LOCUS       NM_002268               8952 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens karyopherin subunit alpha 4 (KPNA4), mRNA.
ACCESSION   NM_002268 NM_032771 XR_108508 XR_112567 XR_113535
VERSION     NM_002268.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8952)
  AUTHORS   Khoroshkin,M., Buyan,A., Dodel,M., Navickas,A., Yu,J., Trejo,F.,
            Doty,A., Baratam,R., Zhou,S., Lee,S.B., Joshi,T., Garcia,K.,
            Choi,B., Miglani,S., Subramanyam,V., Modi,H., Carpenter,C.,
            Markett,D., Corces,M.R., Mardakheh,F.K., Kulakovskiy,I.V. and
            Goodarzi,H.
  TITLE     Systematic identification of post-transcriptional regulatory
            modules
  JOURNAL   Nat Commun 15 (1), 7872 (2024)
   PUBMED   39251607
  REMARK    Erratum:[Nat Commun. 2024 Oct 28;15(1):9277. doi:
            10.1038/s41467-024-52903-4.. PMID: 39468017]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8952)
  AUTHORS   Kliche,J., Simonetti,L., Krystkowiak,I., Kuss,H., Diallo,M.,
            Rask,E., Nilsson,J., Davey,N.E. and Ivarsson,Y.
  TITLE     Proteome-scale characterisation of motif-based interactome rewiring
            by disease mutations
  JOURNAL   Mol Syst Biol 20 (9), 1025-1048 (2024)
   PUBMED   39009827
REFERENCE   3  (bases 1 to 8952)
  AUTHORS   Ju,J., Zhang,H., Lin,M., Yan,Z., An,L., Cao,Z., Geng,D., Yue,J.,
            Tang,Y., Tian,L., Chen,F., Han,Y., Wang,W., Zhao,S., Jiao,S. and
            Zhou,Z.
  TITLE     The alanyl-tRNA synthetase AARS1 moonlights as a lactyltransferase
            to promote YAP signaling in gastric cancer
  JOURNAL   J Clin Invest 134 (10), e174587 (2024)
   PUBMED   38512451
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8952)
  AUTHORS   Kliche,J., Garvanska,D.H., Simonetti,L., Badgujar,D.,
            Dobritzsch,D., Nilsson,J., Davey,N.E. and Ivarsson,Y.
  TITLE     Large-scale phosphomimetic screening identifies phospho-modulated
            motif-based protein interactions
  JOURNAL   Mol Syst Biol 19 (7), e11164 (2023)
   PUBMED   37219487
REFERENCE   5  (bases 1 to 8952)
  AUTHORS   Yang,W., Yao,Y., Yang,S. and Ke,Y.
  TITLE     Circular RNA hsa_circ_0008003 promotes the progression of
            non-small-cell lung cancer by sponging miR-548I and regulating
            KPNA4 expression
  JOURNAL   Thorac Cancer 14 (6), 544-554 (2023)
   PUBMED   36573325
  REMARK    GeneRIF: Circular RNA hsa_circ_0008003 promotes the progression of
            non-small-cell lung cancer by sponging miR-548I and regulating
            KPNA4 expression.
REFERENCE   6  (bases 1 to 8952)
  AUTHORS   Seki,T., Tada,S., Katada,T. and Enomoto,T.
  TITLE     Cloning of a cDNA encoding a novel importin-alpha homologue, Qip1:
            discrimination of Qip1 and Rch1 from hSrp1 by their ability to
            interact with DNA helicase Q1/RecQL
  JOURNAL   Biochem Biophys Res Commun 234 (1), 48-53 (1997)
   PUBMED   9168958
REFERENCE   7  (bases 1 to 8952)
  AUTHORS   Di Marzio,P., Choe,S., Ebright,M., Knoblauch,R. and Landau,N.R.
  TITLE     Mutational analysis of cell cycle arrest, nuclear localization and
            virion packaging of human immunodeficiency virus type 1 Vpr
  JOURNAL   J Virol 69 (12), 7909-7916 (1995)
   PUBMED   7494303
REFERENCE   8  (bases 1 to 8952)
  AUTHORS   Gallay,P., Swingler,S., Song,J., Bushman,F. and Trono,D.
  TITLE     HIV nuclear import is governed by the phosphotyrosine-mediated
            binding of matrix to the core domain of integrase
  JOURNAL   Cell 83 (4), 569-576 (1995)
   PUBMED   7585960
REFERENCE   9  (bases 1 to 8952)
  AUTHORS   Bukrinsky,M.I., Sharova,N., Dempsey,M.P., Stanwick,T.L.,
            Bukrinskaya,A.G., Haggerty,S. and Stevenson,M.
  TITLE     Active nuclear import of human immunodeficiency virus type 1
            preintegration complexes
  JOURNAL   Proc Natl Acad Sci U S A 89 (14), 6580-6584 (1992)
   PUBMED   1631159
REFERENCE   10 (bases 1 to 8952)
  AUTHORS   Sharova,N. and Bukrinskaya,A.
  TITLE     p17 and p17-containing gag precursors of input human
            immunodeficiency virus are transported into the nuclei of infected
            cells
  JOURNAL   AIDS Res Hum Retroviruses 7 (3), 303-306 (1991)
   PUBMED   2064827
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC034493.2 and AC078868.14.
            
            On Nov 23, 2018 this sequence version replaced NM_002268.4.
            
            Summary: The nuclear import of karyophilic proteins is directed by
            short amino acid sequences termed nuclear localization signals
            (NLSs). Karyopherins, or importins, are cytoplasmic proteins that
            recognize NLSs and dock NLS-containing proteins to the nuclear pore
            complex. The protein encoded by this gene shares the sequence
            similarity with Xenopus importin-alpha and Saccharomyces cerevisiae
            Srp1. This protein is found to interact with the NLSs of DNA
            helicase Q1 and SV40 T antigen. [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853567.21922.1,
                                           SRR11853565.21203.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000334256.9/ ENSP00000334373.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3785              BC034493.2         18-3802
            3786-8952           AC078868.14        8835-14001          c
FEATURES             Location/Qualifiers
     source          1..8952
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q25.33"
     gene            1..8952
                     /gene="KPNA4"
                     /gene_synonym="IPOA3; QIP1; SRP3"
                     /note="karyopherin subunit alpha 4"
                     /db_xref="GeneID:3840"
                     /db_xref="HGNC:HGNC:6397"
                     /db_xref="MIM:602970"
     exon            1..358
                     /gene="KPNA4"
                     /gene_synonym="IPOA3; QIP1; SRP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             290..1855
                     /gene="KPNA4"
                     /gene_synonym="IPOA3; QIP1; SRP3"
                     /note="importin subunit alpha-4; importin alpha Q1;
                     karyopherin alpha 4 (importin alpha 3)"
                     /codon_start=1
                     /product="importin subunit alpha-3"
                     /protein_id="NP_002259.1"
                     /db_xref="CCDS:CCDS3191.1"
                     /db_xref="GeneID:3840"
                     /db_xref="HGNC:HGNC:6397"
                     /db_xref="MIM:602970"
                     /translation="MADNEKLDNQRLKNFKNKGRDLETMRRQRNEVVVELRKNKRDEH
                     LLKRRNVPHEDICEDSDIDGDYRVQNTSLEAIVQNASSDNQGIQLSAVQAARKLLSSD
                     RNPPIDDLIKSGILPILVHCLERDDNPSLQFEAAWALTNIASGTSEQTQAVVQSNAVP
                     LFLRLLHSPHQNVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFISPSIPITFLR
                     NVTWVMVNLCRHKDPPPPMETIQEILPALCVLIHHTDVNILVDTVWALSYLTDAGNEQ
                     IQMVIDSGIVPHLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDALSHFPAL
                     LTHPKEKINKEAVWFLSNITAGNQQQVQAVIDANLVPMIIHLLDKGDFGTQKEAAWAI
                     SNLTISGRKDQVAYLIQQNVIPPFCNLLTVKDAQVVQVVLDGLSNILKMAEDEAETIG
                     NLIEECGGLEKIEQLQNHENEDIYKLAYEIIDQFFSSDDIDEDPSLVPEAIQGGTFGF
                     NSSANVPTEGFQF"
     exon            359..403
                     /gene="KPNA4"
                     /gene_synonym="IPOA3; QIP1; SRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            404..493
                     /gene="KPNA4"
                     /gene_synonym="IPOA3; QIP1; SRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            494..523
                     /gene="KPNA4"
                     /gene_synonym="IPOA3; QIP1; SRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            524..576
                     /gene="KPNA4"
                     /gene_synonym="IPOA3; QIP1; SRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            577..672
                     /gene="KPNA4"
                     /gene_synonym="IPOA3; QIP1; SRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            673..758
                     /gene="KPNA4"
                     /gene_synonym="IPOA3; QIP1; SRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            759..845
                     /gene="KPNA4"
                     /gene_synonym="IPOA3; QIP1; SRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            846..1015
                     /gene="KPNA4"
                     /gene_synonym="IPOA3; QIP1; SRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1060
                     /gene="KPNA4"
                     /gene_synonym="IPOA3; QIP1; SRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1192
                     /gene="KPNA4"
                     /gene_synonym="IPOA3; QIP1; SRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1321
                     /gene="KPNA4"
                     /gene_synonym="IPOA3; QIP1; SRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1426
                     /gene="KPNA4"
                     /gene_synonym="IPOA3; QIP1; SRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1427..1498
                     /gene="KPNA4"
                     /gene_synonym="IPOA3; QIP1; SRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1499..1661
                     /gene="KPNA4"
                     /gene_synonym="IPOA3; QIP1; SRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1662..1756
                     /gene="KPNA4"
                     /gene_synonym="IPOA3; QIP1; SRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1757..8952
                     /gene="KPNA4"
                     /gene_synonym="IPOA3; QIP1; SRP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3762..3767
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KPNA4"
                     /gene_synonym="IPOA3; QIP1; SRP3"
                     /note="hexamer: AATAAA"
     regulatory      3769..3774
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KPNA4"
                     /gene_synonym="IPOA3; QIP1; SRP3"
                     /note="hexamer: ATTAAA"
     polyA_site      3781
                     /gene="KPNA4"
                     /gene_synonym="IPOA3; QIP1; SRP3"
                     /note="major polyA site"
     polyA_site      3792
                     /gene="KPNA4"
                     /gene_synonym="IPOA3; QIP1; SRP3"
                     /note="major polyA site"
     regulatory      8932..8937
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KPNA4"
                     /gene_synonym="IPOA3; QIP1; SRP3"
                     /note="hexamer: AATAAA"
     polyA_site      8952
                     /gene="KPNA4"
                     /gene_synonym="IPOA3; QIP1; SRP3"
                     /note="major polyA site"
ORIGIN      
        1 agatcgaggc tgcctccccc tctcagccgg cagcacattc cgtcgccttg ccgccgcccg
       61 gccccacagt tgtctttgcc ggagctgcag tcgcgctggg gttagggcgg gggggcgggc
      121 ggggagagga gaaggccgcg gcggaggcag gtgagaggag gaaggaagcg gcggcgcggc
      181 gggcacagca gctcaggcgg cggcccggtt cctgggagtg tcggtgcggc gcgttggttg
      241 gggcggatcc cgcggggccc gggcggggga aggagtcacc ggcccggcca tggcggacaa
      301 cgagaaactg gacaaccaac ggctcaagaa tttcaagaac aaaggccgcg acttggagac
      361 tatgagaaga caacgaaatg aagttgtagt tgaattaagg aagaataaaa gagatgaaca
      421 tctcttaaag agaaggaatg taccacatga agatatctgt gaagactctg atatagatgg
      481 tgattataga gtgcaaaata cctctctaga agctattgtt caaaatgctt caagtgataa
      541 ccaaggaatt caattaagtg cagttcaagc tgctaggaag cttttgtcca gtgatcgaaa
      601 tccaccaatt gatgacttaa taaaatctgg aatattgccc attttagtcc attgtcttga
      661 aagagatgac aatccttctt tacagtttga agctgcatgg gctttgacaa acattgcatc
      721 tggaacttct gaacaaactc aagcagtagt tcagtccaat gctgtgccac ttttcctgag
      781 gcttctccat tcaccccatc agaatgtctg tgagcaagca gtgtgggcat tgggaaatat
      841 cataggtgat gggccccagt gtagagatta tgtcataagt cttggagttg tgaaaccttt
      901 actttccttc ataagtccat ctattcctat aacattctta agaaatgtta cttgggttat
      961 ggtcaactta tgtcgccaca aagacccacc accaccaatg gaaaccattc aggagattct
     1021 tccagccctt tgtgttttaa ttcatcacac agatgtaaat atactggtag acacagtctg
     1081 ggccctctct taccttactg atgctggcaa tgaacaaata cagatggtaa tagactctgg
     1141 aatagttcct catttggttc ctctgctcag ccaccaggaa gttaaagttc agactgctgc
     1201 acttagagct gtgggcaaca ttgttactgg aactgatgag caaacacaag tagttttgaa
     1261 ctgtgatgct ctttcacact tcccagcact cctgacacat cccaaagaga aaattaataa
     1321 agaagcagtg tggttcctct ccaacatcac tgcaggaaat cagcagcagg tacaggcagt
     1381 aattgatgcc aatcttgtac caatgataat acaccttttg gataaggggg attttggcac
     1441 tcaaaaagaa gctgcttggg ccataagtaa cttaacaatt agtggaagga aagatcaagt
     1501 ggcttacctt atccaacaaa atgttatccc acctttttgc aacttgctga ctgtaaaaga
     1561 tgcacaagtt gtgcaagtag tactcgatgg actaagtaat atattaaaaa tggctgaaga
     1621 tgaggcagaa accataggca atcttataga agaatgtgga gggctggaga aaattgaaca
     1681 acttcaaaat catgaaaatg aagacatcta caaattggcc tatgagatca ttgatcagtt
     1741 cttctcttca gatgatattg atgaagaccc tagccttgtt ccagaggcaa ttcaaggcgg
     1801 aacatttggt ttcaattcat ctgccaatgt accaacagaa gggttccagt tttagaaaga
     1861 tgttgtggaa gttaggtaca atgcagcact gagatatata tatatatatg tgtgtgtgta
     1921 tatatatata tatatacata tatataaaaa ggtttgatcc atcaagcttg gctcatggga
     1981 tctgctgctg cattaaatcg ggaaagaaaa tgtgaagatt tcatttggaa tcacagaaaa
     2041 tgcccaaatg aggtcaagat ggcgagtggg tgcgagtgag aatgagtggc aaaatgtaat
     2101 gaaaacttta catgaatgct tatttaggtt gttcaaagta aaaagggcta caggtcacag
     2161 atcgtcagtg cctgagaaag aacattgact tactctatat caattgaggg gaaagtgcag
     2221 taccgtcatc ttcaagcctt gtaagcataa aagagaatag gctgcccata taagtcaaag
     2281 gaaaatgagc ccaggccttg ctatgaagca gtgtgtgaat ggacaatgtt gaatgaatgt
     2341 ctggctcagt gatggagagc caggttcatc tttgaaatct agggctcttc actcatgaag
     2401 cagactccta gtcctggagt gactgtgtac gagagcgtgg ttgtggtgct gtatgtgaac
     2461 gcatgcaagc ttgattcacc ttcagggggc tgataaccta gtaaatcatc aaaatgagat
     2521 cataagtgtt aatgtacact ggacatgaaa acaaagactg gtttagcagc agacattggt
     2581 ttactctgca gcctgtgttt tctgtttccc cctttcccac ctccttcccc ccacccaatc
     2641 cttttttttt tcttttttgc ttttcttttc ttttttttta gtttttattt actttaccta
     2701 gtatgccttt ttttagttgc ttctcaagtc agaaaacttt tcaggaaggt ttccctgtgc
     2761 atttgcacca gatgaatgtt tgatgctatg aaaagctttc catatcatca aaactaattt
     2821 gtgtagattt ttgcatgaaa aaaatcataa atttccctca aaatagactg tgttgcagta
     2881 cacaagttgc cataatagta taaaacagta aaatgtgctt aaaaggccat ccttttcatt
     2941 ttcagagata acataaagat ctttgcatga ggtaaatcta cagcatagtt catttttaga
     3001 ttttgttgag tcctgtaaag aagaagaaga aaaaagtttc agttgtggta gaataccgtg
     3061 ctgtgtttaa atgttacttg ttttcaaact ttgttttcta tgaaaatgat atggaaactt
     3121 ctaaaatgga atttggtgca tatgtactgc tgaataaaga ccgatgaaga ggtttgagta
     3181 gatgtacaaa tcaagtaatg gtttgaacac ctttaataat atgcctaatc tgttcaattg
     3241 ttttagaatc tttttatctt agatgtaggc agccatgaac aatctatttt gagccacttt
     3301 agggagaaaa ctttgtattt ttaaaacttg cataaaagtt atgcaagtgg tttttataaa
     3361 ttggaataat acctcagttt tgaggttatg cacactaaat taaatgtgac ataaattaat
     3421 ttgtacaaaa agaactcttt ataaggtggc tcattgtagg aaatcctgtg ccttcccctt
     3481 tgagcacaag tgttgcatga acaacagttt gctataagaa acataccaga ttagccacca
     3541 ttagcatcta tatctacttt gtgtttaaaa atcaactggt aattctgaaa cactgtagaa
     3601 tggataaaaa ttattttgtg atcataactc tttgttgaac tagagtattt ttgcagcatt
     3661 ccttgtcatc agaaacatgg ttaaagttta aaactagaag cagcagaaaa ctagcttgta
     3721 aaatttatcc aagtagagtg caggctaggc tgtcttgggg aaataaacat taaaacttaa
     3781 agcaatgttt tacatggggt gtgtgtgtgt ggtgtgtgga tttttttttt tttataaagt
     3841 tagagtataa ttcaatggct tacattagct tcctgtcttt ttacctagaa ccagcataat
     3901 aagaaatttc tttggttctg tcatttcagt atggacatat taatatttta gcccactgag
     3961 tttgtccagt tgacaccatc agtgcttcag ttttctctct atccaaagca aggttttaac
     4021 tttccttcat tctccagtaa aacagaccga gacaacttga actatatttt gagtattgct
     4081 atatcttcaa catatagctc caaatgatgg attgtataca aagcatagta cagaaggttt
     4141 cagtaattgg aaggtgaaca cagcaatgct ttacataatt tgtgtttttt agtaaaaaat
     4201 attggattca aagtaagcca atgagcttgt atacaaattt tatatacaaa ttattgtata
     4261 gaacagtgat atggaaaata ggtaagggtg atattaatat ctctgggtat aaggactacc
     4321 ttatcgttta aatattttat ttccatctat agcctaatat agaacattga ttttctagta
     4381 gaaattctgg gaagggcttt tctgtctctg aaattgattc agtacagttg acagttcatc
     4441 acggttacct ggttaaacac tttttttttt tttttaattc tccagtgatc taggaaattg
     4501 tttcattttt aacacaggct tatttctgat ggggatgggg gcatagaata atatgcctaa
     4561 taagctaaac gttcttaacg tttcatgtct taaactgtct ttttgaacat tgagaccacc
     4621 tcaagtgctg taaaaataag aatgttatat taggggtgtg tgagacgccc tagtctaaaa
     4681 tctatcttta aatatatttc ctttgtaatt ttcaaagact tcagtaattg tgtgttatgg
     4741 tggaaataat actttccatt ggtccacatt gctctggacc aaacctggag catttctata
     4801 attagagcta tctatgaatc attaaaaatg gatctagaat aattttgggg agagggagtg
     4861 tatcatttag tttaggctta cctcagcagc acttcatagg gtgaggagtt gtttgtttct
     4921 ttaaaggtat aactgcattg taaaatgact gggtttattg taacagtaat ttatgggggc
     4981 accctttttg gattctccat tgcctcagtt tcctcaagga aaaagttaca gagattaagc
     5041 taaattttga atttagagaa taactgctgt gtaattttgg tataattacc ataaatttag
     5101 tgtcttaaaa cacaacatac attatttcac aatttctgta ggtcaagagt gtagttaggt
     5161 tttctgctca gggtctcaca aggctgcaat aaaggtgtca gccagagctg cagtcttatc
     5221 tgaagctagg gggtcctctt ttatgcacat atggcaaaat ccattgccta gcaactgaag
     5281 aaatcatggg aacttcttca aggccagcaa gagaatctct gatctcaggg aaggccttaa
     5341 gcgctttttt aaaggtctca cctgattaga tcaggccacc tacccaccag ggtgatctcc
     5401 cttttgatta acccaaagcc aaactgatga ggtaccttca ttacccctgc aaaatccctt
     5461 cacctttgcc ctgcattgta gtccaatcac aggggtgata cgcatcatat tcaaagatcc
     5521 tgttcacagt caagggaggg ggttatatgg agtatgtata ccagggaatc ttgggagcca
     5581 tcttaagagt tcttcctatg acaaggactc aactatttag aactggaaca atttacaagt
     5641 gatagcctta tatagttatc atagcaagct tatttgggga tcaaggttgc ctctgagaac
     5701 ctaatgaaaa ctggaccagc ttccccaaaa agtgtatata catggtagtt tttcatacag
     5761 ttttagggga ttcataagag tccatgaatt acagtctgtc ccaacccttc cctttagatg
     5821 atgagttgtt gaggtgactt gcccaaggtc acacagctac taagggccaa ataaagccca
     5881 catctcaact cccatactgc ccagggcttc taattactat tctaaaggta atctaaattc
     5941 atttaaattt gtgaaccaat gcaaaaaaat gtgaatgtag ctttttggat attttttttg
     6001 tttactaagg aatgggtaac attgttatag aagcttgcct aagagttttg aaattagttg
     6061 acctttttga gtttccaaaa ttgaatcttc cattgtagct attaaagtga actataaata
     6121 ggccaacttt aattgttaac tcctcgggtt tggtggatta tctaccattt atatataaaa
     6181 tttcagttag aatccaccat tggcgttttg aaggccaaga tagctgagta tcttatcctt
     6241 tttgtaactt cttgattatt ttacttattg gcaaaattca ttaactgtca gccaataatt
     6301 taatattatg ggaggaaaaa attttgccca gatatctgag gcaatactcc caaacactaa
     6361 caaactgatg cctaacaaac ttgacatttt gaacacttaa agttttccct aaacttttta
     6421 ataagcacat taataaagta tgcttttaaa tatatatgta caataatttt taaaagttgc
     6481 tgcaagatgc cttcaaatca atatgcacgt tggtggcatt agtgcagtct tctattttta
     6541 tttttttgag acacagtctc gctctgtggc ccaggctgga gtgtagtggc gcaatctcgg
     6601 ctcactgcaa cctctgcctc aagggttcaa gcaattctgc ctcagcctcc tgagtagctg
     6661 ggattacagg agtacgctac cacgcctggc taatttttgt atttttagta gaaatggggt
     6721 ttcaccgtat tggccaggct ggtattggaa tcctgaccgc aaatgatctg cccacctcgg
     6781 cttcccaaag tgctgggatt acaggcgtga gccactgcgc ccaaccagcc ttaattctta
     6841 ataaaggaag ttgaaaaata atgaacattg gtaaaactat tctagtgtga tcagaagcaa
     6901 atttggactg tagtgtcaaa ttgataaaaa actaagcaca ccaatcatgt ataagaaaag
     6961 tagatttaac atttttttcc ctaaacactt aacccagaag ttaacaataa tcttgaaaat
     7021 tccttttaaa tccaggccct ttaggtgatg gcagtttgac tcaggatgtc caagtccagt
     7081 gtattttcaa taaaattgac ttgacagcta ctgctctggg tgtaagagca gttgactgtg
     7141 aggaaaagta aatggttcta cagattcttt atgatctacc tcccaccaga ggactgcagt
     7201 actcccttgt tatttatatt ttctgcccca atttttgcct tctccacaaa ttttatacct
     7261 tttgtagctg cctactccag attacttcac ctttccagac tatcagttct tccactttta
     7321 ttcttcataa agaaaattcc aataacctgt ttcacttagg tttttctatt actcttcaag
     7381 catgaatcct aatttccctg actatatctt acctctgatc tccataactg atggattcct
     7441 atcctagact atgttactct aatattaccc aagattttct ccagcctgtt tttactctta
     7501 ctttgaaaca gctgtttaaa atgactcgta atctgcttaa atctacatgc tttttgtggt
     7561 tctcaatcca gttacctacc ttccagataa ttccctcact gtcctgtcct ctccattcct
     7621 ctgatgttta agccctgtga gccacctttc ccccatcctt tgtgcatagt taccatttta
     7681 ctctttcttg ttgcccaggc aggaatgcag tggtgccatc ttggctcact gcaacctcca
     7741 cctcctaggt tcaagcgatt ctcctgcctc agcctcctga gtagctggga ccacaagcgt
     7801 gcaccaccac gcccggctaa tttttgtatt tttagtagag atggggtttc accacgttgg
     7861 ccaggctggt ctcgaactcc tgacctcaga tgatccaccc tccttggcct cccaaagtgc
     7921 tgggattgca ggcgtgagcc accgcctggc caccatttta ctctttttag gtacagtaat
     7981 ctaatatcca aagtcttgga ctcagctaaa gagggtattt accttaaaaa aaaaaaaaaa
     8041 aagactccat cttttgattc ataattgtgg tgggggcggg gaatcaagac aaccttagtc
     8101 actttggtat taccataatt cttgtctttt cagggttgtc ctgttcagct gcataaaaca
     8161 tcatgtattc taggtatttc ctaccttcac ttacattttt acttgccgat gtgctgcctt
     8221 cataaatggg tatattccgc cacacatcta gtaagccccc aatgcagtac acaatgtgta
     8281 tcactgataa aactcgcact tctgccatgt cagtattata ttcagttgag tggtctttag
     8341 catagtggca gtcctagtca tcctaacctt ttagttaagg taaaattaca tatgtttata
     8401 gaactcatat agacaagcta gtttttaaaa tcttcctttt aaccagttta ggatgatcta
     8461 ggatagctaa gttacctaca tggtgactgt tcggtctaat tcagaaacag aagtactaaa
     8521 agaatactaa aaagttttta cccattatct ctatccctgt tttctttttg caattctcag
     8581 ctgcagggag caagaaaata cacagcagat aggaaatgtt tgtttgcatc ctggctttct
     8641 caaccgcact ttacgtcctt gaatattcta gatatttact ccttcaagaa gtcaggagta
     8701 tatccaggcc tacctatcat ccttgccatc cccattaacc ctcatttttc agtatgtgtt
     8761 ttacatttat ggttattttt cagtctatag tatctgttca ctcattgctc tatcacatct
     8821 gagtttctcc gtctttcttt ccactagatt gtaagctcct taagggcaag gtcggcatat
     8881 aagcaaagtt ctgtaaacac cgtgaaggta ccatgagttc tatgggtact caataaatgc
     8941 ttgtgataat ga
//
