LOCUS       NM_005557               1658 bp    mRNA    linear   PRI 07-OCT-2024
DEFINITION  Homo sapiens keratin 16 (KRT16), mRNA.
ACCESSION   NM_005557
VERSION     NM_005557.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1658)
  AUTHORS   Kurtovic,M., Pitesa,N., Conkas,J., Hajpek,H., Vucic,M., Musani,V.,
            Ozretic,P. and Sabol,M.
  TITLE     GLI Transcriptional Targets S100A7 and KRT16 Show Upregulated
            Expression Patterns in Epidermis Overlying the Tumor Mass in
            Melanoma Samples
  JOURNAL   Int J Mol Sci 25 (11), 6084 (2024)
   PUBMED   38892279
  REMARK    GeneRIF: GLI Transcriptional Targets S100A7 and KRT16 Show
            Upregulated Expression Patterns in Epidermis Overlying the Tumor
            Mass in Melanoma Samples.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1658)
  AUTHORS   Wang,W., Zhu,L., Zhou,J., Liu,X., Xiao,M., Chen,N., Huang,X.,
            Chen,H., Pei,X. and Zhang,H.
  TITLE     Targeting the KRT16-vimentin axis for metastasis in lung cancer
  JOURNAL   Pharmacol Res 193, 106818 (2023)
   PUBMED   37315823
  REMARK    GeneRIF: Targeting the KRT16-vimentin axis for metastasis in lung
            cancer.
REFERENCE   3  (bases 1 to 1658)
  AUTHORS   Wang,S., Bai,Q., Lee,M., Lin,Z., Cai,L. and Wang,H.
  TITLE     A novel KRT16 frameshift variant causing pachyonychia congenita by
            re-initiation of translation
  JOURNAL   J Eur Acad Dermatol Venereol 37 (2), e166-e168 (2023)
   PUBMED   36149327
  REMARK    GeneRIF: A novel KRT16 frameshift variant causing pachyonychia
            congenita by re-initiation of translation.
REFERENCE   4  (bases 1 to 1658)
  AUTHORS   Lu,Z., Peng,H., Li,R., Xu,X. and Peng,J.
  TITLE     BarH-like homeobox 2 represses the transcription of keratin 16 and
            affects Ras signaling pathway to suppress nasopharyngeal carcinoma
            progression
  JOURNAL   Bioengineered 13 (2), 3122-3136 (2022)
   PUBMED   35037835
  REMARK    GeneRIF: BarH-like homeobox 2 represses the transcription of
            keratin 16 and affects Ras signaling pathway to suppress
            nasopharyngeal carcinoma progression.
REFERENCE   5  (bases 1 to 1658)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 1658)
  AUTHORS   Paladini,R.D., Takahashi,K., Gant,T.M. and Coulombe,P.A.
  TITLE     cDNA cloning and bacterial expression of the human type I keratin
            16
  JOURNAL   Biochem Biophys Res Commun 215 (2), 517-523 (1995)
   PUBMED   7487986
REFERENCE   7  (bases 1 to 1658)
  AUTHORS   Smith,F.J.D., Hansen,C.D., Hull,P.R., Kaspar,R.L., McLean,W.H.I.,
            O'Toole,E. and Sprecher,E.
  TITLE     Pachyonychia Congenita
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301457
REFERENCE   8  (bases 1 to 1658)
  AUTHORS   Rasmussen,H.H., van Damme,J., Puype,M., Gesser,B., Celis,J.E. and
            Vandekerckhove,J.
  TITLE     Microsequences of 145 proteins recorded in the two-dimensional gel
            protein database of normal human epidermal keratinocytes
  JOURNAL   Electrophoresis 13 (12), 960-969 (1992)
   PUBMED   1286667
REFERENCE   9  (bases 1 to 1658)
  AUTHORS   Rosenberg,M., RayChaudhury,A., Shows,T.B., Le Beau,M.M. and
            Fuchs,E.
  TITLE     A group of type I keratin genes on human chromosome 17:
            characterization and expression
  JOURNAL   Mol Cell Biol 8 (2), 722-736 (1988)
   PUBMED   2451124
REFERENCE   10 (bases 1 to 1658)
  AUTHORS   RayChaudhury,A., Marchuk,D., Lindhurst,M. and Fuchs,E.
  TITLE     Three tightly linked genes encoding human type I keratins:
            conservation of sequence in the 5'-untranslated leader and
            5'-upstream regions of coexpressed keratin genes
  JOURNAL   Mol Cell Biol 6 (2), 539-548 (1986)
   PUBMED   2431270
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Michael Rogers. The reference sequence was
            derived from DC394235.1, AK290853.1 and BC039169.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_005557.3.
            
            Summary: The protein encoded by this gene is a member of the
            keratin gene family. The keratins are intermediate filament
            proteins responsible for the structural integrity of epithelial
            cells and are subdivided into cytokeratins and hair keratins. Most
            of the type I cytokeratins consist of acidic proteins which are
            arranged in pairs of heterotypic keratin chains and are clustered
            in a region of chromosome 17q12-q21. This keratin has been
            coexpressed with keratin 14 in a number of epithelial tissues,
            including esophagus, tongue, and hair follicles. Mutations in this
            gene are associated with type 1 pachyonychia congenita,
            non-epidermolytic palmoplantar keratoderma and unilateral
            palmoplantar verrucous nevus. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC039169.1, SRR14038191.750529.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968189,
                                           SAMEA1968968 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000301653.9/ ENSP00000301653.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 DC394235.1         61-62
            3-702               AK290853.1         1-700
            703-1658            BC039169.1         674-1629
FEATURES             Location/Qualifiers
     source          1..1658
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.2"
     gene            1..1658
                     /gene="KRT16"
                     /gene_synonym="CK16; FNEPPK; K16; K1CP; KRT16A; NEPPK;
                     PC1"
                     /note="keratin 16"
                     /db_xref="GeneID:3868"
                     /db_xref="HGNC:HGNC:6423"
                     /db_xref="MIM:148067"
     exon            1..610
                     /gene="KRT16"
                     /gene_synonym="CK16; FNEPPK; K16; K1CP; KRT16A; NEPPK;
                     PC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..1501
                     /gene="KRT16"
                     /gene_synonym="CK16; FNEPPK; K16; K1CP; KRT16A; NEPPK;
                     PC1"
                     /note="focal non-epidermolytic palmoplantar keratoderma;
                     cytokeratin 16; keratin 16, type I"
                     /codon_start=1
                     /product="keratin, type I cytoskeletal 16"
                     /protein_id="NP_005548.2"
                     /db_xref="CCDS:CCDS11401.1"
                     /db_xref="GeneID:3868"
                     /db_xref="HGNC:HGNC:6423"
                     /db_xref="MIM:148067"
                     /translation="MTTCSRQFTSSSSMKGSCGIGGGIGGGSSRISSVLAGGSCRAPS
                     TYGGGLSVSSRFSSGGACGLGGGYGGGFSSSSSFGSGFGGGYGGGLGAGFGGGLGAGF
                     GGGFAGGDGLLVGSEKVTMQNLNDRLASYLDKVRALEEANADLEVKIRDWYQRQRPSE
                     IKDYSPYFKTIEDLRNKIIAATIENAQPILQIDNARLAADDFRTKYEHELALRQTVEA
                     DVNGLRRVLDELTLARTDLEMQIEGLKEELAYLRKNHEEEMLALRGQTGGDVNVEMDA
                     APGVDLSRILNEMRDQYEQMAEKNRRDAETWFLSKTEELNKEVASNSELVQSSRSEVT
                     ELRRVLQGLEIELQSQLSMKASLENSLEETKGRYCMQLSQIQGLIGSVEEQLAQLRCE
                     MEQQSQEYQILLDVKTRLEQEIATYRRLLEGEDAHLSSQQASGQSYSSREVFTSSSSS
                     SSRQTRPILKEQSSSSFSQGQSS"
     exon            611..693
                     /gene="KRT16"
                     /gene_synonym="CK16; FNEPPK; K16; K1CP; KRT16A; NEPPK;
                     PC1"
                     /inference="alignment:Splign:2.1.0"
     exon            694..850
                     /gene="KRT16"
                     /gene_synonym="CK16; FNEPPK; K16; K1CP; KRT16A; NEPPK;
                     PC1"
                     /inference="alignment:Splign:2.1.0"
     exon            851..1012
                     /gene="KRT16"
                     /gene_synonym="CK16; FNEPPK; K16; K1CP; KRT16A; NEPPK;
                     PC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1138
                     /gene="KRT16"
                     /gene_synonym="CK16; FNEPPK; K16; K1CP; KRT16A; NEPPK;
                     PC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1359
                     /gene="KRT16"
                     /gene_synonym="CK16; FNEPPK; K16; K1CP; KRT16A; NEPPK;
                     PC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..1406
                     /gene="KRT16"
                     /gene_synonym="CK16; FNEPPK; K16; K1CP; KRT16A; NEPPK;
                     PC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1658
                     /gene="KRT16"
                     /gene_synonym="CK16; FNEPPK; K16; K1CP; KRT16A; NEPPK;
                     PC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1630..1635
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KRT16"
                     /gene_synonym="CK16; FNEPPK; K16; K1CP; KRT16A; NEPPK;
                     PC1"
                     /note="hexamer: AATAAA"
     polyA_site      1658
                     /gene="KRT16"
                     /gene_synonym="CK16; FNEPPK; K16; K1CP; KRT16A; NEPPK;
                     PC1"
                     /note="major polyA site"
ORIGIN      
        1 acagcacgct ctcagccttc ctgagcacct ttccttcttt cagccaactg ctcactcgct
       61 cacctccctc cttggcacca tgaccacctg cagccgccag ttcacctcct ccagctccat
      121 gaagggctcc tgcggcatcg gaggcggcat cgggggcggc tccagccgca tctcctccgt
      181 cctggccgga gggtcctgcc gtgcccccag cacctacggg ggcggcctgt ctgtctcctc
      241 tcgcttctcc tctgggggag cctgcgggct ggggggcggc tatggcggtg gcttcagcag
      301 cagcagcagc tttggtagtg gcttcggggg aggatatggt ggtggccttg gtgctggctt
      361 cggtggtggc ttgggtgctg gctttggtgg tggttttgct ggtggtgatg ggcttctggt
      421 gggcagtgag aaggtgacca tgcagaacct caatgaccgc ctggcctcct acctggacaa
      481 ggtgcgtgct ctggaggagg ccaacgccga cctggaagtg aagatccgtg actggtacca
      541 gaggcagcgg cccagtgaga tcaaagacta cagtccctac ttcaagacca tcgaggacct
      601 gaggaacaag atcattgcgg ccaccattga gaatgcgcag cccattttgc agattgacaa
      661 tgccaggctg gcagccgatg acttcaggac caagtatgag catgaactgg ccctgcggca
      721 gactgtggag gccgacgtca atggcctgcg ccgggtgttg gatgagctga ccctggccag
      781 gactgacctg gagatgcaga tcgaaggcct gaaggaggag ctggcctacc tgaggaagaa
      841 ccacgaggag gagatgcttg ctctgagagg tcagaccggc ggagatgtga acgtggagat
      901 ggatgctgca cctggcgtgg acctgagccg catcctgaat gagatgcgtg accagtacga
      961 gcagatggca gagaaaaacc gcagagacgc tgagacctgg ttcctgagca agaccgagga
     1021 gctgaacaaa gaagtggcct ccaacagcga actggtacag agcagccgca gtgaggtgac
     1081 ggagctccgg agggtgctcc agggcctgga gattgagctg cagtcccagc tcagcatgaa
     1141 agcatccctg gagaacagcc tggaggagac caaaggccgc tactgcatgc agctgtccca
     1201 gatccaggga ctgattggca gtgtggagga gcagctggcc cagctacgct gtgagatgga
     1261 gcagcagagc caggagtacc agatcttgct ggatgtgaag acgcggctgg agcaggagat
     1321 tgccacctac cgccgcctgc tggagggcga ggatgcccac ctttcctccc agcaagcatc
     1381 tggccaatcc tattcttccc gcgaggtctt cacctcctcc tcgtcctctt cgagccgtca
     1441 gacccggccc atcctcaagg agcagagctc atccagcttc agccagggcc agagctccta
     1501 gaactgagct gcctctacca cagcctcctg cccaccagct ggcctcacct cctgaaggcc
     1561 cgggtcagga ccctgctctc ctggcgcagt tcccagctat ctcccctgct cctctgctgg
     1621 tggtgggcta ataaagctga ctttctggtt gatgcaaa
//
