LOCUS       NM_153490               1714 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens keratin 13 (KRT13), transcript variant 1, mRNA.
ACCESSION   NM_153490
VERSION     NM_153490.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1714)
  AUTHORS   Goda,H., Nakashiro,K.I., Sano,Y., Adachi,T., Tokuzen,N.,
            Kuribayashi,N., Hino,S. and Uchida,D.
  TITLE     KRT13 and UPK1B for differential diagnosis between metastatic lung
            carcinoma from oral squamous cell carcinoma and lung squamous cell
            carcinoma
  JOURNAL   Sci Rep 13 (1), 22626 (2023)
   PUBMED   38114532
  REMARK    GeneRIF: KRT13 and UPK1B for differential diagnosis between
            metastatic lung carcinoma from oral squamous cell carcinoma and
            lung squamous cell carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1714)
  AUTHORS   Takenaka,W., Yokoyama,Y., Ikehata,K., Kouda,S., Hirose,H.,
            Minami,K., Hamada,Y., Mori,S., Koizumi,M. and Yamamoto,H.
  TITLE     KRT13 is upregulated in pancreatic cancer stem-like cells and
            associated with radioresistance
  JOURNAL   J Radiat Res 64 (2), 284-293 (2023)
   PUBMED   36610719
  REMARK    GeneRIF: KRT13 is upregulated in pancreatic cancer stem-like cells
            and associated with radioresistance.
REFERENCE   3  (bases 1 to 1714)
  AUTHORS   Lennartz,M., Ullmann,V.S., Gorbokon,N., Uhlig,R., Rico,S.D.,
            Kind,S., Reiswich,V., Viehweger,F., Kluth,M., Hube-Magg,C.,
            Bernreuther,C., Buscheck,F., Putri,D., Clauditz,T.S., Fraune,C.,
            Hinsch,A., Jacobsen,F., Krech,T., Lebock,P., Steurer,S.,
            Burandt,E., Minner,S., Marx,A.H., Simon,R., Sauter,G. and Menz,A.
  TITLE     Cytokeratin 13 (CK13) expression in cancer: a tissue microarray
            study on 10,439 tumors
  JOURNAL   APMIS 131 (2), 77-91 (2023)
   PUBMED   36269681
  REMARK    GeneRIF: Cytokeratin 13 (CK13) expression in cancer: a tissue
            microarray study on 10,439 tumors.
REFERENCE   4  (bases 1 to 1714)
  AUTHORS   Kim,D.K., Weller,B., Lin,C.W., Sheykhkarimli,D., Knapp,J.J.,
            Dugied,G., Zanzoni,A., Pons,C., Tofaute,M.J., Maseko,S.B.,
            Spirohn,K., Laval,F., Lambourne,L., Kishore,N., Rayhan,A.,
            Sauer,M., Young,V., Halder,H., la Rosa,N.M., Pogoutse,O.,
            Strobel,A., Schwehn,P., Li,R., Rothballer,S.T., Altmann,M.,
            Cassonnet,P., Cote,A.G., Vergara,L.E., Hazelwood,I., Liu,B.B.,
            Nguyen,M., Pandiarajan,R., Dohai,B., Coloma,P.A.R., Poirson,J.,
            Giuliana,P., Willems,L., Taipale,M., Jacob,Y., Hao,T., Hill,D.E.,
            Brun,C., Twizere,J.C., Krappmann,D., Heinig,M., Falter,C., Aloy,P.,
            Demeret,C., Vidal,M., Calderwood,M.A., Roth,F.P. and
            Falter-Braun,P.
  TITLE     A proteome-scale map of the SARS-CoV-2-human contactome
  JOURNAL   Nat Biotechnol 41 (1), 140-149 (2023)
   PUBMED   36217029
REFERENCE   5  (bases 1 to 1714)
  AUTHORS   Yin,L., Li,Q., Mrdenovic,S., Chu,G.C., Wu,B.J., Bu,H., Duan,P.,
            Kim,J., You,S., Lewis,M.S., Liang,G., Wang,R., Zhau,H.E. and
            Chung,L.W.K.
  TITLE     KRT13 promotes stemness and drives metastasis in breast cancer
            through a plakoglobin/c-Myc signaling pathway
  JOURNAL   Breast Cancer Res 24 (1), 7 (2022)
   PUBMED   35078507
  REMARK    GeneRIF: KRT13 promotes stemness and drives metastasis in breast
            cancer through a plakoglobin/c-Myc signaling pathway.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1714)
  AUTHORS   Vinores,S.A., Van Niel,E., Kim,H.J. and Campochiaro,P.A.
  TITLE     Simultaneous expression of keratin and glial fibrillary acidic
            protein by the same cells in epiretinal membranes
  JOURNAL   Invest Ophthalmol Vis Sci 33 (12), 3361-3366 (1992)
   PUBMED   1385351
REFERENCE   7  (bases 1 to 1714)
  AUTHORS   Romano,V., Raimondi,E., Bosco,P., Feo,S., Di Pietro,C., Leube,R.E.,
            Troyanovsky,S.M. and Ceratto,N.
  TITLE     Chromosomal mapping of human cytokeratin 13 gene (KRT13)
  JOURNAL   Genomics 14 (2), 495-497 (1992)
   PUBMED   1385306
REFERENCE   8  (bases 1 to 1714)
  AUTHORS   Mischke,D., Wachter,E., Hochstrasser,K., Wild,A.G. and Schulz,P.
  TITLE     The N-, but not the C-terminal domains of human keratins 13 and 15
            are closely related
  JOURNAL   Nucleic Acids Res 17 (19), 7984 (1989)
   PUBMED   2477803
REFERENCE   9  (bases 1 to 1714)
  AUTHORS   Schulz,P., Wachter,E., Hochstrasser,K., Wild,A.G. and Mischke,D.
  TITLE     Sequence of a human keratin 13 specific cDNA encompassing coil 1B
            through the 3' end
  JOURNAL   Biochem Biophys Res Commun 162 (3), 1522-1527 (1989)
   PUBMED   2475110
REFERENCE   10 (bases 1 to 1714)
  AUTHORS   Turyk,M.E., Golub,T.R., Wood,N.B., Hawkins,J.L. and Wilbanks,G.D.
  TITLE     Growth and characterization of epithelial cells from normal human
            uterine ectocervix and endocervix
  JOURNAL   In Vitro Cell Dev Biol 25 (6), 544-556 (1989)
   PUBMED   2472374
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Michael Rogers. The reference sequence was
            derived from AC019349.28.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_153490.2.
            
            Summary: The protein encoded by this gene is a member of the
            keratin gene family. The keratins are intermediate filament
            proteins responsible for the structural integrity of epithelial
            cells and are subdivided into cytokeratins and hair keratins. Most
            of the type I cytokeratins consist of acidic proteins which are
            arranged in pairs of heterotypic keratin chains. This type I
            cytokeratin is paired with keratin 4 and expressed in the
            suprabasal layers of non-cornified stratified epithelia. Mutations
            in this gene and keratin 4 have been associated with the autosomal
            dominant disorder White Sponge Nevus. The type I cytokeratins are
            clustered in a region of chromosome 17q21.2. Alternative splicing
            of this gene results in multiple transcript variants; however, not
            all variants have been described. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK223077.1, ERR279827.5455.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2147975, SAMEA2156670
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000246635.8/ ENSP00000246635.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-557               AC019349.28        92523-93079
            558-640             AC019349.28        94410-94492
            641-797             AC019349.28        94692-94848
            798-959             AC019349.28        95037-95198
            960-1085            AC019349.28        95323-95448
            1086-1306           AC019349.28        95541-95761
            1307-1332           AC019349.28        96391-96416
            1333-1714           AC019349.28        96773-97154
FEATURES             Location/Qualifiers
     source          1..1714
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.2"
     gene            1..1714
                     /gene="KRT13"
                     /gene_synonym="CK13; K13; WSN2"
                     /note="keratin 13"
                     /db_xref="GeneID:3860"
                     /db_xref="HGNC:HGNC:6415"
                     /db_xref="MIM:148065"
     exon            1..557
                     /gene="KRT13"
                     /gene_synonym="CK13; K13; WSN2"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..1439
                     /gene="KRT13"
                     /gene_synonym="CK13; K13; WSN2"
                     /note="isoform a is encoded by transcript variant 1;
                     cytokeratin 13; keratin, type I cytoskeletal 13; CK-13;
                     keratin 13, type I"
                     /codon_start=1
                     /product="keratin, type I cytoskeletal 13 isoform a"
                     /protein_id="NP_705694.3"
                     /db_xref="CCDS:CCDS11396.1"
                     /db_xref="GeneID:3860"
                     /db_xref="HGNC:HGNC:6415"
                     /db_xref="MIM:148065"
                     /translation="MSLRLQSSSASYGGGFGGGSCQLGGGRGVSTCSTRFVSGGSAGG
                     YGGGVSCGFGGGAGSGFGGGYGGGLGGGYGGGLGGGFGGGFAGGFVDFGACDGGLLTG
                     NEKITMQNLNDRLASYLEKVRALEEANADLEVKIRDWHLKQSPASPERDYSPYYKTIE
                     ELRDKILTATIENNRVILEIDNARLAADDFRLKYENELALRQSVEADINGLRRVLDEL
                     TLSKTDLEMQIESLNEELAYMKKNHEEEMKEFSNQVVGQVNVEMDATPGIDLTRVLAE
                     MREQYEAMAERNRRDAEEWFHTKSAELNKEVSTNTAMIQTSKTEITELRRTLQGLEIE
                     LQSQLSMKAGLENTVAETECRYALQLQQIQGLISSIEAQLSELRSEMECQNQEYKMLL
                     DIKTRLEQEIATYRSLLEGQDAKMIGFPSSAGSVSPRSTSVTTTSSASVTTTSNASGR
                     RTSDVRRP"
     exon            558..640
                     /gene="KRT13"
                     /gene_synonym="CK13; K13; WSN2"
                     /inference="alignment:Splign:2.1.0"
     exon            641..797
                     /gene="KRT13"
                     /gene_synonym="CK13; K13; WSN2"
                     /inference="alignment:Splign:2.1.0"
     exon            798..959
                     /gene="KRT13"
                     /gene_synonym="CK13; K13; WSN2"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1085
                     /gene="KRT13"
                     /gene_synonym="CK13; K13; WSN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1306
                     /gene="KRT13"
                     /gene_synonym="CK13; K13; WSN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1307..1332
                     /gene="KRT13"
                     /gene_synonym="CK13; K13; WSN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1714
                     /gene="KRT13"
                     /gene_synonym="CK13; K13; WSN2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1685..1690
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KRT13"
                     /gene_synonym="CK13; K13; WSN2"
                     /note="hexamer: AATAAA"
     polyA_site      1714
                     /gene="KRT13"
                     /gene_synonym="CK13; K13; WSN2"
                     /note="major polyA site"
ORIGIN      
        1 acagtcctcg gcccaggcca agcaagcttc tatctgcacc tgctctcaat cctgctctca
       61 ccatgagcct ccgcctgcag agctcctctg ccagctatgg aggtggtttc gggggtggct
      121 cttgccagct gggaggaggc cgtggtgtct ctacctgttc aactcggttt gtgtccgggg
      181 gatcagctgg gggctatgga ggcggcgtga gctgtggttt tggtggaggg gctggtagtg
      241 gctttggagg tggctatgga ggtggccttg gaggtggcta tggaggtggc cttggaggtg
      301 gctttggtgg gggttttgct ggtggctttg ttgactttgg tgcttgtgat ggcggcctcc
      361 tcactggcaa tgagaagatc accatgcaga acctcaacga ccgcctggct tcctacctgg
      421 agaaggtgcg cgccctggag gaggccaacg ctgacctgga ggtgaagatc cgtgactggc
      481 acctgaagca gagcccagct agccctgagc gggactacag cccctactac aagaccattg
      541 aagagctccg ggacaagatc ctgaccgcca ccattgaaaa caaccgggtc atcctggaga
      601 ttgacaatgc caggctggct gcggacgact tcaggctcaa gtatgagaat gagctggccc
      661 tgcgccagag cgtggaggcc gacatcaacg gcctgcgccg ggtgctggat gagctcactc
      721 tgtctaagac tgacctggag atgcagatcg agagcctgaa tgaagagcta gcctacatga
      781 agaagaacca tgaagaggag atgaaggaat ttagcaacca ggtggtcggc caggtcaacg
      841 tggagatgga tgccacccca ggcattgacc tgacccgcgt gctggcagag atgagggagc
      901 agtacgaggc catggcagag aggaaccgcc gggatgctga ggaatggttc cacaccaaga
      961 gtgcagagct gaacaaggag gtgtctacca acactgccat gattcagacc agcaagacag
     1021 agatcacgga gctcaggcgc acgctccaag gcctggagat tgagctgcag tcccagctga
     1081 gcatgaaagc ggggctggag aacacggtgg cagagacgga gtgccgctat gccctgcagc
     1141 tgcagcagat ccagggactc atcagcagca tcgaggccca gctgagcgag ctccgcagtg
     1201 agatggagtg ccagaaccaa gagtacaaga tgctgctgga catcaagaca cgtctggagc
     1261 aggagatcgc cacctaccgc agcctgctcg agggccagga cgccaagatg attggtttcc
     1321 cttcctcagc aggaagcgtc agcccccgta gcacctctgt taccacgact tctagtgcct
     1381 ctgttaccac cacctctaat gcctctggtc gccgcacttc tgatgtccgt aggccttaaa
     1441 tctgcctggc gtcccctccc tctgtcttca gcacccagag gaggagagag ccggcagttc
     1501 cctgcaggag agaggagggg ctgctggacc caaggctcag tccctctgct ctcaggaccc
     1561 cctgtcctga ctctctcctg atggtgggcc ctctgtgctc ttctcttccg gtcggatctc
     1621 tctcctctct gacctggata cgctttggtt tctcaacttc tctaccccaa agaaaagatt
     1681 attcaataaa gtttcctgcc tttctgcaaa cata
//
