in human epidermal keratinocytes
  JOURNAL   PLoS One 12 (3), e0174626 (2017)
   PUBMED   28362807
  REMARK    GeneRIF: K24 may be suggested as a potential differentiation marker
            and anti-proliferative factor in the epidermis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1883)
  AUTHORS   Hong,Y., Ho,K.S., Eu,K.W. and Cheah,P.Y.
  TITLE     A susceptibility gene set for early onset colorectal cancer that
            integrates diverse signaling pathways: implication for
            tumorigenesis
  JOURNAL   Clin Cancer Res 13 (4), 1107-1114 (2007)
   PUBMED   17317818
REFERENCE   7  (bases 1 to 1883)
  AUTHORS   Schweizer,J., Bowden,P.E., Coulombe,P.A., Langbein,L., Lane,E.B.,
            Magin,T.M., Maltais,L., Omary,M.B., Parry,D.A., Rogers,M.A. and
            Wright,M.W.
  TITLE     New consensus nomenclature for mammalian keratins
  JOURNAL   J Cell Biol 174 (2), 169-174 (2006)
   PUBMED   16831889
REFERENCE   8  (bases 1 to 1883)
  AUTHORS   Sprecher,E., Itin,P., Whittock,N.V., McGrath,J.A., Meyer,R.,
            DiGiovanna,J.J., Bale,S.J., Uitto,J. and Richard,G.
  TITLE     Refined mapping of Naegeli-Franceschetti- Jadassohn syndrome to a 6
            cM interval on chromosome 17q11.2-q21 and investigation of
            candidate genes
  JOURNAL   J Invest Dermatol 119 (3), 692-698 (2002)
   PUBMED   12230514
  REMARK    GeneRIF: KRT24 encodes a new keratin protein that bears high
            similarity to the type I keratins and displays a unique expression
            profile; sequence aberrations were not found in
            Naegeli-Franceschetti-Jadassohn syndrome
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC090283.7, AK000268.1 and
            BC111968.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_019016.2.
            
            Summary: This gene encodes a member of the type I (acidic) keratin
            family, which belongs to the superfamily of intermediate filament
            (IF) proteins. Keratins are heteropolymeric structural proteins
            which form the intermediate filament. These filaments, along with
            actin microfilaments and microtubules, compose the cytoskeleton of
            epithelial cells. The type I keratin genes are clustered in a
            region of chromosome 17q12-q21. [provided by RefSeq, Jun 2009].
            
            Transcript Variant: This variant (1, coding) represents the allele
            encoded by the GRCh38 reference genome and encodes isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK000268.1, BC111968.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264651.3/ ENSP00000264651.2
            polymorphic pseudogene :: based on alignments, homology
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AC090283.7         146981-146982
            3-27                AK000268.1         1-25
            28-1709             BC111968.1         1-1682
            1710-1883           AK000268.1         1709-1882
FEATURES             Location/Qualifiers
     source          1..1883
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.2"
     gene            1..1883
                     /gene="KRT24"
                     /gene_synonym="CK-24; K24; KA24"
                     /note="keratin 24"
                     /db_xref="GeneID:192666"
                     /db_xref="HGNC:HGNC:18527"
                     /db_xref="MIM:607742"
     exon            1..674
                     /gene="KRT24"
                     /gene_synonym="CK-24; K24; KA24"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..1637
                     /gene="KRT24"
                     /gene_synonym="CK-24; K24; KA24"
                     /note="cytokeratin-24; type I keratin-24; keratin 24, type
                     I"
                     /codon_start=1
                     /product="keratin, type I cytoskeletal 24"
                     /protein_id="NP_061889.2"
                     /db_xref="CCDS:CCDS11372.1"
                     /db_xref="GeneID:192666"
                     /db_xref="HGNC:HGNC:18527"
                     /db_xref="MIM:607742"
                     /translation="MSCSSRASSSRAGGSSSARVSAGGSSFSSGSRCGLGGSSAQGFR
                     GGASSCSLSGGSSGAFGGSFGGGFGSCSVGGGFGGASGSGTGFGGGSSFGGVSGFGRG
                     SGFCGSSRFSSGATGGFYSYGGGMGGGVGDGGLFSGGEKQTMQNLNDRLANYLDKVRA
                     LEEANTDLENKIKEWYDKYGPGSGDGGSGRDYSKYYSIIEDLRNQIIAATVENAGIIL
                     HIDNARLAADDFRLKYENELCLRQSVEADINGLRKVLDDLTMTRSDLEMQIESFTEEL
                     AYLRKNHEEEMKNMQGSSGGEVTVEMNAAPGTDLTKLLNDMRAQYEELAEQNRREAEE
                     RFNKQSASLQAQISTDAGAATSAKNEITELKRTLQALEIELQSQLAMKSSLEGTLADT
                     EAGYVAQLSEIQTQISALEEEICQIWGETKCQNAEYKQLLDIKTRLEVEIETYRRLLD
                     GEGGGSSFAEFGGRNSGSVNMGSRDLVSGDSRSGSCSGQGRDSSKTRVTKTIVEELVD
                     GKVVSSQVSSISEVKVK"
     exon            675..757
                     /gene="KRT24"
                     /gene_synonym="CK-24; K24; KA24"
                     /inference="alignment:Splign:2.1.0"
     exon            758..914
                     /gene="KRT24"
                     /gene_synonym="CK-24; K24; KA24"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1076
                     /gene="KRT24"
                     /gene_synonym="CK-24; K24; KA24"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1202
                     /gene="KRT24"
                     /gene_synonym="CK-24; K24; KA24"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1420
                     /gene="KRT24"
                     /gene_synonym="CK-24; K24; KA24"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..1533
                     /gene="KRT24"
                     /gene_synonym="CK-24; K24; KA24"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..1883
                     /gene="KRT24"
                     /gene_synonym="CK-24; K24; KA24"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1860..1865
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KRT24"
                     /gene_synonym="CK-24; K24; KA24"
                     /note="hexamer: AATAAA"
     polyA_site      1883
                     /gene="KRT24"
                     /gene_synonym="CK-24; K24; KA24"
                     /note="major polyA site"
ORIGIN      
        1 acactcttcg tcatcacctc tcctattcgc ctggacaagc tcatgtttgc aggagcacca
       61 tgtcttgctc gtctcgcgcc tcctcctcca gggctggagg cagcagctca gccagggtgt
      121 ctgctggtgg aagcagcttc agcagtggaa gcagatgtgg tctggggggc agctcggccc
      181 agggcttccg aggaggagcc agcagctgca gcctgagtgg ggggtctagc ggtgcttttg
      241 ggggcagctt tggagggggc tttggtagct gctcagtagg gggtggtttt gggggagctt
      301 caggctctgg gacaggattt ggtgggggtt ctagctttgg cggggtctct ggatttggca
      361 ggggttctgg attctgtggg agttctagat tcagcagtgg tgctactgga ggcttctaca
      421 gctatggtgg tggtatggga ggtggtgttg gcgatggggg gcttttctct ggaggggaaa
      481 agcaaaccat gcagaacctc aatgaccgct tggccaatta cctagacaag gtcagagccc
      541 tggaggaggc taacactgat ctggagaaca aaatcaagga gtggtatgac aaatatgggc
      601 ctgggtctgg agacggtgga tcgggaagag attatagcaa atactattca ataattgaag
      661 atctcagaaa ccagatcatt gctgccactg ttgaaaatgc tgggatcatt ttgcacattg
      721 acaatgccag attggctgct gatgacttca gactgaagta tgagaacgag ctgtgtctcc
      781 ggcagagcgt ggaggctgac atcaatggcc tgcggaaagt cctggatgac ctgactatga
      841 cccgctctga cctggagatg cagattgaga gtttcaccga ggagctagcc tacctgagga
      901 agaaccacga ggaggaaatg aagaatatgc aaggaagctc tggaggggag gtgaccgtag
      961 aaatgaatgc tgcgccaggg accgacctga ccaaattact gaatgacatg agggcgcagt
     1021 acgaggagct ggctgagcaa aaccgccgag aggctgagga gcggttcaac aagcagagcg
     1081 catcactaca agcacaaatc tccactgatg ctggggcagc cacttctgcc aagaatgaga
     1141 taacagaact aaaacgtacc ctgcaagccc tggaaattga gcttcagtcc caactggcca
     1201 tgaaaagctc cctggaggga accctggctg acacagaagc tggctacgtg gctcagctgt
     1261 cagaaattca aacgcagatc agtgccctgg aggaggagat ctgccagatc tggggtgaga
     1321 ctaaatgcca gaacgcagag tacaagcaat tgctggacat caagacacgc ctggaggtgg
     1381 agatcgagac ctaccgccgc ctgctcgatg gagagggagg tggttctagt tttgcagaat
     1441 ttggtggtag aaactcagga tctgtaaaca tgggatccag ggatctggta tctggtgact
     1501 caagatctgg aagctgttct ggtcaaggac gagattcaag caagactaga gtgactaaga
     1561 ctatcgtaga ggagttggtg gatggcaagg ttgtctcgtc tcaagtcagc agtatttctg
     1621 aggtgaaagt taaataagga acttccagat caacaaaagt gtctttcaaa gaaaaaaaaa
     1681 tcaagaagga cacaagcgaa gaaatggcat caatctaggc atctttctgg ataatttcag
     1741 gaaaagcttc agtccagaaa tggatgacta gccaactttt ctgcatcttc ttatttcctc
     1801 attagaatgc tcttgaaata gctgaattaa caactttgct ttaattgttt ctatgcttca
     1861 ataaatttac ttttgcaagt taa
//
