LOCUS       NM_023008               2989 bp    mRNA    linear   PRI 10-FEB-2024
DEFINITION  Homo sapiens KRI1 homolog (KRI1), mRNA.
ACCESSION   NM_023008
VERSION     NM_023008.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2989)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   2  (bases 1 to 2989)
  AUTHORS   Trynka,G., Zhernakova,A., Romanos,J., Franke,L., Hunt,K.A.,
            Turner,G., Bruinenberg,M., Heap,G.A., Platteel,M., Ryan,A.W., de
            Kovel,C., Holmes,G.K., Howdle,P.D., Walters,J.R., Sanders,D.S.,
            Mulder,C.J., Mearin,M.L., Verbeek,W.H., Trimble,V., Stevens,F.M.,
            Kelleher,D., Barisani,D., Bardella,M.T., McManus,R., van Heel,D.A.
            and Wijmenga,C.
  TITLE     Coeliac disease-associated risk variants in TNFAIP3 and REL
            implicate altered NF-kappaB signalling
  JOURNAL   Gut 58 (8), 1078-1083 (2009)
   PUBMED   19240061
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   3  (bases 1 to 2989)
  AUTHORS   Imabayashi,H., Mori,T., Gojo,S., Kiyono,T., Sugiyama,T., Irie,R.,
            Isogai,T., Hata,J., Toyama,Y. and Umezawa,A.
  TITLE     Redifferentiation of dedifferentiated chondrocytes and
            chondrogenesis of human bone marrow stromal cells via chondrosphere
            formation with expression profiling by large-scale cDNA analysis
  JOURNAL   Exp Cell Res 288 (1), 35-50 (2003)
   PUBMED   12878157
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA438802.1, BC112251.1, BC002890.2 and BM676050.1.
            
            On May 17, 2019 this sequence version replaced NM_023008.4.
            
            Summary: This gene overlaps with the gene for cysteine
            endopeptidase AUT-like 4 in a head-to-tail orientation. [provided
            by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK300780.1, SRR11853559.16363.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000312962.12/ ENSP00000320917.9
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-143               DA438802.1         17-159
            144-556             DA438802.1         161-573
            557-2191            BC112251.1         230-1864
            2192-2498           BC002890.2         1873-2179
            2499-2989           BM676050.1         19-509              c
FEATURES             Location/Qualifiers
     source          1..2989
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..2989
                     /gene="KRI1"
                     /note="KRI1 homolog"
                     /db_xref="GeneID:65095"
                     /db_xref="HGNC:HGNC:25769"
     exon            1..105
                     /gene="KRI1"
                     /inference="alignment:Splign:2.1.0"
     CDS             12..2123
                     /gene="KRI1"
                     /codon_start=1
                     /product="protein KRI1 homolog"
                     /protein_id="NP_075384.4"
                     /db_xref="CCDS:CCDS12242.2"
                     /db_xref="GeneID:65095"
                     /db_xref="HGNC:HGNC:25769"
                     /translation="MPEPRGSSQLRVNAAFAARYNRYREREELQRLKDRYGDRDSSSD
                     SSSESDSSDERVEFDPQQERDFYKTLSLLKKKDPRIYQKDATFYNRTASSSDSEEDPE
                     ALEKQKKVRPMYLKDYERKVILEKAGKYVDEENSDGETSNHRLQETSSQSYVEEQKQL
                     KESFRAFVEDSEDEDGAGEGGSSLLQKRAKTRQEKAQEEADYIEWLKGQKEIRNPDSL
                     KELTHLKEYWNDPELDEGERFLRDYILNKRYEEEEEEEEDEEEMEEEEGVHGPPVQLA
                     VDDSSDEGELFLKKQEDFEQKYNFRFEEPDSASVKTYPRSIASSVRRKDERRKEKREE
                     TRERKKREKAKKQEELKQLKNLKRKEILAKLEKLRKVTGNEMLGLEEGDLEDDFDPAQ
                     HDQLMQKCFGDEYYGAVEEEKPQFEEEEGLEDDWNWDTWDGPEQEGDWSQQELHCEDP
                     NFNMDADYDPSQPRKKKREAPLTGKKKRKSPFAAAVGQEKPVFEPGDKTFEEYLDEYY
                     RLDYEDIIDDLPCRFKYRTVVPCDFGLSTEEILAADDKELNRWCSLKKTCMYRSEQEE
                     LRDKRAYSQKAQNSWKKRQVFKSLCREEAETPAEATGKPQRDEAGPQRQLPALDGSLM
                     GPESPPAQEEEAPVSPHKKPAPQKRRRAKKARLLGPTVMLGGCEFSRQRLQAFGLNPK
                     RLHFRQLGRQRRKQQGPKNSS"
     exon            106..179
                     /gene="KRI1"
                     /inference="alignment:Splign:2.1.0"
     exon            180..285
                     /gene="KRI1"
                     /inference="alignment:Splign:2.1.0"
     exon            286..394
                     /gene="KRI1"
                     /inference="alignment:Splign:2.1.0"
     exon            395..449
                     /gene="KRI1"
                     /inference="alignment:Splign:2.1.0"
     exon            450..499
                     /gene="KRI1"
                     /inference="alignment:Splign:2.1.0"
     exon            500..596
                     /gene="KRI1"
                     /inference="alignment:Splign:2.1.0"
     exon            597..674
                     /gene="KRI1"
                     /inference="alignment:Splign:2.1.0"
     exon            675..811
                     /gene="KRI1"
                     /inference="alignment:Splign:2.1.0"
     exon            812..938
                     /gene="KRI1"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1034
                     /gene="KRI1"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1205
                     /gene="KRI1"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1281
                     /gene="KRI1"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..1370
                     /gene="KRI1"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1497
                     /gene="KRI1"
                     /inference="alignment:Splign:2.1.0"
     exon            1498..1628
                     /gene="KRI1"
                     /inference="alignment:Splign:2.1.0"
     exon            1629..1693
                     /gene="KRI1"
                     /inference="alignment:Splign:2.1.0"
     exon            1694..1792
                     /gene="KRI1"
                     /inference="alignment:Splign:2.1.0"
     exon            1793..2989
                     /gene="KRI1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2498..2503
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KRI1"
                     /note="hexamer: ATTAAA"
     polyA_site      2525
                     /gene="KRI1"
                     /note="major polyA site"
     regulatory      2961..2966
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KRI1"
                     /note="hexamer: AATAAA"
     polyA_site      2989
                     /gene="KRI1"
                     /note="major polyA site"
ORIGIN      
        1 acagaaccgc catgccggaa ccgcgcgggt cgtcgcagct gcgggtgaac gcggcgtttg
       61 ccgcgcggta caaccgctac cgggagcgcg aggaactgca gcggctgaag gatcgctacg
      121 gggaccgaga cagcagcagc gactccagct ccgagtcgga ctcaagcgac gagcgcgtgg
      181 aatttgatcc ccagcaggag cgggactttt acaaaacgct ctccttgttg aagaagaagg
      241 acccccgcat ttatcagaaa gatgccacct tctataacag aacagcatcg tcatcagaca
      301 gtgaggagga cccagaagcc ttggagaagc agaagaaagt gcggcccatg tacctgaagg
      361 actacgagag gaaggttatc ttggagaagg caggcaaata tgttgatgag gagaactcag
      421 acggggagac ttccaatcac agactccagg agacatcgtc gcaaagttat gtggaggaac
      481 agaaacagct caaggaaagc ttccgggcat ttgtggagga cagtgaggac gaggacggcg
      541 ctggggaggg cggctccagt ttgctgcaga aacgtgccaa aaccaggcag gagaaggccc
      601 aggaggaggc cgactacatc gagtggctga agggacagaa agagattcgg aacccagatt
      661 ccctgaagga actgacgcat ctcaaggaat actggaacga ccctgagttg gatgaagggg
      721 agcggttcct gcgggattac atcctcaaca aacgctatga ggaggaggaa gaggaggagg
      781 aagatgaaga ggaaatggag gaagaggagg gggtccacgg tcccccagtc cagctggctg
      841 tggacgactc ctcagacgaa ggggagctgt ttctgaagaa acaggaggac tttgaacaga
      901 agtacaattt ccgtttcgag gagccggact cagcatcggt caagacctac ccacgcagca
      961 tcgcgtcctc cgtgcgccgt aaggatgagc gcagaaagga gaagagggaa gagactcggg
     1021 agcgaaagaa gagggagaaa gcaaagaagc aggaagagct caagcagctg aagaacctga
     1081 agaggaagga gattctggcc aagctggaga agctgcggaa agtaacaggc aacgagatgc
     1141 tgggcctcga ggagggggac cttgaagacg acttcgaccc tgcccagcac gaccagctca
     1201 tgcagaagtg ctttggggac gagtactacg gggccgtgga ggaggagaag ccacaatttg
     1261 aggaagaaga agggcttgaa gacgactgga actgggacac gtgggacggg cctgagcagg
     1321 agggagactg gagccagcag gagctgcact gtgaggaccc caacttcaac atggacgccg
     1381 actacgaccc cagccagccg aggaagaaaa agcgcgaggc ccccttgacg ggcaagaaga
     1441 agcgcaagtc gcccttcgcc gcggccgtgg ggcaggagaa gcccgtgttt gaacccgggg
     1501 acaagacgtt cgaggagtac ctggatgagt attaccggct ggactacgag gacatcatcg
     1561 acgacctgcc ctgtcgcttc aagtaccgca cagtggtgcc ctgtgacttt ggcctcagca
     1621 ctgaggagat cctcgctgct gacgataagg agctgaaccg gtggtgctcc ctaaagaaga
     1681 cctgcatgta caggtcagag caggaggagc tgcgggacaa gcgggcgtac agccagaagg
     1741 cccagaactc atggaaaaag cggcaggtct tcaagtcact ctgccgagaa gaggcagaga
     1801 cacctgcgga agccacaggg aagccacaga gagatgaagc cggcccacag aggcagctgc
     1861 cagcccttga tggcagcttg atggggccgg agagtccccc agcacaggaa gaggaagccc
     1921 ctgtatcacc ccacaagaag ccagcccccc agaagcggag gagggccaag aaggcacggc
     1981 tgctgggccc cactgtgatg cttggtggat gcgagttcag ccgccagaga ctgcaggcct
     2041 ttggcctcaa ccccaaacgg ctgcacttcc gccagctggg ccggcagcgg aggaaacaac
     2101 aggggcccaa gaacagctcc tgagcaccag ggagcaggca ggggcctcag gctcctctcc
     2161 tcaaatcaag ccctggacag gtctcgcacc cacaagtact atctgctgca gagatcctct
     2221 catctgtggc caggcacgcc tgtaatccca gcactttggg aggccgaggt gaaaggatca
     2281 cttgagccca ggaattggag accagcgtgg gcaacttagc gagactccat ctctacaaaa
     2341 tgtggtgaca catgcctgta gtcccagcta ctcaggaggc tggggaagga agatcactta
     2401 aggccatgag tttgaggcta cagagagcta tgattgcacc actgcactcc agcctgggca
     2461 acaaagcaag accctgtctc ttgaaaaaaa aaaaaaaatt aaaaaacacg tgtagctgtg
     2521 ggtaaggaag tcgtcccatt ttatggatgt ggaaactgag gctgacttaa acttcccgtg
     2581 acttggagct ctcacctcga gacacctccc agaccccaca tcccctcaga acgctgcgcc
     2641 cagccacacc cacgatcaag ttacacagct ttattggccc ccagcagcca cagttccccc
     2701 aagggggctt tgggacaggg agggcccggg cgtccagtgc aaactacagt acgtgagtca
     2761 ggccctgagg ggggtgcccg gggtcctcct tccctaccct gccaggaggg ccccgctggt
     2821 gggagacagg tgtatgggct ctgtgggctc tgtccctggc tgaatggccc cagactggtt
     2881 gcagctgggc ttgaggggct gacaacagga agtaccatca tcactgccag agctcaagat
     2941 cccacacccg acatgacata aataaaaaaa taaatagtgt tgtatcttt
//
