LOCUS       NM_001130913            2759 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens KRAB box domain containing 5 (KRBOX5), transcript
            variant 14, mRNA.
ACCESSION   NM_001130913
VERSION     NM_001130913.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2759)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2759)
  AUTHORS   Nowick,K. and Stubbs,L.
  TITLE     Lineage-specific transcription factors and the evolution of gene
            regulatory networks
  JOURNAL   Brief Funct Genomics 9 (1), 65-78 (2010)
   PUBMED   20081217
  REMARK    Review article
REFERENCE   3  (bases 1 to 2759)
  AUTHORS   Hamilton,A.T., Huntley,S., Tran-Gyamfi,M., Baggott,D.M., Gordon,L.
            and Stubbs,L.
  TITLE     Evolutionary expansion and divergence in the ZNF91 subfamily of
            primate-specific zinc finger genes
  JOURNAL   Genome Res 16 (5), 584-594 (2006)
   PUBMED   16606703
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC074050.3 and BC018134.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001130913.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC018134.1, SRR1660807.109815.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000316491.14/ ENSP00000319222.9
            RefSeq Select criteria :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                AC074050.3         8568-8597           c
            31-2759             BC018134.1         1-2729
FEATURES             Location/Qualifiers
     source          1..2759
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p11.2"
     gene            1..2759
                     /gene="KRBOX5"
                     /gene_synonym="ZNF720"
                     /note="KRAB box domain containing 5"
                     /db_xref="GeneID:124411"
                     /db_xref="HGNC:HGNC:26987"
     exon            1..192
                     /gene="KRBOX5"
                     /gene_synonym="ZNF720"
                     /inference="alignment:Splign:2.1.0"
     CDS             190..570
                     /gene="KRBOX5"
                     /gene_synonym="ZNF720"
                     /note="isoform 9 is encoded by transcript variant 14;
                     putative protein ZNF720; zinc finger protein 720; KRAB
                     domain-containing protein 5"
                     /codon_start=1
                     /product="KRAB domain-containing protein 5 isoform 9"
                     /protein_id="NP_001124385.1"
                     /db_xref="CCDS:CCDS45473.1"
                     /db_xref="GeneID:124411"
                     /db_xref="HGNC:HGNC:26987"
                     /translation="MGLLTFRDVAIEFSREEWEHLDSDQKLLYGDVMLENYGNLVSLG
                     LAVSKPDLITFLEQRKEPWNVKSAETVAIQPDIFSHDTQGLLRKKLIEASFQKVILDG
                     YGSCGPQNLNLRKEWESEGKIILW"
     exon            193..319
                     /gene="KRBOX5"
                     /gene_synonym="ZNF720"
                     /inference="alignment:Splign:2.1.0"
     exon            320..415
                     /gene="KRBOX5"
                     /gene_synonym="ZNF720"
                     /inference="alignment:Splign:2.1.0"
     exon            416..550
                     /gene="KRBOX5"
                     /gene_synonym="ZNF720"
                     /inference="alignment:Splign:2.1.0"
     exon            551..2759
                     /gene="KRBOX5"
                     /gene_synonym="ZNF720"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1062..1067
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KRBOX5"
                     /gene_synonym="ZNF720"
                     /note="hexamer: AATAAA"
     polyA_site      1080
                     /gene="KRBOX5"
                     /gene_synonym="ZNF720"
     regulatory      2741..2746
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KRBOX5"
                     /gene_synonym="ZNF720"
                     /note="hexamer: AATAAA"
     polyA_site      2759
                     /gene="KRBOX5"
                     /gene_synonym="ZNF720"
                     /note="major polyA site"
ORIGIN      
        1 gggatttggc ggtggccttt gttggctgca gtaagagctc agtctcttca ccaggggctc
       61 ccagtccttc catctgggag gccaaggcgg cttcgcgttc tgagaataga cagaacctct
      121 gttactctgt gaccggcagg caccgggaga tccgtagctc agacgccagg acatcccgga
      181 agctgggaaa tgggactgtt gacattcagg gatgtggcca tagaattctc tcgggaggag
      241 tgggaacacc tggactcaga tcagaagctt ttatatgggg atgtgatgtt agagaactac
      301 ggaaacctgg tctctctggg tctcgctgtc tctaagccgg acctgatcac ctttttggag
      361 caaaggaaag agccctggaa tgtgaagagt gcagagacag tagccatcca gccagatatc
      421 ttttctcatg atactcaagg cctcttaaga aagaagctta tagaagcatc attccaaaaa
      481 gtgatattgg atggatatgg gagctgtggc cctcagaatt taaacttaag gaaagagtgg
      541 gaaagtgagg gcaaaataat cctatggtga aaaaaatcaa caagataatc tctgcttgag
      601 aaaaaggacc aaagacaagt gaattttctg agggtgatga aagtgttgct tcgaaaaggg
      661 gtgaagttta tatgggtcta tttatttgtc taacatgtac agttaaggtt tatgccttgc
      721 aatgtatgta catcttcaca aaaaaaatct taaaaaaatt aaatgggtgg gggtagggaa
      781 agggttgaag tatagatgaa gcagaagtgg tacatgatta gtagttgaag ctgggggcag
      841 gtctatatat tttattttta tgtctttaat agcatttgta taaatgtaca atattcgttt
      901 acaatgttag ctcaggatct tgtttacctt tggacaggga gggagggaga aatttatttt
      961 ctgggtagga gtaaagctgg ttctattcct cagttatgta aattatctgt tataatccaa
     1021 aaagctttac atgaatgttt ctgtatgtaa tgtggtatat caataaaaaa ttaaatatta
     1081 catatttgca ccagaatcct aactcactat ctcagaatgt tagcagcatt ttcttttgtt
     1141 gtaaagtgga acacaatctc atggcattag cagatgggtt tgaatattct aaagtatcaa
     1201 cgtcctaatc tcatgggcac ctcttgggtc tttccatttt tgccttcatt tgctaagtgg
     1261 catgcttttg attttttgag atgaaacttt ttcccagcaa agtcttttcc ccacagtgat
     1321 gctctgaaag ccaggacacc tagcacagga ccctgggcat agtatgcact cagtacatgt
     1381 ggagcatgtt gatcaggaac aaaaggagta gcaaaggtca gttcctgcaa aggtgagtag
     1441 ataatacagg tatgactgaa aggctgcaac tcaggagtaa acattttaca ttcattcaag
     1501 agacaatttg caactagtac accaaaaaat tttggcttga agcagtactt tggggacttg
     1561 gctaaactct gtaatcactt ggagaacttt aaacaatact gacgtctggg ccctactcca
     1621 gggattttga ttttattggt ctgttgcaat ttaggttttg ggaattgtag ggcctccgca
     1681 tgtgactgta atgtggagcc aggggtgaga cccactgttt cagggtgagg gatgcattag
     1741 ctgtgtgtga tttccatgtg tgctgcaagt atttaaccta tgaccactcc tgcatttgga
     1801 gtcttggaaa ttgcagcagg aggaaatgtc tctctacaga tctatttttt atgtcacttg
     1861 cttttagagt aagaggttat ttcaggcaca gtaatttgat ttaatctgtt ttcaaatact
     1921 aaatctgaaa atactaaaat gaaaagaatt tgcaaatgtg agaatttgca aacatgtgga
     1981 gtgtgttctt atgtgctttc cagtttctct gatgataaga aatgagtaat gttgggcctt
     2041 gatttcctaa actcagccct cagtcacttt ctcaaattat ttgaagacct tccaagttgc
     2101 ttcagaagca ttgtccaaag gagattattc ccagtagtga agaataatag atggatgaga
     2161 atgtctaagg aatcctactt ctgtcgcaga agtggcactc tccagaacct caagggccca
     2221 tggagttcat gggctttgga gtcaggcaga gttgaccctg agtcccatcc cagcctctta
     2281 atagactagt tacttgactt ggaacagtta tgcaagacaa agcacaatga tactgattgc
     2341 agtaatggga acaattcatt cctctctgta tccatgccct ttgcaatgca tgtttttagc
     2401 tactcccatg gagggaaaga ttctgttttt ccagtccttg gatctgactg gccttatttg
     2461 ctgtggccaa ttcatactta ctgttctagt gaaacaatta ggcatgtttt gctcctcatt
     2521 ctagacttta attaaaatta aaattttatg atattttatt tctactgtat tttgctgtat
     2581 tcattctgct cagtattcta gttcaccggt cctcttatct ctgtttaatt tagtggtgaa
     2641 cctatacatt gtctggtaac ttaattttgt attttcgtat tctattgggc tgtcgttcaa
     2701 atgtggcttt taaacttcag ttacttgttc tttctacaaa aataaacatt gattttcta
//
