LOCUS       NM_000422               1517 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens keratin 17 (KRT17), mRNA.
ACCESSION   NM_000422
VERSION     NM_000422.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1517)
  AUTHORS   Xu,Y., Cohen,E., Johnson,C.N., Parent,C.A. and Coulombe,P.A.
  TITLE     Repeated stress to the skin amplifies neutrophil infiltration in a
            keratin 17- and PKCalpha-dependent manner
  JOURNAL   PLoS Biol 22 (8), e3002779 (2024)
   PUBMED   39159283
  REMARK    GeneRIF: Repeated stress to the skin amplifies neutrophil
            infiltration in a keratin 17- and PKCalpha-dependent manner.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1517)
  AUTHORS   Romashin,D., Rusanov,A., Tolstova,T., Varshaver,A., Netrusov,A.,
            Kozhin,P. and Luzgina,N.
  TITLE     Loss of mutant p53 in HaCaT keratinocytes promotes cadmium-induced
            keratin 17 expression and cell death
  JOURNAL   Biochem Biophys Res Commun 709, 149834 (2024)
   PUBMED   38547608
  REMARK    GeneRIF: Loss of mutant p53 in HaCaT keratinocytes promotes
            cadmium-induced keratin 17 expression and cell death.
REFERENCE   3  (bases 1 to 1517)
  AUTHORS   Delgado-Coka,L., Horowitz,M., Torrente-Goncalves,M., Roa-Pena,L.,
            Leiton,C.V., Hasan,M., Babu,S., Fassler,D., Oentoro,J., Bai,J.K.,
            Petricoin,E.F. 3rd, Matrisian,L.M., Blais,E.M., Marchenko,N.,
            Allard,F.D., Jiang,W., Larson,B., Hendifar,A., Chen,C.,
            Abousamra,S., Samaras,D., Kurc,T., Saltz,J., Escobar-Hoyos,L.F. and
            Shroyer,K.R.
  TITLE     Keratin 17 modulates the immune topography of pancreatic cancer
  JOURNAL   J Transl Med 22 (1), 443 (2024)
   PUBMED   38730319
  REMARK    GeneRIF: Keratin 17 modulates the immune topography of pancreatic
            cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1517)
  AUTHORS   Lozar,T., Wang,W., Gavrielatou,N., Christensen,L., Lambert,P.F.,
            Harari,P.M., Rimm,D.L., Burtness,B., Grasic Kuhar,C. and
            Carchman,E.H.
  TITLE     Emerging Prognostic and Predictive Significance of Stress Keratin
            17 in HPV-Associated and Non HPV-Associated Human Cancers: A
            Scoping Review
  JOURNAL   Viruses 15 (12), 2320 (2023)
   PUBMED   38140561
  REMARK    GeneRIF: Emerging Prognostic and Predictive Significance of Stress
            Keratin 17 in HPV-Associated and Non HPV-Associated Human Cancers:
            A Scoping Review.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1517)
  AUTHORS   Wu,L., Ding,W., Wang,X., Li,X. and Yang,J.
  TITLE     Interference KRT17 reverses doxorubicin resistance in
            triple-negative breast cancer cells by Wnt/beta-catenin signaling
            pathway
  JOURNAL   Genes Genomics 45 (10), 1329-1338 (2023)
   PUBMED   37634232
  REMARK    GeneRIF: Interference KRT17 reverses doxorubicin resistance in
            triple-negative breast cancer cells by Wnt/beta-catenin signaling
            pathway.
REFERENCE   6  (bases 1 to 1517)
  AUTHORS   Smith,F.J.D., Hansen,C.D., Hull,P.R., Kaspar,R.L., McLean,W.H.I.,
            O'Toole,E. and Sprecher,E.
  TITLE     Pachyonychia Congenita
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301457
REFERENCE   7  (bases 1 to 1517)
  AUTHORS   Troyanovsky,S.M., Leube,R.E. and Franke,W.W.
  TITLE     Characterization of the human gene encoding cytokeratin 17 and its
            expression pattern
  JOURNAL   Eur J Cell Biol 59 (1), 127-137 (1992)
   PUBMED   1281771
REFERENCE   8  (bases 1 to 1517)
  AUTHORS   Flohr,T., Buwitt,U., Bonnekoh,B., Decker,T. and Bottger,E.C.
  TITLE     Interferon-gamma regulates expression of a novel keratin class I
            gene
  JOURNAL   Eur J Immunol 22 (4), 975-979 (1992)
   PUBMED   1372562
REFERENCE   9  (bases 1 to 1517)
  AUTHORS   Trask,D.K., Band,V., Zajchowski,D.A., Yaswen,P., Suh,T. and
            Sager,R.
  TITLE     Keratins as markers that distinguish normal and tumor-derived
            mammary epithelial cells
  JOURNAL   Proc Natl Acad Sci U S A 87 (6), 2319-2323 (1990)
   PUBMED   1690428
REFERENCE   10 (bases 1 to 1517)
  AUTHORS   Kartasova,T., Cornelissen,B.J., Belt,P. and van de Putte,P.
  TITLE     Effects of UV, 4-NQO and TPA on gene expression in cultured human
            epidermal keratinocytes
  JOURNAL   Nucleic Acids Res 15 (15), 5945-5962 (1987)
   PUBMED   2442723
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP226061.1 and BC011901.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_000422.2.
            
            Summary: This gene encodes the type I intermediate filament chain
            keratin 17, expressed in nail bed, hair follicle, sebaceous glands,
            and other epidermal appendages. Mutations in this gene lead to
            Jackson-Lawler type pachyonychia congenita and steatocystoma
            multiplex. [provided by RefSeq, Aug 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189658.58324.1,
                                           SRR5189658.113620.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000311208.13/ ENSP00000308452.8
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                BP226061.1         56-73
            19-1517             BC011901.2         1-1499
FEATURES             Location/Qualifiers
     source          1..1517
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.2"
     gene            1..1517
                     /gene="KRT17"
                     /gene_synonym="39.1; CK-17; K17; PC; PC2; PCHC1"
                     /note="keratin 17"
                     /db_xref="GeneID:3872"
                     /db_xref="HGNC:HGNC:6427"
                     /db_xref="MIM:148069"
     exon            1..498
                     /gene="KRT17"
                     /gene_synonym="39.1; CK-17; K17; PC; PC2; PCHC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..1365
                     /gene="KRT17"
                     /gene_synonym="39.1; CK-17; K17; PC; PC2; PCHC1"
                     /note="cytokeratin-17; keratin 17, type I"
                     /codon_start=1
                     /product="keratin, type I cytoskeletal 17"
                     /protein_id="NP_000413.1"
                     /db_xref="CCDS:CCDS11402.1"
                     /db_xref="GeneID:3872"
                     /db_xref="HGNC:HGNC:6427"
                     /db_xref="MIM:148069"
                     /translation="MTTSIRQFTSSSSIKGSSGLGGGSSRTSCRLSGGLGAGSCRLGS
                     AGGLGSTLGGSSYSSCYSFGSGGGYGSSFGGVDGLLAGGEKATMQNLNDRLASYLDKV
                     RALEEANTELEVKIRDWYQRQAPGPARDYSQYYRTIEELQNKILTATVDNANILLQID
                     NARLAADDFRTKFETEQALRLSVEADINGLRRVLDELTLARADLEMQIENLKEELAYL
                     KKNHEEEMNALRGQVGGEINVEMDAAPGVDLSRILNEMRDQYEKMAEKNRKDAEDWFF
                     SKTEELNREVATNSELVQSGKSEISELRRTMQALEIELQSQLSMKASLEGNLAETENR
                     YCVQLSQIQGLIGSVEEQLAQLRCEMEQQNQEYKILLDVKTRLEQEIATYRRLLEGED
                     AHLTQYKKEPVTTRQVRTIVEEVQDGKVISSREQVHQTTR"
     exon            499..581
                     /gene="KRT17"
                     /gene_synonym="39.1; CK-17; K17; PC; PC2; PCHC1"
                     /inference="alignment:Splign:2.1.0"
     exon            582..738
                     /gene="KRT17"
                     /gene_synonym="39.1; CK-17; K17; PC; PC2; PCHC1"
                     /inference="alignment:Splign:2.1.0"
     exon            739..900
                     /gene="KRT17"
                     /gene_synonym="39.1; CK-17; K17; PC; PC2; PCHC1"
                     /inference="alignment:Splign:2.1.0"
     exon            901..1026
                     /gene="KRT17"
                     /gene_synonym="39.1; CK-17; K17; PC; PC2; PCHC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1247
                     /gene="KRT17"
                     /gene_synonym="39.1; CK-17; K17; PC; PC2; PCHC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1270
                     /gene="KRT17"
                     /gene_synonym="39.1; CK-17; K17; PC; PC2; PCHC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1517
                     /gene="KRT17"
                     /gene_synonym="39.1; CK-17; K17; PC; PC2; PCHC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1495..1500
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KRT17"
                     /gene_synonym="39.1; CK-17; K17; PC; PC2; PCHC1"
                     /note="hexamer: AATAAA"
     polyA_site      1517
                     /gene="KRT17"
                     /gene_synonym="39.1; CK-17; K17; PC; PC2; PCHC1"
                     /note="major polyA site"
ORIGIN      
        1 acacaacttg gggcccctct cctctccagc ccttctcctg tgtgcctgcc tcctgccgcc
       61 gccaccatga ccacctccat ccgccagttc acctcctcca gctccatcaa gggctcctcc
      121 ggcctggggg gcggctcgtc ccgcacctcc tgccggctgt ctggcggcct gggtgccggc
      181 tcctgcaggc tgggatctgc tggcggcctg ggcagcaccc tcgggggtag cagctactcc
      241 agctgctaca gctttggctc tggtggtggc tatggcagca gctttggggg tgttgatggg
      301 ctgctggctg gaggtgagaa ggccaccatg cagaacctca atgaccgcct ggcctcctac
      361 ctggacaagg tgcgtgccct ggaggaggcc aacactgagc tggaggtgaa gatccgtgac
      421 tggtaccaga ggcaggcccc ggggcccgcc cgtgactaca gccagtacta caggacaatt
      481 gaggagctgc agaacaagat cctcacagcc accgtggaca atgccaacat cctgctacag
      541 attgacaatg cccgtctggc tgctgatgac ttccgcacca agtttgagac agagcaggcc
      601 ctgcgcctga gtgtggaggc cgacatcaat ggcctgcgca gggtgctgga tgagctgacc
      661 ctggccagag ccgacctgga gatgcagatt gagaacctca aggaggagct ggcctacctg
      721 aagaagaacc acgaggagga gatgaacgcc ctgcgaggcc aggtgggtgg tgagatcaat
      781 gtggagatgg acgctgcccc aggcgtggac ctgagccgca tcctcaacga gatgcgtgac
      841 cagtatgaga agatggcaga gaagaaccgc aaggatgccg aggattggtt cttcagcaag
      901 acagaggaac tgaaccgcga ggtggccacc aacagtgagc tggtgcagag tggcaagagt
      961 gagatctcgg agctccggcg caccatgcag gccttggaga tagagctgca gtcccagctc
     1021 agcatgaaag catccctgga gggcaacctg gcggagacag agaaccgcta ctgcgtgcag
     1081 ctgtcccaga tccaggggct gattggcagc gtggaggagc agctggccca gcttcgctgc
     1141 gagatggagc agcagaacca ggaatacaaa atcctgctgg atgtgaagac gcggctggag
     1201 caggagattg ccacctaccg ccgcctgctg gagggagagg atgcccacct gactcagtac
     1261 aagaaagaac cggtgaccac ccgtcaggtg cgtaccattg tggaagaggt ccaggatggc
     1321 aaggtcatct cctcccgcga gcaggtccac cagaccaccc gctgaggact cagctacccc
     1381 ggccggccac ccaggaggca gggaggcagc cgccccatct gccccacagt ctccggcctc
     1441 tccagcctca gccccctgct tcagtccctt ccccatgctt ccttgcctga tgacaataaa
     1501 gcttgttgac tcagcta
//
