LOCUS       NM_000421               2143 bp    mRNA    linear   PRI 07-DEC-2024
DEFINITION  Homo sapiens keratin 10 (KRT10), transcript variant 1, mRNA.
ACCESSION   NM_000421 XM_352919
VERSION     NM_000421.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2143)
  AUTHORS   van der Velden,J.J.A.J., van Gisbergen,M.W., Kamps,M.A.F.,
            Janssen,R., Diercks,G.F.H., Steijlen,P.M., van Geel,M. and
            Bolling,M.C.
  TITLE     Variants in the L12 linker domain of KRT10 are causal to atypical
            epidermolytic ichthyosis
  JOURNAL   J Dermatol 51 (9), 1180-1186 (2024)
   PUBMED   39072839
  REMARK    GeneRIF: Variants in the L12 linker domain of KRT10 are causal to
            atypical epidermolytic ichthyosis.
REFERENCE   2  (bases 1 to 2143)
  AUTHORS   Huang,X., Yin,G., Zhou,B., Cai,Y., Hu,J., Huang,J., Chen,Z., Liu,Q.
            and Feng,X.
  TITLE     KRT10 plays an important role in the release of viral genome from
            endosomes during H9N2 subtype AIV replication in HeLa cells
  JOURNAL   Vet Microbiol 284, 109824 (2023)
   PUBMED   37406407
  REMARK    GeneRIF: KRT10 plays an important role in the release of viral
            genome from endosomes during H9N2 subtype AIV replication in HeLa
            cells.
REFERENCE   3  (bases 1 to 2143)
  AUTHORS   Huang,T.L. and Chou,C.C.
  TITLE     Effect of mutations on the hydrophobic interactions of the
            hierarchical molecular structure and mechanical properties of
            epithelial keratin 1/10
  JOURNAL   Int J Biol Macromol 212, 442-450 (2022)
   PUBMED   35623459
  REMARK    GeneRIF: Effect of mutations on the hydrophobic interactions of the
            hierarchical molecular structure and mechanical properties of
            epithelial keratin 1/10.
REFERENCE   4  (bases 1 to 2143)
  AUTHORS   Caporali,S., Didona,B., Paradisi,M., Mauriello,A., Campione,E.,
            Falconi,M., Iacovelli,F., Minieri,M., Pieri,M., Bernardini,S. and
            Terrinoni,A.
  TITLE     Post Zygotic, Somatic, Deletion in KERATIN 1 V1 Domain Generates
            Structural Alteration of the K1/K10 Dimer, Producing a Monolateral
            Palmar Epidermolytic Nevus
  JOURNAL   Int J Mol Sci 22 (13), 6901 (2021)
   PUBMED   34199056
  REMARK    GeneRIF: Post Zygotic, Somatic, Deletion in KERATIN 1 V1 Domain
            Generates Structural Alteration of the K1/K10 Dimer, Producing a
            Monolateral Palmar Epidermolytic Nevus.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2143)
  AUTHORS   Kim,J. and Villadsen,R.
  TITLE     The Expression Pattern of Epidermal Differentiation Marker Keratin
            10 in the Normal Human Breast and Breast Cancer Cells
  JOURNAL   J Histochem Cytochem 68 (8), 561-570 (2020)
   PUBMED   32618487
  REMARK    GeneRIF: The Expression Pattern of Epidermal Differentiation Marker
            Keratin 10 in the Normal Human Breast and Breast Cancer Cells.
REFERENCE   6  (bases 1 to 2143)
  AUTHORS   Rasmussen,H.H., van Damme,J., Puype,M., Gesser,B., Celis,J.E. and
            Vandekerckhove,J.
  TITLE     Microsequences of 145 proteins recorded in the two-dimensional gel
            protein database of normal human epidermal keratinocytes
  JOURNAL   Electrophoresis 13 (12), 960-969 (1992)
   PUBMED   1286667
REFERENCE   7  (bases 1 to 2143)
  AUTHORS   Cheng,J., Syder,A.J., Yu,Q.C., Letai,A., Paller,A.S. and Fuchs,E.
  TITLE     The genetic basis of epidermolytic hyperkeratosis: a disorder of
            differentiation-specific epidermal keratin genes
  JOURNAL   Cell 70 (5), 811-819 (1992)
   PUBMED   1381287
REFERENCE   8  (bases 1 to 2143)
  AUTHORS   Rothnagel,J.A., Dominey,A.M., Dempsey,L.D., Longley,M.A.,
            Greenhalgh,D.A., Gagne,T.A., Huber,M., Frenk,E., Hohl,D. and
            Roop,D.R.
  TITLE     Mutations in the rod domains of keratins 1 and 10 in epidermolytic
            hyperkeratosis
  JOURNAL   Science 257 (5073), 1128-1130 (1992)
   PUBMED   1380725
REFERENCE   9  (bases 1 to 2143)
  AUTHORS   Tkachenko,A.V., Buchman,V.L., Bliskovsky,V.V., Shvets,Yu.P. and
            Kisselev,L.L.
  TITLE     Exons I and VII of the gene (Ker10) encoding human keratin 10
            undergo structural rearrangements within repeats
  JOURNAL   Gene 116 (2), 245-251 (1992)
   PUBMED   1378806
REFERENCE   10 (bases 1 to 2143)
  AUTHORS   Korge,B.P., Gan,S.Q., McBride,O.W., Mischke,D. and Steinert,P.M.
  TITLE     Extensive size polymorphism of the human keratin 10 chain resides
            in the C-terminal V2 subdomain due to variable numbers and sizes of
            glycine loops
  JOURNAL   Proc Natl Acad Sci U S A 89 (3), 910-914 (1992)
   PUBMED   1371013
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC090283.7.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 21, 2020 this sequence version replaced NM_000421.4.
            
            Summary: This gene encodes a member of the type I (acidic)
            cytokeratin family, which belongs to the superfamily of
            intermediate filament (IF) proteins. Keratins are heteropolymeric
            structural proteins which form the intermediate filament. These
            filaments, along with actin microfilaments and microtubules,
            compose the cytoskeleton of epithelial cells. Mutations in this
            gene are associated with epidermolytic hyperkeratosis. This gene is
            located within a cluster of keratin family members on chromosome
            17q21. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC034697.1, M77663.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145893, SAMEA2147596
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000269576.6/ ENSP00000269576.5
            RefSeq Select criteria :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-656               AC090283.7         28119-28774
            657-739             AC090283.7         29616-29698
            740-896             AC090283.7         30066-30222
            897-1058            AC090283.7         30310-30471
            1059-1184           AC090283.7         30559-30684
            1185-1402           AC090283.7         30999-31216
            1403-1777           AC090283.7         31572-31946
            1778-2143           AC090283.7         32251-32616
FEATURES             Location/Qualifiers
     source          1..2143
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.2"
     gene            1..2143
                     /gene="KRT10"
                     /gene_synonym="BCIE; BIE; CK10; EHK; EHK2; EHK2A; EHK2B;
                     IHL; K10; KPP"
                     /note="keratin 10"
                     /db_xref="GeneID:3858"
                     /db_xref="HGNC:HGNC:6413"
                     /db_xref="MIM:148080"
     exon            1..656
                     /gene="KRT10"
                     /gene_synonym="BCIE; BIE; CK10; EHK; EHK2; EHK2A; EHK2B;
                     IHL; K10; KPP"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..1784
                     /gene="KRT10"
                     /gene_synonym="BCIE; BIE; CK10; EHK; EHK2; EHK2A; EHK2B;
                     IHL; K10; KPP"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cytokeratin 10; keratin, type I cytoskeletal 10; CK-10;
                     keratin 10, type I"
                     /codon_start=1
                     /product="keratin, type I cytoskeletal 10 isoform 1"
                     /protein_id="NP_000412.4"
                     /db_xref="CCDS:CCDS11377.1"
                     /db_xref="GeneID:3858"
                     /db_xref="HGNC:HGNC:6413"
                     /db_xref="MIM:148080"
                     /translation="MSVRYSSSKHYSSSRSGGGGGGGGCGGGGGVSSLRISSSKGSLG
                     GGFSSGGFSGGSFSRGSSGGGCFGGSSGGYGGLGGFGGGSFRGSYGSSSFGGSYGGIF
                     GGGSFGGGSFGGGSFGGGGFGGGGFGGGFGGGFGGDGGLLSGNEKVTMQNLNDRLASY
                     LDKVRALEESNYELEGKIKEWYEKHGNSHQGEPRDYSKYYKTIDDLKNQILNLTTDNA
                     NILLQIDNARLAADDFRLKYENEVALRQSVEADINGLRRVLDELTLTKADLEMQIESL
                     TEELAYLKKNHEEEMKDLRNVSTGDVNVEMNAAPGVDLTQLLNNMRSQYEQLAEQNRK
                     DAEAWFNEKSKELTTEIDNNIEQISSYKSEITELRRNVQALEIELQSQLALKQSLEAS
                     LAETEGRYCVQLSQIQAQISALEEQLQQIRAETECQNTEYQQLLDIKIRLENEIQTYR
                     SLLEGEGSSGGGGRGGGSFGGGYGGGSSGGGSSGGGHGGGHGGSSGGGYGGGSSGGGS
                     SGGGYGGGSSSGGHGGSSSGGYGGGSSGGGGGGYGGGSSGGGSSSGGGYGGGSSSGGH
                     KSSSSGSVGESSSKGPRY"
     exon            657..739
                     /gene="KRT10"
                     /gene_synonym="BCIE; BIE; CK10; EHK; EHK2; EHK2A; EHK2B;
                     IHL; K10; KPP"
                     /inference="alignment:Splign:2.1.0"
     exon            740..896
                     /gene="KRT10"
                     /gene_synonym="BCIE; BIE; CK10; EHK; EHK2; EHK2A; EHK2B;
                     IHL; K10; KPP"
                     /inference="alignment:Splign:2.1.0"
     exon            897..1058
                     /gene="KRT10"
                     /gene_synonym="BCIE; BIE; CK10; EHK; EHK2; EHK2A; EHK2B;
                     IHL; K10; KPP"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1184
                     /gene="KRT10"
                     /gene_synonym="BCIE; BIE; CK10; EHK; EHK2; EHK2A; EHK2B;
                     IHL; K10; KPP"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1402
                     /gene="KRT10"
                     /gene_synonym="BCIE; BIE; CK10; EHK; EHK2; EHK2A; EHK2B;
                     IHL; K10; KPP"
                     /inference="alignment:Splign:2.1.0"
     exon            1403..1777
                     /gene="KRT10"
                     /gene_synonym="BCIE; BIE; CK10; EHK; EHK2; EHK2A; EHK2B;
                     IHL; K10; KPP"
                     /inference="alignment:Splign:2.1.0"
     exon            1778..2143
                     /gene="KRT10"
                     /gene_synonym="BCIE; BIE; CK10; EHK; EHK2; EHK2A; EHK2B;
                     IHL; K10; KPP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2117..2122
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KRT10"
                     /gene_synonym="BCIE; BIE; CK10; EHK; EHK2; EHK2A; EHK2B;
                     IHL; K10; KPP"
                     /note="hexamer: AATAAA"
     polyA_site      2143
                     /gene="KRT10"
                     /gene_synonym="BCIE; BIE; CK10; EHK; EHK2; EHK2A; EHK2B;
                     IHL; K10; KPP"
                     /note="major polyA site"
ORIGIN      
        1 aggcactccc tgggctaaac agcatcacca tgtctgttcg atacagctca agcaagcact
       61 actcttcctc ccgcagtgga ggaggaggag gaggaggagg atgtggagga ggaggaggag
      121 tgtcatccct aagaatttct agcagcaaag gctcccttgg tggaggattt agctcagggg
      181 ggttcagtgg tggctctttt agccgtggga gctctggtgg gggctgcttt gggggctcat
      241 caggtggcta tggaggatta ggaggttttg gtggaggtag ctttcgtgga agctatggaa
      301 gtagcagctt tggtgggagt tatggaggca tctttggagg gggcagtttc ggaggtggca
      361 gctttggtgg gggcagcttt ggtggaggcg gctttggtgg aggcggcttt ggaggaggct
      421 ttggtggtgg atttggagga gatggtggcc ttctctctgg aaatgaaaaa gtaaccatgc
      481 agaatctgaa tgaccgcctg gcttcctact tggacaaagt tcgggctctg gaagaatcaa
      541 actatgagct ggaaggcaaa atcaaggagt ggtatgaaaa gcatggcaac tcacatcagg
      601 gggagcctcg tgactacagc aaatactaca aaaccatcga tgaccttaaa aatcagattc
      661 tcaacctaac aactgataat gccaacatcc tgcttcagat cgacaatgcc aggctggcag
      721 ctgatgactt caggctgaag tatgagaatg aggtagctct gcgccagagc gtggaggctg
      781 acatcaacgg cctgcgtagg gtgctggatg agctgaccct gaccaaggct gacctggaga
      841 tgcaaattga gagcctgact gaagagctgg cctatctgaa gaagaaccac gaggaggaaa
      901 tgaaagacct tcgaaatgtg tccactggtg atgtgaatgt ggaaatgaat gctgccccgg
      961 gtgttgatct gactcaactt ctgaataaca tgagaagcca atatgaacaa cttgctgaac
     1021 aaaaccgcaa agatgctgaa gcctggttca atgaaaagag caaggaactg actacagaaa
     1081 ttgataataa cattgaacag atatccagct ataaatctga gattactgaa ttgagacgta
     1141 atgtacaagc tctggagata gaactacagt cccaactggc cttgaaacaa tccctggaag
     1201 cctccttggc agaaacagaa ggtcgctact gtgtgcagct ctcacagatt caggcccaga
     1261 tatccgctct ggaagaacag ttgcaacaga ttcgagctga aaccgagtgc cagaatactg
     1321 aataccaaca actcctggat attaagatcc gactggagaa tgaaattcaa acctaccgca
     1381 gcctgctaga aggagaggga agttccggag gcggcggacg cggcggcgga agtttcggcg
     1441 gcggctacgg cggcggaagc tccggcggcg gaagctccgg cggcggccac ggcggcggcc
     1501 acggcggcag ttccggcggc ggctacggag gcggaagctc cggcggcgga agctccggcg
     1561 gcggctacgg gggcggaagc tccagcggcg gccacggcgg cagttccagc ggcggctacg
     1621 gtggtggcag ttccggcggc ggcggcggcg gctacggggg cggcagctcc ggcggcggca
     1681 gcagctccgg cggcggatac ggcggcggca gctccagcgg aggccacaag tcctcctctt
     1741 ccgggtccgt gggcgagtct tcatctaagg gaccaagata ctaacaaaac cagagtaatc
     1801 aagacaatta ttgaagaggt ggcgcccgac ggtagagttc tttcatctat ggttgaatca
     1861 gaaaccaaga aacactacta ttaaactgca tcaagaggaa agagtctccc ttcacacaga
     1921 ccattattta cagatgcatg gaaaacaaag tctccaagaa aacacttctg tcttgatggt
     1981 ctatggaaat agaccttgaa aataaggtgt ctacaaggtg ttttgtggtt tctgtatttc
     2041 ttcttttcac tttaccagaa agtgttcttt aatggaaaga aaaacaactt tctgttctca
     2101 tttactaatg aatttcaata aactttctta ctgatgcaaa cta
//
