LOCUS       NM_007043              10104 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens KRR1 small subunit processome component homolog
            (KRR1), mRNA.
ACCESSION   NM_007043
VERSION     NM_007043.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10104)
  AUTHORS   Singh,S., Vanden Broeck,A., Miller,L., Chaker-Margot,M. and
            Klinge,S.
  TITLE     Nucleolar maturation of the human small subunit processome
  JOURNAL   Science 373 (6560), eabj5338 (2021)
   PUBMED   34516797
REFERENCE   2  (bases 1 to 10104)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 10104)
  AUTHORS   Buljan,M., Ciuffa,R., van Drogen,A., Vichalkovski,A., Mehnert,M.,
            Rosenberger,G., Lee,S., Varjosalo,M., Pernas,L.E., Spegg,V.,
            Snijder,B., Aebersold,R. and Gstaiger,M.
  TITLE     Kinase Interaction Network Expands Functional and Disease Roles of
            Human Kinases
  JOURNAL   Mol Cell 79 (3), 504-520 (2020)
   PUBMED   32707033
REFERENCE   4  (bases 1 to 10104)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 10104)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 10104)
  AUTHORS   Andersen,J.S., Lyon,C.E., Fox,A.H., Leung,A.K., Lam,Y.W., Steen,H.,
            Mann,M. and Lamond,A.I.
  TITLE     Directed proteomic analysis of the human nucleolus
  JOURNAL   Curr Biol 12 (1), 1-11 (2002)
   PUBMED   11790298
REFERENCE   7  (bases 1 to 10104)
  AUTHORS   Chan,H.Y., Brogna,S. and O'Kane,C.J.
  TITLE     Dribble, the Drosophila KRR1p homologue, is involved in rRNA
            processing
  JOURNAL   Mol Biol Cell 12 (5), 1409-1419 (2001)
   PUBMED   11359931
REFERENCE   8  (bases 1 to 10104)
  AUTHORS   Sasaki,T., Toh-E,A. and Kikuchi,Y.
  TITLE     Yeast Krr1p physically and functionally interacts with a novel
            essential Kri1p, and both proteins are required for 40S ribosome
            biogenesis in the nucleolus
  JOURNAL   Mol Cell Biol 20 (21), 7971-7979 (2000)
   PUBMED   11027267
REFERENCE   9  (bases 1 to 10104)
  AUTHORS   Gromadka,R., Kaniak,A., Slonimski,P.P. and Rytka,J.
  TITLE     A novel cross-phylum family of proteins comprises a KRR1 (YCL059c)
            gene which is essential for viability of Saccharomyces cerevisiae
            cells
  JOURNAL   Gene 171 (1), 27-32 (1996)
   PUBMED   8675026
REFERENCE   10 (bases 1 to 10104)
  AUTHORS   Epplen,C. and Epplen,J.T.
  TITLE     Expression of (cac)n/(gtg)n simple repetitive sequences in mRNA of
            human lymphocytes
  JOURNAL   Hum Genet 93 (1), 35-41 (1994)
   PUBMED   7505766
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC005225.1 and AC121761.4.
            
            On Nov 22, 2018 this sequence version replaced NM_007043.6.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC033887.2, SRR14038197.1810552.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000229214.9/ ENSP00000229214.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1069              BC005225.1         25-1093
            1070-3328           AC121761.4         167790-170048       c
            3329-10104          AC121761.4         161014-167789       c
FEATURES             Location/Qualifiers
     source          1..10104
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q21.2"
     gene            1..10104
                     /gene="KRR1"
                     /gene_synonym="HRB2; RIP-1"
                     /note="KRR1 small subunit processome component homolog"
                     /db_xref="GeneID:11103"
                     /db_xref="HGNC:HGNC:5176"
                     /db_xref="MIM:612817"
     exon            1..97
                     /gene="KRR1"
                     /gene_synonym="HRB2; RIP-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..1158
                     /gene="KRR1"
                     /gene_synonym="HRB2; RIP-1"
                     /note="Rev interacting protein; rev-interacting protein 1;
                     HIV-1 Rev-binding protein 2; KRR-R motif-containing
                     protein 1; KRR1, small subunit (SSU) processome component,
                     homolog; HIV-1 rev binding protein 2"
                     /codon_start=1
                     /product="KRR1 small subunit processome component homolog"
                     /protein_id="NP_008974.5"
                     /db_xref="CCDS:CCDS9012.1"
                     /db_xref="GeneID:11103"
                     /db_xref="HGNC:HGNC:5176"
                     /db_xref="MIM:612817"
                     /translation="MASPSLERPEKGAGKSEFRNQKPKPENQDESELLTVPDGWKEPA
                     FSKEDNPRGLLEESSFATLFPKYREAYLKECWPLVQKALNEHHVNATLDLIEGSMTVC
                     TTKKTFDPYIIIRARDLIKLLARSVSFEQAVRILQDDVACDIIKIGSLVRNKERFVKR
                     RQRLIGPKGSTLKALELLTNCYIMVQGNTVSAIGPFSGLKEVRKVVLDTMKNIHPIYN
                     IKSLMIKRELAKDSELRSQSWERFLPQFKHKNVNKRKEPKKKTVKKEYTPFPPPQPES
                     QIDKELASGEYFLKANQKKRQKMEAIKAKQAEAISKRQEERNKAFIPPKEKPIVKPKE
                     ASTETKIDVASIKEKVKKAKNKKLGALTAEEIALKMEADEKKKKKKK"
     exon            98..270
                     /gene="KRR1"
                     /gene_synonym="HRB2; RIP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            271..405
                     /gene="KRR1"
                     /gene_synonym="HRB2; RIP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            406..531
                     /gene="KRR1"
                     /gene_synonym="HRB2; RIP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            532..615
                     /gene="KRR1"
                     /gene_synonym="HRB2; RIP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            616..672
                     /gene="KRR1"
                     /gene_synonym="HRB2; RIP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            673..843
                     /gene="KRR1"
                     /gene_synonym="HRB2; RIP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            844..921
                     /gene="KRR1"
                     /gene_synonym="HRB2; RIP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1015
                     /gene="KRR1"
                     /gene_synonym="HRB2; RIP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..10104
                     /gene="KRR1"
                     /gene_synonym="HRB2; RIP-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1394..1399
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KRR1"
                     /gene_synonym="HRB2; RIP-1"
                     /note="hexamer: ATTAAA"
     polyA_site      1416
                     /gene="KRR1"
                     /gene_synonym="HRB2; RIP-1"
                     /note="major polyA site"
     regulatory      4041..4046
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KRR1"
                     /gene_synonym="HRB2; RIP-1"
                     /note="hexamer: AATAAA"
     polyA_site      4069
                     /gene="KRR1"
                     /gene_synonym="HRB2; RIP-1"
     regulatory      5106..5111
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KRR1"
                     /gene_synonym="HRB2; RIP-1"
                     /note="hexamer: AATAAA"
     polyA_site      5135
                     /gene="KRR1"
                     /gene_synonym="HRB2; RIP-1"
                     /note="major polyA site"
     regulatory      6683..6688
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KRR1"
                     /gene_synonym="HRB2; RIP-1"
                     /note="hexamer: AATAAA"
     polyA_site      6705
                     /gene="KRR1"
                     /gene_synonym="HRB2; RIP-1"
     regulatory      8371..8376
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KRR1"
                     /gene_synonym="HRB2; RIP-1"
                     /note="hexamer: AATAAA"
     polyA_site      8398
                     /gene="KRR1"
                     /gene_synonym="HRB2; RIP-1"
     regulatory      10086..10091
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KRR1"
                     /gene_synonym="HRB2; RIP-1"
                     /note="hexamer: AATAAA"
     polyA_site      10104
                     /gene="KRR1"
                     /gene_synonym="HRB2; RIP-1"
ORIGIN      
        1 agcagcttgc aaatggcgtc tccctcgctg gagcggccag aaaaaggcgc tggaaaaagt
       61 gaatttcgta accagaagcc gaagccggag aaccaagatg aatcagaact ccttacggtt
      121 cctgatggtt ggaaggaacc agctttttcc aaagaggaca atcccagagg acttttggag
      181 gagagcagtt tcgcaacttt gttcccaaaa tacagggaag cttacttgaa agagtgttgg
      241 ccattggtgc agaaagcctt aaatgaacat catgttaatg caaccctgga cctgatcgaa
      301 ggcagcatga ctgtttgtac tacaaagaag acttttgatc catatatcat cattagggcc
      361 agagatctga taaaactgtt agcaaggagt gtttcatttg aacaggcagt acgaattctt
      421 caggatgatg ttgcatgtga catcattaaa ataggttctt tagtaaggaa taaagagaga
      481 tttgtaaaac gaagacaacg gcttattggt cccaaaggat ctacattgaa ggcattggaa
      541 ctcttaacta attgttacat tatggttcag ggaaacacag tttcagccat tggacctttt
      601 agtggcttaa aagaggttag aaaagtagtc cttgatacta tgaagaatat tcatccaatt
      661 tataacatta aaagcttaat gattaagaga gagttggcaa aagattctga attacgatca
      721 caaagttggg agagattttt gccacagttc aaacacaaaa atgtgaataa acgcaaggaa
      781 ccaaagaaaa aaactgttaa gaaagaatat acgccattcc caccaccaca accagaaagt
      841 cagatcgata aagaattggc tagtggtgaa tactttttga aggcaaatca gaagaagcgg
      901 cagaaaatgg aagcaataaa ggctaaacaa gcagaagcca tcagtaagag acaagaggaa
      961 agaaacaaag catttattcc acctaaggaa aaaccaattg tgaaacctaa ggaagcttct
     1021 actgaaacta aaattgatgt ggccagcatc aaggaaaagg ttaagaaagc aaagaataag
     1081 aaactgggag ctcttacagc tgaagaaatt gcacttaaga tggaggcaga tgaaaagaaa
     1141 aagaagaaaa aaaagtaaca tacccaaaac tccttgacta gaactatctc cttttgtaaa
     1201 ggattttgag atatcaggca ttagttgcct tatttgtgag aaattttctg agggcttttt
     1261 ttttttttgg tggtggtggt tgttcataga agagtgttct ttataaatta tattattatt
     1321 gtattttttg aaaaatttat acgagaaagt ggtatataag tctttgtata cattacgacc
     1381 attgtgatta tccattaaat ccagtgtctg atgctattgg ttagtaatga tgtcccagca
     1441 tttgatgttc cctctctaat gataacaagt aaatatttag gtttatccct tttgaaagtt
     1501 tggttttact tttaacagtc catgaacaga aaattaaggc ctctaaaatc agatccccta
     1561 gttactcctc tgttctgaat ctggggaagt agtaaaccaa aaagacaggg aaaaccagat
     1621 atttagagtc gaagcagcat gcaaaaaata ataatgtttt taactaatga aggctactgg
     1681 agttactaag aatcacctaa aaatgtgcta ctgtaccttg ctcattttgc agatttagaa
     1741 gctgaaacat gggttaggtt acttactaaa agtccacctg tggcaacctg caaataatgc
     1801 ttatttatac taaagatgag tttatctgat agagttagga aatttcttct tttgagtaag
     1861 agtattgcta taacatatat ttttttctga aatgttttaa aatagaagta cacctaattg
     1921 ttattggtta aaaaaaaagc catatgtgaa tgaggttggt ttttgggttt tttctttcct
     1981 gaattgtatt agtccaaaag aactaaatta gggtacttgt gctgtaccaa aatggtaatt
     2041 ataacagaca gtattagaat tactgaatta acaatgagaa agagagaagt gtatctgtta
     2101 cgtggatata tgggccagcc tggatataca acagagtagt aacctgtgaa acaaacatag
     2161 aatatcctct tagacattgt tcctcataat gcactgacag aattcacata gctcttaatg
     2221 aaacaattta agattgatgt acgtacgttt gacttggtct cgctgtcggt taactgtaaa
     2281 gttaggggga agaaagaaaa aaaattaaaa gggtagacac agttgagagt tttattttaa
     2341 aaagctaagt cttataatta tgaccattaa cttgctttgg ctttattgca gtgactttcc
     2401 aagtttaatt attcaaaact ttttgaactg actgaattaa cttggtattt ttaagttgac
     2461 tttttacata aactttataa accttttata aaaaggaaac tataccatta ctataaatgg
     2521 aaaatcattt tacacatcat acctagcagg taataaaatt taaaaaataa aaattaaata
     2581 ttagaatgtg agaaatttat taaaatatag ttctaaaaat aagtttcttc ctgagaagaa
     2641 tgatactgtt tatgatgaat ccatagtgaa aagacagtga cctctctttc atccagtcta
     2701 gtatatcact aaatcatcat tacgatgttt ggctatcaag tcattaatta ctgtcctcct
     2761 ttcactgagc tttattcaaa ttttgacaat cagagcactg ggaagaaata aattccacaa
     2821 ctgcctttag ccttctggat actttctttt ataaaataga aaccttttcc acaccagttc
     2881 tgcagcagtc gctattagat gctcgtggta gaacccatca atcatctggt cctctgggta
     2941 ctggtgagca tccctggtct tcatacctgt gagtgggctt tgtggtgaat tactgtaaat
     3001 atgctaccct cacttttctt ggcagttatg tcgatgaaat caagagtgtg atgttctagt
     3061 tatttttttt tatatatatt tttaaatgtt caatattcaa ctattgaaac aaatgtacat
     3121 ctgtgaacta gctaaaatca tcttatgtac cactaatatg cccagcacat tttgtaaaac
     3181 agtcctgatt tggcctccaa gggtatttat tgaactacca gcagtatcta ggagaccacg
     3241 aaggaatacc acgaaggaat ttatgctcca gtgcttgcca taatttgtct gagaaggaat
     3301 ctgttaaata aaagctttta tcctctaacc tttaccttca tcagacctta taaaaggtca
     3361 aatggtgatt cttaagtttt ttagtcacaa atcttactta ttcagtatta gtgcgaagag
     3421 tagaatactt tcaagtaagc ctaaacttac atgaaaacaa attacataaa tctagctctg
     3481 agaataggaa attagtgaca agatcaatct gtaagatgtt gagcacttat ctgaagtaaa
     3541 tgggtaatga gtttcacatc ttataaatac aagttagcat gtgttttctc aagagtccaa
     3601 gggttttcat tattggacta cagctttaat cttctaaatg ttattcccca agattaaaga
     3661 gcatctcaag ttagatcacc aaagatcaaa agctaaaacc agaagtattt ttgtcattgt
     3721 ggtggtggta gtgttactaa ttgcctagat ttttaaaggg aaacattttt ttcactgggt
     3781 tgtttcgttg aaaaaaatag aagcagaaac ttgcccaaag tcacagtggt caaactggaa
     3841 attgcaccaa aacttggcat actggttctg aaatccatag ttttagccct tatgtatact
     3901 ggttaatttg gaaggaagaa atatatacgt tctgaagtga agagtgagtg aaaggaagaa
     3961 ttcagtgaat acattgatac cttgatatta tctgcattgt ggctacatgt tacttttctt
     4021 cacaagagtg atataagtga aataaagaat gattggactg ggagaaaaat ggctcagaaa
     4081 actttgcaaa agtacgactg tatgtaaaga taagtattca acattaaatg ggaaggagga
     4141 gagcaagcag tttaatatat agaattttat aattttaggc ctgcaaggga ccttataaaa
     4201 catgagcaat ggaacacttt tttccaaact aaatttcgtg cagtggaact tggccgactc
     4261 tgtccttcct ctattctaag caccctactc tagcccggct gctctgagtt cagtttgtta
     4321 caaatatgga cacgaaagta ccacaggctt tgcacagctt aattgaagtt tccccttcac
     4381 accatggtaa aaaaacatac tgggatggaa gggtttgtgt ctagaacaag aacaagaaat
     4441 aaactcttgg tcacttacta atatttcaaa atcacaaagc agaattttgc ttggatgttt
     4501 agtaaaacat ccttggaaat ttaactgctt gcagcttcta cacttcttca ttaaatgctg
     4561 tctggctaat aaaaagtgcc atgttgcagc tttattttat tttcattttt tggagataga
     4621 ccctcactgt gtcacccagg ctggagtgca gtggtacaat ctctgctcac tgcaacctcc
     4681 acctcctggg ctcaagtgat tgtcctgcct cagcctcctg agtagctggg gttacgggcg
     4741 tccaccacca cacccagcta gtttttgtat ttttagtaga gggggttttt gccatgttgg
     4801 ccaggctggg catggtggca tggtaatctc agctacttgg gaggctgagg caggaggatc
     4861 gcctgaaccc gtgagatgga ggttgcagtg agctgagatc acaccactgc actctagcat
     4921 gggtgacaga gcaagactct gtctcaaaaa aaaaaaacaa aaaaaaaaac gaaaacagaa
     4981 ttctgtttgt ttggatgacc tgttatactt atttttgatc ttgctgaaat aagcaaatct
     5041 taggaatctt agtctacagt ttctgacagt tttttttgtt gttgttgttt gaccaattag
     5101 aactaaataa aaagaacgtg attttcacat ttaaatttct cttaaatgta ttcctagaac
     5161 agtaagccat tggtttaatt gctacttgat gccagtttcc ttgaagatag ccgttaagat
     5221 aaaacatggt ttcattgtta attctgtaga aagttacatg ttactattat gttattctat
     5281 tggtgtattg ttccttttac tcaccacaga gattgtccaa acacttgtca ttattggggc
     5341 aggcactgca ggtggctcct ctcttatatg gccaagttgg gtaattccct ctgtaaagca
     5401 gaagaaggat gtccattaga agtttttcgg ttttttaaaa ttgcaattta ctatgaatcc
     5461 ttaactaaat ccagaagaat agtggagtga agtacaaagg tccagagagt tggtaataga
     5521 agtgaagaca ggaaggcaga aatggaaggc tgctaatatt tgcatagttc attctatgta
     5581 cctgtgtcta tgcacctgtt ttaatctgca tcccatttaa ttgtgacagc tctgagagga
     5641 agttattctt gttttacaga tgagacaaaa gatgtaagag atacctttaa tcacaattta
     5701 tacacttcag agtcagagga aacctggatt taactccagg gctgtgctcc ctctctttac
     5761 ctaccctctg gcctatatga ttactgccat ttaaaaaact gtccatctta gaaaagctat
     5821 ggtgacccac attcaatatt ctcagttggt cagccctcca taattttcac tggataggag
     5881 ccatttggct ggtgccttcc aaaaaaataa taaataatgg tatgggggaa tttctaaagt
     5941 acaaattgtt ttcacataca agatgtgata tgaataatag ctgctaatta gtgagcacta
     6001 ccatgtgctt gtctttgttc taaacaacct tgaatgaaat aatcttcaca aaaaccctat
     6061 gaggaagtta ctgttgtcta tttataccca ttatatagct agaggctgag tcacagagta
     6121 taagtaattg accaaggtca cagactagaa agtgaaataa tatccaagca ttttatatcc
     6181 ccataaatat cctcatagta gtaatgggga gagggggcac atttatctca atgaacctgc
     6241 cattgcacta attttttttg gaactctgct tttggaaaaa gttctaaact tttttgtgta
     6301 atcgtaccct ttggcagtct ggtgaggcct atgggctctt tctcaacata gtttgttgtt
     6361 aaatgcataa aatacatagg attataaagg aaaccaatta aattgaaata gttatcaaaa
     6421 tgtttaaaac aagatttgtg ataaagtaat atgtgcttct ctattaagat ctaccggggg
     6481 ctattagttt caatgcagtg atgaacacaa actatatttt gagttctctg cagcaagtgg
     6541 aatgtggtat gaaaatatct gatatttaca aagatgatac tgctaagtca gagtcacgtt
     6601 tattgctaat atgatggtgg agtgttgtct tcattcataa tgaaaggaaa tgttattttt
     6661 aatagaggtt agtgaaaata aaaataaaac tattttctaa tcaaagttta tggtcctcct
     6721 ctccccagca ctctacaatt acctccaaag ttgagaactc tcaccttaga cacacaactt
     6781 tataacgata ccttatttcc aaccccaaat ctatgttctt atctcatttt gctccaaatt
     6841 ttaagttgct tcagaaattt aattagccct ctgcttactc tacaccatgg aaaaaaggta
     6901 atatagtaga aattctgata gcaatttcaa aagatgtcca aaatagacat taatcattgg
     6961 aatgtctttc attgttaata agcacagtat taagtggttt aagttctaga atgattttaa
     7021 taaagtcatt tatgatactt agttgtgcat tccaaactgt aaaggaaaag gtaaaaaatg
     7081 ctacttaaaa ataagctaaa aaccaagaca gtcggtgagg tctgtggaaa tggtagtatt
     7141 catcttggga gaaacatgct actggaaagg cctggatttg tctagatggg agtcattaag
     7201 actgtgggac ctaaagtatt cagcacaata aagcaacagg acatttcaat gttttccctg
     7261 gtagcctgag agagaagagg gttggggtta tgggacccag gggaagaccg aagacaaatc
     7321 tttaaagaaa aagataaata tgggtaaggg tccctaaggc agtgacggcc taagcacact
     7381 ggtactatct tgactatctt gtggtcaaag ttatttcctc ttctgtgcta taatcctctc
     7441 ctccactaat ccactctgag taaagatctg ttacacacca tacccttgtt catggtgccc
     7501 aggggaaatg aagaggagag tattacaggc aactggaaga ttaagcatcc cagaccccat
     7561 tctgaggtat cagaaatatt gaggaggata ctggacttcc taagattatg tggaatgggg
     7621 gcctacaact ttttgtgtat aggaaaataa tacctcagag ggcagagggc aaagggaaat
     7681 gaggacattc ctaactggtc tctctgtttt accttttatg ctcctctaat ccattttcca
     7741 tccagactga tgtccaaatt taaaggtctc atcgctcccc tgcttaatat acttgaatga
     7801 cttcttatgt aaactttgtc atgatctaaa agttcccgct agatctgcaa ctgccttcct
     7861 ccccccgttt catctgttta gcagaccgag ggcaccagtc tctgtggttt aaacttgcca
     7921 aacttttctt cacggaagtt ttgctgttct tttctccact agacagctgt tccagaagtt
     7981 cttatgtctg attccttctc attcttcatg cctaagctta aatataacac aagaagccct
     8041 tccctgatta ttctaaacag gggccttgcc tattgatagt ttctattaca gtattattta
     8101 tagttcctta attgccccat aatgatgcag ttattttact tgtattttta ttatctgttt
     8161 gccccataaa tattactctc ataaagacag agactgccct gttctccttt ggagctcagt
     8221 aaaacaaata tttgttgaat aaatgaatat ttgaagttag tctttatgga agcattataa
     8281 ctttggttgt aagttttata atttaatatt gtttataact ctgaagataa gtgagtctaa
     8341 accaggaaaa tttacattta tactttaatg aataaaaatc atgaatactt acaaaacatt
     8401 cactattgcc aagcattata tatacctagt attttacaaa gccttctctt gtcactttca
     8461 tagctactct aagtgatggg tcctgtaacc ctgatctatt ggaggttaaa ctgagattca
     8521 gagttaactt gtccagggtc acacagtaaa ttaattgtat cttaaccatt aaaaatgtca
     8581 tatgaggccg ggtgtagtgg ctcatgccta taatcccagc actctgggag gctgaggcag
     8641 gtggatcact ttagcccagg agttggagat gagcctgggc aatatggcaa aactctgtct
     8701 ctacaaaaaa attaactggg catggtggca tgtgcctgta gtctcaggta ctaggaaggc
     8761 tgagttggga ggattgcttg agcctgggag gttaagcctg cagtgaaccg taagcgagcc
     8821 actgtactcc agcctgggtg acagagtgag agaccctgtc tcaaaaaaaa aaaaaaaagt
     8881 catgaaaagt taccactaac tgaattatgg ctttgtctag ttttttctgg gttttcttta
     8941 ttttccaact cttaagatat taagtcaaag ctgtcatctt cagaatgacg ctttgtctcc
     9001 tccttcacac ctacagcact cagtcagagt atcgagcatg tcttctgcac attacaccag
     9061 ggaaatggct ttctttcagc caatctccag gaatccaaaa attcaaaggc aacaaattaa
     9121 agatcattat atatattgca aatggttaaa aacctttaaa atataaaaac ttttataaat
     9181 aagaaaatct agtagaaaaa tggtcagccc acatgattca cagaaaaagg aatataaata
     9241 gacaattatg tgaagaaatt tataattact agtaatcaca gagatgcaaa agaaagcaaa
     9301 tgaaatgcca tttccatcaa attagaaaat actaagaaat tataatacct agtactgatg
     9361 gtgaaataca aattgatata atggtggaat gtaatttggc aatatgtact taaaacaaaa
     9421 atggtcacag tctttacgtg ctagtatctc aaggaattat agggaaatag aagtgactga
     9481 agatacatat atgaggttgt tcatcatata ttaaatgaaa atatagtgaa caatctaaat
     9541 tcttcaacag gatggtggta ccatcaagag catggactct ggagctagac agccagatca
     9601 aagtccatca gtgatagtca ctaactgtag aactttgggc aggttgctga cccgtgtgtg
     9661 ccttgctgtt ctcatttgcc aaacaggggt agtaatagga gccatctcat aaacttctgg
     9721 tgaagattaa gttaatatat gtgaagcact ttaacagtgc tgagagcatt gtaagcatta
     9781 tataaacaat ctatcatttt tatgattaaa atcacttaaa attttgaaaa ggaaaatttt
     9841 tcacagcata attttaagtg aaaaatagaa aatgtatatt ttcagtatga tcagatttct
     9901 aaatatgtgt atgacacaag cacacatatg taagtttaaa gaaagtagga ggaaggtgtt
     9961 tgccctgttt cccaaagtgg gaactatatc tgttttaaaa acaactgtca aaagtaaatg
    10021 aaataggtta tataagttga ggaatctgtt ttgctttgaa aattgtgtaa aattgccaag
    10081 tttctaataa accaataaat ataa
//
