LOCUS       NM_015515               2209 bp    mRNA    linear   PRI 01-OCT-2024
DEFINITION  Homo sapiens keratin 23 (KRT23), transcript variant 1, mRNA.
ACCESSION   NM_015515 XM_005257198 XM_005277789
VERSION     NM_015515.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2209)
  AUTHORS   Chen,D., Cao,H., Zheng,X., Wang,H., Han,Z. and Wang,W.
  TITLE     Immune checkpoint gene signature assesses immune infiltration
            profiles in bladder cancer and identifies KRT23 as an
            immunotherapeutic target
  JOURNAL   BMC Cancer 24 (1), 1024 (2024)
   PUBMED   39160525
  REMARK    GeneRIF: Immune checkpoint gene signature assesses immune
            infiltration profiles in bladder cancer and identifies KRT23 as an
            immunotherapeutic target.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2209)
  AUTHORS   Ren,M., Gao,Y., Chen,Q., Zhao,H., Zhao,X. and Yue,W.
  TITLE     The Overexpression of Keratin 23 Promotes Migration of Ovarian
            Cancer via Epithelial-Mesenchymal Transition
  JOURNAL   Biomed Res Int 2020, 8218735 (2020)
   PUBMED   33204716
  REMARK    GeneRIF: The Overexpression of Keratin 23 Promotes Migration of
            Ovarian Cancer via Epithelial-Mesenchymal Transition.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2209)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2209)
  AUTHORS   Kim,D., Brocker,C.N., Takahashi,S., Yagai,T., Kim,T., Xie,G.,
            Wang,H., Qu,A. and Gonzalez,F.J.
  TITLE     Keratin 23 Is a Peroxisome Proliferator-Activated Receptor
            Alpha-Dependent, MYC-Amplified Oncogene That Promotes Hepatocyte
            Proliferation
  JOURNAL   Hepatology 70 (1), 154-167 (2019)
   PUBMED   30697791
  REMARK    GeneRIF: highly elevated in hepatocellular carcinoma
REFERENCE   5  (bases 1 to 2209)
  AUTHORS   Kinast,V., Leber,S.L., Brown,R.J.P., Vieyres,G., Behrendt,P.,
            Essbach,C., Strnad,P., Vondran,F.W.R., Cornberg,M., Wex,C.,
            Pietschmann,T., Haybaeck,J., Todt,D. and Steinmann,E.
  TITLE     Identification of Keratin 23 as a Hepatitis C Virus-Induced Host
            Factor in the Human Liver
  JOURNAL   Cells 8 (6), 610 (2019)
   PUBMED   31216713
  REMARK    GeneRIF: AUthors investigated KRT23 mRNA levels in datasets from
            liver biopsies of chronic hepatitis C (CHC) patients and in primary
            human hepatocytes experimentally infected with HCV, in addition to
            hepatoma cells. In each of these specimens, we observed an
            HCV-dependent increase of mRNA levels. Importantly, the KRT23
            protein levels in patient plasma decreased upon viral clearance.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2209)
  AUTHORS   Schweizer,J., Bowden,P.E., Coulombe,P.A., Langbein,L., Lane,E.B.,
            Magin,T.M., Maltais,L., Omary,M.B., Parry,D.A., Rogers,M.A. and
            Wright,M.W.
  TITLE     New consensus nomenclature for mammalian keratins
  JOURNAL   J Cell Biol 174 (2), 169-174 (2006)
   PUBMED   16831889
REFERENCE   7  (bases 1 to 2209)
  AUTHORS   Suzuki,A., Ji,G., Numabe,Y., Muramatsu,M., Gomi,K., Kanazashi,M.,
            Ogata,Y., Shimizu,E., Shibukawa,Y., Ito,A., Ito,T., Sugaya,A.,
            Arai,T., Yamada,S., Deguchi,S. and Kamoi,K.
  TITLE     Single nucleotide polymorphisms associated with aggressive
            periodontitis and severe chronic periodontitis in Japanese
  JOURNAL   Biochem Biophys Res Commun 317 (3), 887-892 (2004)
   PUBMED   15081423
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 2209)
  AUTHORS   Tolstonog,G.V., Sabasch,M. and Traub,P.
  TITLE     Cytoplasmic intermediate filaments are stably associated with
            nuclear matrices and potentially modulate their DNA-binding
            function
  JOURNAL   DNA Cell Biol 21 (3), 213-239 (2002)
   PUBMED   12015898
REFERENCE   9  (bases 1 to 2209)
  AUTHORS   Hesse,M., Magin,T.M. and Weber,K.
  TITLE     Genes for intermediate filament proteins and the draft sequence of
            the human genome: novel keratin genes and a surprisingly high
            number of pseudogenes related to keratin genes 8 and 18
  JOURNAL   J Cell Sci 114 (Pt 14), 2569-2575 (2001)
   PUBMED   11683385
REFERENCE   10 (bases 1 to 2209)
  AUTHORS   Zhang,J.S., Wang,L., Huang,H., Nelson,M. and Smith,D.I.
  TITLE     Keratin 23 (K23), a novel acidic keratin, is highly induced by
            histone deacetylase inhibitors during differentiation of pancreatic
            cancer cells
  JOURNAL   Genes Chromosomes Cancer 30 (2), 123-135 (2001)
   PUBMED   11135429
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Michael Rogers. The reference sequence was
            derived from AC004231.2, DA846104.1, BC028356.2 and AA649738.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 31, 2019 this sequence version replaced NM_015515.4.
            
            Summary: The protein encoded by this gene is a member of the
            keratin family. The keratins are intermediate filament proteins
            responsible for the structural integrity of epithelial cells and
            are subdivided into cytokeratins and hair keratins. The type I
            cytokeratins consist of acidic proteins which are arranged in pairs
            of heterotypic keratin chains. The type I cytokeratin genes are
            clustered in a region of chromosome 17q12-q21. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Sep
            2013].
            
            Transcript Variant: This variant (1) encodes the larger isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC028356.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000209718.8/ ENSP00000209718.3
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-301               AC004231.2         26296-26596
            302-791             AC004231.2         26989-27478
            792-1345            DA846104.1         1-554
            1346-1828           BC028356.2         1123-1605
            1829-2057           AC004231.2         40862-41090
            2058-2209           AA649738.1         141-292
FEATURES             Location/Qualifiers
     source          1..2209
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.2"
     gene            1..2209
                     /gene="KRT23"
                     /gene_synonym="CK23; HAIK1; K23"
                     /note="keratin 23"
                     /db_xref="GeneID:25984"
                     /db_xref="HGNC:HGNC:6438"
                     /db_xref="MIM:606194"
     exon            1..301
                     /gene="KRT23"
                     /gene_synonym="CK23; HAIK1; K23"
                     /inference="alignment:Splign:2.1.0"
     exon            302..1047
                     /gene="KRT23"
                     /gene_synonym="CK23; HAIK1; K23"
                     /inference="alignment:Splign:2.1.0"
     CDS             652..1920
                     /gene="KRT23"
                     /gene_synonym="CK23; HAIK1; K23"
                     /note="isoform 1 is encoded by transcript variant 1;
                     histone deacetylase inducible keratin 23;
                     hyperacetylation-inducible type I keratin; keratin, type I
                     cytoskeletal 23; cytokeratin 23; type I intermediate
                     filament cytokeratin; CK-23; keratin 23 (histone
                     deacetylase inducible); keratin 23, type I"
                     /codon_start=1
                     /product="keratin, type I cytoskeletal 23 isoform 1"
                     /protein_id="NP_056330.3"
                     /db_xref="CCDS:CCDS11380.1"
                     /db_xref="GeneID:25984"
                     /db_xref="HGNC:HGNC:6438"
                     /db_xref="MIM:606194"
                     /translation="MNSGHSFSQTPSASFHGAGGGWGRPRSFPRAPTVHGGAGGARIS
                     LSFTTRSCPPPGGSWGSGRSSPLLGGNGKATMQNLNDRLASYLEKVRALEEANMKLES
                     RILKWHQQRDPGSKKDYSQYEENITHLQEQIVDGKMTNAQIILLIDNARMAVDDFNLK
                     YENEHSFKKDLEIEVEGLRRTLDNLTIVTTDLEQEVEGMRKELILMKKHHEQEMEKHH
                     VPSDFNVNVKVDTGPREDLIKVLEDMRQEYELIIKKKHRDLDTWYKEQSAAMSQEAAS
                     PATVQSRQGDIHELKRTFQALEIDLQTQYSTKSALENMLSETQSRYSCKLQDMQEIIS
                     HYEEELTQLRHELERQNNEYQVLLGIKTHLEKEITTYRRLLEGESEGTREESKSSMKV
                     SATPKIKAITQETINGRLVLCQVNEIQKHA"
     exon            1048..1130
                     /gene="KRT23"
                     /gene_synonym="CK23; HAIK1; K23"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1287
                     /gene="KRT23"
                     /gene_synonym="CK23; HAIK1; K23"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1449
                     /gene="KRT23"
                     /gene_synonym="CK23; HAIK1; K23"
                     /inference="alignment:Splign:2.1.0"
     exon            1450..1572
                     /gene="KRT23"
                     /gene_synonym="CK23; HAIK1; K23"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..1793
                     /gene="KRT23"
                     /gene_synonym="CK23; HAIK1; K23"
                     /inference="alignment:Splign:2.1.0"
     exon            1794..1825
                     /gene="KRT23"
                     /gene_synonym="CK23; HAIK1; K23"
                     /inference="alignment:Splign:2.1.0"
     exon            1826..2209
                     /gene="KRT23"
                     /gene_synonym="CK23; HAIK1; K23"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2191..2196
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KRT23"
                     /gene_synonym="CK23; HAIK1; K23"
                     /note="hexamer: AATAAA"
     polyA_site      2209
                     /gene="KRT23"
                     /gene_synonym="CK23; HAIK1; K23"
                     /note="major polyA site"
ORIGIN      
        1 agtaactagc acgtggctcc cgcccccaga ctgcttcttt attcattcct aacctttacc
       61 ttggcagatg aaatataaga ttcatcaacc acatttgaca gcccatggca ggtttcctgt
      121 tttccatcgt ccctctgcag gtcacagaca cacagagccc agccgtggca ggctcagccg
      181 gggtccgggg ctgctaacaa cggctacatt cctcccccag ggccaaggga aatcctgagc
      241 gcaggccagg gttgtttggt tttgaggtgt gctgggatga aaggcaccct ggaagtggaa
      301 ggtaaatgaa caatggaaaa acttcacggc aagattagaa agatacctga gcccaatacc
      361 cgcctgatgt cgtgggccac acctccgggt taccagggga agggaggaag caaactgtca
      421 tattgatgtg gctctaaaca acaacagtgt gcgaaggccc aggggcactt tgggattgac
      481 caagaggaaa cacaagttgc acaatgatac aatcttgttg gtacaattgt cagagaaggg
      541 aactcccaca gcaaaggcca taaaaccatc cagggcagtc tggggcggct cagttctgcg
      601 gtgccaggga gtggagcaga gctcagcccc gtcccaaaca cagatgggac catgaactcc
      661 ggacacagct tcagccagac cccctcggcc tccttccatg gcgccggagg tggctggggc
      721 cggcccagga gcttccccag ggctcccacc gtccatggcg gtgcgggggg agcccgcatc
      781 tccctgtcct tcaccacgcg gagctgccca ccccctggag ggtcttgggg ttctggaaga
      841 agcagccccc tactaggcgg aaatgggaag gccaccatgc agaatctcaa cgaccgcctg
      901 gcctcctacc tggagaaggt tcgcgccctg gaggaggcca acatgaagct ggaaagccgc
      961 atcctgaaat ggcaccagca gagagatcct ggcagtaaga aagattattc ccagtatgag
     1021 gaaaacatca cacacctgca ggagcagata gtggatggta agatgaccaa tgctcagatt
     1081 attcttctca ttgacaatgc caggatggca gtggatgact tcaacctcaa gtatgaaaat
     1141 gaacactcct ttaagaaaga cttggaaatt gaagtcgagg gcctccgaag gaccttagac
     1201 aacctgacca ttgtcacaac agacctagaa caggaggtgg aaggaatgag gaaagagctc
     1261 attctcatga agaagcacca tgagcaggaa atggagaagc atcatgtgcc aagtgacttc
     1321 aatgtcaatg tgaaggtgga tacaggtccc agggaagatc tgattaaggt cctggaggat
     1381 atgagacaag aatatgagct tataataaag aagaagcatc gagacttgga cacttggtat
     1441 aaagaacagt ctgcagccat gtcccaggag gcagccagtc cagccactgt gcagagcaga
     1501 caaggtgaca tccacgaact gaagcgcaca ttccaggccc tggagattga cctgcagaca
     1561 cagtacagca cgaaatctgc tttggaaaac atgttatccg agacccagtc tcggtactcc
     1621 tgcaagctcc aggacatgca agagatcatc tcccactatg aggaggaact gacgcagcta
     1681 cgccatgaac tggagcggca gaacaatgaa taccaagtgc tgctgggcat caaaacccac
     1741 ctggagaagg aaatcaccac gtaccgacgg ctcctggagg gagagagtga agggacacgg
     1801 gaagaatcaa agtcgagcat gaaagtgtct gcaactccaa agatcaaggc cataacccag
     1861 gagaccatca acggaagatt agttctttgt caagtgaatg aaatccaaaa gcacgcatga
     1921 gaccaatgaa agtttccgcc tgttgtaaaa tctattttcc cccaaggaaa gtccttgcac
     1981 agacaccagt gagtgagttc taaaagatac ccttggaatt atcagactca gaaactttta
     2041 tttttttttt ctgtaacagt ctcaccagac ttctcataat gctcttaata tattgcactt
     2101 ttctaatcaa agtgcgagtt tatgagggta aagctctact ttcctactgc agccttcaga
     2161 ttctcatcat tttgcatcta ttttgtagcc aataaaactc cgcactagc
//
