LOCUS       NM_001369787            5293 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens KRAS proto-oncogene, GTPase (KRAS), transcript variant
            d, mRNA.
ACCESSION   NM_001369787 XM_011520653
VERSION     NM_001369787.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5293)
  AUTHORS   Gomes-Fernandes,B., Trindade,L.M., de Castro Bastos Rodrigues,M.,
            Cardoso,J.P.D., Lima,F.T., Rogerio,L., de Vasconcelos Generoso,S.,
            Carneiro,J.G., da Silva,R.G., de Souza,R.P., De Marco,L. and
            Bastos-Rodrigues,L.
  TITLE     Association between KRAS mutation and alcohol consumption in
            Brazilian patients with colorectal cancer
  JOURNAL   Sci Rep 14 (1), 26445 (2024)
   PUBMED   39488539
  REMARK    GeneRIF: Association between KRAS mutation and alcohol consumption
            in Brazilian patients with colorectal cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5293)
  AUTHORS   Chu,T., Zhang,R., Liu,X., Lin,L., Li,Y., Niu,Z., Quan,H., Zhao,Y.
            and Li,Y.
  TITLE     Influence of recipient KRAS gene rs712 polymorphisms on the overall
            survival rate of hepatocellular carcinoma after hepatic
            transplantation
  JOURNAL   Clin Exp Med 24 (1), 246 (2024)
   PUBMED   39460812
  REMARK    GeneRIF: Influence of recipient KRAS gene rs712 polymorphisms on
            the overall survival rate of hepatocellular carcinoma after hepatic
            transplantation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5293)
  AUTHORS   Chen,Y., Zheng,Y. and Liu,S.
  TITLE     KRAS mutation promotes the colonization of Fusobacterium nucleatum
            in colorectal cancer by down-regulating SERTAD4
  JOURNAL   J Cell Mol Med 28 (20), e70182 (2024)
   PUBMED   39462261
  REMARK    GeneRIF: KRAS mutation promotes the colonization of Fusobacterium
            nucleatum in colorectal cancer by down-regulating SERTAD4.
REFERENCE   4  (bases 1 to 5293)
  AUTHORS   Moog,U. and Dobyns,W.B.
  TITLE     Encephalocraniocutaneous Lipomatosis
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   35099867
REFERENCE   5  (bases 1 to 5293)
  AUTHORS   Gripp,K.W. and Weaver,K.N.
  TITLE     HRAS-Related Costello Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301680
REFERENCE   6  (bases 1 to 5293)
  AUTHORS   Rauen,K.A.
  TITLE     Cardiofaciocutaneous Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301365
REFERENCE   7  (bases 1 to 5293)
  AUTHORS   Roberts,A.E.
  TITLE     Noonan Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301303
REFERENCE   8  (bases 1 to 5293)
  AUTHORS   Grimmond,S.M., Raghavan,D. and Russell,P.J.
  TITLE     Detection of a rare point mutation in Ki-ras of a human bladder
            cancer xenograft by polymerase chain reaction and direct sequencing
  JOURNAL   Urol Res 20 (2), 121-126 (1992)
   PUBMED   1553789
REFERENCE   9  (bases 1 to 5293)
  AUTHORS   Haritani,H., Esumi,M., Uchida,T. and Shikata,T.
  TITLE     Oncogene expression in the liver tissue of patients with
            nonneoplastic liver disease
  JOURNAL   Cancer 67 (10), 2594-2598 (1991)
   PUBMED   2015559
REFERENCE   10 (bases 1 to 5293)
  AUTHORS   Slebos,R.J., Habets,G.G., Evers,S.G., Mooi,W.J. and Rodenhuis,S.
  TITLE     Allele-specific detection of K-ras oncogene expression in human
            non-small-cell lung carcinomas
  JOURNAL   Int J Cancer 48 (1), 51-56 (1991)
   PUBMED   1850383
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC087239.18 and AC092794.10.
            
            On Apr 18, 2019 this sequence version replaced XM_011520653.3.
            
            Summary: This gene, a Kirsten ras oncogene homolog from the
            mammalian ras gene family, encodes a protein that is a member of
            the small GTPase superfamily. A single amino acid substitution is
            responsible for an activating mutation. The transforming protein
            that results is implicated in various malignancies, including lung
            adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas
            and colorectal carcinoma. Alternative splicing leads to variants
            encoding two isoforms that differ in the C-terminal region.
            [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.157404.1,
                                           SRR1660807.32200.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-166               AC087239.18        152724-152889
            167-288             AC087239.18        158258-158379
            289-467             AC092794.10        236-414
            468-627             AC092794.10        1875-2034
            628-5293            AC092794.10        17737-22402
FEATURES             Location/Qualifiers
     source          1..5293
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p12.1"
     gene            1..5293
                     /gene="KRAS"
                     /gene_synonym="'C-K-RAS; C-K-RAS; c-Ki-ras; c-Ki-ras2;
                     CFC2; K-Ras; K-Ras 2; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B;
                     KI-RAS; KRAS1; KRAS2; NS; NS3; OES; RALD; RASK2"
                     /note="KRAS proto-oncogene, GTPase"
                     /db_xref="GeneID:3845"
                     /db_xref="HGNC:HGNC:6407"
                     /db_xref="MIM:190070"
     exon            1..166
                     /gene="KRAS"
                     /gene_synonym="'C-K-RAS; C-K-RAS; c-Ki-ras; c-Ki-ras2;
                     CFC2; K-Ras; K-Ras 2; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B;
                     KI-RAS; KRAS1; KRAS2; NS; NS3; OES; RALD; RASK2"
                     /inference="alignment:Splign:2.1.0"
     exon            167..288
                     /gene="KRAS"
                     /gene_synonym="'C-K-RAS; C-K-RAS; c-Ki-ras; c-Ki-ras2;
                     CFC2; K-Ras; K-Ras 2; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B;
                     KI-RAS; KRAS1; KRAS2; NS; NS3; OES; RALD; RASK2"
                     /inference="alignment:Splign:2.1.0"
     CDS             178..744
                     /gene="KRAS"
                     /gene_synonym="'C-K-RAS; C-K-RAS; c-Ki-ras; c-Ki-ras2;
                     CFC2; K-Ras; K-Ras 2; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B;
                     KI-RAS; KRAS1; KRAS2; NS; NS3; OES; RALD; RASK2"
                     /EC_number="3.6.5.2"
                     /note="isoform b is encoded by transcript variant d;
                     v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog;
                     transforming protein p21; c-Kirsten-ras protein; K-ras p21
                     protein; oncogene KRAS2; PR310 c-K-ras oncogene; cellular
                     c-Ki-ras2 proto-oncogene; Kirsten rat sarcoma viral
                     proto-oncogene; GTPase KRas; KRAS-ENOPH fusion;
                     Kras-Enoph1 fusion protein; Kirsten rat sarcoma viral
                     oncogene homolog; cellular transforming proto-oncogene;
                     proto-oncogene GTPase"
                     /codon_start=1
                     /product="GTPase KRas isoform b"
                     /protein_id="NP_001356716.1"
                     /db_xref="CCDS:CCDS8702.1"
                     /db_xref="GeneID:3845"
                     /db_xref="HGNC:HGNC:6407"
                     /db_xref="MIM:190070"
                     /translation="MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQV
                     VIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKR
                     VKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTLV
                     REIRKHKEKMSKDGKKKKKKSKTKCVIM"
     exon            289..467
                     /gene="KRAS"
                     /gene_synonym="'C-K-RAS; C-K-RAS; c-Ki-ras; c-Ki-ras2;
                     CFC2; K-Ras; K-Ras 2; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B;
                     KI-RAS; KRAS1; KRAS2; NS; NS3; OES; RALD; RASK2"
                     /inference="alignment:Splign:2.1.0"
     exon            468..627
                     /gene="KRAS"
                     /gene_synonym="'C-K-RAS; C-K-RAS; c-Ki-ras; c-Ki-ras2;
                     CFC2; K-Ras; K-Ras 2; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B;
                     KI-RAS; KRAS1; KRAS2; NS; NS3; OES; RALD; RASK2"
                     /inference="alignment:Splign:2.1.0"
     exon            628..5293
                     /gene="KRAS"
                     /gene_synonym="'C-K-RAS; C-K-RAS; c-Ki-ras; c-Ki-ras2;
                     CFC2; K-Ras; K-Ras 2; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B;
                     KI-RAS; KRAS1; KRAS2; NS; NS3; OES; RALD; RASK2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3582..3587
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KRAS"
                     /gene_synonym="'C-K-RAS; C-K-RAS; c-Ki-ras; c-Ki-ras2;
                     CFC2; K-Ras; K-Ras 2; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B;
                     KI-RAS; KRAS1; KRAS2; NS; NS3; OES; RALD; RASK2"
                     /note="hexamer: AATAAA"
     polyA_site      3608
                     /gene="KRAS"
                     /gene_synonym="'C-K-RAS; C-K-RAS; c-Ki-ras; c-Ki-ras2;
                     CFC2; K-Ras; K-Ras 2; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B;
                     KI-RAS; KRAS1; KRAS2; NS; NS3; OES; RALD; RASK2"
     regulatory      5273..5278
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KRAS"
                     /gene_synonym="'C-K-RAS; C-K-RAS; c-Ki-ras; c-Ki-ras2;
                     CFC2; K-Ras; K-Ras 2; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B;
                     KI-RAS; KRAS1; KRAS2; NS; NS3; OES; RALD; RASK2"
                     /note="hexamer: AATAAA"
     polyA_site      5293
                     /gene="KRAS"
                     /gene_synonym="'C-K-RAS; C-K-RAS; c-Ki-ras; c-Ki-ras2;
                     CFC2; K-Ras; K-Ras 2; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B;
                     KI-RAS; KRAS1; KRAS2; NS; NS3; OES; RALD; RASK2"
                     /note="major polyA site"
ORIGIN      
        1 ctaggcggcg gccgcggcgg cggaggcagc agcggcggcg gcagtggcgg cggcgaaggt
       61 ggcggcggct cggccagtac tcccggcccc cgccatttcg gactgggagc gagcgcggcg
      121 caggcactga aggcggcggc ggggccagag gctcagcggc tcccaggcct gctgaaaatg
      181 actgaatata aacttgtggt agttggagct ggtggcgtag gcaagagtgc cttgacgata
      241 cagctaattc agaatcattt tgtggacgaa tatgatccaa caatagagga ttcctacagg
      301 aagcaagtag taattgatgg agaaacctgt ctcttggata ttctcgacac agcaggtcaa
      361 gaggagtaca gtgcaatgag ggaccagtac atgaggactg gggagggctt tctttgtgta
      421 tttgccataa ataatactaa atcatttgaa gatattcacc attatagaga acaaattaaa
      481 agagttaagg actctgaaga tgtacctatg gtcctagtag gaaataaatg tgatttgcct
      541 tctagaacag tagacacaaa acaggctcag gacttagcaa gaagttatgg aattcctttt
      601 attgaaacat cagcaaagac aagacagggt gttgatgatg ccttctatac attagttcga
      661 gaaattcgaa aacataaaga aaagatgagc aaagatggta aaaagaagaa aaagaagtca
      721 aagacaaagt gtgtaattat gtaaatacaa tttgtacttt tttcttaagg catactagta
      781 caagtggtaa tttttgtaca ttacactaaa ttattagcat ttgttttagc attacctaat
      841 ttttttcctg ctccatgcag actgttagct tttaccttaa atgcttattt taaaatgaca
      901 gtggaagttt ttttttcctc taagtgccag tattcccaga gttttggttt ttgaactagc
      961 aatgcctgtg aaaaagaaac tgaataccta agatttctgt cttggggctt ttggtgcatg
     1021 cagttgatta cttcttattt ttcttaccaa ttgtgaatgt tggtgtgaaa caaattaatg
     1081 aagcttttga atcatcccta ttctgtgttt tatctagtca cataaatgga ttaattacta
     1141 atttcagttg agaccttcta attggttttt actgaaacat tgagggaaca caaatttatg
     1201 ggcttcctga tgatgattct tctaggcatc atgtcctata gtttgtcatc cctgatgaat
     1261 gtaaagttac actgttcaca aaggttttgt ctcctttcca ctgctattag tcatggtcac
     1321 tctccccaaa atattatatt ttttctataa aaagaaaaaa atggaaaaaa attacaaggc
     1381 aatggaaact attataaggc catttccttt tcacattaga taaattacta taaagactcc
     1441 taatagcttt tcctgttaag gcagacccag tatgaaatgg ggattattat agcaaccatt
     1501 ttggggctat atttacatgc tactaaattt ttataataat tgaaaagatt ttaacaagta
     1561 taaaaaattc tcataggaat taaatgtagt ctccctgtgt cagactgctc tttcatagta
     1621 taactttaaa tcttttcttc aacttgagtc tttgaagata gttttaattc tgcttgtgac
     1681 attaaaagat tatttgggcc agttatagct tattaggtgt tgaagagacc aaggttgcaa
     1741 ggccaggccc tgtgtgaacc tttgagcttt catagagagt ttcacagcat ggactgtgtc
     1801 cccacggtca tccagtgttg tcatgcattg gttagtcaaa atggggaggg actagggcag
     1861 tttggatagc tcaacaagat acaatctcac tctgtggtgg tcctgctgac aaatcaagag
     1921 cattgctttt gtttcttaag aaaacaaact cttttttaaa aattactttt aaatattaac
     1981 tcaaaagttg agattttggg gtggtggtgt gccaagacat taattttttt tttaaacaat
     2041 gaagtgaaaa agttttacaa tctctaggtt tggctagttc tcttaacact ggttaaatta
     2101 acattgcata aacacttttc aagtctgatc catatttaat aatgctttaa aataaaaata
     2161 aaaacaatcc ttttgataaa tttaaaatgt tacttatttt aaaataaatg aagtgagatg
     2221 gcatggtgag gtgaaagtat cactggacta ggaagaaggt gacttaggtt ctagataggt
     2281 gtcttttagg actctgattt tgaggacatc acttactatc catttcttca tgttaaaaga
     2341 agtcatctca aactcttagt tttttttttt tacaactatg taatttatat tccatttaca
     2401 taaggataca cttatttgtc aagctcagca caatctgtaa atttttaacc tatgttacac
     2461 catcttcagt gccagtcttg ggcaaaattg tgcaagaggt gaagtttata tttgaatatc
     2521 cattctcgtt ttaggactct tcttccatat tagtgtcatc ttgcctccct accttccaca
     2581 tgccccatga cttgatgcag ttttaatact tgtaattccc ctaaccataa gatttactgc
     2641 tgctgtggat atctccatga agttttccca ctgagtcaca tcagaaatgc cctacatctt
     2701 atttcctcag ggctcaagag aatctgacag ataccataaa gggatttgac ctaatcacta
     2761 attttcaggt ggtggctgat gctttgaaca tctctttgct gcccaatcca ttagcgacag
     2821 taggattttt caaacctggt atgaatagac agaaccctat ccagtggaag gagaatttaa
     2881 taaagatagt gctgaaagaa ttccttaggt aatctataac taggactact cctggtaaca
     2941 gtaatacatt ccattgtttt agtaaccaga aatcttcatg caatgaaaaa tactttaatt
     3001 catgaagctt actttttttt tttggtgtca gagtctcgct cttgtcaccc aggctggaat
     3061 gcagtggcgc catctcagct cactgcaacc tccatctccc aggttcaagc gattctcgtg
     3121 cctcggcctc ctgagtagct gggattacag gcgtgtgcca ctacactcaa ctaatttttg
     3181 tatttttagg agagacgggg tttcaccctg ttggccaggc tggtctcgaa ctcctgacct
     3241 caagtgattc acccaccttg gcctcataaa cctgttttgc agaactcatt tattcagcaa
     3301 atatttattg agtgcctacc agatgccagt caccacacaa ggcactgggt atatggtatc
     3361 cccaaacaag agacataatc ccggtcctta ggtagtgcta gtgtggtctg taatatctta
     3421 ctaaggcctt tggtatacga cccagagata acacgatgcg tattttagtt ttgcaaagaa
     3481 ggggtttggt ctctgtgcca gctctataat tgttttgcta cgattccact gaaactcttc
     3541 gatcaagcta ctttatgtaa atcacttcat tgttttaaag gaataaactt gattatattg
     3601 tttttttatt tggcataact gtgattcttt taggacaatt actgtacaca ttaaggtgta
     3661 tgtcagatat tcatattgac ccaaatgtgt aatattccag ttttctctgc ataagtaatt
     3721 aaaatatact taaaaattaa tagttttatc tgggtacaaa taaacaggtg cctgaactag
     3781 ttcacagaca aggaaacttc tatgtaaaaa tcactatgat ttctgaattg ctatgtgaaa
     3841 ctacagatct ttggaacact gtttaggtag ggtgttaaga cttacacagt acctcgtttc
     3901 tacacagaga aagaaatggc catacttcag gaactgcagt gcttatgagg ggatatttag
     3961 gcctcttgaa tttttgatgt agatgggcat ttttttaagg tagtggttaa ttacctttat
     4021 gtgaactttg aatggtttaa caaaagattt gtttttgtag agattttaaa gggggagaat
     4081 tctagaaata aatgttacct aattattaca gccttaaaga caaaaatcct tgttgaagtt
     4141 tttttaaaaa aagctaaatt acatagactt aggcattaac atgtttgtgg aagaatatag
     4201 cagacgtata ttgtatcatt tgagtgaatg ttcccaagta ggcattctag gctctattta
     4261 actgagtcac actgcatagg aatttagaac ctaactttta taggttatca aaactgttgt
     4321 caccattgca caattttgtc ctaatatata catagaaact ttgtggggca tgttaagtta
     4381 cagtttgcac aagttcatct catttgtatt ccattgattt tttttttctt ctaaacattt
     4441 tttcttcaaa cagtatataa ctttttttag gggatttttt tttagacagc aaaaactatc
     4501 tgaagatttc catttgtcaa aaagtaatga tttcttgata attgtgtagt aatgtttttt
     4561 agaacccagc agttacctta aagctgaatt tatatttagt aacttctgtg ttaatactgg
     4621 atagcatgaa ttctgcattg agaaactgaa tagctgtcat aaaatgaaac tttctttcta
     4681 aagaaagata ctcacatgag ttcttgaaga atagtcataa ctagattaag atctgtgttt
     4741 tagtttaata gtttgaagtg cctgtttggg ataatgatag gtaatttaga tgaatttagg
     4801 ggaaaaaaaa gttatctgca gatatgttga gggcccatct ctccccccac acccccacag
     4861 agctaactgg gttacagtgt tttatccgaa agtttccaat tccactgtct tgtgttttca
     4921 tgttgaaaat acttttgcat ttttcctttg agtgccaatt tcttactagt actatttctt
     4981 aatgtaacat gtttacctgg aatgtatttt aactattttt gtatagtgta aactgaaaca
     5041 tgcacatttt gtacattgtg ctttcttttg tgggacatat gcagtgtgat ccagttgttt
     5101 tccatcattt ggttgcgctg acctaggaat gttggtcata tcaaacatta aaaatgacca
     5161 ctcttttaat tgaaattaac ttttaaatgt ttataggagt atgtgctgtg aagtgatcta
     5221 aaatttgtaa tatttttgtc atgaactgta ctactcctaa ttattgtaat gtaataaaaa
     5281 tagttacagt gac
//
