LOCUS       NM_172229               1995 bp    mRNA    linear   PRI 09-JUL-2024
DEFINITION  Homo sapiens kringle containing transmembrane protein 2 (KREMEN2),
            transcript variant 4, mRNA.
ACCESSION   NM_172229
VERSION     NM_172229.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1995)
  AUTHORS   Hou,R., Wang,Y., Cao,S., Sun,X. and Jiang,L.
  TITLE     N6-Methyladenosine-Modified KREMEN2 Promotes Tumorigenesis and
            Malignant Progression of High-Grade Serous Ovarian Cancer
  JOURNAL   Lab Invest 104 (6), 102059 (2024)
   PUBMED   38615731
  REMARK    GeneRIF: N[6]-Methyladenosine-Modified KREMEN2 Promotes
            Tumorigenesis and Malignant Progression of High-Grade Serous
            Ovarian Cancer.
REFERENCE   2  (bases 1 to 1995)
  AUTHORS   Sumia,I., Pierani,A. and Causeret,F.
  TITLE     Kremen1-induced cell death is regulated by homo- and
            heterodimerization
  JOURNAL   Cell Death Discov 5, 91 (2019)
   PUBMED   31069116
  REMARK    GeneRIF: KREMEN2 is upregulated in cancers, consistent with its
            role in inhibiting Kremen1-induced cell death
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1995)
  AUTHORS   Dun,X., Jiang,H., Zou,J., Shi,J., Zhou,L., Zhu,R. and Hou,J.
  TITLE     Differential expression of DKK-1 binding receptors on stromal cells
            and myeloma cells results in their distinct response to secreted
            DKK-1 in myeloma
  JOURNAL   Mol Cancer 9, 247 (2010)
   PUBMED   20846389
  REMARK    GeneRIF: The mRNA expression levels of DKK-1 binding receptor
            LRP5/6 and Krm1/2 in SCs from patients with MM were significantly
            higher than those in myeloma cells and in SCs from healthy donors.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1995)
  AUTHORS   Mao,B., Wu,W., Davidson,G., Marhold,J., Li,M., Mechler,B.M.,
            Delius,H., Hoppe,D., Stannek,P., Walter,C., Glinka,A. and Niehrs,C.
  TITLE     Kremen proteins are Dickkopf receptors that regulate
            Wnt/beta-catenin signalling
  JOURNAL   Nature 417 (6889), 664-667 (2002)
   PUBMED   12050670
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC009383.2, AB086405.1 and
            BC003533.1.
            
            On Nov 22, 2018 this sequence version replaced NM_172229.2.
            
            Summary: This gene encodes a high-affinity dickkopf homolog 1
            (DKK1) transmembrane receptor. A similar protein in mouse functions
            interacts with with DKK1 to block wingless (WNT)/beta-catenin
            signaling. The encoded protein forms a ternary membrane complex
            with DKK1 and the WNT receptor lipoprotein receptor-related protein
            6 (LRP6), and induces rapid endocytosis and removal of LRP6 from
            the plasma membrane. It contains extracellular kringle, WSC, and
            CUB domains. Alternatively spliced transcript variants encoding
            distinct isoforms have been observed for this gene. [provided by
            RefSeq, Dec 2011].
            
            Transcript Variant: This variant (4) represents the longest
            transcript and encodes the longest isoform (d).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB086405.1, SRR7346977.865336.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145893 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000303746.10/ ENSP00000304422.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-246               BC009383.2         60-305
            247-1635            AB086405.1         1-1389
            1636-1995           BC003533.1         1423-1782
FEATURES             Location/Qualifiers
     source          1..1995
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..1995
                     /gene="KREMEN2"
                     /gene_synonym="KRM2"
                     /note="kringle containing transmembrane protein 2"
                     /db_xref="GeneID:79412"
                     /db_xref="HGNC:HGNC:18797"
                     /db_xref="MIM:609899"
     exon            1..340
                     /gene="KREMEN2"
                     /gene_synonym="KRM2"
                     /inference="alignment:Splign:2.1.0"
     CDS             247..1635
                     /gene="KREMEN2"
                     /gene_synonym="KRM2"
                     /note="isoform d precursor is encoded by transcript
                     variant 4; kremen protein 2; dickkopf receptor 2; kringle
                     domain-containing transmembrane protein 2;
                     kringle-containing protein marking the eye and the nose"
                     /codon_start=1
                     /product="kremen protein 2 isoform d precursor"
                     /protein_id="NP_757384.1"
                     /db_xref="CCDS:CCDS10483.1"
                     /db_xref="GeneID:79412"
                     /db_xref="HGNC:HGNC:18797"
                     /db_xref="MIM:609899"
                     /translation="MGTQALQGFLFLLFLPLLQPRGASAGSLHSPGLSECFQVNGADY
                     RGHQNRTGPRGAGRPCLFWDQTQQHSYSSASDPHGRWGLGAHNFCRNPDGDVQPWCYV
                     AETEEGIYWRYCDIPSCHMPGYLGCFVDSGAPPALSGPSGTSTKLTVQVCLRFCRMKG
                     YQLAGVEAGYACFCGSESDLARGRLAPATDCDQICFGHPGQLCGGDGRLGVYEVSVGS
                     CQGNWTAPQGVIYSPDFPDEYGPDRNCSWALGPPGAALELTFRLFELADPRDRLELRD
                     AASGSLLRAFDGARPPPSGPLRLGTAALLLTFRSDARGHAQGFALTYRGLQDAAEDPE
                     APEGSAQTPAAPLDGANVSCSPRPGAPPAAIGARVFSTVTAVSVLLLLLLGLLRPLRR
                     RSCLLAPGKGPPALGASRGPRRSWAVWYQQPRGVALPCSPGDPQAEGSAAGYRPLSAS
                     SQSSLRSLISAL"
     exon            341..515
                     /gene="KREMEN2"
                     /gene_synonym="KRM2"
                     /inference="alignment:Splign:2.1.0"
     exon            516..607
                     /gene="KREMEN2"
                     /gene_synonym="KRM2"
                     /inference="alignment:Splign:2.1.0"
     exon            608..732
                     /gene="KREMEN2"
                     /gene_synonym="KRM2"
                     /inference="alignment:Splign:2.1.0"
     exon            733..886
                     /gene="KREMEN2"
                     /gene_synonym="KRM2"
                     /inference="alignment:Splign:2.1.0"
     exon            887..1219
                     /gene="KREMEN2"
                     /gene_synonym="KRM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1345
                     /gene="KREMEN2"
                     /gene_synonym="KRM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1424
                     /gene="KREMEN2"
                     /gene_synonym="KRM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..1995
                     /gene="KREMEN2"
                     /gene_synonym="KRM2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1975..1980
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KREMEN2"
                     /gene_synonym="KRM2"
                     /note="hexamer: AATAAA"
     polyA_site      1995
                     /gene="KREMEN2"
                     /gene_synonym="KRM2"
                     /note="major polyA site"
ORIGIN      
        1 agattccccc cggagagacc cgggtaggga cagggacaga gagacgcctc taggggcaga
       61 ggccctggga ggcaaagacc cccaggagag atttacccac cccagacgga aagcgcggct
      121 cagagtcgga cgaggggaga ctgtcagagg acaacgcccc ctaggtctcc tgggagaccc
      181 cgaagcgacc ccgggggcag cccgggccgt gtccgggcga gggtgaccta tccttggttg
      241 agagcgatgg ggacacaagc cctgcagggc ttcctctttc tcctcttcct cccgctgctg
      301 cagccgcgtg gggcctcggc tgggagcctg cacagtccag gcctgtccga atgcttccag
      361 gtgaatgggg ctgactaccg cggccaccag aaccgcactg gcccgcgcgg ggcgggccgc
      421 ccgtgcctct tctgggacca gacgcagcaa cacagctaca gcagcgccag cgacccccac
      481 ggccgctggg ggctgggcgc gcacaacttc tgccgtaacc cagacggtga cgtgcagccg
      541 tggtgctacg tggctgagac agaggagggc atctactggc gctactgcga catcccctcc
      601 tgtcacatgc caggctacct gggatgcttt gtggactcag gggcaccccc agccctcagc
      661 ggccccagcg gcacctccac gaagctcacg gtccaggtgt gcctacgctt ctgccgcatg
      721 aaggggtacc agctggcggg cgtggaggcc ggttacgcct gcttctgtgg ctctgaaagc
      781 gacctggccc ggggacgcct ggcccccgcc accgactgtg accagatctg tttcggccac
      841 cctggacagc tgtgtggcgg cgatgggcgg ctgggcgtct atgaagtgtc ggtgggctcc
      901 tgccagggga actggacagc gcctcagggc gtcatctact ccccggactt cccggacgag
      961 tacgggccgg accggaactg cagctgggcc ctgggcccgc caggcgccgc gctggagctc
     1021 accttccgcc tcttcgagct ggccgacccg cgcgaccggc tggagctgcg cgacgcggct
     1081 tcgggcagcc tgctccgcgc cttcgatggc gcccgcccac cgccgtccgg gccgctgcgc
     1141 ctgggcactg ccgcgctgct gctcaccttc cgaagcgacg cgcgcggcca cgcgcaaggc
     1201 ttcgcgctca cctaccgcgg gctgcaggac gccgctgagg acccagaggc ccccgagggc
     1261 tcggcccaga cccccgcggc gcccctcgac ggggccaacg tgagctgcag ccccaggcct
     1321 ggggctccgc cggccgcgat tggggcccgg gtcttctcga cggtgacggc tgtctcggtg
     1381 ctgctgctgc tgctcctggg gctgctgcgt ccgctgcgcc gacggagctg tctgctggct
     1441 ccgggaaaag ggcccccggc gctgggggct tccaggggcc ccaggagaag ctgggctgtg
     1501 tggtaccaac agccccgagg ggtggccttg ccctgctccc ccggggaccc ccaggctgag
     1561 ggttctgccg cgggctaccg gcctctgagt gcctccagcc agagctccct gcgctcgctc
     1621 atctccgctc tctgactctg ggccccgagg gtccgctggg cccgccgccg gcgagatgga
     1681 cacctgagat gctgtgctgc gccctgcctc ggccttgcgc ctgtgtaggg gcagctcggc
     1741 ctctggtcgc cttggggaga ccaaaagtcg gacaggaaac atctggtgct attatctggg
     1801 acttggcctg accgtggggg tccagatggt ccaggccctc tccatggacc tgtatgtggg
     1861 ggtggtctct ggtttcggag gtctttgaac ccctctgggg gtggtcctgg actgccgtcc
     1921 tcagtgagag gtcacaggtc agcaaaaaca gtcaaaaaac ccccacagat tttgaataaa
     1981 ggatctactt tggta
//
