LOCUS       NM_002276               1390 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens keratin 19 (KRT19), mRNA.
ACCESSION   NM_002276
VERSION     NM_002276.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1390)
  AUTHORS   Rao,Y., Li,J., Shi,L., Chen,X., Hu,Y., Mao,Y., Zhang,X. and Liu,X.
  TITLE     Silencing CK19 regulates ferroptosis by affecting the expression of
            GPX4 and ACSL4 in oral squamous cell carcinoma in vivo and in vitro
  JOURNAL   Sci Rep 14 (1), 15968 (2024)
   PUBMED   38987531
  REMARK    GeneRIF: Silencing CK19 regulates ferroptosis by affecting the
            expression of GPX4 and ACSL4 in oral squamous cell carcinoma in
            vivo and in vitro.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1390)
  AUTHORS   Taher,M.Y., Hassouna,E.M., El-Hadidi,A.S., El-Aassar,O.S. and
            Bakosh,M.F.
  TITLE     Predictive Value of Serum CYFRA 21-1 and CK19-2G2 for Tumor
            Aggressiveness and Overall Survival in Hepatitis C-Related
            Hepatocellular Carcinoma Among Egyptians: A Prospective Study
  JOURNAL   J Gastrointest Cancer 55 (2), 749-758 (2024)
   PUBMED   38231289
  REMARK    GeneRIF: Predictive Value of Serum CYFRA 21-1 and CK19-2G2 for
            Tumor Aggressiveness and Overall Survival in Hepatitis C-Related
            Hepatocellular Carcinoma Among Egyptians: A Prospective Study.
REFERENCE   3  (bases 1 to 1390)
  AUTHORS   Kruger,J., Fischer,A., Breunig,M., Allgower,C., Schulte,L.,
            Merkle,J., Mulaw,M.A., Okeke,N., Melzer,M.K., Morgenstern,C.,
            Azoitei,N., Seufferlein,T., Barth,T.F., Siebert,R., Hohwieler,M.
            and Kleger,A.
  TITLE     DNA methylation-associated allelic inactivation regulates Keratin
            19 gene expression during pancreatic development and carcinogenesis
  JOURNAL   J Pathol 261 (2), 139-155 (2023)
   PUBMED   37555362
  REMARK    GeneRIF: DNA methylation-associated allelic inactivation regulates
            Keratin 19 gene expression during pancreatic development and
            carcinogenesis.
REFERENCE   4  (bases 1 to 1390)
  AUTHORS   Fallatah,A., Anastasakis,D.G., Manzourolajdad,A., Sharma,P.,
            Wang,X., Jacob,A., Alsharif,S., Elgerbi,A., Coulombe,P.A.,
            Hafner,M. and Chung,B.M.
  TITLE     Keratin 19 binds and regulates cytoplasmic HNRNPK mRNA targets in
            triple-negative breast cancer
  JOURNAL   BMC Mol Cell Biol 24 (1), 26 (2023)
   PUBMED   37592256
  REMARK    GeneRIF: Keratin 19 binds and regulates cytoplasmic HNRNPK mRNA
            targets in triple-negative breast cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1390)
  AUTHORS   Rahadiani,N., Sarwanti,S., Handjari,D.R., Stephanie,M. and
            Krisnuhoni,E.
  TITLE     Clinical implications of Cytokeratin 19 expression in patients with
            oral squamous cell carcinoma
  JOURNAL   Pathologica 115 (3), 155-163 (2023)
   PUBMED   37387440
  REMARK    GeneRIF: Clinical implications of Cytokeratin 19 expression in
            patients with oral squamous cell carcinoma.
REFERENCE   6  (bases 1 to 1390)
  AUTHORS   Rasmussen,H.H., van Damme,J., Puype,M., Gesser,B., Celis,J.E. and
            Vandekerckhove,J.
  TITLE     Microsequences of 145 proteins recorded in the two-dimensional gel
            protein database of normal human epidermal keratinocytes
  JOURNAL   Electrophoresis 13 (12), 960-969 (1992)
   PUBMED   1286667
REFERENCE   7  (bases 1 to 1390)
  AUTHORS   Eckert,R.L.
  TITLE     Sequence of the human 40-kDa keratin reveals an unusual structure
            with very high sequence identity to the corresponding bovine
            keratin
  JOURNAL   Proc Natl Acad Sci U S A 85 (4), 1114-1118 (1988)
   PUBMED   2448790
REFERENCE   8  (bases 1 to 1390)
  AUTHORS   Blumenberg,M.
  TITLE     Concerted gene duplications in the two keratin gene families
  JOURNAL   J Mol Evol 27 (3), 203-211 (1988)
   PUBMED   2458477
REFERENCE   9  (bases 1 to 1390)
  AUTHORS   Stasiak,P.C. and Lane,E.B.
  TITLE     Sequence of cDNA coding for human keratin 19
  JOURNAL   Nucleic Acids Res 15 (23), 10058 (1987)
   PUBMED   2447559
REFERENCE   10 (bases 1 to 1390)
  AUTHORS   Bader,B.L., Magin,T.M., Hatzfeld,M. and Franke,W.W.
  TITLE     Amino acid sequence and gene organization of cytokeratin no. 19, an
            exceptional tail-less intermediate filament protein
  JOURNAL   EMBO J 5 (8), 1865-1875 (1986)
   PUBMED   2428612
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Michael Rogers. The reference sequence was
            derived from BP328445.1, DA068330.1, BG490639.1 and BC007628.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_002276.4.
            
            Summary: The protein encoded by this gene is a member of the
            keratin family. The keratins are intermediate filament proteins
            responsible for the structural integrity of epithelial cells and
            are subdivided into cytokeratins and hair keratins. The type I
            cytokeratins consist of acidic proteins which are arranged in pairs
            of heterotypic keratin chains. Unlike its related family members,
            this smallest known acidic cytokeratin is not paired with a basic
            cytokeratin in epithelial cells. It is specifically expressed in
            the periderm, the transiently superficial layer that envelopes the
            developing epidermis. The type I cytokeratins are clustered in a
            region of chromosome 17q12-q21. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.204644.1,
                                           SRR3476690.834544.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361566.7/ ENSP00000355124.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-150               BP328445.1         89-238
            151-503             DA068330.1         215-567
            504-632             BG490639.1         488-616
            633-1390            BC007628.1         618-1375
FEATURES             Location/Qualifiers
     source          1..1390
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.2"
     gene            1..1390
                     /gene="KRT19"
                     /gene_synonym="CK19; K19; K1CS"
                     /note="keratin 19"
                     /db_xref="GeneID:3880"
                     /db_xref="HGNC:HGNC:6436"
                     /db_xref="MIM:148020"
     exon            1..481
                     /gene="KRT19"
                     /gene_synonym="CK19; K19; K1CS"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..1264
                     /gene="KRT19"
                     /gene_synonym="CK19; K19; K1CS"
                     /note="keratin, type I, 40-kd; cytokeratin 19; 40-kDa
                     keratin intermediate filament; CK-19; keratin 19, type I"
                     /codon_start=1
                     /product="keratin, type I cytoskeletal 19"
                     /protein_id="NP_002267.2"
                     /db_xref="CCDS:CCDS11399.1"
                     /db_xref="GeneID:3880"
                     /db_xref="HGNC:HGNC:6436"
                     /db_xref="MIM:148020"
                     /translation="MTSYSYRQSSATSSFGGLGGGSVRFGPGVAFRAPSIHGGSGGRG
                     VSVSSARFVSSSSSGAYGGGYGGVLTASDGLLAGNEKLTMQNLNDRLASYLDKVRALE
                     AANGELEVKIRDWYQKQGPGPSRDYSHYYTTIQDLRDKILGATIENSRIVLQIDNARL
                     AADDFRTKFETEQALRMSVEADINGLRRVLDELTLARTDLEMQIEGLKEELAYLKKNH
                     EEEISTLRGQVGGQVSVEVDSAPGTDLAKILSDMRSQYEVMAEQNRKDAEAWFTSRTE
                     ELNREVAGHTEQLQMSRSEVTDLRRTLQGLEIELQSQLSMKAALEDTLAETEARFGAQ
                     LAHIQALISGIEAQLGDVRADSERQNQEYQRLMDIKSRLEQEIATYRSLLEGQEDHYN
                     NLSASKVL"
     exon            482..564
                     /gene="KRT19"
                     /gene_synonym="CK19; K19; K1CS"
                     /inference="alignment:Splign:2.1.0"
     exon            565..721
                     /gene="KRT19"
                     /gene_synonym="CK19; K19; K1CS"
                     /inference="alignment:Splign:2.1.0"
     exon            722..883
                     /gene="KRT19"
                     /gene_synonym="CK19; K19; K1CS"
                     /inference="alignment:Splign:2.1.0"
     exon            884..1009
                     /gene="KRT19"
                     /gene_synonym="CK19; K19; K1CS"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1390
                     /gene="KRT19"
                     /gene_synonym="CK19; K19; K1CS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1367..1372
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KRT19"
                     /gene_synonym="CK19; K19; K1CS"
                     /note="hexamer: AATAAA"
     polyA_site      1390
                     /gene="KRT19"
                     /gene_synonym="CK19; K19; K1CS"
                     /note="major polyA site"
ORIGIN      
        1 gctcctcccg cgaatcgcag cttctgagac cagggttgct ccgtccgtgc tccgcctcgc
       61 catgacttcc tacagctatc gccagtcgtc ggccacgtcg tccttcggag gcctgggcgg
      121 cggctccgtg cgttttgggc cgggggtcgc ctttcgcgcg cccagcattc acgggggctc
      181 cggcggccgc ggcgtatccg tgtcctccgc ccgctttgtg tcctcgtcct cctcgggggc
      241 ctacggcggc ggctacggcg gcgtcctgac cgcgtccgac gggctgctgg cgggcaacga
      301 gaagctaacc atgcagaacc tcaacgaccg cctggcctcc tacctggaca aggtgcgcgc
      361 cctggaggcg gccaacggcg agctagaggt gaagatccgc gactggtacc agaagcaggg
      421 gcctgggccc tcccgcgact acagccacta ctacacgacc atccaggacc tgcgggacaa
      481 gattcttggt gccaccattg agaactccag gattgtcctg cagatcgaca atgcccgtct
      541 ggctgcagat gacttccgaa ccaagtttga gacggaacag gctctgcgca tgagcgtgga
      601 ggccgacatc aacggcctgc gcagggtgct ggatgagctg accctggcca ggaccgacct
      661 ggagatgcag atcgaaggcc tgaaggaaga gctggcctac ctgaagaaga accatgagga
      721 ggaaatcagt acgctgaggg gccaagtggg aggccaggtc agtgtggagg tggattccgc
      781 tccgggcacc gatctcgcca agatcctgag tgacatgcga agccaatatg aggtcatggc
      841 cgagcagaac cggaaggatg ctgaagcctg gttcaccagc cggactgaag aattgaaccg
      901 ggaggtcgct ggccacacgg agcagctcca gatgagcagg tccgaggtta ctgacctgcg
      961 gcgcaccctt cagggtcttg agattgagct gcagtcacag ctgagcatga aagctgcctt
     1021 ggaagacaca ctggcagaaa cggaggcgcg ctttggagcc cagctggcgc atatccaggc
     1081 gctgatcagc ggtattgaag cccagctggg cgatgtgcga gctgatagtg agcggcagaa
     1141 tcaggagtac cagcggctca tggacatcaa gtcgcggctg gagcaggaga ttgccaccta
     1201 ccgcagcctg ctcgagggac aggaagatca ctacaacaat ttgtctgcct ccaaggtcct
     1261 ctgaggcagc aggctctggg gcttctgctg tcctttggag ggtgtcttct gggtagaggg
     1321 atgggaagga agggaccctt acccccggct cttctcctga cctgccaata aaaatttatg
     1381 gtccaaggga
//
