LOCUS       NM_152349               2703 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens keratin 222 (KRT222), mRNA.
ACCESSION   NM_152349
VERSION     NM_152349.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2703)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 2703)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2703)
  AUTHORS   Schweizer,J., Bowden,P.E., Coulombe,P.A., Langbein,L., Lane,E.B.,
            Magin,T.M., Maltais,L., Omary,M.B., Parry,D.A., Rogers,M.A. and
            Wright,M.W.
  TITLE     New consensus nomenclature for mammalian keratins
  JOURNAL   J Cell Biol 174 (2), 169-174 (2006)
   PUBMED   16831889
REFERENCE   4  (bases 1 to 2703)
  AUTHORS   Hesse,M., Zimek,A., Weber,K. and Magin,T.M.
  TITLE     Comprehensive analysis of keratin gene clusters in humans and
            rodents
  JOURNAL   Eur J Cell Biol 83 (1), 19-26 (2004)
   PUBMED   15085952
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC073508.7, DB465511.1, BC032815.1, DB543411.1 and CV570846.1.
            
            On Nov 23, 2018 this sequence version replaced NM_152349.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.27660.1,
                                           SRR1803611.124566.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000394052.5/ ENSP00000377616.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                AC073508.7         73118-73130         c
            14-174              DB465511.1         1-161
            175-1103            BC032815.1         121-1049
            1104-1207           DB543411.1         351-454
            1208-1748           CV570846.1         63-603
            1749-2703           AC073508.7         62618-63572         c
FEATURES             Location/Qualifiers
     source          1..2703
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.2"
     gene            1..2703
                     /gene="KRT222"
                     /gene_synonym="KA21; KRT222P"
                     /note="keratin 222"
                     /db_xref="GeneID:125113"
                     /db_xref="HGNC:HGNC:28695"
     exon            1..174
                     /gene="KRT222"
                     /gene_synonym="KA21; KRT222P"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..966
                     /gene="KRT222"
                     /gene_synonym="KA21; KRT222P"
                     /note="keratin-222 pseudogene; keratin 222, type II"
                     /codon_start=1
                     /product="keratin-like protein KRT222"
                     /protein_id="NP_689562.1"
                     /db_xref="CCDS:CCDS11371.1"
                     /db_xref="GeneID:125113"
                     /db_xref="HGNC:HGNC:28695"
                     /translation="MELSQLLNEIRANYEKILTRNQIETVLSTRIQLEEDISKKMDKD
                     EEALKAAQAELKEARRQWHHLQVEIESLHAVERGLENSLHASEQHYQMQLQDLETVIE
                     GLEKELQEVRRGIEKQLQEHEMLLNTKMRLEQEIATYRHLLEKEEIRYYGCIQGGKKD
                     KKPTTSRVGFVLPSAIINEISFTTKVPQKYENENVETVTKQAILNGSIVKESTEAHGT
                     IQTEKVDEVIKEWEGSFFKDNPRLRKKSVSLRFDLHLAATDEGCLETKQDNLPDIEVR
                     LIMRRSCSIPSIKPPSTAN"
     exon            175..303
                     /gene="KRT222"
                     /gene_synonym="KA21; KRT222P"
                     /inference="alignment:Splign:2.1.0"
     exon            304..524
                     /gene="KRT222"
                     /gene_synonym="KA21; KRT222P"
                     /inference="alignment:Splign:2.1.0"
     exon            525..601
                     /gene="KRT222"
                     /gene_synonym="KA21; KRT222P"
                     /inference="alignment:Splign:2.1.0"
     exon            602..737
                     /gene="KRT222"
                     /gene_synonym="KA21; KRT222P"
                     /inference="alignment:Splign:2.1.0"
     exon            738..2703
                     /gene="KRT222"
                     /gene_synonym="KA21; KRT222P"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1113..1118
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KRT222"
                     /gene_synonym="KA21; KRT222P"
                     /note="hexamer: AATAAA"
     polyA_site      1138
                     /gene="KRT222"
                     /gene_synonym="KA21; KRT222P"
                     /note="major polyA site"
     regulatory      1191..1196
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KRT222"
                     /gene_synonym="KA21; KRT222P"
                     /note="hexamer: AATAAA"
     polyA_site      1208
                     /gene="KRT222"
                     /gene_synonym="KA21; KRT222P"
     regulatory      1986..1991
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KRT222"
                     /gene_synonym="KA21; KRT222P"
                     /note="hexamer: AATAAA"
     polyA_site      2006
                     /gene="KRT222"
                     /gene_synonym="KA21; KRT222P"
     regulatory      2680..2685
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KRT222"
                     /gene_synonym="KA21; KRT222P"
                     /note="hexamer: AATAAA"
     polyA_site      2703
                     /gene="KRT222"
                     /gene_synonym="KA21; KRT222P"
ORIGIN      
        1 gcgcagaccg agcagactgc cgcagcgact catcctatcg ataaggttca gttagccaag
       61 gtggaggatg ggaaaagaat ggaactgtcc cagctactca atgagatcag ggcaaactat
      121 gaaaagatcc tcaccagaaa tcagatagag acggtgctct caacaaggat ccagctagaa
      181 gaagacataa gcaaaaaaat ggacaaagat gaagaggctt tgaaggcagc tcaagcagaa
      241 ctcaaggagg cccgacgcca gtggcaccac ctgcaagtgg aaattgaatc tctccatgct
      301 gtggaaaggg gccttgaaaa ctccctacat gccagcgagc agcattacca gatgcagctg
      361 caagacctag agactgtgat tgaaggacta gaaaaagagc tacaggaagt aaggcgcggc
      421 atcgaaaagc agcttcaaga gcacgagatg cttctcaaca cgaagatgag gctggaacaa
      481 gaaatagcaa cttatcgcca cctcctagaa aaagaagaaa tcagatatta tggttgtatc
      541 caaggtggga aaaaagacaa aaagcctacc acaagtagag ttggttttgt tttaccatca
      601 gccattataa atgaaatatc ttttactaca aaagtcccac aaaagtatga gaatgaaaat
      661 gtagaaacag taaccaaaca ggcaatctta aatgggagta tcgttaagga gagcactgaa
      721 gctcatggca ctattcagac agagaaagtg gatgaagtta ttaaagaatg ggaaggttct
      781 ttctttaaag ataaccctcg attgaggaaa aagtctgttt ctcttcgatt tgatcttcat
      841 ttagcagcca ctgatgaagg gtgtttagag actaagcagg ataatctacc agatatagaa
      901 gtcaggctta tcatgagaag atcatgcagt attccctcta tcaaacctcc atcaacagct
      961 aattaatcca aagatagtat ttgacttgat tggaaaatgt taggatggac caaggtgggc
     1021 cataccaact ccctctgtcc caaaatgtaa gttattacgt atgtatggaa aatgttatga
     1081 tcaatatgtg gttctcttca gaagaaaaaa acaataaagg acatttctct gaatctaatt
     1141 atggagatag acatatatat atatatatga atgagaggga gtagcttaaa aataaaatca
     1201 caaatccagt acagtctctt tctttatatt ctcccaatag tcttcttttt cccttgaaac
     1261 ttcatcagag actgtaagca ttaacctggt ttagtaaagt ctttgtaatt tttttcaatg
     1321 gctgaatacg ctaaggaaaa aagaattgtt tgaataggat tgtgttaaga gtcacactga
     1381 gttattcacc attattccat gactggttaa acctacaatg tttgttctat ttttcaaaaa
     1441 gagcaattat aaacaagttt ttaaaggggg actcactatt cacctaatga ggattcttct
     1501 ttttgagata aatcatttgt atactgagaa aaatgagtta ttttccatga gaaattctga
     1561 gcaaactata gaacacaccc cagggctaat ttgagataag tacaattaag ttaatctaca
     1621 tatatctaaa aggttttttt tgtaataagt atctgatttc cggaagattt actttactca
     1681 aggaacttta aaggttgtat cccccaccaa aaaaagaaaa aaaatcagaa ggccaactgc
     1741 gcaaacaaaa catgaaaagc aaattgaaaa ggtagttact atagttatca gaacagttac
     1801 ccaccatccc agtttttcca actgtaaagc taaatgtgat tagattgttt gctataagcc
     1861 gtagataaga tactatatga agtattataa atatttcttg caatcattta tgtgaactaa
     1921 gataacggta ttgttatcta agctaagagt atttagagga tttgttttta aatcgttcaa
     1981 attgtaataa atatgggtag aaaatatatt tgtgaataag tgaggtattg ttgcaaagtt
     2041 tttaaaataa cctaatttgt ttaatacagg tatatttaag atcttaataa atacctgttt
     2101 taagacatta gaaatttata agttcttaat tcttttctaa gcagaaaaag tagctgagta
     2161 caactcacca tactttttcc cagctaaagt atcatctaag ggctatagct acgttagcat
     2221 tttagtacag cctttaaaat atttctctct ctctctcctc tctcttctcc tctatctctc
     2281 tctccatata tacttattat atatatacat atatataatt tatatatatg tatatatata
     2341 tttcaaccag aaaaatgtat gttttaacca ggaaaatatt atgttaaata atctttaaca
     2401 taatacaggg atataaaatt tttaattttc tttcaattac ttcagattcc ttttagtctg
     2461 gtttattcta tttagtgaaa agggatgatt ttgttttgtc aaggatataa cagcatgtta
     2521 agtgcttatt cttgcataag catctgacct aaaatacatc ctatacataa aaaatgtttc
     2581 atttgatatt gctaaatgct actaacttta ttaaagcttt aaaaatgcaa tcatataagc
     2641 tattgtacta aagttactgt actaagcaac agtgatcata ataaagcaat atatctagca
     2701 taa
//
