LOCUS       NM_001025231            2531 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens keratinocyte proline rich protein (KPRP), mRNA.
ACCESSION   NM_001025231
VERSION     NM_001025231.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2531)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2531)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2531)
  AUTHORS   Suga,H., Oka,T., Sugaya,M., Sato,Y., Ishii,T., Nishida,H.,
            Ishikawa,S., Fukayama,M. and Sato,S.
  TITLE     Keratinocyte Proline-Rich Protein Deficiency in Atopic Dermatitis
            Leads to Barrier Disruption
  JOURNAL   J Invest Dermatol 139 (9), 1867-1875 (2019)
   PUBMED   30905808
  REMARK    GeneRIF: By allelic copy number analysis at missense
            single-nucleotide polymorphisms on 26 genes with copy number
            variation, study identified a significant association between
            atopic dermatitis and human KPRP. Human KPRP expression, which was
            localized to the upper granular layer of epidermis, was
            significantly decreased in atopic dermatitis compared with normal
            skin.
REFERENCE   4  (bases 1 to 2531)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 2531)
  AUTHORS   Lee,W.H., Jang,S., Lee,J.S., Lee,Y., Seo,E.Y., You,K.H., Lee,S.C.,
            Nam,K.I., Kim,J.M., Kee,S.H., Yang,J.M., Seo,Y.J., Park,J.K.,
            Kim,C.D. and Lee,J.H.
  TITLE     Molecular cloning and expression of human keratinocyte proline-rich
            protein (hKPRP), an epidermal marker isolated from calcium-induced
            differentiating keratinocytes
  JOURNAL   J Invest Dermatol 125 (5), 995-1000 (2005)
   PUBMED   16297201
  REMARK    GeneRIF: A human gene encoding keratinocyte proline-rich protein
            (hKPRP), an epidermal marker expressed in stratified squamous
            epithelia, has a potential role in keratinocytes differentiation.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL353779.11.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 25, 2021 this sequence version replaced NM_001025231.2.
            
            Summary: This gene encodes a proline-rich skin protein possibly
            involved in keratinocyte differentiation. [provided by RefSeq, Jul
            2016].
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000606109.2/ ENSP00000475216.1
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, expression, longest
                                         protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                AL353779.11        42428-42462
            36-2531             AL353779.11        43964-46459
FEATURES             Location/Qualifiers
     source          1..2531
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..2531
                     /gene="KPRP"
                     /gene_synonym="C1orf45"
                     /note="keratinocyte proline rich protein"
                     /db_xref="GeneID:448834"
                     /db_xref="HGNC:HGNC:31823"
                     /db_xref="MIM:613260"
     exon            1..35
                     /gene="KPRP"
                     /gene_synonym="C1orf45"
                     /inference="alignment:Splign:2.1.0"
     exon            36..2531
                     /gene="KPRP"
                     /gene_synonym="C1orf45"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..1803
                     /gene="KPRP"
                     /gene_synonym="C1orf45"
                     /note="keratinocyte expressed, proline-rich protein"
                     /codon_start=1
                     /product="keratinocyte proline-rich protein"
                     /protein_id="NP_001020402.1"
                     /db_xref="CCDS:CCDS30862.1"
                     /db_xref="GeneID:448834"
                     /db_xref="HGNC:HGNC:31823"
                     /db_xref="MIM:613260"
                     /translation="MCDQQQIQCRLPLQQCCVKGPSFCSSQSPFAQSQVVVQAPCEMQ
                     IVDCPASCPVQVCQVSDQAPCQSQTTQVKCQSKTKQVKGQAQCQSKTTQVKGQAASQS
                     QTSSVQSQAPCQSEVSYVQCEASQPVQTCFVECAPVCYTETCYVECPVQNYVPCPAPQ
                     PVQMYRGRPAVCQPQGRFSTQCQYQGSYSSCGPQFQSRATCNNYTPQFQLRPSYSSCF
                     PQYRSRTSFSPCVPQCQTQGSYGSFTEQHRSRSTSRCLPPPRRLQLFPRSCSPPRRFE
                     PCSSSYLPLRPSEGFPNYCTPPRRSEPIYNSRCPRRPISSCSQRRGPKCRIEISSPCC
                     PRQVPPQRCPVEIPPIRRRSQSCGPQPSWGASCPELRPHVEPRPLPSFCPPRRLDQCP
                     ESPLQRCPPPAPRPRLRPEPCISLEPRPRPLPRQLSEPCLYPEPLPALRPTPRPVPLP
                     RPGQCEIPEPRPCLQPCEHPEPCPRPEPIPLPAPCPSPEPCRETWRSPSPCWGPNPVP
                     YPGDLGCHESSPHRLDTEAPYCGPSSYNQGQESGAGCGPGDVFPERRGQDGHGDQGNA
                     FAGVKGEAKSAYF"
     regulatory      2506..2511
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KPRP"
                     /gene_synonym="C1orf45"
                     /note="hexamer: AATAAA"
     polyA_site      2527
                     /gene="KPRP"
                     /gene_synonym="C1orf45"
                     /note="major polyA site"
ORIGIN      
        1 gcctcagcct gaaggactgc ttgcctgtga ggagggtcac tcttgactgg ctgcatcagg
       61 accatgtgtg accagcagca gatccagtgc cgcctgccgc tccaacagtg ctgcgtcaag
      121 ggtccctcct tctgctcctc tcaatccccc tttgcccaga gccaagtggt ggttcaagcc
      181 ccttgtgaga tgcaaattgt ggactgccct gcatcatgcc cagttcaagt ttgccaggtg
      241 tcagaccagg ctccatgcca gtctcagacc acacaggtga agtgccagtc taagaccaag
      301 caggtgaagg gccaggctca atgtcagtct aagaccaccc aggtgaaggg ccaggctgca
      361 tcccaatctc aaacttcctc tgttcaaagc caggctccat gccaatctga ggtgtcctac
      421 gtgcagtgcg aagcgtcaca acctgttcag acttgcttcg tagaatgtgc tccagtttgt
      481 tatacagaaa cttgttatgt agaatgccca gtccagaact atgtaccctg tccagctcct
      541 cagcctgtcc agatgtatag agggcgtcct gcagtgtgcc agcctcaggg aagattctcc
      601 acccagtgcc agtatcaagg ctcctatagc agttgtggcc cccagtttca gtcaagggct
      661 acctgcaaca actacacccc ccagttccag ttgaggcctt cctacagcag ctgtttccct
      721 cagtatcggt cccggacttc atttagtccc tgtgtgcccc agtgccagac ccagggctcc
      781 tatgggagct tcactgaaca gcaccgctct cggagcacca gcagatgcct tcctcctcct
      841 cggcggctgc agcttttccc ccgcagctgt tccccaccaa gacgttttga gccctgctcc
      901 agcagctacc tgccactaag accctctgaa ggtttcccta actactgcac cccaccccgc
      961 cgctctgaac ccatatataa cagtcgctgt cctcgccgcc ccatttcaag ctgctctcag
     1021 agacgtggcc ccaagtgccg aatcgagatt tcctccccgt gctgccccag gcaggttccc
     1081 ccacagaggt gtcctgttga gattcctccc atcagacgcc gctcccagag ctgtggcccg
     1141 cagccctcct ggggcgcctc ctgccctgag ctgaggccac acgtagagcc acgtccactc
     1201 ccaagcttct gtccaccacg gcgtcttgac cagtgtccag agtcaccact gcagcgatgt
     1261 ccacctcctg ctccacgtcc acgtctgcgc ccagaaccat gcataagtct agaaccacgc
     1321 ccgcgtcctc taccacgaca actttcagaa ccttgtttgt atccagaacc acttccagca
     1381 ctacgtccaa caccgcggcc agttcccctt cctcgcccag ggcagtgtga gattccagag
     1441 ccacgtccat gcctgcagcc ctgtgagcac ccagagcctt gtccacgacc agagccaatt
     1501 cccctgccgg cgccctgccc aagcccggag ccctgcaggg agacttggcg cagccccagc
     1561 ccatgctggg gcccaaatcc agttccatac ccaggagacc taggctgtca tgagtctagt
     1621 ccacaccgcc tagacaccga agctccctac tgtggcccat ccagttacaa ccaggggcaa
     1681 gagagtggtg ctggctgtgg gcctggtgat gtgtttccag agcggagggg tcaggatggc
     1741 catggagacc aaggcaatgc ctttgctgga gtgaaagggg aagcaaagag tgcttatttt
     1801 taaaggaaag gtgactgaga taaccctctc tcctgctctg aaaatgttgt tcctcctatt
     1861 ccacaatttc cagtacgctc ttgtttgaat ctctccaaag atattcagag actccctatt
     1921 acgaaggtga tgtccaaact cctttgccta tcatccaaag atccacacct gggtctcaga
     1981 tgcctctcca gcctcacgtg tcactcctcg cccgtacgca tcctcggctc tagccagacc
     2041 agtctggcca ctgggcacag cttgggtgtt ccccaggcca tactttagat gtccctgcct
     2101 ccaagcctct gctcactctt ccccactctg cctggaccac ttctctcctc ctccccagct
     2161 tctgaaatcc accccatctt tcagtgcctc tcccttggag ccttctttgc ttgttcccac
     2221 tcacaagaac ctgtgccgac ttcctagaac tcactgcatc ccccgcacta cttggtaact
     2281 gcctggtgac atctcttgaa ttgttatttc actttgcagg catgtcttcc ttatctgccc
     2341 aactaggttg taaactccca actgagtgga gtcggagaat ctctaaatct cagtgtctat
     2401 cctggggctg gctgttgctt agcaaggctt gtgggttggc agcttgaacc atgttctgtc
     2461 ctgatgctca actgcaggaa ctgaggtgag aggaggccat gtgacaataa agatcattat
     2521 gtactcactg c
//
