LOCUS       NM_002275               1712 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens keratin 15 (KRT15), mRNA.
ACCESSION   NM_002275
VERSION     NM_002275.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1712)
  AUTHORS   Tommasi,C., Yogev,O., Yee,M.B., Drousioti,A., Jones,M., Ring,A.,
            Singh,M., Dry,I., Atkins,O., Naeem,A.S., Kriplani,N., Akbar,A.N.,
            Haas,J.G., O'Toole,E.A., Kinchington,P.R. and Breuer,J.
  TITLE     Upregulation of keratin 15 is required for varicella-zoster virus
            replication in keratinocytes and is attenuated in the live
            attenuated vOka vaccine strain
  JOURNAL   Virol J 21 (1), 253 (2024)
   PUBMED   39385182
  REMARK    GeneRIF: Upregulation of keratin 15 is required for
            varicella-zoster virus replication in keratinocytes and is
            attenuated in the live attenuated vOka vaccine strain.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1712)
  AUTHORS   Yang,X., Liu,Z., Wang,X., Han,Z., Zhang,C. and Guo,L.
  TITLE     Tumor keratin 15 expression links with less extent of invasion and
            better prognosis in papillary thyroid cancer patients receiving
            tumor resection
  JOURNAL   Ir J Med Sci 193 (1), 9-15 (2024)
   PUBMED   37243844
  REMARK    GeneRIF: Tumor keratin 15 expression links with less extent of
            invasion and better prognosis in papillary thyroid cancer patients
            receiving tumor resection.
REFERENCE   3  (bases 1 to 1712)
  AUTHORS   Yang,H., Li,A., Li,A., Zhao,F. and Zhang,T.
  TITLE     Upregulated keratin 15 links to the occurrence of lymphovascular
            invasion, stromal cervical invasion as well as unfavorable survival
            profile in endometrial cancer patients
  JOURNAL   Medicine (Baltimore) 101 (29), e29686 (2022)
   PUBMED   35866777
  REMARK    GeneRIF: Upregulated keratin 15 links to the occurrence of
            lymphovascular invasion, stromal cervical invasion as well as
            unfavorable survival profile in endometrial cancer patients.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1712)
  AUTHORS   Chen,W. and Miao,C.
  TITLE     KRT15 promotes colorectal cancer cell migration and invasion
            through beta-catenin/MMP-7 signaling pathway
  JOURNAL   Med Oncol 39 (5), 68 (2022)
   PUBMED   35477819
  REMARK    GeneRIF: KRT15 promotes colorectal cancer cell migration and
            invasion through beta-catenin/MMP-7 signaling pathway.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1712)
  AUTHORS   Lin,J.B., Feng,Z., Qiu,M.L., Luo,R.G., Li,X. and Liu,B.
  TITLE     KRT 15 as a prognostic biomarker is highly expressed in esophageal
            carcinoma
  JOURNAL   Future Oncol 16 (25), 1903-1909 (2020)
   PUBMED   32449621
  REMARK    GeneRIF: KRT 15 as a prognostic biomarker is highly expressed in
            esophageal carcinoma.
REFERENCE   6  (bases 1 to 1712)
  AUTHORS   Barletta,C., Batticane,N., Ragusa,R.M., Leube,R., Peschle,C. and
            Romano,V.
  TITLE     Subchromosomal localization of two human cytokeratin genes (KRT4
            and KRT15) by in situ hybridization
  JOURNAL   Cytogenet Cell Genet 54 (3-4), 148-150 (1990)
   PUBMED   1702379
REFERENCE   7  (bases 1 to 1712)
  AUTHORS   Bader,B.L., Jahn,L. and Franke,W.W.
  TITLE     Low level expression of cytokeratins 8, 18 and 19 in vascular
            smooth muscle cells of human umbilical cord and in cultured cells
            derived therefrom, with an analysis of the chromosomal locus
            containing the cytokeratin 19 gene
  JOURNAL   Eur J Cell Biol 47 (2), 300-319 (1988)
   PUBMED   2468493
REFERENCE   8  (bases 1 to 1712)
  AUTHORS   Leube,R.E., Bader,B.L., Bosch,F.X., Zimbelmann,R., Achtstaetter,T.
            and Franke,W.W.
  TITLE     Molecular characterization and expression of the
            stratification-related cytokeratins 4 and 15
  JOURNAL   J Cell Biol 106 (4), 1249-1261 (1988)
   PUBMED   2452170
REFERENCE   9  (bases 1 to 1712)
  AUTHORS   Romano,V., Bosco,P., Rocchi,M., Costa,G., Leube,R.E., Franke,W.W.
            and Romeo,G.
  TITLE     Chromosomal assignments of human type I and type II cytokeratin
            genes to different chromosomes
  JOURNAL   Cytogenet Cell Genet 48 (3), 148-151 (1988)
   PUBMED   2466616
REFERENCE   10 (bases 1 to 1712)
  AUTHORS   Blumenberg,M. and Savtchenko,E.S.
  TITLE     Linkage of human keratin genes
  JOURNAL   Cytogenet Cell Genet 42 (1-2), 65-71 (1986)
   PUBMED   2424675
  REMARK    Erratum:[Cytogenet Cell Genet 1992;61(2):160]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Michael Rogers. The reference sequence was
            derived from AC019349.28.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 24, 2018 this sequence version replaced NM_002275.3.
            
            Summary: The protein encoded by this gene is a member of the
            keratin gene family. The keratins are intermediate filament
            proteins responsible for the structural integrity of epithelial
            cells and are subdivided into cytokeratins and hair keratins. Most
            of the type I cytokeratins consist of acidic proteins which are
            arranged in pairs of heterotypic keratin chains and are clustered
            in a region on chromosome 17q21.2. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC002641.2, AK122864.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145893, SAMEA2147596
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000254043.8/ ENSP00000254043.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-561               AC019349.28        79245-79805
            562-644             AC019349.28        80970-81052
            645-801             AC019349.28        81171-81327
            802-963             AC019349.28        81870-82031
            964-1089            AC019349.28        82125-82250
            1090-1310           AC019349.28        82443-82663
            1311-1336           AC019349.28        83461-83486
            1337-1712           AC019349.28        84015-84390
FEATURES             Location/Qualifiers
     source          1..1712
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.2"
     gene            1..1712
                     /gene="KRT15"
                     /gene_synonym="CK15; K15; K1CO"
                     /note="keratin 15"
                     /db_xref="GeneID:3866"
                     /db_xref="HGNC:HGNC:6421"
                     /db_xref="MIM:148030"
     exon            1..561
                     /gene="KRT15"
                     /gene_synonym="CK15; K15; K1CO"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..1434
                     /gene="KRT15"
                     /gene_synonym="CK15; K15; K1CO"
                     /note="keratin-15, beta; type I cytoskeletal 15;
                     cytokeratin 15; keratin-15, basic; CK-15; keratin 15, type
                     I"
                     /codon_start=1
                     /product="keratin, type I cytoskeletal 15"
                     /protein_id="NP_002266.3"
                     /db_xref="CCDS:CCDS11398.1"
                     /db_xref="GeneID:3866"
                     /db_xref="HGNC:HGNC:6421"
                     /db_xref="MIM:148030"
                     /translation="MTTTFLQTSSSTFGGGSTRGGSLLAGGGGFGGGSLSGGGGSRSI
                     SASSARFVSSGSGGGYGGGMRVCGFGGGAGSVFGGGFGGGVGGGFGGGFGGGDGGLLS
                     GNEKITMQNLNDRLASYLDKVRALEEANADLEVKIHDWYQKQTPTSPECDYSQYFKTI
                     EELRDKIMATTIDNSRVILEIDNARLAADDFRLKYENELALRQGVEADINGLRRVLDE
                     LTLARTDLEMQIEGLNEELAYLKKNHEEEMKEFSSQLAGQVNVEMDAAPGVDLTRVLA
                     EMREQYEAMAEKNRRDVEAWFFSKTEELNKEVASNTEMIQTSKTEITDLRRTMQELEI
                     ELQSQLSMKAGLENSLAETECRYATQLQQIQGLIGGLEAQLSELRCEMEAQNQEYKML
                     LDIKTRLEQEIATYRSLLEGQDAKMAGIAIREASSGGGGSSSNFHINVEESVDGQVVS
                     SHKREI"
     exon            562..644
                     /gene="KRT15"
                     /gene_synonym="CK15; K15; K1CO"
                     /inference="alignment:Splign:2.1.0"
     exon            645..801
                     /gene="KRT15"
                     /gene_synonym="CK15; K15; K1CO"
                     /inference="alignment:Splign:2.1.0"
     exon            802..963
                     /gene="KRT15"
                     /gene_synonym="CK15; K15; K1CO"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1089
                     /gene="KRT15"
                     /gene_synonym="CK15; K15; K1CO"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1310
                     /gene="KRT15"
                     /gene_synonym="CK15; K15; K1CO"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1336
                     /gene="KRT15"
                     /gene_synonym="CK15; K15; K1CO"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..1712
                     /gene="KRT15"
                     /gene_synonym="CK15; K15; K1CO"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1683..1688
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KRT15"
                     /gene_synonym="CK15; K15; K1CO"
                     /note="hexamer: AATAAA"
     polyA_site      1712
                     /gene="KRT15"
                     /gene_synonym="CK15; K15; K1CO"
                     /note="major polyA site"
ORIGIN      
        1 ctggtacctc ctgccagcat ctcttgggtt tgctgagaac tcacgggctc cagctacctg
       61 gccatgacca ccacatttct gcaaacttct tcctccacct ttgggggtgg ctcaacccga
      121 gggggttccc tcctggctgg gggaggtggc tttggtgggg ggagtctctc tgggggaggt
      181 ggaagccgaa gtatctcagc ttcttctgct aggtttgtct cttcagggtc aggaggagga
      241 tatgggggtg gcatgagggt ctgtggcttt ggtggagggg ctggtagtgt tttcggtgga
      301 ggctttggag ggggcgttgg tgggggtttt ggtggtggct ttggtggtgg cgatggtggt
      361 ctcctctctg gcaatgagaa aattaccatg cagaacctca atgaccgcct ggcctcctac
      421 ctggacaagg tacgtgccct ggaggaggcc aatgctgacc tggaggtgaa gatccatgac
      481 tggtaccaga agcagacccc aaccagccca gaatgcgact acagccaata cttcaagacc
      541 attgaagagc tccgggacaa gatcatggcc accaccatcg acaactcccg ggtcatcctg
      601 gagatcgaca atgccaggct ggctgcggac gacttcaggc tcaagtatga gaatgagctg
      661 gccctgcgcc agggcgttga ggctgacatc aacggcttgc gccgagtcct ggatgagctg
      721 accctggcca ggactgacct ggagatgcag atcgagggcc tgaatgagga gctagcctac
      781 ctgaagaaga accacgaaga ggagatgaag gagttcagca gccagctggc cggccaggtc
      841 aatgtggaga tggacgcagc accgggtgtg gacctgaccc gtgtgctggc agagatgagg
      901 gagcagtacg aggccatggc ggagaagaac cgccgggatg tcgaggcctg gttcttcagc
      961 aagactgagg agctgaacaa agaggtggcc tccaacacag aaatgatcca gaccagcaag
     1021 acggagatca cagacctgag acgcacgatg caggagctgg agatcgagct gcagtcccag
     1081 ctcagcatga aagctgggct ggagaactca ctggccgaga cagagtgccg ctatgccacg
     1141 cagctgcagc agatccaggg gctcattggt ggcctggagg cccagctgag tgagctccga
     1201 tgcgagatgg aggctcagaa ccaggagtac aagatgctgc ttgacataaa gacacggctg
     1261 gagcaggaga tcgctactta ccgcagcctg ctcgagggcc aggatgccaa gatggctggc
     1321 attgccatca gggaagcctc ttcaggaggt ggtggtagca gcagcaattt ccacatcaat
     1381 gtagaagagt cagtggatgg acaggtggtt tcttcccaca agagagaaat ctaagtgtct
     1441 attgcaggag aaacgtccct tgccactccc cactctcatc aggccaagtg gaggactggc
     1501 cagagggcct gcacatgcaa actccagtcc ctgccttcag agagctgaaa agggtccctc
     1561 ggtcttttat ttcagggctt tgcatgcgct ctattccccc tctgcctctc cccaccttct
     1621 ttggagcaag gagatgcagc tgtattgtgt aacaagctca tttgtacagt gtctgttcat
     1681 gtaataaaga attacttttc cttttgcaaa ta
//
