LOCUS       XM_024453514            6805 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens karyopherin subunit alpha 1 (KPNA1),
            transcript variant X2, mRNA.
ACCESSION   XM_024453514
VERSION     XM_024453514.2
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000003.12) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_024453514.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6805
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
     gene            1..6805
                     /gene="KPNA1"
                     /gene_synonym="IPOA5; NPI-1; RCH2; SRP1"
                     /note="karyopherin subunit alpha 1; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 4
                     mRNAs, 34 ESTs, 1747 long SRA reads, 20 Proteins, and 100%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 48 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:3836"
                     /db_xref="HGNC:HGNC:6394"
                     /db_xref="MIM:600686"
     CDS             106..1722
                     /gene="KPNA1"
                     /gene_synonym="IPOA5; NPI-1; RCH2; SRP1"
                     /codon_start=1
                     /product="importin subunit alpha-5 isoform X1"
                     /protein_id="XP_024309282.1"
                     /db_xref="GeneID:3836"
                     /db_xref="HGNC:HGNC:6394"
                     /db_xref="MIM:600686"
                     /translation="MTTPGKENFRLKSYKNKSLNPDEMRRRREEEGLQLRKQKREEQL
                     FKRRNVATAEEETEEEVMSDGGFHEAQISNMEMAPGGVITSDMIEMIFSKSPEQQLSA
                     TQKFRKLLSKEPNPPIDEVISTPGVVARFVEFLKRKENCTLQFESAWVLTNIASGNSL
                     QTRIVIQAGAVPIFIELLSSEFEDVQEQAVWALGNIAGDSTMCRDYVLDCNILPPLLQ
                     LFSKQNRLTMTRNAVWALSNLCRGKSPPPEFAKVSPCLNVLSWLLFVSDTDVLADACW
                     ALSYLSDGPNDKIQAVIDAGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVI
                     LNCSALQSLLHLLSSPKESIKKEACWTISNITAGNRAQIQTVIDANIFPALISILQTA
                     EFRTRKEAAWAITNATSGGSAEQIKYLVELGCIKPLCDLLTVMDSKIVQVALNGLENI
                     LRLGEQEAKRNGTGINPYCALIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGTED
                     EDSSIAPQVDLNQQQYIFQQCEAPMEGFQL"
ORIGIN      
        1 gcactgcgaa cgccggctga gctgagtctc gctgctcggt gcgaggcggc ggagagcgag
       61 gcctggtgag caccgccgag gcgcgggcca gctcttcgag aaatcatgac caccccagga
      121 aaagagaact ttcgcctgaa aagttacaag aacaaatctc tgaatcccga tgagatgcgc
      181 aggaggaggg aggaagaagg actgcagtta cgaaagcaga aaagagaaga gcagttattc
      241 aagcggagaa atgttgctac agcagaagaa gaaacagaag aagaagttat gtcagatgga
      301 ggctttcatg aggctcagat tagtaacatg gagatggcac caggtggtgt catcacttct
      361 gacatgattg aaatgatatt ttccaaaagc ccagagcaac agctttcagc aacacagaaa
      421 ttcaggaagc tgctttcaaa agaacctaac cctcctattg atgaagttat cagcacacca
      481 ggagtagtgg ccaggtttgt ggagttcctc aaacgaaaag agaattgtac actgcagttt
      541 gaatcagctt gggtactgac aaatattgct tcaggaaatt ctcttcagac ccgaattgtg
      601 attcaggcag gagctgtgcc catcttcata gagttgctca gctcagagtt tgaagatgtc
      661 caggaacagg cagtctgggc tcttggcaac attgctggag atagtaccat gtgcagggac
      721 tatgtcttag actgcaatat ccttccccct cttttgcagt tattttcaaa gcaaaaccgc
      781 ctgaccatga cccggaatgc agtatgggct ttgtctaatc tctgtagagg gaaaagtcca
      841 cctccagaat ttgcaaaggt ttctccatgt ctgaatgtgc tttcctggtt gctgtttgtc
      901 agtgacactg atgtactggc tgatgcctgc tgggccctct catatctatc agatggaccc
      961 aatgataaaa ttcaagcggt catcgatgcg ggagtatgta ggagacttgt ggaactgctg
     1021 atgcataatg attataaagt ggtttctcct gctttgcgag ctgtgggaaa cattgtcaca
     1081 ggggatgata ttcagacaca ggtaattctg aattgctcag ctctgcagag tttattgcat
     1141 ttgctgagta gcccaaagga atctatcaaa aaggaagcat gttggacgat atctaatatt
     1201 acagctggaa atagggcaca gatccagact gtgatagatg ccaacatttt cccagccctc
     1261 attagtattt tacaaactgc tgaatttcgg acaagaaaag aagcagcttg ggccatcaca
     1321 aatgcaactt ctggaggatc agctgaacag atcaagtacc tagtagaact gggttgtatc
     1381 aagccgctct gtgatctcct cacggtcatg gactctaaga ttgtacaggt tgccctaaat
     1441 ggcttggaaa atatcctgag gcttggagaa caggaagcca aaaggaatgg cactggcatt
     1501 aacccttact gtgctttgat tgaagaagct tatggtctgg ataaaattga gttcttacag
     1561 agtcatgaaa accaggagat ctaccaaaag gcctttgatc ttattgagca ttacttcggg
     1621 accgaagatg aagacagcag cattgcaccc caggttgacc ttaaccagca gcagtacatc
     1681 ttccaacagt gtgaggctcc tatggaaggt ttccagcttt gaagcaatac tctgctttca
     1741 cgtacctgtg tcagaccagg ctacccagtc gagtcctctt gtggagccca cagtcctcat
     1801 ggagctaact tctcaaatgt tttccataat actgtttgcg ctcatttgct tgccttgcgc
     1861 acctgctctc ttacacacat ctggaaaacc tccggctctc tgtggtggaa tacccttcta
     1921 ataaaagggt aaccagaacg gcccactctc ttttacggaa aaatccctag gctttggaga
     1981 tccgcactta cattagagtt atgggaatat acacatatta atgtggctcc ctttttcttg
     2041 tgggggaata aaagaggact cctcctcatt ccctttaaca tgggggaaaa aactgacatt
     2101 aaaagatgag actaaatctt tatcttgaat tttacacaac tacttacgac aagggagatg
     2161 tttagacctg ttgtgtatac ttcagagtac ttttcatgag ttcttccaca gtgaaccctt
     2221 ggattacctg gtggcttttt ctagccagat ttgcattaat ccttactgag attggatggt
     2281 tttctttcct ctattggcgc cattcttcag atattaaagt taaaccatcc actccctcac
     2341 cttcagcctt cagtgaatgt gctttctagt tgtcaggaat gctgaagaat taacactttg
     2401 actcctaaat gtgatactgg tttgtagatt cccttagagc agaaaggaga ggggcacata
     2461 ttaatttgta tcgcttttgc ttctctttgg tcttttgtgt cttagaattt ggaagtggtt
     2521 catttctgtt gctggtatga ggatttcgaa tacttagtaa tcgaaaacca tatcctgtaa
     2581 tttaataaaa aaaactaagg acgaaaaaac cctccaattt tcccaaatgc aatcagtgta
     2641 actaggggct gtgtttctgc attaaaataa atgtttcagg ctttgtggtc ctgatcaagg
     2701 tcctcattaa aaaattggag ttcaccctag gtgcttttcc cctctgtgac tggcagataa
     2761 cacatacttt tgaaagtaac tttgggattt ttttcttagg tgcagctcga ttctaatctt
     2821 ttcatgctgc acacgattcc tttaatgtag catccttatc tgaaagaaat aaccatcttc
     2881 tcaacatgac ctgcttaacc caaataagaa cagtgatctt ataacctcat tgtttcctaa
     2941 tcattttatt tcatctcctg ctagtactgt gccgcttccc cctcccccca cacaaaataa
     3001 aaacagtatc tgccttctgg ctcatttaat gatgactgca atctgtacct gcaaatggcg
     3061 cttccagtac tgtgttcagt gatccacatt tgtgcttgga ctggaatgaa aaaatacgct
     3121 taattgccaa gacaactgca aatgagttca atacgacttc tcggtgctag ttggccatct
     3181 tgactcaatg ttgggataca ctaccagaga agattttttt gttgatgtgc tgttcaaagt
     3241 gaattctgaa ggaaaaggtt gctcacctct gtttcagagc ataccctttt aaaccttttt
     3301 agacttgtcc tcttctagaa ttcattataa ccccaaagtg taaaaactat ttggaagttg
     3361 cccctgacaa gctattatac atctctggta aatcctgctg aatgtaaggg atattcagag
     3421 cttttcatac ctcatcatga tgttatttaa gcagccaact tatgtgacct gatttaaact
     3481 tttaaaaaat ccacttcatt caaactagaa agagtcaaag acaaaggaca tttatcagcc
     3541 aagagtgtga cgcattcttc gcatctagtc tgtagtagtg tctgtgctct gggatggata
     3601 ccgtctgatg tctgtttgtt attgatggcg cagccactgc aaaactagtc aactcccatc
     3661 tataactgtt actttttcta gtgctgcttt gtgctgagag aacattttag tttactgcac
     3721 ttgacctgta aaagactgat tctttgtaat tttagggata aattaggtgg ttaatttaaa
     3781 gaagaaattt caatgttgcc tttacatcac attaaaatat aacttctttc agaaggataa
     3841 tagaagcact gattcatagt aaaaatcttg tttttagctt tgactttttt gtggctgttt
     3901 tttaaaattg taaattacta gtaacatgtc atttctatag gatgttttaa attatgtacc
     3961 ttccattgga tagttaaaat aatttcattt tataagccaa tttgagtggg aaagatacaa
     4021 agcacacagt tgtctcccca cattaggaag agtagtgtgc attcagacat tcggaatttt
     4081 tgctagtagt tggagatgtt tcagtgagtg aattaaaaca aagtctattt aactgacgtg
     4141 atctattttg tgtctaaaac agaggaattt atcttgtcct agaagttcat gaactataag
     4201 atctaagttt ttttttcttt tttaacaata aaatgatttt ttcttaaagt atcaaagttg
     4261 gaattggcta aaagtgaagt agcataactc agatatgttg gaacttggta ctgaagcagg
     4321 ctttttggta acagaaatga cattttaagg ggtaactgta tatcctgttt ttagttcttt
     4381 gcctctcaga ttctgttaac ttagtttaaa ttcactgaat accctaccac taaggcgttg
     4441 ctcattacaa aagcatgtta atttcaatac aggaaaactc ttttgtagtt ttatatatgg
     4501 attggggaaa gtgactttgt tttacttttc ctttttattc ccctccatcc tccaaacttc
     4561 caatctatat tatttgtaat gagaactttg gtgggggaaa aaaagcatta agagaatttt
     4621 ggatgtaaag gcatctggta tctgatggac cagcaggtag atgtggttgg attgagaaat
     4681 tttgggtaag gtagatgata gaagaaagag attttaggag acacagttct ctgtggaaca
     4741 ctttctttca tgttcctgta actaattgat caagaccctt ttaaacgctt atctttgtca
     4801 gttccgcttt tgaaaaaact attgccctag gattgtttct tccatatgac agatgaaggt
     4861 tattggctct gagtcatttt tggcattatc gtcacagata aaaagattgg caattaatct
     4921 cataaaaaat ctgaattatt ccagattgct gccgattttt gcctaagaaa caatatgtaa
     4981 gtatatttta taaaccaaac tttgtcaacc aattctattg tacgtctacc cacaggcaac
     5041 tttgaattta cttctctagt gctaaataaa catttcagcg atttaatccc ccaacttggg
     5101 ggatgcatta tgaaaaggtt ttcctggagt caaggggttt ttctttctcg ctagttttgt
     5161 gaaaattttt atatcaatag gcaaatcatt ataacttttt aggggttgat ggtttttaag
     5221 tatattggaa attgtggtgt ctaaggatga tgttcagtga agaaaaggga tccactttta
     5281 gaaaccagca ttgtttgctt tcaactttca tactgtatgc taactcctac gttccaaaat
     5341 gtgctcattt gcagacacag gtatgcctat atacatggaa gtctcaaatc tgaattttta
     5401 tccatctcaa tatgaccatt tctctctgtt gtgagctgaa cagattaagt atatatctgc
     5461 caggttggga aatattttgg tctatctttt cctgtcatca gaacttaatt taaaaaaatt
     5521 atcaaaggtc agatgtgact actacagtaa gttggctatc ataaagaata ttccataaaa
     5581 tgttttatct gccatacaaa attactgggt ttatggccgg atgtggtggc tcatgcctgt
     5641 aatcccagca gttcaggatt acaggttata tacaggttat aacaatggat accaggacat
     5701 cagaatatct gataaagcaa atatttatat gctaatttaa aatatcaaat tgctactgga
     5761 cataaaatac atctggaagc ttggggtaag aagaaagaaa agaagtgttc cgttctgttt
     5821 tcaactaagg gtaaacgaag tcccagagtg ttttccctgt aggtcaaatt aaggtaacat
     5881 gtctttattt gatcatctat tgtacaccag atacctggct aagggctttc cttttttctc
     5941 atgtagtctt ccaaatgttc tttgataatt gtcactatat tatagatgac aaagtgaaga
     6001 cttacgagaa attactttgc cccaaggtta caacacttag atggctgtcc aagggcgggg
     6061 aagagccctg caaattctgt gtcttgaaga aagcagtggc cacgcagtag ttccgtgccc
     6121 aggatctccc agaactagac ttggcaacca cagctgggcc agcctttttt gttagaccat
     6181 tcttcctgac tcctgcttac catcagcacc cttaaaatga cgaaatcagg cttaagttgc
     6241 ttttaggtta cacagactgg agtgtaggcc ctctcaggcc aaacatcttt cctcttctgt
     6301 ggtgctaaaa ttctgtatga ccagacaagt atggtaatag gttttttttt tttttttttt
     6361 tgtgcaaatg attttgtgtt tagtaaaata atggctaaac acatggatcc attcaaacgc
     6421 acaaatgtgg aaagtattga cacggaagga aaggctttga agaattactg cctcaggaag
     6481 cagtgccatg gatgcgaatt taacacagtc tacttcttcc taaaggaata tcatcccaag
     6541 gaatgtcaaa aattaaaatc accttttaat gtactggttg ttgagtgttt ctgctttacc
     6601 tcaagtcatt ctgaccactc tacatcctgc ttcaaagtgt tctgacactt agatttggaa
     6661 tggctctaat gattctttgt acttgaatgt ggtctgtcag gccatgggtg agtgccttgc
     6721 acatagtaga cattcaataa atactaaatg aaggaatatg catgcatctt tgtgatgtta
     6781 gtaaagggtg cttgataaaa gaaaa
//
