LOCUS       NM_019010               1804 bp    mRNA    linear   PRI 11-SEP-2024
DEFINITION  Homo sapiens keratin 20 (KRT20), mRNA.
ACCESSION   NM_019010
VERSION     NM_019010.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1804)
  AUTHORS   Ismael,A.T., Abdulhameed,R.A., Jalal,J.A., Tawfeeq,R.D., Ommar,A.
            and Jalal,A.
  TITLE     Expression of cytokeratin 7/20 and Ki67 in Helicobacter
            pylori-associated gastritis and intestinal metaplasia
  JOURNAL   J Infect Dev Ctries 18 (7), 1032-1040 (2024)
   PUBMED   39078783
  REMARK    GeneRIF: Expression of cytokeratin 7/20 and Ki67 in Helicobacter
            pylori-associated gastritis and intestinal metaplasia.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1804)
  AUTHORS   Bommannan,K., Arumugam,J.R., Radhakrishnan,V. and Sundersingh,S.
  TITLE     Relevance of CD20 antigen expression among paediatric patients with
            B-lineage acute lymphoblastic leukaemia
  JOURNAL   Br J Haematol 204 (4), 1367-1374 (2024)
   PUBMED   38444113
  REMARK    GeneRIF: Relevance of CD20 antigen expression among paediatric
            patients with B-lineage acute lymphoblastic leukaemia.
REFERENCE   3  (bases 1 to 1804)
  AUTHORS   Schuster,S.J., Huw,L.Y., Bolen,C.R., Maximov,V., Polson,A.G.,
            Hatzi,K., Lasater,E.A., Assouline,S.E., Bartlett,N.L., Budde,L.E.,
            Matasar,M.J., Koeppen,H., Piccione,E.C., Wilson,D., Wei,M.C.,
            Yin,S. and Penuel,E.
  TITLE     Loss of CD20 expression as a mechanism of resistance to
            mosunetuzumab in relapsed/refractory B-cell lymphomas
  JOURNAL   Blood 143 (9), 822-832 (2024)
   PUBMED   38048694
  REMARK    GeneRIF: Loss of CD20 expression as a mechanism of resistance to
            mosunetuzumab in relapsed/refractory B-cell lymphomas.
REFERENCE   4  (bases 1 to 1804)
  AUTHORS   Asgari,M., Firouzi,F., Abolhasani,M., Bahadoram,M., Barahman,M.,
            Madjd,Z., Mehrazam,M., Hassanzadeh,S. and Akade,E.
  TITLE     P53, CK20, and FGFR3 Overexpression is Associated with the
            Characteristics of Urothelial Cell Carcinoma of the Bladder
  JOURNAL   Asian Pac J Cancer Prev 24 (9), 3125-3131 (2023)
   PUBMED   37774064
  REMARK    GeneRIF: The Association of P53, CK29, and FGFR3 Overexpression
            with the Characteristics of Urothelial Cell Carcinoma of the
            Bladder.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1804)
  AUTHORS   Kaku,H., Aoyagi,K., Sudo,T., Tanaka,Y., Minami,T., Isobe,T.,
            Kizaki,J., Umetani,Y., Murakami,N., Fujita,F. and Akagi,Y.
  TITLE     Significance of Intraperitoneal-free KRT20 and CEACAM6 mRNA
            Expression for Peritoneal Recurrence of Gastric Cancer
  JOURNAL   Anticancer Res 42 (8), 4003-4010 (2022)
   PUBMED   35896219
  REMARK    GeneRIF: Significance of Intraperitoneal-free KRT20 and CEACAM6
            mRNA Expression for Peritoneal Recurrence of Gastric Cancer.
REFERENCE   6  (bases 1 to 1804)
  AUTHORS   Rogers,M.A., Langbein,L., Winter,H., Ehmann,C., Praetzel,S.,
            Korn,B. and Schweizer,J.
  TITLE     Characterization of a cluster of human high/ultrahigh sulfur
            keratin-associated protein genes embedded in the type I keratin
            gene domain on chromosome 17q12-21
  JOURNAL   J Biol Chem 276 (22), 19440-19451 (2001)
   PUBMED   11279113
REFERENCE   7  (bases 1 to 1804)
  AUTHORS   Barrett,A.W., Cort,E.M., Patel,P. and Berkovitz,B.K.
  TITLE     An immunohistological study of cytokeratin 20 in human and
            mammalian oral epithelium
  JOURNAL   Arch Oral Biol 45 (10), 879-887 (2000)
   PUBMED   10973561
REFERENCE   8  (bases 1 to 1804)
  AUTHORS   Moll,R., Zimbelmann,R., Goldschmidt,M.D., Keith,M., Laufer,J.,
            Kasper,M., Koch,P.J. and Franke,W.W.
  TITLE     The human gene encoding cytokeratin 20 and its expression during
            fetal development and in gastrointestinal carcinomas
  JOURNAL   Differentiation 53 (2), 75-93 (1993)
   PUBMED   8359595
REFERENCE   9  (bases 1 to 1804)
  AUTHORS   Calnek,D. and Quaroni,A.
  TITLE     Differential localization by in situ hybridization of distinct
            keratin mRNA species during intestinal epithelial cell development
            and differentiation
  JOURNAL   Differentiation 53 (2), 95-104 (1993)
   PUBMED   7689500
REFERENCE   10 (bases 1 to 1804)
  AUTHORS   Moll,R., Schiller,D.L. and Franke,W.W.
  TITLE     Identification of protein IT of the intestinal cytoskeleton as a
            novel type I cytokeratin with unusual properties and expression
            patterns
  JOURNAL   J Cell Biol 111 (2), 567-580 (1990)
   PUBMED   1696264
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Michael Rogers. The reference sequence was
            derived from DA426874.1, BC031559.1 and DB242980.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_019010.2.
            
            Summary: The protein encoded by this gene is a member of the
            keratin family. The keratins are intermediate filament proteins
            responsible for the structural integrity of epithelial cells and
            are subdivided into cytokeratins and hair keratins. The type I
            cytokeratins consist of acidic proteins which are arranged in pairs
            of heterotypic keratin chains. This cytokeratin is a major cellular
            protein of mature enterocytes and goblet cells and is specifically
            expressed in the gastric and intestinal mucosa. The type I
            cytokeratin genes are clustered in a region of chromosome
            17q12-q21. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK312744.1, BC031559.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2152474
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000167588.4/ ENSP00000167588.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                DA426874.1         2-16
            16-1752             BC031559.1         1-1737
            1753-1804           DB242980.1         518-569
FEATURES             Location/Qualifiers
     source          1..1804
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.2"
     gene            1..1804
                     /gene="KRT20"
                     /gene_synonym="CD20; CK-20; CK20; K20; KRT21"
                     /note="keratin 20"
                     /db_xref="GeneID:54474"
                     /db_xref="HGNC:HGNC:20412"
                     /db_xref="MIM:608218"
     exon            1..447
                     /gene="KRT20"
                     /gene_synonym="CD20; CK-20; CK20; K20; KRT21"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..1332
                     /gene="KRT20"
                     /gene_synonym="CD20; CK-20; CK20; K20; KRT21"
                     /note="cytokeratin 20; keratin, type I cytoskeletal 20;
                     protein IT; keratin 20, type I"
                     /codon_start=1
                     /product="keratin, type I cytoskeletal 20 precursor"
                     /protein_id="NP_061883.1"
                     /db_xref="CCDS:CCDS11379.1"
                     /db_xref="GeneID:54474"
                     /db_xref="HGNC:HGNC:20412"
                     /db_xref="MIM:608218"
                     /translation="MDFSRRSFHRSLSSSLQAPVVSTVGMQRLGTTPSVYGGAGGRGI
                     RISNSRHTVNYGSDLTGGGDLFVGNEKMAMQNLNDRLASYLEKVRTLEQSNSKLEVQI
                     KQWYETNAPRAGRDYSAYYRQIEELRSQIKDAQLQNARCVLQIDNAKLAAEDFRLKYE
                     TERGIRLTVEADLQGLNKVFDDLTLHKTDLEIQIEELNKDLALLKKEHQEEVDGLHKH
                     LGNTVNVEVDAAPGLNLGVIMNEMRQKYEVMAQKNLQEAKEQFERQTAVLQQQVTVNT
                     EELKGTEVQLTELRRTSQSLEIELQSHLSMKESLEHTLEETKARYSSQLANLQSLLSS
                     LEAQLMQIRSNMERQNNEYHILLDIKTRLEQEIATYRRLLEGEDVKTTEYQLSTLEER
                     DIKKTRKIKTVVQEVVDGKVVSSEVKEVEENI"
     exon            448..530
                     /gene="KRT20"
                     /gene_synonym="CD20; CK-20; CK20; K20; KRT21"
                     /inference="alignment:Splign:2.1.0"
     exon            531..687
                     /gene="KRT20"
                     /gene_synonym="CD20; CK-20; CK20; K20; KRT21"
                     /inference="alignment:Splign:2.1.0"
     exon            688..849
                     /gene="KRT20"
                     /gene_synonym="CD20; CK-20; CK20; K20; KRT21"
                     /inference="alignment:Splign:2.1.0"
     exon            850..975
                     /gene="KRT20"
                     /gene_synonym="CD20; CK-20; CK20; K20; KRT21"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1196
                     /gene="KRT20"
                     /gene_synonym="CD20; CK-20; CK20; K20; KRT21"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1234
                     /gene="KRT20"
                     /gene_synonym="CD20; CK-20; CK20; K20; KRT21"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1804
                     /gene="KRT20"
                     /gene_synonym="CD20; CK-20; CK20; K20; KRT21"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1498..1503
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KRT20"
                     /gene_synonym="CD20; CK-20; CK20; K20; KRT21"
                     /note="hexamer: TATAAA"
     polyA_site      1516
                     /gene="KRT20"
                     /gene_synonym="CD20; CK-20; CK20; K20; KRT21"
     regulatory      1718..1723
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KRT20"
                     /gene_synonym="CD20; CK-20; CK20; K20; KRT21"
                     /note="hexamer: AATAAA"
     polyA_site      1738
                     /gene="KRT20"
                     /gene_synonym="CD20; CK-20; CK20; K20; KRT21"
                     /note="major polyA site"
ORIGIN      
        1 agacacactc tgccccaacc atcctgaagc tacaggtgct ccctcctgga atctccaatg
       61 gatttcagtc gcagaagctt ccacagaagc ctgagctcct ccttgcaggc ccctgtagtc
      121 agtacagtgg gcatgcagcg cctcgggacg acacccagcg tttatggggg tgctggaggc
      181 cggggcatcc gcatctccaa ctccagacac acggtgaact atgggagcga tctcacaggc
      241 ggcggggacc tgtttgttgg caatgagaaa atggccatgc agaacctaaa tgaccgtcta
      301 gcgagctacc tagaaaaggt gcggaccctg gagcagtcca actccaaact tgaagtgcaa
      361 atcaagcagt ggtacgaaac caacgccccg agggctggtc gcgactacag tgcatattac
      421 agacaaattg aagagctgcg aagtcagatt aaggatgctc aactgcaaaa tgctcggtgt
      481 gtcctgcaaa ttgataatgc taaactggct gctgaggact tcagactgaa gtatgagact
      541 gagagaggaa tacgtctaac agtggaagct gatctccaag gcctgaataa ggtctttgat
      601 gacctaaccc tacataaaac agatttggag attcaaattg aagaactgaa taaagaccta
      661 gctctcctca aaaaggagca tcaggaggaa gtcgatggcc tacacaagca tctgggcaac
      721 actgtcaatg tggaggttga tgctgctcca ggcctgaacc ttggcgtcat catgaatgaa
      781 atgaggcaga agtatgaagt catggcccag aagaaccttc aagaggccaa agaacagttt
      841 gagagacaga ctgcagttct gcagcaacag gtcacagtga atactgaaga attaaaagga
      901 actgaggttc aactaacgga gctgagacgc acctcccaga gccttgagat agaactccag
      961 tcccatctca gcatgaaaga gtctttggag cacactctag aggagaccaa ggcccgttac
     1021 agcagccagt tagccaacct ccagtcgctg ttgagctctc tggaggccca actgatgcag
     1081 attcggagta acatggaacg ccagaacaac gaataccata tccttcttga cataaagact
     1141 cgacttgaac aggaaattgc tacttaccgc cgccttctgg aaggagaaga cgtaaaaact
     1201 acagaatatc agttaagcac cctggaagag agagatataa agaaaaccag gaagattaag
     1261 acagtcgtgc aagaagtagt ggatggcaag gtcgtgtcat ctgaagtcaa agaggtggaa
     1321 gaaaatatct aaatagctac cagaaggaga tgctgctgag gttttgaaag aaatttggct
     1381 ataatcttat ctttgctccc tgcaagaaat cagccataag aaagcactat taatactctg
     1441 cagtgattag aaggggtggg gtggcgggaa tcctatttat cagactctgt aattgaatat
     1501 aaatgtttta ctcagaggag ctgcaaattg cctgcaaaaa tgaaatccag tgagcactag
     1561 aatatttaaa acatcattac tgccatcttt atcatgaagc acatcaatta caagctgtag
     1621 accacctaat atcaatttgt aggtaatgtt cctgaaaatt gcaatacatt tcaattatac
     1681 taaacctcac aaagtagagg aatccatgta aattgcaaat aaaccacttt ctaatttttt
     1741 cctgtttctg aattgtaaaa ccccctttgg gagtccctgg tttcttattg agccaatttc
     1801 tggg
//
