LOCUS       NM_014708               6974 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens kinetochore associated 1 (KNTC1), mRNA.
ACCESSION   NM_014708
VERSION     NM_014708.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6974)
  AUTHORS   Zhong,L., Dong,Y. and Liu,S.
  TITLE     KNTC1 knockdown inhibits the proliferation and migration of
            osteosarcoma cells by MCM2
  JOURNAL   Mol Carcinog 63 (8), 1599-1610 (2024)
   PUBMED   38818892
  REMARK    GeneRIF: KNTC1 knockdown inhibits the proliferation and migration
            of osteosarcoma cells by MCM2.
REFERENCE   2  (bases 1 to 6974)
  AUTHORS   Wang,J., Ding,Z., Shu,W. and Zhuge,Y.
  TITLE     The role of KNTC1 in the regulation of proliferation, migration and
            tumorigenesis in colorectal cancer
  JOURNAL   Cell Signal 108, 110728 (2023)
   PUBMED   37230198
  REMARK    GeneRIF: The role of KNTC1 in the regulation of proliferation,
            migration and tumorigenesis in colorectal cancer.
REFERENCE   3  (bases 1 to 6974)
  AUTHORS   Zhao,Q., Li,Y., Liang,Q., Zhao,J., Kang,K., Hou,M., Zhang,X.,
            Du,R., Kong,L., Liang,B. and Huang,W.
  TITLE     The infertile individual analysis based on whole-exome sequencing
            in chinese multi-ethnic groups
  JOURNAL   Genes Genomics 45 (4), 531-542 (2023)
   PUBMED   36115009
  REMARK    GeneRIF: The infertile individual analysis based on whole-exome
            sequencing in chinese multi-ethnic groups.
REFERENCE   4  (bases 1 to 6974)
  AUTHORS   Tong,H., Liu,X., Peng,C., Shen,B. and Zhu,Z.
  TITLE     Silencing of KNTC1 inhibits hepatocellular carcinoma cells
            progression via suppressing PI3K/Akt pathway
  JOURNAL   Cell Signal 101, 110498 (2023)
   PUBMED   36273753
  REMARK    GeneRIF: Silencing of KNTC1 inhibits hepatocellular carcinoma cells
            progression via suppressing PI3K/Akt pathway.
REFERENCE   5  (bases 1 to 6974)
  AUTHORS   Liu,R., Liu,R., Guo,Z., Ren,J., Huang,J., Luo,Q. and Tan,Q.
  TITLE     shRNA-mediated knockdown of KNTC1 inhibits non-small-cell lung
            cancer through regulating PSMB8
  JOURNAL   Cell Death Dis 13 (8), 685 (2022)
   PUBMED   35933405
  REMARK    GeneRIF: shRNAmediated knockdown of KNTC1 inhibits non-small-cell
            lung cancer through regulating PSMB8.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6974)
  AUTHORS   Chan,Y.W., Fava,L.L., Uldschmid,A., Schmitz,M.H., Gerlich,D.W.,
            Nigg,E.A. and Santamaria,A.
  TITLE     Mitotic control of kinetochore-associated dynein and spindle
            orientation by human Spindly
  JOURNAL   J Cell Biol 185 (5), 859-874 (2009)
   PUBMED   19468067
REFERENCE   7  (bases 1 to 6974)
  AUTHORS   Famulski,J.K. and Chan,G.K.
  TITLE     Aurora B kinase-dependent recruitment of hZW10 and hROD to
            tensionless kinetochores
  JOURNAL   Curr Biol 17 (24), 2143-2149 (2007)
   PUBMED   18065224
  REMARK    GeneRIF: Aurora B kinase activity is required for the accumulation
            of tension-sensitive mitotic-checkpoint components, such as ZW10
            and ROD, in order to maintain mitotic-checkpoint arrest.
REFERENCE   8  (bases 1 to 6974)
  AUTHORS   Williams,B.C., Li,Z., Liu,S., Williams,E.V., Leung,G., Yen,T.J. and
            Goldberg,M.L.
  TITLE     Zwilch, a new component of the ZW10/ROD complex required for
            kinetochore functions
  JOURNAL   Mol Biol Cell 14 (4), 1379-1391 (2003)
   PUBMED   12686595
REFERENCE   9  (bases 1 to 6974)
  AUTHORS   Scaerou,F., Starr,D.A., Piano,F., Papoulas,O., Karess,R.E. and
            Goldberg,M.L.
  TITLE     The ZW10 and Rough Deal checkpoint proteins function together in a
            large, evolutionarily conserved complex targeted to the kinetochore
  JOURNAL   J Cell Sci 114 (Pt 17), 3103-3114 (2001)
   PUBMED   11590237
REFERENCE   10 (bases 1 to 6974)
  AUTHORS   Chan,G.K., Jablonski,S.A., Starr,D.A., Goldberg,M.L. and Yen,T.J.
  TITLE     Human Zw10 and ROD are mitotic checkpoint proteins that bind to
            kinetochores
  JOURNAL   Nat Cell Biol 2 (12), 944-947 (2000)
   PUBMED   11146660
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC127002.3 and AC026333.28.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_014708.5.
            
            Summary: This gene encodes a protein that is one of many involved
            in mechanisms to ensure proper chromosome segregation during cell
            division. Experimental evidence indicated that the encoded protein
            functioned in a similar manner to that of the Drosophila rough deal
            protein. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC150278.1, D79988.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000333479.12/ ENSP00000328236.6
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-103               AC127002.3         108094-108196
            104-305             AC127002.3         110836-111037
            306-426             AC127002.3         115509-115629
            427-542             AC127002.3         119184-119299
            543-621             AC127002.3         120521-120599
            622-699             AC127002.3         122895-122972
            700-734             AC127002.3         124445-124479
            735-845             AC127002.3         125004-125114
            846-939             AC127002.3         127021-127114
            940-992             AC127002.3         127467-127519
            993-1108            AC127002.3         128260-128375
            1109-1163           AC127002.3         128760-128814
            1164-1262           AC026333.28        3786-3884
            1263-1306           AC026333.28        5339-5382
            1307-1372           AC026333.28        5478-5543
            1373-1448           AC026333.28        5641-5716
            1449-1574           AC026333.28        11404-11529
            1575-1664           AC026333.28        11620-11709
            1665-1718           AC026333.28        15941-15994
            1719-1780           AC026333.28        16658-16719
            1781-1892           AC026333.28        22281-22392
            1893-2036           AC026333.28        23701-23844
            2037-2093           AC026333.28        24896-24952
            2094-2195           AC026333.28        25045-25146
            2196-2315           AC026333.28        26957-27076
            2316-2459           AC026333.28        27162-27305
            2460-2558           AC026333.28        28302-28400
            2559-2662           AC026333.28        29563-29666
            2663-2762           AC026333.28        29820-29919
            2763-2897           AC026333.28        30915-31049
            2898-3017           AC026333.28        31692-31811
            3018-3090           AC026333.28        33925-33997
            3091-3158           AC026333.28        34623-34690
            3159-3439           AC026333.28        36725-37005
            3440-3612           AC026333.28        38298-38470
            3613-3710           AC026333.28        38913-39010
            3711-3849           AC026333.28        39656-39794
            3850-3906           AC026333.28        40721-40777
            3907-4070           AC026333.28        41731-41894
            4071-4175           AC026333.28        42732-42836
            4176-4304           AC026333.28        44627-44755
            4305-4421           AC026333.28        45357-45473
            4422-4531           AC026333.28        48296-48405
            4532-4739           AC026333.28        51751-51958
            4740-4829           AC026333.28        55556-55645
            4830-5001           AC026333.28        56589-56760
            5002-5060           AC026333.28        56849-56907
            5061-5277           AC026333.28        57047-57263
            5278-5351           AC026333.28        58584-58657
            5352-5562           AC026333.28        58897-59107
            5563-5672           AC026333.28        59326-59435
            5673-5719           AC026333.28        63404-63450
            5720-5798           AC026333.28        64842-64920
            5799-5917           AC026333.28        67132-67250
            5918-6053           AC026333.28        67646-67781
            6054-6149           AC026333.28        69011-69106
            6150-6206           AC026333.28        69490-69546
            6207-6261           AC026333.28        72363-72417
            6262-6325           AC026333.28        72502-72565
            6326-6455           AC026333.28        74499-74628
            6456-6545           AC026333.28        75901-75990
            6546-6691           AC026333.28        76482-76627
            6692-6782           AC026333.28        78618-78708
            6783-6974           AC026333.28        80225-80416
FEATURES             Location/Qualifiers
     source          1..6974
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.31"
     gene            1..6974
                     /gene="KNTC1"
                     /gene_synonym="ROD"
                     /note="kinetochore associated 1"
                     /db_xref="GeneID:9735"
                     /db_xref="HGNC:HGNC:17255"
                     /db_xref="MIM:607363"
     exon            1..103
                     /gene="KNTC1"
                     /gene_synonym="ROD"
                     /inference="alignment:Splign:2.1.0"
     exon            104..305
                     /gene="KNTC1"
                     /gene_synonym="ROD"
                     /inference="alignment:Splign:2.1.0"
     CDS             177..6806
                     /gene="KNTC1"
                     /gene_synonym="ROD"
                     /note="Rough Deal homolog, centromere/kinetochore protein"
                     /codon_start=1
                     /product="kinetochore-associated protein 1"
                     /protein_id="NP_055523.1"
                     /db_xref="CCDS:CCDS45002.1"
                     /db_xref="GeneID:9735"
                     /db_xref="HGNC:HGNC:17255"
                     /db_xref="MIM:607363"
                     /translation="MWNDIELLTNDDTGSGYLSVGSRKEHGTALYQVDLLVKISSEKA
                     SLNPKIQACSLSDGFIIVADQSVILLDSICRSLQLHLVFDTEVDVVGLCQEGKFLLVG
                     ERSGNLHLIHVTSKQTLLTNAFVQKANDENRRTYQNLVIEKDGSNEGTYYMLLLTYSG
                     FFCITNLQLLKIQQAIENVDFSTAKKLQGQIKSSFISTENYHTLGCLSLVAGDLASEV
                     PVIIGGTGNCAFSKWEPDSSKKGMTVKNLIDAEIIKGAKKFQLIDNLLFVLDTDNVLS
                     LWDIYTLTPVWNWPSLHVEEFLLTTEADSPSSVTWQGITNLKLIALTASANKKMKNLM
                     VYSLPTMEILYSLEVSSVSSLVQTGISTDTIYLLEGVCKNDPKLSEDSVSVLVLRCLT
                     EALPENRLSRLLHKHRFAEAESFAIQFGLDVELVYKVKSNHILEKLALSSVDASEQTE
                     WQQLVDDAKENLHKIQDDEFVVNYCLKAQWITYETTQEMLNYAKTRLLKKEDKTALIY
                     SDGLKEVLRAHAKLTTFYGAFGPEKFSGSSWIEFLNNEDDLKDIFLQLKEGNLVCAQY
                     LWLRHRANFESRFDVKMLESLLNSMSASVSLQKLCPWFKNDVIPFVRRTVPEGQIILA
                     KWLEQAARNLELTDKANWPENGLQLAEIFFTAEKTDELGLASSWHWISLKDYQNTEEV
                     CQLRTLVNNLRELITLHRKYNCKLALSDFEKENTTTIVFRMFDKVLAPELIPSILEKF
                     IRVYMREHDLQEEELLLLYIEDLLNRCSSKSTSLFETAWEAKAMAVIACLSDTDLIFD
                     AVLKIMYAAVVPWSAAVEQLVKQHLEMDHPKVKLLQESYKLMEMKKLLRGYGIREVNL
                     LNKEIMRVVRYILKQDVPSSLEDALKVAQAFMLSDDEIYSLRIIDLIDREQGEDCLLL
                     LKSLPPAEAEKTAERVIIWARLALQEEPDHSKEGKAWRMSVAKTSVDILKILCDIQKD
                     NLQKKDECEEMLKLFKEVASLQENFEVFLSFEDYSNSSLVADLREQHIKAHEVAQAKH
                     KPGSTPEPIAAEVRSPSMESKLHRQALALQMSKQELEAELTLRALKDGNIKTALKKCS
                     DLFKYHCNADTGKLLFLTCQKLCQMLADNVPVTVPVGLNLPSMIHDLASQAATICSPD
                     FLLDALELCKHTLMAVELSRQCQMDDCGILMKASFGTHKDPYEEWSYSDFFSEDGIVL
                     ESQMVLPVIYELISSLVPLAESKRYPLESTSLPYCSLNEGDGLVLPVINSISALLQNL
                     QESSQWELALRFVVGSFGTCLQHSVSNFMNATLSEKLFGETTLVKSRHVVMELKEKAV
                     IFIRENATTLLHKVFNCRLVDLDLALGYCTLLPQKDVFENLWKLIDKAWQNYDKILAI
                     SLVGSELASLYQEIEMGLKFRELSTDAQWGIRLGKLGISFQPVFRQHFLTKKDLIKAL
                     VENIDMDTSLILEYCSTFQLDCDAVLQLFIETLLHNTNAGQGQGDASMDSAKRRHPKL
                     LAKALEMVPLLTSTKDLVISLSGILHKLDPYDYEMIEVVLKVIERADEKITNININQA
                     LSILKHLKSYRRISPPVDLEYQYMLEHVITLPSAAQTRLPFHLIFFGTAQNFWKILST
                     ELSEESFPTLLLISKLMKFSLDTLYVSTAKHVFEKKLKPKLLKLTQAKSSTLINKEIT
                     KITQTIESCLLSIVNPEWAVAIAISLAQDIPEGSFKISALKFCLYLAERWLQNIPSQD
                     EKREKAEALLKKLHIQYRRSGTEAVLIAHKLNTEEYLRVIGKPAHLIVSLYEHPSINQ
                     RIQNSSGTDYPDIHAAAKEIAEVNEINLEKVWDMLLEKWLCPSTKPGEKPSELFELQE
                     DEALRRVQYLLLSRPIDYSSRMLFVFATSTTTTLGMHQLTFAHRTRALQCLFYLADKE
                     TIESLFKKPIEEVKSYLRCITFLASFETLNIPITYELFCSSPKEGMIKGLWKNHSHES
                     MAVRLVTELCLEYKIYDLQLWNGLLQKLLGFNMIPYLRKVLKAISSIHSLWQVPYFSK
                     AWQRVIQIPLLSASCPLSPDQLSDCSESLIAVLECPVSGDLDLIGVARQYIQLELPAF
                     ALACLMLMPHSEKRHQQIKNFLGSCDPQVILKQLEEHMNTGQLAGFSHQIRSLILNNI
                     INKKEFGILAKTKYFQMLKMHAMNTNNITELVNYLANDLSLDEASVLITEYSKHCGKP
                     VPPDTAPCEILKMFLSGLS"
     exon            306..426
                     /gene="KNTC1"
                     /gene_synonym="ROD"
                     /inference="alignment:Splign:2.1.0"
     exon            427..542
                     /gene="KNTC1"
                     /gene_synonym="ROD"
                     /inference="alignment:Splign:2.1.0"
     exon            543..621
                     /gene="KNTC1"
                     /gene_synonym="ROD"
                     /inference="alignment:Splign:2.1.0"
     exon            622..699
                     /gene="KNTC1"
                     /gene_synonym="ROD"
                     /inference="alignment:Splign:2.1.0"
     exon            700..734
                     /gene="KNTC1"
                     /gene_synonym="ROD"
                     /inference="alignment:Splign:2.1.0"
     exon            735..845
                     /gene="KNTC1"
                     /gene_synonym="ROD"
                     /inference="alignment:Splign:2.1.0"
     exon            846..939
                     /gene="KNTC1"
                     /gene_synonym="ROD"
                     /inference="alignment:Splign:2.1.0"
     exon            940..992
                     /gene="KNTC1"
                     /gene_synonym="ROD"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1108
                     /gene="KNTC1"
                     /gene_synonym="ROD"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1163
                     /gene="KNTC1"
                     /gene_synonym="ROD"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1262
                     /gene="KNTC1"
                     /gene_synonym="ROD"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..1306
                     /gene="KNTC1"
                     /gene_synonym="ROD"
                     /inference="alignment:Splign:2.1.0"
     exon            1307..1372
                     /gene="KNTC1"
                     /gene_synonym="ROD"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1448
                     /gene="KNTC1"
                     /gene_synonym="ROD"
                     /inference="alignment:Splign:2.1.0"
     exon            1449..1574
                     /gene="KNTC1"
                     /gene_synonym="ROD"
                     /inference="alignment:Splign:2.1.0"
     exon            1575..1664
                     /gene="KNTC1"
                     /gene_synonym="ROD"
                     /inference="alignment:Splign:2.1.0"
     exon            1665..1718
                     /gene="KNTC1"
                     /gene_synonym="ROD"
                     /inference="alignment:Splign:2.1.0"
     exon            1719..1780
                     /gene="KNTC1"
                     /gene_synonym="ROD"
                     /inference="alignment:Splign:2.1.0"
     exon            1781..1892
                     /gene="KNTC1"
                     /gene_synonym="ROD"
                     /inference="alignment:Splign:2.1.0"
     exon            1893..2036
                     /gene="KNTC1"
                     /gene_synonym="ROD"
                     /inference="alignment:Splign:2.1.0"
     exon            2037..2093
                     /gene="KNTC1"
                     /gene_synonym="ROD"
                     /inference="alignment:Splign:2.1.0"
     exon            2094..2195
                     /gene="KNTC1"
                     /gene_synonym="ROD"
                     /inference="alignment:Splign:2.1.0"
     exon            2196..2315
                     /gene="KNTC1"
                     /gene_synonym="ROD"
                     /inference="alignment:Splign:2.1.0"
     exon            2316..2459
                     /gene="KNTC1"
                     /gene_synonym="ROD"
                     /inference="alignment:Splign:2.1.0"
     exon            2460..2558
                     /gene="KNTC1"
                     /gene_synonym="ROD"
                     /inference="alignment:Splign:2.1.0"
     exon            2559..2662
                     /gene="KNTC1"
                     /gene_synonym="ROD"
                     /inference="alignment:Splign:2.1.0"
     exon            2663..2762
                     /gene="KNTC1"
                     /gene_synonym="ROD"
                     /inference="alignment:Splign:2.1.0"
     exon            2763..2897
                     /gene="KNTC1"
                     /gene_synonym="ROD"
                     /inference="alignment:Splign:2.1.0"
     exon            2898..3017
                     /gene="KNTC1"
                     /gene_synonym="ROD"
                     /inference="alignment:Splign:2.1.0"
     exon            3018..3090
                     /gene="KNTC1"
                     /gene_synonym="ROD"
                     /inference="alignment:Splign:2.1.0"
     exon            3091..3158
                     /gene="KNTC1"
                     /gene_synonym="ROD"
                     /inference="alignment:Splign:2.1.0"
     exon            3159..3439
                     /gene="KNTC1"
                     /gene_synonym="ROD"
                     /inference="alignment:Splign:2.1.0"
     exon            3440..3612
                     /gene="KNTC1"
                     /gene_synonym="ROD"
                     /inference="alignment:Splign:2.1.0"
     exon            3613..3710
                     /gene="KNTC1"
                     /gene_synonym="ROD"
                     /inference="alignment:Splign:2.1.0"
     exon            3711..3849
                     /gene="KNTC1"
                     /gene_synonym="ROD"
                     /inference="alignment:Splign:2.1.0"
     exon            3850..3906
                     /gene="KNTC1"
                     /gene_synonym="ROD"
                     /inference="alignment:Splign:2.1.0"
     exon            3907..4070
                     /gene="KNTC1"
                     /gene_synonym="ROD"
                     /inference="alignment:Splign:2.1.0"
     exon            4071..4175
                     /gene="KNTC1"
                     /gene_synonym="ROD"
                     /inference="alignment:Splign:2.1.0"
     exon            4176..4304
                     /gene="KNTC1"
                     /gene_synonym="ROD"
                     /inference="alignment:Splign:2.1.0"
     exon            4305..4421
                     /gene="KNTC1"
                     /gene_synonym="ROD"
                     /inference="alignment:Splign:2.1.0"
     exon            4422..4531
                     /gene="KNTC1"
                     /gene_synonym="ROD"
                     /inference="alignment:Splign:2.1.0"
     exon            4532..4739
                     /gene="KNTC1"
                     /gene_synonym="ROD"
                     /inference="alignment:Splign:2.1.0"
     exon            4740..4829
                     /gene="KNTC1"
                     /gene_synonym="ROD"
                     /inference="alignment:Splign:2.1.0"
     exon            4830..5001
                     /gene="KNTC1"
                     /gene_synonym="ROD"
                     /inference="alignment:Splign:2.1.0"
     exon            5002..5060
                     /gene="KNTC1"
                     /gene_synonym="ROD"
                     /inference="alignment:Splign:2.1.0"
     exon            5061..5277
                     /gene="KNTC1"
                     /gene_synonym="ROD"
                     /inference="alignment:Splign:2.1.0"
     exon            5278..5351
                     /gene="KNTC1"
                     /gene_synonym="ROD"
                     /inference="alignment:Splign:2.1.0"
     exon            5352..5562
                     /gene="KNTC1"
                     /gene_synonym="ROD"
                     /inference="alignment:Splign:2.1.0"
     exon            5563..5672
                     /gene="KNTC1"
                     /gene_synonym="ROD"
                     /inference="alignment:Splign:2.1.0"
     exon            5673..5719
                     /gene="KNTC1"
                     /gene_synonym="ROD"
                     /inference="alignment:Splign:2.1.0"
     exon            5720..5798
                     /gene="KNTC1"
                     /gene_synonym="ROD"
                     /inference="alignment:Splign:2.1.0"
     exon            5799..5917
                     /gene="KNTC1"
                     /gene_synonym="ROD"
                     /inference="alignment:Splign:2.1.0"
     exon            5918..6053
                     /gene="KNTC1"
                     /gene_synonym="ROD"
                     /inference="alignment:Splign:2.1.0"
     exon            6054..6149
                     /gene="KNTC1"
                     /gene_synonym="ROD"
                     /inference="alignment:Splign:2.1.0"
     exon            6150..6206
                     /gene="KNTC1"
                     /gene_synonym="ROD"
                     /inference="alignment:Splign:2.1.0"
     exon            6207..6261
                     /gene="KNTC1"
                     /gene_synonym="ROD"
                     /inference="alignment:Splign:2.1.0"
     exon            6262..6325
                     /gene="KNTC1"
                     /gene_synonym="ROD"
                     /inference="alignment:Splign:2.1.0"
     exon            6326..6455
                     /gene="KNTC1"
                     /gene_synonym="ROD"
                     /inference="alignment:Splign:2.1.0"
     exon            6456..6545
                     /gene="KNTC1"
                     /gene_synonym="ROD"
                     /inference="alignment:Splign:2.1.0"
     exon            6546..6691
                     /gene="KNTC1"
                     /gene_synonym="ROD"
                     /inference="alignment:Splign:2.1.0"
     exon            6692..6782
                     /gene="KNTC1"
                     /gene_synonym="ROD"
                     /inference="alignment:Splign:2.1.0"
     exon            6783..6974
                     /gene="KNTC1"
                     /gene_synonym="ROD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6939..6944
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KNTC1"
                     /gene_synonym="ROD"
                     /note="hexamer: AATAAA"
     polyA_site      6974
                     /gene="KNTC1"
                     /gene_synonym="ROD"
                     /note="major polyA site"
ORIGIN      
        1 aatttaagcc tgtggcatgg aacctaaaga ctagaggcgg ttgtgtgagt caggaagagg
       61 ggccagatat ctgagtgttc ctctttagtt tcttcaattg cagataatat ggtgtctaat
      121 tttatgttgt tcaggaaaga cagtggttcc tgactcagga agacagtctc agaaacatgt
      181 ggaatgatat tgagctgcta acaaatgatg ataccggaag tgggtacctg agtgtcggtt
      241 caagaaaaga acatggaact gctttatatc aagtagattt gctagtgaag atctcttctg
      301 aaaaggcctc attaaatcca aagatacagg catgcagctt aagtgatggg tttattattg
      361 tagccgacca atcagtgata ttgcttgaca gtatttgtag atcacttcaa ttgcatcttg
      421 tctttgatac tgaagtggat gtagttggcc tttgtcaaga aggaaagttt cttttggttg
      481 gcgagagaag tggcaaccta catcttattc atgtaacatc aaaacaaaca ctactcacta
      541 atgcatttgt tcagaaagct aacgatgaaa atcggcggac ttaccagaat cttgtcattg
      601 agaaggatgg ttcaaatgaa ggtacctatt atatgctact tcttacatac agtggatttt
      661 tttgtattac aaaccttcag cttttaaaaa ttcaacaagc aattgagaat gtagacttca
      721 gtacagcaaa aaagttacaa ggacaaatca agtccagttt tatttctact gaaaattatc
      781 atactcttgg ttgtctcagt cttgtggctg gagatttagc aagtgaagtt cctgtgataa
      841 ttgggggaac cggtaattgt gcattctcaa aatgggaacc agattcttcc aagaaaggaa
      901 tgacagttaa gaaccttatt gatgcagaga ttattaaagg tgcaaagaag ttccagctga
      961 tagacaatct actttttgtt cttgatactg ataacgtgct gagtttatgg gatatttaca
     1021 ctctaactcc tgtatggaac tggccctctc ttcacgtaga agagtttctt cttactacag
     1081 aagcagactc tccttcatca gtcacgtggc aaggaattac aaatctcaaa ttaatagctc
     1141 tgacagcttc agctaataag aagatgaaaa acctcatggt ttattcatta cctacaatgg
     1201 aaatactata ttctttggaa gtatctagtg tttcttctct ggtccaaaca ggaattagca
     1261 cagataccat atacctttta gaaggagttt gcaaaaatga tccaaaattg tctgaagact
     1321 cagtctctgt gttagtactc agatgtctta cggaagcttt accagaaaac agattgagtc
     1381 ggttacttca caaacacaga tttgctgaag ctgagagttt tgccattcag tttggactag
     1441 atgttgagct tgtttacaag gtcaagtcaa atcatatatt ggagaaactg gcattgagtt
     1501 ctgtggatgc cagtgaacag accgaatggc aacaacttgt agacgacgct aaggaaaatc
     1561 tacataagat ccaggatgat gaatttgtgg tgaattactg cctgaaagct cagtggataa
     1621 cctatgaaac cactcaagag atgctgaatt atgccaaaac caggcttttg aagaaagaag
     1681 ataaaactgc tctcatttat tctgatggct tgaaagaggt gctaagagct catgcaaaat
     1741 tgactacttt ttatggagca tttggaccag aaaaattcag tggcagttct tggattgaat
     1801 ttctaaataa tgaagatgat cttaaagata tttttttaca gctaaaagaa ggaaaccttg
     1861 tttgtgcaca gtatctttgg cttcgacatc gggcaaactt tgaaagcaga tttgatgtga
     1921 aaatgctgga gagcttgctc aactcaatgt ctgcatcagt ctctttgcaa aagctgtgtc
     1981 catggtttaa aaatgatgtg attccatttg taagaaggac tgtgcctgaa ggacagataa
     2041 ttcttgcaaa atggttggaa caagcagcca ggaaccttga attaactgat aaggcaaatt
     2101 ggccagaaaa tggacttcaa ttggcagaga tattttttac agcagaaaaa acagacgagt
     2161 tgggattggc atcttcctgg cattggattt ccttgaaaga ttatcagaac acagaggaag
     2221 tatgtcagct aaggactttg gtaaataact tgcgagagtt gatcacgttg cataggaagt
     2281 acaactgcaa attagccctc tctgattttg agaaggaaaa tacaaccacc atagtgttcc
     2341 gaatgtttga taaagtgctg gccccagagc ttattccctc catcttagag aagtttataa
     2401 gagtttacat gagagaacat gacttgcaag aggaggaact tctcttgctg tacatagagg
     2461 atttactgaa tagatgcagc tcaaagtcca catcactctt tgaaacagca tgggaagcaa
     2521 aggccatggc agtaatagcg tgtttatctg acacggacct catatttgat gccgtgctca
     2581 agatcatgta tgcggcagtg gttccttgga gtgcagctgt ggagcaactg gtgaaacagc
     2641 acctggaaat ggaccatccc aaagtcaagt tattacagga aagttacaaa ctaatggaga
     2701 tgaaaaaact tttacgaggc tatggaataa gagaggtaaa tctcttaaac aaggaaataa
     2761 tgagagtggt tagatacatt ctcaaacaag atgtcccatc ttctttagaa gatgctttaa
     2821 aggtagccca agcgtttatg ttatctgatg atgagatcta cagtctaaga attattgacc
     2881 tgattgatag agaacagggt gaagactgtc tccttctgtt gaagtctttg cctcctgctg
     2941 aagctgagaa aactgcagaa agagtcatca tatgggcacg actggcatta caagaagagc
     3001 cagatcattc taaagagggc aaggcctgga gaatgtctgt agcgaagaca tccgtggaca
     3061 ttcttaagat actatgtgac attcagaaag acaatctgca gaagaaggac gaatgtgaag
     3121 aaatgttgaa actatttaaa gaggttgcta gcttacagga gaactttgag gtctttcttt
     3181 catttgaaga ttatagcaat agttccctgg tagcagatct ccgtgagcag cacattaaag
     3241 ctcacgaagt tgcacaggcg aaacacaaac ctgggagcac cccagagccc atagctgctg
     3301 aggtgaggag cccaagcatg gaatcaaagc tgcacagaca ggcactggcc ctgcagatgt
     3361 ccaaacaaga gctggaggca gagctgacct tgagagcctt aaaagatggg aacatcaaaa
     3421 cagcactgaa aaaatgcagc gacttgttta agtatcactg caatgctgac actgggaaat
     3481 tgctatttct gacatgtcag aagctttgtc agatgttggc tgataatgtc ccagtgacag
     3541 tgcctgtggg actgaatctt ccttccatga tacatgatct agcaagccaa gctgccacca
     3601 tttgcagtcc agatttttta ctagatgctt tagaactatg taaacatact ttaatggctg
     3661 tagagctttc cagacaatgc caaatggatg actgtggaat cctcatgaaa gcttcttttg
     3721 ggacacataa agatccatat gaagagtggt cttacagtga cttcttcagt gaagatggaa
     3781 ttgttcttga gtcacagatg gtgcttccag tgatttatga actgatttca tctcttgtgc
     3841 ctctagctga aagcaagaga tatcccttgg agtctaccag tttgccatac tgctccctta
     3901 atgaaggaga tggccttgtt ttacctgtta taaattccat ctctgccctg cttcagaatc
     3961 ttcaggaatc tagccagtgg gagctagccc taagatttgt ggttggttca tttggtacct
     4021 gtcttcagca ctctgtgtca aacttcatga atgccacttt gagtgaaaag ttatttggag
     4081 agactacatt agttaaatca aggcatgttg ttatggaatt gaaagaaaaa gctgttatat
     4141 ttatcaggga aaatgctaca acactactgc acaaagtatt taattgtcgc ttggtagatc
     4201 ttgacctggc gttgggttac tgcactctct tacctcaaaa agatgtgttt gaaaatctct
     4261 ggaagctcat agataaagca tggcagaatt acgacaaaat cttggcaata tctctggtgg
     4321 gctctgagct ggcaagtctc tatcaggaaa tagaaatggg gcttaagttc cgtgaactca
     4381 gtactgatgc ccagtggggc attcgtcttg gtaaacttgg tatttctttt caaccagttt
     4441 tcaggcaaca ttttctcacc aagaaagacc tcattaaagc tcttgtggag aatatagata
     4501 tggacacaag cctcattttg gaatattgca gcacatttca gttggactgc gatgcagttc
     4561 ttcagctctt cattgaaacg ctgctccaca acacaaatgc cggccaaggc cagggagatg
     4621 caagcatgga ctctgcaaag cggcggcatc ccaaactcct ggccaaagcc cttgagatgg
     4681 ttcctttact gacgagcaca aaagatttgg tcatcagtct tagtggaata ctacataagt
     4741 tggatcctta tgactatgaa atgattgaag ttgtcttgaa agttatagaa cgagctgatg
     4801 aaaagataac caatattaat attaatcagg cattgagtat tctgaaacat ttgaagtcat
     4861 acagaagaat ttctcctccc gtggatctag aatatcagta tatgttggaa catgtcataa
     4921 ctttgccatc agctgcccaa actagactgc cttttcacct gatattcttt ggcacagcac
     4981 agaacttctg gaaaattctc tctacagaac tcagtgaaga atctttccca acattgctct
     5041 taatttcgaa attaatgaag ttctctctgg acactctgta cgtgtctaca gcaaaacacg
     5101 ttttcgaaaa aaaactgaag ccaaagctcc tgaagttaac acaagctaaa tcctcaacac
     5161 tgattaacaa ggaaataact aagatcacgc agaccatcga atcctgctta ctctctatag
     5221 tcaacccaga gtgggctgta gctattgcca tcagccttgc ccaggatatc cctgaaggtt
     5281 ccttcaagat atctgctttg aaattctgcc tttatttagc tgagagatgg ctacagaata
     5341 tcccatcgca ggacgaaaaa cgtgaaaaag ccgaggcttt gttgaagaag cttcatatcc
     5401 agtaccggcg atcgggcaca gaagctgtgc tcatagccca caagctgaac actgaggaat
     5461 atttaagagt gatcggaaag ccagcacatc ttattgtcag tctctacgaa catcctagca
     5521 tcaatcaaag aattcagaat tcatctggca cagattatcc tgatattcat gcagcagcta
     5581 aagaaatagc cgaagtcaat gaaattaatt tggaaaaagt ctgggacatg ttgttggaaa
     5641 aatggctatg cccttcaaca aaacctggtg aaaaaccatc agaattattt gaacttcaag
     5701 aagatgaagc cctacgaaga gtgcagtatc tcctcctgtc tcgtccaatt gattatagtt
     5761 caagaatgct gtttgtattt gcaacatcaa ctacaaccac attaggtatg catcagttaa
     5821 cttttgccca tagaactcga gctcttcagt gtctcttcta tttggctgac aaggaaacta
     5881 tagaatctct ctttaaaaaa cccattgaag aagtgaaatc ttatttgaga tgtataactt
     5941 ttctggcatc atttgagact ttgaatatcc ccatcacata tgaattattt tgcagcagtc
     6001 ctaaagaagg aatgattaag ggtctgtgga aaaaccacag ccacgagtcc atggcagtaa
     6061 gattggtgac tgagctgtgt ttagaataca aaatctatga cctgcagctt tggaatggac
     6121 tcttgcaaaa gcttctgggc ttcaatatga ttccttatct aaggaaagtt ttaaaagcca
     6181 tctccagtat ccattcttta tggcaggttc cctacttcag caaagcgtgg cagcgtgtga
     6241 tacagatacc actgctttca gcctcttgtc ctttaagtcc tgatcagctg tcagattgtt
     6301 ctgagagtct catcgctgtc ctcgaatgtc cagtctcagg tgatcttgac ctgatcggag
     6361 tcgccaggca gtatatccag ttagaacttc cggcttttgc attagcttgt ctgatgctca
     6421 tgccccactc agagaaaaga caccagcaaa ttaagaattt tctgggttcc tgtgaccctc
     6481 aggttatttt aaagcaattg gaagagcata tgaacacggg ccagctagca ggattttcac
     6541 atcaaattag aagtctgatt ttgaataata tcatcaataa gaaggagttt gggattttgg
     6601 caaagaccaa atactttcaa atgttgaaga tgcatgcgat gaataccaac aatatcactg
     6661 agctagtgaa ctatttggca aatgacttaa gtttagatga agcttcagtc ttgataactg
     6721 aatattcaaa gcactgcggg aaacctgtgc ctccagacac tgctccctgt gaaattctga
     6781 agatgtttct tagtggatta tcgtaaatca ctgaaccttt ttttcaagaa ggacaagaat
     6841 tttggagtct gctattaatg gaccatattt attacagttt ttaaattgta caatctctgt
     6901 attatagcta tttgtctaac attaccccac atgtaataaa taaaacaata tgagcataat
     6961 tgccccataa agaa
//
