LOCUS       NM_016618               1807 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens lysine rich coiled-coil 1 (KRCC1), transcript variant
            1, mRNA.
ACCESSION   NM_016618
VERSION     NM_016618.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1807)
  AUTHORS   Neizer-Ashun,F., Dwivedi,S.K.D., Dey,A., Thavathiru,E., Berry,W.L.,
            Lees-Miller,S.P., Mukherjee,P. and Bhattacharya,R.
  TITLE     KRCC1, a modulator of the DNA damage response
  JOURNAL   Nucleic Acids Res 50 (19), 11028-11039 (2022)
   PUBMED   36243983
REFERENCE   2  (bases 1 to 1807)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 1807)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1807)
  AUTHORS   Dwivedi,S.K.D., Shameer,K., Dey,A., Mustafi,S.B., Xiong,X.,
            Bhattacharya,U., Neizer-Ashun,F., Rao,G., Wang,Y., Ivan,C.,
            Yang,D., Dudley,J.T., Xu,C., Wren,J.D., Mukherjee,P. and
            Bhattacharya,R.
  TITLE     KRCC1: A potential therapeutic target in ovarian cancer
  JOURNAL   FASEB J 34 (2), 2287-2300 (2020)
   PUBMED   31908025
  REMARK    GeneRIF: KRCC1: A potential therapeutic target in ovarian cancer.
REFERENCE   5  (bases 1 to 1807)
  AUTHORS   Lai,M.Y. and Lau,Y.L.
  TITLE     Measurement of binding strength between prey proteins interacting
            with Toxoplasma gondii SAG1 and SAG2 using isothermal titration
            calorimetry (ITC)
  JOURNAL   Acta Parasitol 63 (1), 106-113 (2018)
   PUBMED   29351065
  REMARK    GeneRIF: By observing the data obtained from the isothermal
            titration calorimetry assay, both of the human proteins (KRCC1 and
            ZFAND6) were demonstrated to bind to their respective Toxoplasma
            gondii SAG1 and SAG2 proteins.
REFERENCE   6  (bases 1 to 1807)
  AUTHORS   Orvedahl,A., Sumpter,R. Jr., Xiao,G., Ng,A., Zou,Z., Tang,Y.,
            Narimatsu,M., Gilpin,C., Sun,Q., Roth,M., Forst,C.V., Wrana,J.L.,
            Zhang,Y.E., Luby-Phelps,K., Xavier,R.J., Xie,Y. and Levine,B.
  TITLE     Image-based genome-wide siRNA screen identifies selective autophagy
            factors
  JOURNAL   Nature 480 (7375), 113-117 (2011)
   PUBMED   22020285
REFERENCE   7  (bases 1 to 1807)
  AUTHORS   Johnson,A.D., Kavousi,M., Smith,A.V., Chen,M.H., Dehghan,A.,
            Aspelund,T., Lin,J.P., van Duijn,C.M., Harris,T.B., Cupples,L.A.,
            Uitterlinden,A.G., Launer,L., Hofman,A., Rivadeneira,F.,
            Stricker,B., Yang,Q., O'Donnell,C.J., Gudnason,V. and Witteman,J.C.
  TITLE     Genome-wide association meta-analysis for total serum bilirubin
            levels
  JOURNAL   Hum Mol Genet 18 (14), 2700-2710 (2009)
   PUBMED   19414484
REFERENCE   8  (bases 1 to 1807)
  AUTHORS   Dominguez,O., Ashhab,Y., Sabater,L., Belloso,E., Caro,P. and
            Pujol-Borrell,R.
  TITLE     Cloning of ARE-containing genes by AU-motif-directed display
  JOURNAL   Genomics 54 (2), 278-286 (1998)
   PUBMED   9828130
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB461504.1, AF208845.1 and AC108479.5.
            
            On Nov 23, 2018 this sequence version replaced NM_016618.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.184964.1,
                                           SRR1660807.100064.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA2467146,
                                           SAMEA2467148 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000347055.4/ ENSP00000340083.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-54                DB461504.1         19-72
            55-1709             AF208845.1         1-1655
            1710-1710           AC108479.5         149031-149031       c
            1711-1807           AF208845.1         1657-1753
FEATURES             Location/Qualifiers
     source          1..1807
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p11.2"
     gene            1..1807
                     /gene="KRCC1"
                     /gene_synonym="CHBP2"
                     /note="lysine rich coiled-coil 1"
                     /db_xref="GeneID:51315"
                     /db_xref="HGNC:HGNC:28039"
     exon            1..158
                     /gene="KRCC1"
                     /gene_synonym="CHBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            159..267
                     /gene="KRCC1"
                     /gene_synonym="CHBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            268..426
                     /gene="KRCC1"
                     /gene_synonym="CHBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            427..1807
                     /gene="KRCC1"
                     /gene_synonym="CHBP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             449..1228
                     /gene="KRCC1"
                     /gene_synonym="CHBP2"
                     /note="cryptogenic hepatitis-binding protein 2"
                     /codon_start=1
                     /product="lysine-rich coiled-coil protein 1"
                     /protein_id="NP_057702.1"
                     /db_xref="CCDS:CCDS2000.1"
                     /db_xref="GeneID:51315"
                     /db_xref="HGNC:HGNC:28039"
                     /translation="MKHSKKTYDSFQDELEDYIKVQKARGLEPKTCFRKMKGDYLETC
                     GYKGEVNSRPTYRMFDQRLPSETIQTYPRSCNIPQTVENRLPQWLPAHDSRLRLDSLS
                     YCQFTRDCFSEKPVPLNFNQQEYICGSHGVEHRVYKHFSSDNSTSTHQASHKQIHQKR
                     KRHPEEGREKSEEERSKHKRKKSCEEIDLDKHKSIQRKKTEVEIETVHVSTEKLKNRK
                     EKKSRDVVSKKEERKRTKKKKEQGQERTEEEMLWDQSILGF"
     regulatory      1787..1792
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KRCC1"
                     /gene_synonym="CHBP2"
                     /note="hexamer: AATAAA"
     polyA_site      1807
                     /gene="KRCC1"
                     /gene_synonym="CHBP2"
                     /note="major polyA site"
ORIGIN      
        1 ctcctcctcc catccagcct gctcggcggc ggaggcggcg gtggcggcag cggttgttcc
       61 tgcctctccg ccacctccac cgcggcttat cccctggctg gcggcgttgg cggggcgggg
      121 gacagtagtt gtagacgccc gcccctgcct cagagaagat accacattga atgaacaaag
      181 actgaacttt gtttacagat accttttata aaagatgtct gtggagtagt gttacagttc
      241 aaataacaaa ggattttgca ttatgagatg agtgagagtg gagaattgga caaaaattga
      301 tttttgatct ctgaattgtg gtttttagct caccagttat tgtgtagtct cactatttga
      361 aaattcatgc tgaaaaactg agtgaatatg atcagatttc tccaccaaat tctcagcctg
      421 ataaggaaaa tcccgttttg tcaacctaat gaagcattca aagaagacat atgactcttt
      481 tcaagatgaa cttgaagatt atattaaagt acagaaagcc agaggcttag agccaaagac
      541 ttgtttcaga aagatgaaag gggactattt ggaaacctgt gggtacaaag gagaggttaa
      601 ttccagaccc acgtatagaa tgtttgacca gagactccca tctgaaacca tccagaccta
      661 cccaagatca tgcaatattc cacaaacagt ggaaaatcgg ttgcctcagt ggttaccagc
      721 ccatgacagc agattgagac tagactctct gagctactgt cagttcacga gggactgttt
      781 ctcagaaaaa ccagtacccc tgaactttaa tcaacaagaa tatatttgtg gctcacatgg
      841 tgtagaacat agagtttaca agcacttctc ctcagataac agtaccagta ctcatcaagc
      901 cagtcacaaa cagatacatc agaagaggaa aaggcaccca gaggaaggca gagaaaaatc
      961 agaggaggag cggtctaagc ataagagaaa aaaaagctgc gaggaaattg acttagacaa
     1021 acacaagagc atccaaagaa agaaaacaga ggtggaaata gaaaccgtac atgtcagtac
     1081 agaaaagctt aagaatcgaa aggagaaaaa aagccgagat gtagtctcta agaaagagga
     1141 acgtaagcgt acaaaaaaga aaaaggaaca aggccaagaa aggacagagg aggaaatgct
     1201 ttgggaccag tctattcttg gattttgaag ctttcaaagt tggttctccc aaagttaaat
     1261 tgaaaaaata ggtgagagct tggttttatg atatccgtgt tcataccact tttcttatgt
     1321 gaataggttc tttaacttct aacaaaggcc tagtaaacaa agtgtttagc atgcttgctc
     1381 tccaacacag aaattgcttt tcctcatttt ctaaaagcat tattacattt tttgaacata
     1441 tagtgtaatt tcctttaatg aaagtgactc tgcttttatt catcaaattg ctttgatggt
     1501 ggaaatattt tctgttggga ggttatttat tttaaattgg aggattaatg acctttgcac
     1561 aatctgtttc ttgattgggt ttgttatagt tttgagttgg gtattttatg ttcattggtt
     1621 tttctctgtg aagcaatttt tttctccttt attagatcta acttgcagtg tattttctag
     1681 gctggaaagt ggaaaatgaa atatattata atcttaggtt acataaagtt tctaaagttt
     1741 caaagagtct tgatacaaaa tcagtttata ttctgaaaat atttataata aagtattcta
     1801 atttcta
//
