LOCUS       NM_001290187            3827 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens KRAB-A domain containing 1 (KRBA1), transcript variant
            2, mRNA.
ACCESSION   NM_001290187
VERSION     NM_001290187.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3827)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC004897.1, BC142722.1, AL831935.1 and BC150330.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 13, 2020 this sequence version replaced NM_001290187.1.
            
            Transcript Variant: This variant (2) encodes the longer isoform
            (2).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC146667.1, SRR14038192.3771081.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000496259.6/ ENSP00000418647.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-60                AC004897.1         60779-60838
            61-2188             BC142722.1         1-2128
            2189-2189           AL831935.1         1670-1670
            2190-3481           BC142722.1         2130-3421
            3482-3827           BC150330.1         3686-4031
FEATURES             Location/Qualifiers
     source          1..3827
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q36.1"
     gene            1..3827
                     /gene="KRBA1"
                     /note="KRAB-A domain containing 1"
                     /db_xref="GeneID:84626"
                     /db_xref="HGNC:HGNC:22228"
     exon            1..116
                     /gene="KRBA1"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..3299
                     /gene="KRBA1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     protein KRBA1"
                     /codon_start=1
                     /product="protein KRBA1 isoform 2"
                     /protein_id="NP_001277116.1"
                     /db_xref="CCDS:CCDS78285.1"
                     /db_xref="GeneID:84626"
                     /db_xref="HGNC:HGNC:22228"
                     /translation="MARQVSITFKDLAVRFSEEEWRLLEEGQREFYRDVMRENYETLV
                     SVGTAELLPLSAFLSPSEPGRAVGGGSHADEGQEPAGCGDPQGGQPRHSLHLTALVQL
                     VKEIPEFLFGEVKGAMDSPESESRGASLDGERASPEAAAREPCPLRGLLSCLPDGPTS
                     QPHLATTPTDSSCSSGPTGDGVQGSPLPIKTADKPWPTRKEGPGALGGEPSPPTHSPS
                     RRKSHRGQERGTSEAGISPGNSPLQGLINCLKEILVPGPRHPETSPSFLPPLPSLGTS
                     RLTRADLGPGSPPWAVKTEAVSGDCPLQGLLHCLKELPEAQDRHPSPSGVGNRRLQEN
                     PGAWKRGSGGPGYLLTPPPHPDLGAGGLLSVKMENSWVQSPPGPASCQPGRQPLSPSA
                     TGDTRGVPQPSWGPEAQAASASSSPLEALEACLKGIPPNGSSPSQLPPTSCSQNPQPG
                     DSRSQKPELQPHRSHSEEATREPVLPLGLQSCVRDGPSRPLAPRGTPTSFSSSSSTDW
                     DLDFGSPVGNQGQHPGKGSPPGSSPLQGLENCLKEIPVPVLRPAWPCSSAADRGPRRA
                     EPRNWTADKEGLRAEACESARLGQGRGEAPTRSLHLVSPQVFTSSCVPACHQRGFKDP
                     GATRPGVWRWLPEGSAPKPSPLHCLESALRGILPVRPLRFACVGGPSPSPSPGSSSSF
                     SGSEGEDPRPEPDLWKPLPQERDRLPSCKPPVPLSPCPGGTPAGSSGGSPGEDPRRTE
                     PRYCSGLGAGTAQDPCPVSQLEKRPRVSEASRGLELGHGRPRVAAKTHERLLPQGPPE
                     LPSESPPPELPPPEAAPPVLPASSLQPPCHCGKPLQQELHSLGAALAEKLDRLATALA
                     GLAQEVATMRTQVNRLGRRPQGPGPMGQASWMWTLPRGPRWAHGPGHRHLPYWRQKGP
                     TRPKPKILRGQGESCRAGDLQGLSRGTARRARPLPPDAPPAEPPGLHCSSSQQLLSST
                     PSCHAAPPAHPLLAHTGGHQSPLPPLVPAALPLQGASPPAASADADVPTSGVAPDGIP
                     ERPKEPSSLLGGVQRALQEELWGGEHRDPRWGAH"
     exon            117..243
                     /gene="KRBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            244..363
                     /gene="KRBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            364..519
                     /gene="KRBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            520..672
                     /gene="KRBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            673..804
                     /gene="KRBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            805..978
                     /gene="KRBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1134
                     /gene="KRBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1332
                     /gene="KRBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1506
                     /gene="KRBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1680
                     /gene="KRBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1681..1833
                     /gene="KRBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1834..2016
                     /gene="KRBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2017..2211
                     /gene="KRBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2212..2352
                     /gene="KRBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2353..2457
                     /gene="KRBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2458..3827
                     /gene="KRBA1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3803..3808
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KRBA1"
                     /note="hexamer: ATTAAA"
     polyA_site      3827
                     /gene="KRBA1"
                     /note="major polyA site"
ORIGIN      
        1 gccttctcct gcgcggacct gggccgccgc cgacgagggt cgcgtgcgcc cgcgccaggg
       61 cccgcgccgg aaaccgagga gtggcgggga ggctgagccc ggggatggcg cgccaggtgt
      121 ccatcacctt caaggacttg gccgtgcggt tctcggagga ggagtggcgg ctcctggagg
      181 aggggcagag ggagttctac cgagacgtga tgcgggagaa ctacgagacg ctggtctctg
      241 tggggacagc tgagctgctc cccctctctg ctttcctgtc accctcagag cctggaagag
      301 ctgttggggg agggagccac gctgatgagg ggcaggagcc tgctggttgt ggagatcccc
      361 aggggggaca gccccggcac agcctgcacc tcacagccct ggtgcagctg gtgaaggaga
      421 tcccagagtt cttgtttgga gaagtcaagg gcgctatgga cagccccgag agcgagagcc
      481 ggggagccag cctggatgga gagagagcga gccccgaggc tgcggcaaga gagccctgcc
      541 ctctccgagg cctgctcagc tgccttccag acggccctac cagccagccc cacctggcca
      601 ccacgcccac cgacagctcg tgttccagtg gcccaactgg tgacggggtc cagggaagtc
      661 ctctccccat caaaactgcc gacaaaccgt ggcctacaag gaaggaaggc ccaggagccc
      721 tgggcgggga gcccagccct cccacccata gccccagcag gaggaagagc cacagaggac
      781 aggagagagg gacctcagag gccggaattt ctcctgggaa cagccccttg caaggcctca
      841 tcaactgtct gaaggaaatc cttgtgcctg ggccccggca ccccgagaca tccccaagct
      901 tcttgccacc tctccctagc ctgggcacgt ccaggctaac cagagcagac ctggggcctg
      961 ggagcccgcc ctgggcagtg aagaccgagg cggtttcagg ggattgtccc ctccagggtc
     1021 tgctacactg tctgaaggag ctccccgagg cccaggacag gcatcccagt ccctcaggag
     1081 tggggaaccg acggctacag gagaatccag gagcctggaa aaggggttct ggagggcctg
     1141 gatacctcct gacccctcct ccccatcctg atcttggagc tggcggtctg ctctctgtga
     1201 agatggagaa cagctgggtc cagagccccc caggacctgc atcctgtcag cctggcaggc
     1261 agcccctcag tccctcagcc actggagaca ccagaggggt cccccaaccc agctggggcc
     1321 ctgaggctca agctgccagt gcctcaagct caccgctgga agccctggaa gcctgtctga
     1381 agggcattcc cccaaatggg tcgtcacctt cccagctgcc acccacttct tgttcccaga
     1441 acccccagcc aggagactct aggtctcaga agcctgaact gcaaccccac agatcacaca
     1501 gtgaagaagc gaccagagag cctgttctgc ctctgggtct gcagagctgt gtgagagatg
     1561 gccccagcag gcccctggcc ccccgaggaa cccccaccag cttctcctca tccagcagca
     1621 ccgactggga cctggatttt gggagtcctg tggggaacca ggggcagcat cctggaaaag
     1681 gaagcccacc aggaagctcc ccactgcagg gtctggagaa ttgtctcaag gagatacctg
     1741 tgcctgtgct gcggcctgcc tggccctgct cctcagcagc agacagggga ccgaggagag
     1801 cagagcccag gaactggaca gcagacaagg aaggactgag ggctgaggcc tgcgagtcag
     1861 cccgtctcgg gcagggtagg ggagaagcgc ccacccggag cctccatctg gtcagcccac
     1921 aggtgttcac ctccagctgc gtccccgcct gccaccagcg ggggttcaaa gaccctgggg
     1981 ccaccaggcc aggagtgtgg aggtggctcc cagaggggtc tgcccccaag ccctccccgc
     2041 tgcactgcct ggagagcgcc ctgaggggga tcttgcctgt aaggcccttg cgcttcgcct
     2101 gcgtgggagg ccccagcccc agccccagcc ccggctccag ctcgagcttc agcggctctg
     2161 aaggagaaga cccgaggcca gagcctgatc tctggaagcc gctcccccag gagagggacc
     2221 gccttcccag ctgtaagcct cctgtccctc tgtccccatg tcctggtggg acccctgctg
     2281 gcagcagtgg cggcagccct ggtgaagacc ccaggagaac agagcccagg tactgcagcg
     2341 gcctcggtgc aggtacagct caggatccct gcccggtttc tcagctggag aaaaggccca
     2401 gggttagtga agcatccaga ggcctggagc ttggacatgg aagacccaga gttgcagcca
     2461 agacccatga gaggctgctc ccccagggcc cgcctgagct gcccagtgag tctccccctc
     2521 cggagctgcc ccctccggaa gctgcgcctc ctgtgttgcc agcctcctcc ctgcagccgc
     2581 catgccactg tgggaagccc ctgcagcagg agctgcacag cctcggtgct gcccttgcgg
     2641 agaagctgga tcggctcgcc acagcgctgg caggcctggc tcaggaagtg gccaccatga
     2701 ggacccaggt gaatcggctg gggaggcgcc cccaaggccc tgggccaatg ggccaagctt
     2761 cctggatgtg gaccctccca cggggacctc gctgggctca tggccctggt cacagacatc
     2821 tgccctactg gaggcagaag ggacccacga ggcctaaacc aaagatcctg cgtggccagg
     2881 gagagagctg cagggctggt gacctgcaag gactctccag agggaccgct cgccgggcac
     2941 gtccgctgcc tccagacgct cccccggcag aacctcctgg gctccactgc agctcttccc
     3001 agcagctgct gtcctctaca cccagctgcc atgctgcgcc gcctgcacac cccctcctcg
     3061 cacataccgg gggccaccag agcccccttc cccctttagt gcctgctgcc ttacccctgc
     3121 agggagcctc tcctcctgca gccagtgcag atgcagacgt gccgacctca ggagtggcac
     3181 cagacgggat cccagagcgg cccaaggagc cgagcagcct gctgggagga gtgcagaggg
     3241 ccctccagga agaactgtgg ggtggggagc acagggaccc gagatggggg gcgcattgat
     3301 ggcattcctc ttctccacat ctgctcgttc ttgccgaggg tgcagtggtg gcgtggaagc
     3361 cctgtcaccc caccccaggc caccctctcc cagaggacgc catctccctt actgttgctg
     3421 ggagcctcgc cctttgtccc aactgggtag agcccccagg tgctgtttgc tcaggaggct
     3481 gctgtggggg tgccttcctc agcctctggc cctcttggct cagattcaat caaatgttgc
     3541 ttccctctcc tgtctttccc actggagccg cccaagcttg taggtgggtg gtgtgcatag
     3601 gccacgtgtg ccccacatat gcagggggtg ccccacacag ctagagcggc caggagagcg
     3661 cctcctaacc accagccgtt cctgatctca ggagccttga agggctgggc tcttgccttc
     3721 ctggagtaaa tattggcaca gatttcattt gagagaactc agccccctgg tctaagctgg
     3781 acttacctct gtggattctg aaattaaaga agtgagttgc taaggaa
//
