LOCUS       NM_001205272             648 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens KRAB box domain containing 1 (KRBOX1), mRNA.
ACCESSION   NM_001205272 XM_003118874 XM_003119893 XM_003120405
VERSION     NM_001205272.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 648)
  AUTHORS   Goldstein,J.I., Jarskog,L.F., Hilliard,C., Alfirevic,A., Duncan,L.,
            Fourches,D., Huang,H., Lek,M., Neale,B.M., Ripke,S., Shianna,K.,
            Szatkiewicz,J.P., Tropsha,A., van den Oord,E.J., Cascorbi,I.,
            Dettling,M., Gazit,E., Goff,D.C., Holden,A.L., Kelly,D.L.,
            Malhotra,A.K., Nielsen,J., Pirmohamed,M., Rujescu,D., Werge,T.,
            Levy,D.L., Josiassen,R.C., Kennedy,J.L., Lieberman,J.A., Daly,M.J.
            and Sullivan,P.F.
  TITLE     Clozapine-induced agranulocytosis is associated with rare HLA-DQB1
            and HLA-B alleles
  JOURNAL   Nat Commun 5, 4757 (2014)
   PUBMED   25187353
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 648)
  AUTHORS   Muzny,D.M., Scherer,S.E., Kaul,R., Wang,J., Yu,J., Sudbrak,R.,
            Buhay,C.J., Chen,R., Cree,A., Ding,Y., Dugan-Rocha,S., Gill,R.,
            Gunaratne,P., Harris,R.A., Hawes,A.C., Hernandez,J., Hodgson,A.V.,
            Hume,J., Jackson,A., Khan,Z.M., Kovar-Smith,C., Lewis,L.R.,
            Lozado,R.J., Metzker,M.L., Milosavljevic,A., Miner,G.R.,
            Morgan,M.B., Nazareth,L.V., Scott,G., Sodergren,E., Song,X.Z.,
            Steffen,D., Wei,S., Wheeler,D.A., Wright,M.W., Worley,K.C.,
            Yuan,Y., Zhang,Z., Adams,C.Q., Ansari-Lari,M.A., Ayele,M.,
            Brown,M.J., Chen,G., Chen,Z., Clendenning,J.,
            Clerc-Blankenburg,K.P., Chen,R., Chen,Z., Davis,C., Delgado,O.,
            Dinh,H.H., Dong,W., Draper,H., Ernst,S., Fu,G.,
            Gonzalez-Garay,M.L., Garcia,D.K., Gillett,W., Gu,J., Hao,B.,
            Haugen,E., Havlak,P., He,X., Hennig,S., Hu,S., Huang,W.,
            Jackson,L.R., Jacob,L.S., Kelly,S.H., Kube,M., Levy,R., Li,Z.,
            Liu,B., Liu,J., Liu,W., Lu,J., Maheshwari,M., Nguyen,B.V.,
            Okwuonu,G.O., Palmeiri,A., Pasternak,S., Perez,L.M., Phelps,K.A.,
            Plopper,F.J., Qiang,B., Raymond,C., Rodriguez,R.,
            Saenphimmachak,C., Santibanez,J., Shen,H., Shen,Y., Subramanian,S.,
            Tabor,P.E., Verduzco,D., Waldron,L., Wang,J., Wang,J., Wang,Q.,
            Williams,G.A., Wong,G.K., Yao,Z., Zhang,J., Zhang,X., Zhao,G.,
            Zhou,J., Zhou,Y., Nelson,D., Lehrach,H., Reinhardt,R., Naylor,S.L.,
            Yang,H., Olson,M., Weinstock,G. and Gibbs,R.A.
  TITLE     The DNA sequence, annotation and analysis of human chromosome 3
  JOURNAL   Nature 440 (7088), 1194-1198 (2006)
   PUBMED   16641997
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC062786.1.
            
            On Nov 30, 2019 this sequence version replaced NM_001205272.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062786.1, DB458286.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000383748.9/ ENSP00000373254.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-648               BC062786.1         31-678
FEATURES             Location/Qualifiers
     source          1..648
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p22.1"
     gene            1..648
                     /gene="KRBOX1"
                     /note="KRAB box domain containing 1"
                     /db_xref="GeneID:100506243"
                     /db_xref="HGNC:HGNC:38708"
     exon            1..70
                     /gene="KRBOX1"
                     /inference="alignment:Splign:2.1.0"
     exon            71..152
                     /gene="KRBOX1"
                     /inference="alignment:Splign:2.1.0"
     CDS             117..503
                     /gene="KRBOX1"
                     /codon_start=1
                     /product="KRAB domain-containing protein 1"
                     /protein_id="NP_001192201.1"
                     /db_xref="CCDS:CCDS54572.1"
                     /db_xref="GeneID:100506243"
                     /db_xref="HGNC:HGNC:38708"
                     /translation="MMTAVSLTTRPQESVAFEDVAVYFTTKEWAIMVPAERALYRDVM
                     LENYEAVAFVVPPTSKPALVSHLEQGKESCFTQPQGVLSRNDWRAGWIGYLELRRYTY
                     LAKAVLRRIVSKIFRNRQCWEDRRKA"
     exon            153..279
                     /gene="KRBOX1"
                     /inference="alignment:Splign:2.1.0"
     exon            280..393
                     /gene="KRBOX1"
                     /inference="alignment:Splign:2.1.0"
     exon            394..648
                     /gene="KRBOX1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      621..626
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KRBOX1"
                     /note="hexamer: ATTAAA"
     polyA_site      648
                     /gene="KRBOX1"
                     /note="major polyA site"
ORIGIN      
        1 gtgaggatcg gcgagtggcg cccaccatct ctgcttgctg aaaagctgca gaggccgcca
       61 ggagcccacg cacctgagac ttttaccttt acccagaaag gaataaaaga ggtcagatga
      121 tgacagctgt gtccttaaca accaggcccc aggaatcagt ggcttttgag gacgtggctg
      181 tgtacttcac tacgaaggaa tgggccatca tggtgcctgc cgagagggcc ttgtacaggg
      241 atgtgatgct ggagaactat gaggctgtgg cctttgtagt gccacccact tccaaaccag
      301 ctttggtctc tcatctggag caagggaaag agtcctgttt cacccagcca cagggagtcc
      361 taagcaggaa tgactggaga gcaggctgga taggatactt ggaactaaga agatatactt
      421 acttagctaa agcagtgtta cgtagaatag tatcaaaaat ttttcgaaat cgtcaatgct
      481 gggaagacag gagaaaagct taattcttga catttaaata ccagttttcc aagtaaggag
      541 ttgatgtaag agccacctta aacgatgtca aatacacatt ttctttttct gtagactggt
      601 agatttaatg tttttcattc attaaaataa ctcattttga tgtacaaa
//
