LOCUS       NP_008974                381 aa            linear   PRI 28-APR-2025
DEFINITION  KRR1 small subunit processome component homolog [Homo sapiens].
ACCESSION   NP_008974
VERSION     NP_008974.5
DBSOURCE    REFSEQ: accession NM_007043.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 381)
  AUTHORS   Singh,S., Vanden Broeck,A., Miller,L., Chaker-Margot,M. and
            Klinge,S.
  TITLE     Nucleolar maturation of the human small subunit processome
  JOURNAL   Science 373 (6560), eabj5338 (2021)
   PUBMED   34516797
REFERENCE   2  (residues 1 to 381)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (residues 1 to 381)
  AUTHORS   Buljan,M., Ciuffa,R., van Drogen,A., Vichalkovski,A., Mehnert,M.,
            Rosenberger,G., Lee,S., Varjosalo,M., Pernas,L.E., Spegg,V.,
            Snijder,B., Aebersold,R. and Gstaiger,M.
  TITLE     Kinase Interaction Network Expands Functional and Disease Roles of
            Human Kinases
  JOURNAL   Mol Cell 79 (3), 504-520 (2020)
   PUBMED   32707033
REFERENCE   4  (residues 1 to 381)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (residues 1 to 381)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (residues 1 to 381)
  AUTHORS   Andersen,J.S., Lyon,C.E., Fox,A.H., Leung,A.K., Lam,Y.W., Steen,H.,
            Mann,M. and Lamond,A.I.
  TITLE     Directed proteomic analysis of the human nucleolus
  JOURNAL   Curr Biol 12 (1), 1-11 (2002)
   PUBMED   11790298
REFERENCE   7  (residues 1 to 381)
  AUTHORS   Chan,H.Y., Brogna,S. and O'Kane,C.J.
  TITLE     Dribble, the Drosophila KRR1p homologue, is involved in rRNA
            processing
  JOURNAL   Mol Biol Cell 12 (5), 1409-1419 (2001)
   PUBMED   11359931
REFERENCE   8  (residues 1 to 381)
  AUTHORS   Sasaki,T., Toh-E,A. and Kikuchi,Y.
  TITLE     Yeast Krr1p physically and functionally interacts with a novel
            essential Kri1p, and both proteins are required for 40S ribosome
            biogenesis in the nucleolus
  JOURNAL   Mol Cell Biol 20 (21), 7971-7979 (2000)
   PUBMED   11027267
REFERENCE   9  (residues 1 to 381)
  AUTHORS   Gromadka,R., Kaniak,A., Slonimski,P.P. and Rytka,J.
  TITLE     A novel cross-phylum family of proteins comprises a KRR1 (YCL059c)
            gene which is essential for viability of Saccharomyces cerevisiae
            cells
  JOURNAL   Gene 171 (1), 27-32 (1996)
   PUBMED   8675026
REFERENCE   10 (residues 1 to 381)
  AUTHORS   Epplen,C. and Epplen,J.T.
  TITLE     Expression of (cac)n/(gtg)n simple repetitive sequences in mRNA of
            human lymphocytes
  JOURNAL   Hum Genet 93 (1), 35-41 (1994)
   PUBMED   7505766
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC005225.1 and AC121761.4.
            
            On Nov 10, 2006 this sequence version replaced NP_008974.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC033887.2, SRR14038197.1810552.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000229214.9/ ENSP00000229214.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..381
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q21.2"
     Protein         1..381
                     /product="KRR1 small subunit processome component homolog"
                     /note="Rev interacting protein; rev-interacting protein 1;
                     HIV-1 Rev-binding protein 2; KRR-R motif-containing
                     protein 1; KRR1, small subunit (SSU) processome component,
                     homolog; HIV-1 rev binding protein 2"
                     /calculated_mol_wt=43534
     Region          1..51
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q13601.4)"
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine. /evidence=ECO:0000269|Ref.6,
                     ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:20068231,
                     ECO:0007744|PubMed:21406692; propagated from
                     UniProtKB/Swiss-Prot (Q13601.4)"
     Site            3
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:20068231,
                     ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163;
                     propagated from UniProtKB/Swiss-Prot (Q13601.4)"
     Site            5
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q13601.4)"
     Region          54..136
                     /region_name="KH-I_KRR1_rpt1"
                     /note="first type I K homology (KH) RNA-binding domain
                     found in KRR1 small subunit processome component and
                     similar proteins; cd22393"
                     /db_xref="CDD:411821"
     Site            order(59,61..68,92..98,109..111,114)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:411821"
     Region          140..231
                     /region_name="KH-I_KRR1_rpt2"
                     /note="second type I K homology (KH) RNA-binding domain
                     found in KRR1 small subunit processome component and
                     similar proteins; cd22394"
                     /db_xref="CDD:411822"
     Site            order(148..149,152..153,188,214)
                     /site_type="other"
                     /note="RNA binding site [nucleotide binding]"
                     /db_xref="CDD:411822"
     Site            order(163,171,174,212,214,216..217,219..220,223)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:411822"
     Region          250..278
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q13601.4)"
     Region          309..338
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q13601.4)"
     CDS             1..381
                     /gene="KRR1"
                     /gene_synonym="HRB2; RIP-1"
                     /coded_by="NM_007043.7:13..1158"
                     /db_xref="CCDS:CCDS9012.1"
                     /db_xref="GeneID:11103"
                     /db_xref="HGNC:HGNC:5176"
                     /db_xref="MIM:612817"
ORIGIN      
        1 maspslerpe kgagksefrn qkpkpenqde selltvpdgw kepafskedn prglleessf
       61 atlfpkyrea ylkecwplvq kalnehhvna tldliegsmt vcttkktfdp yiiirardli
      121 kllarsvsfe qavrilqddv acdiikigsl vrnkerfvkr rqrligpkgs tlkalelltn
      181 cyimvqgntv saigpfsglk evrkvvldtm knihpiynik slmikrelak dselrsqswe
      241 rflpqfkhkn vnkrkepkkk tvkkeytpfp ppqpesqidk elasgeyflk anqkkrqkme
      301 aikakqaeai skrqeernka fippkekpiv kpkeastetk idvasikekv kkaknkklga
      361 ltaeeialkm eadekkkkkk k
//
