LOCUS       NM_004985               5306 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens KRAS proto-oncogene, GTPase (KRAS), transcript variant
            b, mRNA.
ACCESSION   NM_004985
VERSION     NM_004985.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5306)
  AUTHORS   Gomes-Fernandes,B., Trindade,L.M., de Castro Bastos Rodrigues,M.,
            Cardoso,J.P.D., Lima,F.T., Rogerio,L., de Vasconcelos Generoso,S.,
            Carneiro,J.G., da Silva,R.G., de Souza,R.P., De Marco,L. and
            Bastos-Rodrigues,L.
  TITLE     Association between KRAS mutation and alcohol consumption in
            Brazilian patients with colorectal cancer
  JOURNAL   Sci Rep 14 (1), 26445 (2024)
   PUBMED   39488539
  REMARK    GeneRIF: Association between KRAS mutation and alcohol consumption
            in Brazilian patients with colorectal cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5306)
  AUTHORS   Chu,T., Zhang,R., Liu,X., Lin,L., Li,Y., Niu,Z., Quan,H., Zhao,Y.
            and Li,Y.
  TITLE     Influence of recipient KRAS gene rs712 polymorphisms on the overall
            survival rate of hepatocellular carcinoma after hepatic
            transplantation
  JOURNAL   Clin Exp Med 24 (1), 246 (2024)
   PUBMED   39460812
  REMARK    GeneRIF: Influence of recipient KRAS gene rs712 polymorphisms on
            the overall survival rate of hepatocellular carcinoma after hepatic
            transplantation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5306)
  AUTHORS   Chen,Y., Zheng,Y. and Liu,S.
  TITLE     KRAS mutation promotes the colonization of Fusobacterium nucleatum
            in colorectal cancer by down-regulating SERTAD4
  JOURNAL   J Cell Mol Med 28 (20), e70182 (2024)
   PUBMED   39462261
  REMARK    GeneRIF: KRAS mutation promotes the colonization of Fusobacterium
            nucleatum in colorectal cancer by down-regulating SERTAD4.
REFERENCE   4  (bases 1 to 5306)
  AUTHORS   Moog,U. and Dobyns,W.B.
  TITLE     Encephalocraniocutaneous Lipomatosis
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   35099867
REFERENCE   5  (bases 1 to 5306)
  AUTHORS   Gripp,K.W. and Weaver,K.N.
  TITLE     HRAS-Related Costello Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301680
REFERENCE   6  (bases 1 to 5306)
  AUTHORS   Rauen,K.A.
  TITLE     Cardiofaciocutaneous Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301365
REFERENCE   7  (bases 1 to 5306)
  AUTHORS   Roberts,A.E.
  TITLE     Noonan Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301303
REFERENCE   8  (bases 1 to 5306)
  AUTHORS   Grimmond,S.M., Raghavan,D. and Russell,P.J.
  TITLE     Detection of a rare point mutation in Ki-ras of a human bladder
            cancer xenograft by polymerase chain reaction and direct sequencing
  JOURNAL   Urol Res 20 (2), 121-126 (1992)
   PUBMED   1553789
REFERENCE   9  (bases 1 to 5306)
  AUTHORS   Haritani,H., Esumi,M., Uchida,T. and Shikata,T.
  TITLE     Oncogene expression in the liver tissue of patients with
            nonneoplastic liver disease
  JOURNAL   Cancer 67 (10), 2594-2598 (1991)
   PUBMED   2015559
REFERENCE   10 (bases 1 to 5306)
  AUTHORS   Slebos,R.J., Habets,G.G., Evers,S.G., Mooi,W.J. and Rodenhuis,S.
  TITLE     Allele-specific detection of K-ras oncogene expression in human
            non-small-cell lung carcinomas
  JOURNAL   Int J Cancer 48 (1), 51-56 (1991)
   PUBMED   1850383
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from M54968.1, AK292510.1 and
            AC092794.10.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Apr 18, 2019 this sequence version replaced NM_004985.4.
            
            Summary: This gene, a Kirsten ras oncogene homolog from the
            mammalian ras gene family, encodes a protein that is a member of
            the small GTPase superfamily. A single amino acid substitution is
            responsible for an activating mutation. The transforming protein
            that results is implicated in various malignancies, including lung
            adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas
            and colorectal carcinoma. Alternative splicing leads to variants
            encoding two isoforms that differ in the C-terminal region.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (b) is composed of five exons and
            lacks exon 4a which the longer transcript variant (a) includes.
            This predominant variant (b) has a cds that terminates in exon 4b
            and encodes isoform b.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.7529.1,
                                           SRR1803611.125667.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000311936.8/ ENSP00000308495.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-223               M54968.1           3-225
            224-933             AK292510.1         187-896
            934-5306            AC092794.10        18030-22402
FEATURES             Location/Qualifiers
     source          1..5306
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p12.1"
     gene            1..5306
                     /gene="KRAS"
                     /gene_synonym="'C-K-RAS; C-K-RAS; c-Ki-ras; c-Ki-ras2;
                     CFC2; K-Ras; K-Ras 2; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B;
                     KI-RAS; KRAS1; KRAS2; NS; NS3; OES; RALD; RASK2"
                     /note="KRAS proto-oncogene, GTPase"
                     /db_xref="GeneID:3845"
                     /db_xref="HGNC:HGNC:6407"
                     /db_xref="MIM:190070"
     exon            1..179
                     /gene="KRAS"
                     /gene_synonym="'C-K-RAS; C-K-RAS; c-Ki-ras; c-Ki-ras2;
                     CFC2; K-Ras; K-Ras 2; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B;
                     KI-RAS; KRAS1; KRAS2; NS; NS3; OES; RALD; RASK2"
                     /inference="alignment:Splign:2.1.0"
     exon            180..301
                     /gene="KRAS"
                     /gene_synonym="'C-K-RAS; C-K-RAS; c-Ki-ras; c-Ki-ras2;
                     CFC2; K-Ras; K-Ras 2; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B;
                     KI-RAS; KRAS1; KRAS2; NS; NS3; OES; RALD; RASK2"
                     /inference="alignment:Splign:2.1.0"
     CDS             191..757
                     /gene="KRAS"
                     /gene_synonym="'C-K-RAS; C-K-RAS; c-Ki-ras; c-Ki-ras2;
                     CFC2; K-Ras; K-Ras 2; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B;
                     KI-RAS; KRAS1; KRAS2; NS; NS3; OES; RALD; RASK2"
                     /EC_number="3.6.5.2"
                     /note="isoform b is encoded by transcript variant b;
                     v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog;
                     transforming protein p21; c-Kirsten-ras protein; K-ras p21
                     protein; oncogene KRAS2; PR310 c-K-ras oncogene; cellular
                     c-Ki-ras2 proto-oncogene; Kirsten rat sarcoma viral
                     proto-oncogene; GTPase KRas; KRAS-ENOPH fusion;
                     Kras-Enoph1 fusion protein; Kirsten rat sarcoma viral
                     oncogene homolog; cellular transforming proto-oncogene;
                     proto-oncogene GTPase"
                     /codon_start=1
                     /product="GTPase KRas isoform b"
                     /protein_id="NP_004976.2"
                     /db_xref="CCDS:CCDS8702.1"
                     /db_xref="GeneID:3845"
                     /db_xref="HGNC:HGNC:6407"
                     /db_xref="MIM:190070"
                     /translation="MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQV
                     VIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKR
                     VKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTLV
                     REIRKHKEKMSKDGKKKKKKSKTKCVIM"
     exon            302..480
                     /gene="KRAS"
                     /gene_synonym="'C-K-RAS; C-K-RAS; c-Ki-ras; c-Ki-ras2;
                     CFC2; K-Ras; K-Ras 2; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B;
                     KI-RAS; KRAS1; KRAS2; NS; NS3; OES; RALD; RASK2"
                     /inference="alignment:Splign:2.1.0"
     exon            481..640
                     /gene="KRAS"
                     /gene_synonym="'C-K-RAS; C-K-RAS; c-Ki-ras; c-Ki-ras2;
                     CFC2; K-Ras; K-Ras 2; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B;
                     KI-RAS; KRAS1; KRAS2; NS; NS3; OES; RALD; RASK2"
                     /inference="alignment:Splign:2.1.0"
     exon            641..5306
                     /gene="KRAS"
                     /gene_synonym="'C-K-RAS; C-K-RAS; c-Ki-ras; c-Ki-ras2;
                     CFC2; K-Ras; K-Ras 2; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B;
                     KI-RAS; KRAS1; KRAS2; NS; NS3; OES; RALD; RASK2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3595..3600
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KRAS"
                     /gene_synonym="'C-K-RAS; C-K-RAS; c-Ki-ras; c-Ki-ras2;
                     CFC2; K-Ras; K-Ras 2; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B;
                     KI-RAS; KRAS1; KRAS2; NS; NS3; OES; RALD; RASK2"
                     /note="hexamer: AATAAA"
     polyA_site      3621
                     /gene="KRAS"
                     /gene_synonym="'C-K-RAS; C-K-RAS; c-Ki-ras; c-Ki-ras2;
                     CFC2; K-Ras; K-Ras 2; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B;
                     KI-RAS; KRAS1; KRAS2; NS; NS3; OES; RALD; RASK2"
     regulatory      5286..5291
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KRAS"
                     /gene_synonym="'C-K-RAS; C-K-RAS; c-Ki-ras; c-Ki-ras2;
                     CFC2; K-Ras; K-Ras 2; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B;
                     KI-RAS; KRAS1; KRAS2; NS; NS3; OES; RALD; RASK2"
                     /note="hexamer: AATAAA"
     polyA_site      5306
                     /gene="KRAS"
                     /gene_synonym="'C-K-RAS; C-K-RAS; c-Ki-ras; c-Ki-ras2;
                     CFC2; K-Ras; K-Ras 2; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B;
                     KI-RAS; KRAS1; KRAS2; NS; NS3; OES; RALD; RASK2"
                     /note="major polyA site"
ORIGIN      
        1 ctaggcggcg gccgcggcgg cggaggcagc agcggcggcg gcagtggcgg cggcgaaggt
       61 ggcggcggct cggccagtac tcccggcccc cgccatttcg gactgggagc gagcgcggcg
      121 caggcactga aggcggcggc ggggccagag gctcagcggc tcccaggtgc gggagagagg
      181 cctgctgaaa atgactgaat ataaacttgt ggtagttgga gctggtggcg taggcaagag
      241 tgccttgacg atacagctaa ttcagaatca ttttgtggac gaatatgatc caacaataga
      301 ggattcctac aggaagcaag tagtaattga tggagaaacc tgtctcttgg atattctcga
      361 cacagcaggt caagaggagt acagtgcaat gagggaccag tacatgagga ctggggaggg
      421 ctttctttgt gtatttgcca taaataatac taaatcattt gaagatattc accattatag
      481 agaacaaatt aaaagagtta aggactctga agatgtacct atggtcctag taggaaataa
      541 atgtgatttg ccttctagaa cagtagacac aaaacaggct caggacttag caagaagtta
      601 tggaattcct tttattgaaa catcagcaaa gacaagacag ggtgttgatg atgccttcta
      661 tacattagtt cgagaaattc gaaaacataa agaaaagatg agcaaagatg gtaaaaagaa
      721 gaaaaagaag tcaaagacaa agtgtgtaat tatgtaaata caatttgtac ttttttctta
      781 aggcatacta gtacaagtgg taatttttgt acattacact aaattattag catttgtttt
      841 agcattacct aatttttttc ctgctccatg cagactgtta gcttttacct taaatgctta
      901 ttttaaaatg acagtggaag tttttttttc ctctaagtgc cagtattccc agagttttgg
      961 tttttgaact agcaatgcct gtgaaaaaga aactgaatac ctaagatttc tgtcttgggg
     1021 cttttggtgc atgcagttga ttacttctta tttttcttac caattgtgaa tgttggtgtg
     1081 aaacaaatta atgaagcttt tgaatcatcc ctattctgtg ttttatctag tcacataaat
     1141 ggattaatta ctaatttcag ttgagacctt ctaattggtt tttactgaaa cattgaggga
     1201 acacaaattt atgggcttcc tgatgatgat tcttctaggc atcatgtcct atagtttgtc
     1261 atccctgatg aatgtaaagt tacactgttc acaaaggttt tgtctccttt ccactgctat
     1321 tagtcatggt cactctcccc aaaatattat attttttcta taaaaagaaa aaaatggaaa
     1381 aaaattacaa ggcaatggaa actattataa ggccatttcc ttttcacatt agataaatta
     1441 ctataaagac tcctaatagc ttttcctgtt aaggcagacc cagtatgaaa tggggattat
     1501 tatagcaacc attttggggc tatatttaca tgctactaaa tttttataat aattgaaaag
     1561 attttaacaa gtataaaaaa ttctcatagg aattaaatgt agtctccctg tgtcagactg
     1621 ctctttcata gtataacttt aaatcttttc ttcaacttga gtctttgaag atagttttaa
     1681 ttctgcttgt gacattaaaa gattatttgg gccagttata gcttattagg tgttgaagag
     1741 accaaggttg caaggccagg ccctgtgtga acctttgagc tttcatagag agtttcacag
     1801 catggactgt gtccccacgg tcatccagtg ttgtcatgca ttggttagtc aaaatgggga
     1861 gggactaggg cagtttggat agctcaacaa gatacaatct cactctgtgg tggtcctgct
     1921 gacaaatcaa gagcattgct tttgtttctt aagaaaacaa actctttttt aaaaattact
     1981 tttaaatatt aactcaaaag ttgagatttt ggggtggtgg tgtgccaaga cattaatttt
     2041 ttttttaaac aatgaagtga aaaagtttta caatctctag gtttggctag ttctcttaac
     2101 actggttaaa ttaacattgc ataaacactt ttcaagtctg atccatattt aataatgctt
     2161 taaaataaaa ataaaaacaa tccttttgat aaatttaaaa tgttacttat tttaaaataa
     2221 atgaagtgag atggcatggt gaggtgaaag tatcactgga ctaggaagaa ggtgacttag
     2281 gttctagata ggtgtctttt aggactctga ttttgaggac atcacttact atccatttct
     2341 tcatgttaaa agaagtcatc tcaaactctt agtttttttt ttttacaact atgtaattta
     2401 tattccattt acataaggat acacttattt gtcaagctca gcacaatctg taaattttta
     2461 acctatgtta caccatcttc agtgccagtc ttgggcaaaa ttgtgcaaga ggtgaagttt
     2521 atatttgaat atccattctc gttttaggac tcttcttcca tattagtgtc atcttgcctc
     2581 cctaccttcc acatgcccca tgacttgatg cagttttaat acttgtaatt cccctaacca
     2641 taagatttac tgctgctgtg gatatctcca tgaagttttc ccactgagtc acatcagaaa
     2701 tgccctacat cttatttcct cagggctcaa gagaatctga cagataccat aaagggattt
     2761 gacctaatca ctaattttca ggtggtggct gatgctttga acatctcttt gctgcccaat
     2821 ccattagcga cagtaggatt tttcaaacct ggtatgaata gacagaaccc tatccagtgg
     2881 aaggagaatt taataaagat agtgctgaaa gaattcctta ggtaatctat aactaggact
     2941 actcctggta acagtaatac attccattgt tttagtaacc agaaatcttc atgcaatgaa
     3001 aaatacttta attcatgaag cttacttttt ttttttggtg tcagagtctc gctcttgtca
     3061 cccaggctgg aatgcagtgg cgccatctca gctcactgca acctccatct cccaggttca
     3121 agcgattctc gtgcctcggc ctcctgagta gctgggatta caggcgtgtg ccactacact
     3181 caactaattt ttgtattttt aggagagacg gggtttcacc ctgttggcca ggctggtctc
     3241 gaactcctga cctcaagtga ttcacccacc ttggcctcat aaacctgttt tgcagaactc
     3301 atttattcag caaatattta ttgagtgcct accagatgcc agtcaccaca caaggcactg
     3361 ggtatatggt atccccaaac aagagacata atcccggtcc ttaggtagtg ctagtgtggt
     3421 ctgtaatatc ttactaaggc ctttggtata cgacccagag ataacacgat gcgtatttta
     3481 gttttgcaaa gaaggggttt ggtctctgtg ccagctctat aattgttttg ctacgattcc
     3541 actgaaactc ttcgatcaag ctactttatg taaatcactt cattgtttta aaggaataaa
     3601 cttgattata ttgttttttt atttggcata actgtgattc ttttaggaca attactgtac
     3661 acattaaggt gtatgtcaga tattcatatt gacccaaatg tgtaatattc cagttttctc
     3721 tgcataagta attaaaatat acttaaaaat taatagtttt atctgggtac aaataaacag
     3781 gtgcctgaac tagttcacag acaaggaaac ttctatgtaa aaatcactat gatttctgaa
     3841 ttgctatgtg aaactacaga tctttggaac actgtttagg tagggtgtta agacttacac
     3901 agtacctcgt ttctacacag agaaagaaat ggccatactt caggaactgc agtgcttatg
     3961 aggggatatt taggcctctt gaatttttga tgtagatggg cattttttta aggtagtggt
     4021 taattacctt tatgtgaact ttgaatggtt taacaaaaga tttgtttttg tagagatttt
     4081 aaagggggag aattctagaa ataaatgtta cctaattatt acagccttaa agacaaaaat
     4141 ccttgttgaa gtttttttaa aaaaagctaa attacataga cttaggcatt aacatgtttg
     4201 tggaagaata tagcagacgt atattgtatc atttgagtga atgttcccaa gtaggcattc
     4261 taggctctat ttaactgagt cacactgcat aggaatttag aacctaactt ttataggtta
     4321 tcaaaactgt tgtcaccatt gcacaatttt gtcctaatat atacatagaa actttgtggg
     4381 gcatgttaag ttacagtttg cacaagttca tctcatttgt attccattga tttttttttt
     4441 cttctaaaca ttttttcttc aaacagtata taactttttt taggggattt ttttttagac
     4501 agcaaaaact atctgaagat ttccatttgt caaaaagtaa tgatttcttg ataattgtgt
     4561 agtaatgttt tttagaaccc agcagttacc ttaaagctga atttatattt agtaacttct
     4621 gtgttaatac tggatagcat gaattctgca ttgagaaact gaatagctgt cataaaatga
     4681 aactttcttt ctaaagaaag atactcacat gagttcttga agaatagtca taactagatt
     4741 aagatctgtg ttttagttta atagtttgaa gtgcctgttt gggataatga taggtaattt
     4801 agatgaattt aggggaaaaa aaagttatct gcagatatgt tgagggccca tctctccccc
     4861 cacaccccca cagagctaac tgggttacag tgttttatcc gaaagtttcc aattccactg
     4921 tcttgtgttt tcatgttgaa aatacttttg catttttcct ttgagtgcca atttcttact
     4981 agtactattt cttaatgtaa catgtttacc tggaatgtat tttaactatt tttgtatagt
     5041 gtaaactgaa acatgcacat tttgtacatt gtgctttctt ttgtgggaca tatgcagtgt
     5101 gatccagttg ttttccatca tttggttgcg ctgacctagg aatgttggtc atatcaaaca
     5161 ttaaaaatga ccactctttt aattgaaatt aacttttaaa tgtttatagg agtatgtgct
     5221 gtgaagtgat ctaaaatttg taatattttt gtcatgaact gtactactcc taattattgt
     5281 aatgtaataa aaatagttac agtgac
//
