LOCUS       NM_001024679             949 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens KPRP N-terminal and LCE C-terminal like protein
            (KPLCE), mRNA.
ACCESSION   NM_001024679 XM_001721554 XM_001724444 XM_001724465
VERSION     NM_001024679.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 949)
  AUTHORS   Edqvist,P.H., Fagerberg,L., Hallstrom,B.M., Danielsson,A.,
            Edlund,K., Uhlen,M. and Ponten,F.
  TITLE     Expression of human skin-specific genes defined by transcriptomics
            and antibody-based profiling
  JOURNAL   J Histochem Cytochem 63 (2), 129-141 (2015)
   PUBMED   25411189
REFERENCE   2  (bases 1 to 949)
  AUTHORS   Kumar,V., Cheng,S.C., Johnson,M.D., Smeekens,S.P., Wojtowicz,A.,
            Giamarellos-Bourboulis,E., Karjalainen,J., Franke,L., Withoff,S.,
            Plantinga,T.S., van de Veerdonk,F.L., van der Meer,J.W.M.,
            Joosten,L.A.B., Bochud,P.Y., Marchetti,O., Perfect,J.R., Xavier,R.,
            Kullberg,B.J., Wijmenga,C. and Netea,M.G.
  TITLE     Immunochip SNP array identifies novel genetic variants conferring
            susceptibility to candidaemia
  JOURNAL   Nat Commun 5, 4675 (2014)
   PUBMED   25197941
  REMARK    GeneRIF: SNPs in C1orf68 are associated with increased risk of
            candidemia.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 949)
  AUTHORS   Ichikawa,S., Koller,D.L., Padgett,L.R., Lai,D., Hui,S.L.,
            Peacock,M., Foroud,T. and Econs,M.J.
  TITLE     Replication of previous genome-wide association studies of bone
            mineral density in premenopausal American women
  JOURNAL   J Bone Miner Res 25 (8), 1821-1829 (2010)
   PUBMED   20200978
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 949)
  AUTHORS   Toulza,E., Mattiuzzo,N.R., Galliano,M.F., Jonca,N., Dossat,C.,
            Jacob,D., de Daruvar,A., Wincker,P., Serre,G. and Guerrin,M.
  TITLE     Large-scale identification of human genes implicated in epidermal
            barrier function
  JOURNAL   Genome Biol 8 (6), R107 (2007)
   PUBMED   17562024
REFERENCE   5  (bases 1 to 949)
  AUTHORS   Marshall,D., Hardman,M.J., Nield,K.M. and Byrne,C.
  TITLE     Differentially expressed late constituents of the epidermal
            cornified envelope
  JOURNAL   Proc Natl Acad Sci U S A 98 (23), 13031-13036 (2001)
   PUBMED   11698679
REFERENCE   6  (bases 1 to 949)
  AUTHORS   Zhao,X.P. and Elder,J.T.
  TITLE     Positional cloning of novel skin-specific genes from the human
            epidermal differentiation complex
  JOURNAL   Genomics 45 (2), 250-258 (1997)
   PUBMED   9344646
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL353779.11, CU457096.1 and CU446285.1.
            
            On May 17, 2019 this sequence version replaced NM_001024679.2.
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368775.3/ ENSP00000357764.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                AL353779.11        3925-3975
            52-576              CU457096.1         15-539
            577-865             AL353779.11        4501-4789
            866-908             CU446285.1         706-748
            909-949             AL353779.11        4833-4873
FEATURES             Location/Qualifiers
     source          1..949
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..949
                     /gene="KPLCE"
                     /gene_synonym="C1orf68; LEP7; XP32"
                     /note="KPRP N-terminal and LCE C-terminal like protein"
                     /db_xref="GeneID:100129271"
                     /db_xref="HGNC:HGNC:29468"
     exon            1..949
                     /gene="KPLCE"
                     /gene_synonym="C1orf68; LEP7; XP32"
                     /inference="alignment:Splign:2.1.0"
     CDS             1..753
                     /gene="KPLCE"
                     /gene_synonym="C1orf68; LEP7; XP32"
                     /note="skin-specific protein 32; skin-specific protein
                     (xp32)"
                     /codon_start=1
                     /product="protein KPLCE"
                     /protein_id="NP_001019850.1"
                     /db_xref="CCDS:CCDS44226.1"
                     /db_xref="GeneID:100129271"
                     /db_xref="HGNC:HGNC:29468"
                     /translation="MCDQQKQPQFPPSCVKGSGLGAGQGSNGASVKCPVPCQTQTVCV
                     TGPAPCPTQTYVKYQVPCQTQTYVKCPAPCQRTYVKYPTPCQTYVKCPAPCQTTYVKC
                     PTPCQTYVKCPAPCQMTYIKSPAPCQTQTCYVQGASPCQSYYVQAPASGSTSQYCVTD
                     PCSAPCSTSYCCLAPRTFGVSPLRRWIQRPQNCNTGSSGCCENSGSSGCCGSGGCGCS
                     CGCGSSGCCCLGIIPMRSRGPACCDHEDDCCC"
ORIGIN      
        1 atgtgtgacc agcagaagca gccacagttc cctccatctt gtgtgaaagg ttcgggacta
       61 ggggctgggc agggtagcaa tggtgcctct gtgaaatgcc cagttccatg ccagacccaa
      121 actgtctgtg tgacaggccc tgctccatgc cctactcaaa cttatgtgaa gtaccaagtt
      181 ccatgccaga ctcaaaccta cgtgaagtgc ccagctccct gccagaggac ctatgtgaaa
      241 tacccaacac cctgccaaac ctatgtgaag tgcccagctc cctgccagac aacctatgta
      301 aaatgcccaa ctccctgcca aacctacgtg aagtgcccag ctccctgcca gatgacctac
      361 atcaaaagtc cagctccctg ccagacccag acgtgctatg tccagggtgc ttctccttgc
      421 cagagctatt atgttcaagc tcctgcaagt ggctcaacct cccagtactg tgtcactgac
      481 ccatgctctg ctccctgttc caccagctac tgctgtctgg ctccccggac cttcggggtg
      541 agtcccctga gacgctggat tcagcggccc cagaactgca acacaggatc atctggctgc
      601 tgtgagaatt cgggaagctc tggatgctgt ggttctgggg gctgtggctg cagctgtgga
      661 tgtggcagct ctgggtgctg ctgtttggga attatcccca tgaggtcccg aggtcctgca
      721 tgctgtgacc atgaggatga ctgctgctgc taaacatacg acagctcaac tccagaatgc
      781 actgccccgc taccccttct ggaacatgca ccagcttctg gccccctctc tgttagtgcc
      841 agtgatgtag aacctcatca ctttgcctct gtgctttgct tctctaccaa ggcagcctgc
      901 cagagttagt acagtcccca aactttggca tgaataaagc tctgaatgc
//
