LOCUS       NM_002267               4222 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens karyopherin subunit alpha 3 (KPNA3), mRNA.
ACCESSION   NM_002267
VERSION     NM_002267.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4222)
  AUTHORS   Khoroshkin,M., Buyan,A., Dodel,M., Navickas,A., Yu,J., Trejo,F.,
            Doty,A., Baratam,R., Zhou,S., Lee,S.B., Joshi,T., Garcia,K.,
            Choi,B., Miglani,S., Subramanyam,V., Modi,H., Carpenter,C.,
            Markett,D., Corces,M.R., Mardakheh,F.K., Kulakovskiy,I.V. and
            Goodarzi,H.
  TITLE     Systematic identification of post-transcriptional regulatory
            modules
  JOURNAL   Nat Commun 15 (1), 7872 (2024)
   PUBMED   39251607
  REMARK    Erratum:[Nat Commun. 2024 Oct 28;15(1):9277. doi:
            10.1038/s41467-024-52903-4.. PMID: 39468017]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4222)
  AUTHORS   Wang,X.W., Jiang,Y.H., Ye,W., Shao,C.F., Xie,J.J. and Li,X.
  TITLE     SIRT1 promotes the progression and chemoresistance of colorectal
            cancer through the p53/miR-101/KPNA3 axis
  JOURNAL   Cancer Biol Ther 24 (1), 2235770 (2023)
   PUBMED   37575080
  REMARK    GeneRIF: SIRT1 promotes the progression and chemoresistance of
            colorectal cancer through the p53/miR-101/KPNA3 axis.
REFERENCE   3  (bases 1 to 4222)
  AUTHORS   Choi,J., Choi,J.H., Lee,H.W., Seo,D., Lkhagvasuren,G., Kim,J.W.,
            Seo,S.B., Lee,K. and Lee,K.H.
  TITLE     KPNA3 promotes epithelial-mesenchymal transition by regulating
            TGF-beta and AKT signaling pathways in MDA-MB-231, a
            triple-negative breast cancer cell line
  JOURNAL   BMB Rep 56 (2), 120-125 (2023)
   PUBMED   36593106
  REMARK    GeneRIF: KPNA3 promotes epithelial-mesenchymal transition by
            regulating TGF-beta and AKT signaling pathways in MDA-MB-231, a
            triple-negative breast cancer cell line.
REFERENCE   4  (bases 1 to 4222)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 4222)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   6  (bases 1 to 4222)
  AUTHORS   Di Marzio,P., Choe,S., Ebright,M., Knoblauch,R. and Landau,N.R.
  TITLE     Mutational analysis of cell cycle arrest, nuclear localization and
            virion packaging of human immunodeficiency virus type 1 Vpr
  JOURNAL   J Virol 69 (12), 7909-7916 (1995)
   PUBMED   7494303
REFERENCE   7  (bases 1 to 4222)
  AUTHORS   Gallay,P., Swingler,S., Song,J., Bushman,F. and Trono,D.
  TITLE     HIV nuclear import is governed by the phosphotyrosine-mediated
            binding of matrix to the core domain of integrase
  JOURNAL   Cell 83 (4), 569-576 (1995)
   PUBMED   7585960
REFERENCE   8  (bases 1 to 4222)
  AUTHORS   Freed,E.O., Englund,G. and Martin,M.A.
  TITLE     Role of the basic domain of human immunodeficiency virus type 1
            matrix in macrophage infection
  JOURNAL   J Virol 69 (6), 3949-3954 (1995)
   PUBMED   7745752
REFERENCE   9  (bases 1 to 4222)
  AUTHORS   Bukrinsky,M.I., Sharova,N., Dempsey,M.P., Stanwick,T.L.,
            Bukrinskaya,A.G., Haggerty,S. and Stevenson,M.
  TITLE     Active nuclear import of human immunodeficiency virus type 1
            preintegration complexes
  JOURNAL   Proc Natl Acad Sci U S A 89 (14), 6580-6584 (1992)
   PUBMED   1631159
REFERENCE   10 (bases 1 to 4222)
  AUTHORS   Sharova,N. and Bukrinskaya,A.
  TITLE     p17 and p17-containing gag precursors of input human
            immunodeficiency virus are transported into the nuclei of infected
            cells
  JOURNAL   AIDS Res Hum Retroviruses 7 (3), 303-306 (1991)
   PUBMED   2064827
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC035090.2, DN991804.1,
            AK291000.1, AU132188.1 and AI309735.1.
            
            On Nov 22, 2018 this sequence version replaced NM_002267.3.
            
            Summary: The transport of molecules between the nucleus and the
            cytoplasm in eukaryotic cells is mediated by the nuclear pore
            complex (NPC), which consists of 60-100 proteins. Small molecules
            (up to 70 kD) can pass through the nuclear pore by nonselective
            diffusion while larger molecules are transported by an active
            process. The protein encoded by this gene belongs to the importin
            alpha family, and is involved in nuclear protein import. [provided
            by RefSeq, Jan 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.96763.1, BC035090.2
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000261667.8/ ENSP00000261667.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-75                BC035090.2         240-314
            76-547              DN991804.1         103-574
            548-2033            AK291000.1         411-1896
            2034-2485           AU132188.1         253-704
            2486-4217           BC035090.2         2727-4458
            4218-4222           AI309735.1         18-22               c
FEATURES             Location/Qualifiers
     source          1..4222
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q14.2"
     gene            1..4222
                     /gene="KPNA3"
                     /gene_synonym="hSRP1; IPOA4; SPG88; SRP1; SRP1gamma; SRP4"
                     /note="karyopherin subunit alpha 3"
                     /db_xref="GeneID:3839"
                     /db_xref="HGNC:HGNC:6396"
                     /db_xref="MIM:601892"
     exon            1..245
                     /gene="KPNA3"
                     /gene_synonym="hSRP1; IPOA4; SPG88; SRP1; SRP1gamma; SRP4"
                     /inference="alignment:Splign:2.1.0"
     CDS             177..1742
                     /gene="KPNA3"
                     /gene_synonym="hSRP1; IPOA4; SPG88; SRP1; SRP1gamma; SRP4"
                     /note="importin alpha 4; importin subunit alpha-3;
                     importin alpha-3; qip2; SRP1-gamma; importin alpha Q2;
                     karyopherin alpha 3 (importin alpha 4)"
                     /codon_start=1
                     /product="importin subunit alpha-4"
                     /protein_id="NP_002258.2"
                     /db_xref="CCDS:CCDS9421.1"
                     /db_xref="GeneID:3839"
                     /db_xref="HGNC:HGNC:6396"
                     /db_xref="MIM:601892"
                     /translation="MAENPSLENHRIKSFKNKGRDVETMRRHRNEVTVELRKNKRDEH
                     LLKKRNVPQEESLEDSDVDADFKAQNVTLEAILQNATSDNPVVQLSAVQAARKLLSSD
                     RNPPIDDLIKSGILPILVKCLERDDNPSLQFEAAWALTNIASGTSAQTQAVVQSNAVP
                     LFLRLLRSPHQNVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFISPSIPITFLR
                     NVTWVIVNLCRNKDPPPPMETVQEILPALCVLIYHTDINILVDTVWALSYLTDGGNEQ
                     IQMVIDSGVVPFLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDVLSHFPNL
                     LSHPKEKINKEAVWFLSNITAGNQQQVQAVIDAGLIPMIIHQLAKGDFGTQKEAAWAI
                     SNLTISGRKDQVEYLVQQNVIPPFCNLLSVKDSQVVQVVLDGLKNILIMAGDEASTIA
                     EIIEECGGLEKIEVLQQHENEDIYKLAFEIIDQYFSGDDIDEDPCLIPEATQGGTYNF
                     DPTANLQTKEFNF"
     exon            246..290
                     /gene="KPNA3"
                     /gene_synonym="hSRP1; IPOA4; SPG88; SRP1; SRP1gamma; SRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            291..380
                     /gene="KPNA3"
                     /gene_synonym="hSRP1; IPOA4; SPG88; SRP1; SRP1gamma; SRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            381..410
                     /gene="KPNA3"
                     /gene_synonym="hSRP1; IPOA4; SPG88; SRP1; SRP1gamma; SRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            411..463
                     /gene="KPNA3"
                     /gene_synonym="hSRP1; IPOA4; SPG88; SRP1; SRP1gamma; SRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            464..559
                     /gene="KPNA3"
                     /gene_synonym="hSRP1; IPOA4; SPG88; SRP1; SRP1gamma; SRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            560..645
                     /gene="KPNA3"
                     /gene_synonym="hSRP1; IPOA4; SPG88; SRP1; SRP1gamma; SRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            646..732
                     /gene="KPNA3"
                     /gene_synonym="hSRP1; IPOA4; SPG88; SRP1; SRP1gamma; SRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            733..902
                     /gene="KPNA3"
                     /gene_synonym="hSRP1; IPOA4; SPG88; SRP1; SRP1gamma; SRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            903..947
                     /gene="KPNA3"
                     /gene_synonym="hSRP1; IPOA4; SPG88; SRP1; SRP1gamma; SRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1079
                     /gene="KPNA3"
                     /gene_synonym="hSRP1; IPOA4; SPG88; SRP1; SRP1gamma; SRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1208
                     /gene="KPNA3"
                     /gene_synonym="hSRP1; IPOA4; SPG88; SRP1; SRP1gamma; SRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1313
                     /gene="KPNA3"
                     /gene_synonym="hSRP1; IPOA4; SPG88; SRP1; SRP1gamma; SRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1385
                     /gene="KPNA3"
                     /gene_synonym="hSRP1; IPOA4; SPG88; SRP1; SRP1gamma; SRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1548
                     /gene="KPNA3"
                     /gene_synonym="hSRP1; IPOA4; SPG88; SRP1; SRP1gamma; SRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1549..1643
                     /gene="KPNA3"
                     /gene_synonym="hSRP1; IPOA4; SPG88; SRP1; SRP1gamma; SRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1644..4222
                     /gene="KPNA3"
                     /gene_synonym="hSRP1; IPOA4; SPG88; SRP1; SRP1gamma; SRP4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4191..4196
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KPNA3"
                     /gene_synonym="hSRP1; IPOA4; SPG88; SRP1; SRP1gamma; SRP4"
                     /note="hexamer: AATAAA"
     polyA_site      4222
                     /gene="KPNA3"
                     /gene_synonym="hSRP1; IPOA4; SPG88; SRP1; SRP1gamma; SRP4"
                     /note="major polyA site"
ORIGIN      
        1 agtcggcccg cgcctccccc ggcgctactg ccacctcgcg ctcggaggcg tcacagaacg
       61 tgctcttctc tcccctcccc cctcccgctc tccccctcct ccccctcccg ctccaagatt
      121 cgccgccgcc gccgccgcag ccgcaggagt agccgccgcc ggagccgcgc gcagccatgg
      181 ccgagaaccc cagcttggag aaccaccgca tcaagagctt caagaacaag ggccgcgatg
      241 tggaaacaat gcgaagacat agaaatgaag tgacagtgga actgcggaag aacaaaagag
      301 atgaacactt attgaaaaag agaaatgttc cccaagaaga aagtctagaa gattcagatg
      361 ttgatgctga ttttaaagca caaaatgtaa ccctagaagc tatattgcag aatgccacaa
      421 gtgataaccc agtggtccaa ttgagtgctg tccaggcagc aagaaaactg ttatccagtg
      481 acagaaatcc accgattgat gacttaataa aatctgggat tttaccaatt ctagtcaaat
      541 gtctagaaag ggatgataat ccttcattac agtttgaagc tgcttgggca ttaactaaca
      601 tagcatcagg aacttctgca cagactcaag ctgttgtgca gtctaatgca gtacctcttt
      661 ttctgagact tcttcgttca ccacatcaga atgtttgtga acaagcagta tgggctttgg
      721 gaaacattat aggtgatggt cctcaatgta gagattatgt catatcactg ggagttgtca
      781 aacctcttct gtccttcatc agtccctcca tccccatcac cttccttcgg aacgtcacat
      841 gggtcattgt caatctctgc aggaataagg atcccccgcc gcctatggag acagttcagg
      901 agattttgcc agctttatgt gtcctcatat accatacaga tataaacatt cttgtagaca
      961 ctgtttgggc tctgtcatac ttgacagatg gaggtaatga acagatacag atggttattg
     1021 attcaggagt tgtgcccttt cttgtgcccc ttctgagcca tcaggaagtc aaagttcaaa
     1081 cagcagccct cagagcagtt ggcaacatag tgactggcac cgacgagcag acccaggttg
     1141 ttctcaattg tgatgtcctg tcacacttcc caaatctctt atcacaccca aaagagaaga
     1201 taaataagga agcagtgtgg ttcctttcca acataacagc aggcaaccag caacaagttc
     1261 aagctgtaat agatgctgga ttaattccta tgataattca tcagcttgct aagggggact
     1321 ttggaacaca aaaagaagct gcttgggcaa tcagcaactt aacaataagt ggcagaaaag
     1381 atcaggttga gtaccttgta cagcagaatg taataccacc gttctgtaat ttactgtcag
     1441 tgaaagattc tcaagtggtt caggtggttc tagatggtct aaaaaacatt ctgataatgg
     1501 ccggtgatga agcaagcaca atagctgaaa taatagagga atgtggaggt ttggagaaaa
     1561 ttgaagtttt acagcaacat gaaaatgaag acatatataa attagcattt gaaatcatag
     1621 atcagtattt ctctggtgat gatattgatg aagatccctg cctcattcct gaagcaacac
     1681 aaggaggtac ctacaatttt gatccaacag ccaaccttca aacaaaagaa tttaattttt
     1741 aaattcagtt gagtgcagca tctttcccac attcaatatg aagcaccacc agatggctac
     1801 caaatgataa gaacaacagc aacaaaaggc tccaaaacac acatgcctct ttgttttgat
     1861 gcttctaaag caagccatgt ctcagtcact ttgcagttgc caaaagtcac tatcacatgg
     1921 actgtaaatg catatgcatg atttcctaaa ctgttttaga actctcctta acaatctcaa
     1981 ctaccctatt tttccctgtt ccctggtgcc acaggctgac aactgcagtc tccagtttag
     2041 aataaatatt ccatagtggt gacatgtcag ctgcccactg atactccttt ggaaaatggt
     2101 gcgctgtgga tcaagacact ttggtatgat gcatatacaa gttggaagac taaagaggtg
     2161 cagtgtgatc tgagcctcca tcattgtcct ccacaaacat attttcatat tctttatgtg
     2221 gaagaataga ttttaaagta caagccaaat gattttcatt ggtggaactg acacaaaaaa
     2281 agtaacttaa aaacaagaaa cttggttatt gaataaacag ataagtttaa aaaaaaaaaa
     2341 aaactacttc atctaccagt aattgatgtg tttattatct gcctcagaag ccagggttgg
     2401 aggaagaact ttagatatgg atattaatgc ttttgccatt atacctaatt tttgagaaca
     2461 gcaagcccta tttgaccact ctcttcagcc tgtgtgttcc tgctgttttg aagtaatcaa
     2521 atgctgtgca tggtatttta cctgagctgc aacctgttat ggacttgaac ttctgtttaa
     2581 gttgaaagca agagtccctg agtataaagg aaaaacagca aaacaaaaag caaacaaaaa
     2641 aaaactgcaa aagtctaaaa tacccattgg tgatgttttt taaaaaaatc ttgctttcag
     2701 ctttcaggag ttaatattct ttgttttaat ttgataattg gatatggttg atttatattg
     2761 ggtttaaact gtggagcttt catgtttact gtaatttagt cttaaaatat tttttactta
     2821 gtaaccagtg cttttgataa tgtggttggc aacaaaccag caactattta gaagtgtcat
     2881 aagagttcat tctttgagta ttgggaaagt taattcagat cctactcaaa aagcatcttc
     2941 acatattaaa agattcagac agggatctgt gtagaggagt aatttgcagt tatttaacat
     3001 aaacctgatt tgcagtgatc tctaagtaat tctgcaaaat ccggtattac tatgtcaagt
     3061 tattgctttt ggtaaattgt ctgacccagt tattaatgaa agaatatgga tttaaaaatt
     3121 tttaaactaa ataatttgtg ctgtcacaga aatggtattg ttgctcttgt ttactgggta
     3181 taatttccca atgcattgat gtgaagggat agaaaatcta aactaattta gttatccatt
     3241 ggggggtgta tttactgtga tgaagatgag acagatgcca tcagagcttt gtgaatcagc
     3301 tggggtgttt tcactgataa acaacacata gcaggtgtgc attcattaca aatatatgta
     3361 tctgccaagg tggagccact ttaaagagtg agttttgtct tgtatctaaa gtggatacaa
     3421 gcgtatgttt aaactgcaag atttttactt gctagagaat ctgttttaat atagtggttt
     3481 ggcctctgat tatttatagg ttttataaat tttagaatca atttctcttt aaggtggctc
     3541 agatttttca actcttgtgc acataaaatt gagttgaagt tcattgtgcc tttttttctt
     3601 tatccaaatt ttgagttaaa gcttcatatg gtaactgcat cctgttcgga cactatagtc
     3661 taaatttttg aaactgtgtg gtgttcgcta aaagtaggaa taacaacgta aaagctaatt
     3721 aaggtcacaa acttcggtga aacccttaaa agtccaaatc ttcttgatat tgtgaaccgt
     3781 accccttcca gtttagtttc ttctggactt tccttactta actgacagtt accttttaaa
     3841 atttgcacac attatgatta aaattgggcc tctactgtga tgattcctat ttcctctcat
     3901 gttttaaagt gcaaactaac atttaagtga acattagcat caagtagtgc agacacttgt
     3961 atgcatttcc ttgattcaat ttgtgacctt accagttttg aattggaatt gcaccatttc
     4021 gtagataaag gaaactaagt atattgctgc acttttaagt tttcaaaaca gtgtttaaaa
     4081 attgcattgt tatttttttt taaactcagt ttaaaaagac taaaacgttc tttcaaaaga
     4141 ggcatctaaa tgtgttccta attttgtata tgggcttagg ttttgtaacc aataaaaaaa
     4201 gctgctatca aatatgataa aa
//
