LOCUS       NM_001348532            6488 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens lysine rich nucleolar protein 1 (KNOP1), transcript
            variant 7, mRNA.
ACCESSION   NM_001348532 XM_017023231
VERSION     NM_001348532.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6488)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 6488)
  AUTHORS   Mattheisen,M., Samuels,J.F., Wang,Y., Greenberg,B.D., Fyer,A.J.,
            McCracken,J.T., Geller,D.A., Murphy,D.L., Knowles,J.A.,
            Grados,M.A., Riddle,M.A., Rasmussen,S.A., McLaughlin,N.C.,
            Nurmi,E.L., Askland,K.D., Qin,H.D., Cullen,B.A., Piacentini,J.,
            Pauls,D.L., Bienvenu,O.J., Stewart,S.E., Liang,K.Y., Goes,F.S.,
            Maher,B., Pulver,A.E., Shugart,Y.Y., Valle,D., Lange,C. and
            Nestadt,G.
  TITLE     Genome-wide association study in obsessive-compulsive disorder:
            results from the OCGAS
  JOURNAL   Mol Psychiatry 20 (3), 337-344 (2015)
   PUBMED   24821223
REFERENCE   3  (bases 1 to 6488)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 6488)
  AUTHORS   Grasberger,H. and Bell,G.I.
  TITLE     Subcellular recruitment by TSG118 and TSPYL implicates a role for
            zinc finger protein 106 in a novel developmental pathway
  JOURNAL   Int J Biochem Cell Biol 37 (7), 1421-1437 (2005)
   PUBMED   15833274
REFERENCE   5  (bases 1 to 6488)
  AUTHORS   Loftus,B.J., Kim,U.J., Sneddon,V.P., Kalush,F., Brandon,R.,
            Fuhrmann,J., Mason,T., Crosby,M.L., Barnstead,M., Cronin,L.,
            Deslattes Mays,A., Cao,Y., Xu,R.X., Kang,H.L., Mitchell,S.,
            Eichler,E.E., Harris,P.C., Venter,J.C. and Adams,M.D.
  TITLE     Genome duplications and other features in 12 Mb of DNA sequence
            from human chromosome 16p and 16q
  JOURNAL   Genomics 60 (3), 295-308 (1999)
   PUBMED   10493829
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC002550.1.
            
            On Jun 1, 2019 this sequence version replaced NM_001348532.1.
            
            Summary: The protein encoded by this gene is a nucleolar protein
            that interacts with zinc finger 106 protein. The encoded protein
            has several of the same characteristics as nucleostemin and may be
            involved in testis development. [provided by RefSeq, Feb 2017].
            
            Transcript Variant: This variant (7) differs in the 5' UTR and
            coding sequence and lacks an alternate in-frame exon compared to
            variant 1. The resulting isoform (c) is shorter at the N-terminus
            and lacks an alternate internal segment compared to isoform a.
            Variants 7-12 all encode the same isoform (c).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.204399.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148874
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-70                AC002550.1         25905-25974
            71-205              AC002550.1         26647-26781
            206-1125            AC002550.1         29095-30014
            1126-1203           AC002550.1         33546-33623
            1204-6488           AC002550.1         36911-42195
FEATURES             Location/Qualifiers
     source          1..6488
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p12.3"
     gene            1..6488
                     /gene="KNOP1"
                     /gene_synonym="101F10.1; C16orf88; FAM191A; TSG118"
                     /note="lysine rich nucleolar protein 1"
                     /db_xref="GeneID:400506"
                     /db_xref="HGNC:HGNC:34404"
     exon            1..70
                     /gene="KNOP1"
                     /gene_synonym="101F10.1; C16orf88; FAM191A; TSG118"
                     /inference="alignment:Splign:2.1.0"
     exon            71..205
                     /gene="KNOP1"
                     /gene_synonym="101F10.1; C16orf88; FAM191A; TSG118"
                     /inference="alignment:Splign:2.1.0"
     exon            206..1125
                     /gene="KNOP1"
                     /gene_synonym="101F10.1; C16orf88; FAM191A; TSG118"
                     /inference="alignment:Splign:2.1.0"
     CDS             208..1515
                     /gene="KNOP1"
                     /gene_synonym="101F10.1; C16orf88; FAM191A; TSG118"
                     /note="isoform c is encoded by transcript variant 7;
                     family with sequence similarity 191, member A; protein
                     C16orf88; testis-specific gene 118 protein"
                     /codon_start=1
                     /product="lysine-rich nucleolar protein 1 isoform c"
                     /protein_id="NP_001335461.1"
                     /db_xref="GeneID:400506"
                     /db_xref="HGNC:HGNC:34404"
                     /translation="MITKTHKVDLGLPEKKKKKKVVKEPETRYSVLNNDDYFADVSPL
                     RATSPSKSVAHGQAPEMPLVKKKKKKKKGVSTLCEEHVEPETTLPARRTEKSPSLRKQ
                     VFGHLEFLSGEKKNKKSPLAMSHASGVKTSPDPRQGEEETRVGKKLKKHKKEKKGAQD
                     PTAFSVQDPWFCEAREARDVGDTCSVGKKDEEQAALGQKRKRKSPREHNGKVKKKKKI
                     HQEGDALPGHSKPSRSMESSPRKGSKKKPVKVEAPEYIPISDDPKASAKKKMKSKKKV
                     EQPVIEEPALKRKKKKKRKESGVAGDPWKEVRRKALQEEIDRESGKTEASETRKWTGT
                     QFGQWDTAGFENEDQKLKFLRLMGGFKNLSPSFSRPASTIARPNMALGKKAADSLQQN
                     LQRDYDRAMSWKYSRGAGLGFSTAPNKIFYIDRNASKSVKLED"
     exon            1126..1203
                     /gene="KNOP1"
                     /gene_synonym="101F10.1; C16orf88; FAM191A; TSG118"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..6488
                     /gene="KNOP1"
                     /gene_synonym="101F10.1; C16orf88; FAM191A; TSG118"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2042..2047
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KNOP1"
                     /gene_synonym="101F10.1; C16orf88; FAM191A; TSG118"
                     /note="hexamer: AATAAA"
     polyA_site      2073
                     /gene="KNOP1"
                     /gene_synonym="101F10.1; C16orf88; FAM191A; TSG118"
                     /note="major polyA site"
     regulatory      6454..6459
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KNOP1"
                     /gene_synonym="101F10.1; C16orf88; FAM191A; TSG118"
                     /note="hexamer: AATAAA"
     polyA_site      6488
                     /gene="KNOP1"
                     /gene_synonym="101F10.1; C16orf88; FAM191A; TSG118"
ORIGIN      
        1 gactcgaagt ggacttccgg gtcacggcgg agctggctct cacgtggagg cggggaaatt
       61 tcgcccaccg atctcttggc cactccccta ttctgaagtc gtcttggctc tcttgactgc
      121 tcccctattc tgaagtcgtc ttggctctct tgactgctcc cctattctga agtcgtcttg
      181 gctctcctga ctacactatt tcaaggaatg atcaccaaga cacacaaagt agaccttggg
      241 ctcccagaga agaaaaagaa gaagaaagtg gtcaaagaac cagagactcg atactcagtt
      301 ttaaacaatg atgattactt tgctgatgtt tctcctttaa gagctacatc cccctctaag
      361 agtgtggccc atgggcaggc acctgagatg cctctagtga agaaaaagaa gaagaaaaag
      421 aagggtgtca gcaccctttg cgaggagcat gtagaacctg agaccacgct gcctgctaga
      481 cggacagaga agtcacccag cctcaggaag caggtgtttg gccacttgga gttcctcagt
      541 ggggaaaaga aaaataagaa gtcacctcta gccatgtccc atgcctctgg ggtgaaaacc
      601 tccccagacc ctagacaggg tgaggaggaa accagagttg gcaagaagct caaaaaacac
      661 aagaaggaaa aaaagggggc ccaggacccc acagccttct cggtccagga cccttggttc
      721 tgtgaggcca gggaggccag ggatgttggg gacacttgct cagtggggaa gaaggatgag
      781 gaacaggcag ccttggggca gaaacggaag cggaagagcc ccagagaaca caatgggaag
      841 gtgaagaaga aaaaaaaaat ccaccaggag ggagatgccc tcccaggcca ctccaagccc
      901 tccaggtcca tggagagcag ccctaggaaa ggaagtaaaa agaagccagt caaagttgag
      961 gctccggaat acatccccat aagtgatgac cctaaggcct ccgcaaagaa aaagatgaag
     1021 tccaaaaaga aggtagagca gccagtcatc gaggagccag ctctgaaaag gaagaaaaag
     1081 aagaagagga aagagagtgg ggtagcagga gacccttgga aggaggtgag gcgaaaggcc
     1141 ttgcaagaag agatcgatcg cgagtcaggc aaaacggaag cttctgaaac caggaagtgg
     1201 acgggaaccc agtttggcca gtgggatact gctggttttg agaacgagga ccaaaaactg
     1261 aaatttctca gacttatggg tggcttcaaa aacctgtccc cttcgttcag ccgccccgcc
     1321 agcacgattg caaggcccaa catggccctc ggcaagaagg cggctgacag cctgcagcag
     1381 aatctgcagc gggactacga ccgggccatg agctggaagt acagccgggg agccggcctc
     1441 ggcttctcca ccgcccccaa caagatcttt tacattgaca ggaacgcttc caagtcagtc
     1501 aagctggaag attaaactct agagttttgt ccccccaaaa ctgccacaat tgctttgatt
     1561 attccattta tgctggagat tacaaatttt ttttgtgaaa aaatcagatc ttggtgagga
     1621 cctcgagcag taagatataa ataactccca taagcttagc gttccagtaa tggaacacta
     1681 ggcataaatg gtttattcag ttgtgcaaat gaaagccatc tgacagttgg ctcacattga
     1741 acacctgtgg agattaagga cgaggacaac tatattgatg ggcttggatg aactggggca
     1801 gggcagctca tatttcggga gccaggagaa cgagtgagtg ctaaaacctc ctgttttctg
     1861 tgttaaacat tccgtccctg tttgagacat cagtatgtac agttaacttt tgttgagtgt
     1921 ttagcaggta ctagggacat actagtgttt tccttaatgt atttaatctt cataattatg
     1981 aaatgggtgc tattattagc cccatcttat agatgaggca actgaggttc agggataaag
     2041 taataaaatt gcctggggtc acccagccac taagtgcagg gtgttgtact tttgtacccg
     2101 aagccctaag ttcactattc gccactctga atgtcccctt tagggaattt ccaccagaat
     2161 cctcgttggg gattgaaatg tctttagatg gaggaaaaag ttttatgaca agtctgcatc
     2221 tctgataaaa agtggagtga atgaggaacg gagaatcgca aactcctttt ccttcctttt
     2281 cctttcccct gtcatagagc agctgtaggc agagaggtgt ctgagttgtt accaaacaca
     2341 tgtgactgag ctgctgctgc tgggaaatgt gcctctaaac cagtcctgcc ttttccactg
     2401 gtgtcccttc ggccctaagt gctgaggtag gatttttgtg ctttgactgg attctgaaca
     2461 aggcatttta ggaagagtgg ttagtcccgc aaatgaatca atggcagatc ccagggacgt
     2521 gtgtgtgtgt tttgagatag gctctcactc tgtcacccag gctggagtgt agtggcatat
     2581 cacggcttgt tgcaaccact acctatccag cttaagtgat cctcccacct cagcctccca
     2641 agtagctggg actgtgggtg tgcaccacaa caaccagcta gtgtttaaaa ttttttgtag
     2701 agatggggtc tcactatatt gtccaggcta gtcccaaact cctggactca actcatgctc
     2761 ctgcctcagc ccccaagagc tgggatcaca ggtgtgagcc actgtgccca gccccaggga
     2821 tgtgtctgat gagattcttt tttatcacaa ggaagagaat cccaggtgac ttctgtaggt
     2881 ggatattgaa tgccaggagg agatgaacgt gtggagatga cacgggaagt tgcctcatcg
     2941 gctgtgggga cagcgtttcc aagcctggac tctacagcaa gcctcaaaga gctccaggtc
     3001 cagtggccca agtcgcatgt gaccatctgt gaccaccttc tttccactca cctagctttt
     3061 tgcatcccaa aatacaggtt ctgactggga cattttcacg atcgtttggc ctgaacatgc
     3121 ctcctacaga catcccagcc caggcaggcc tcgatggcca gaaagttcag tctcacgtgg
     3181 caggaaggcc tgattagggc ctggttcaac agctcgccaa ggaagcattc tctccatcat
     3241 ctccagtgtt ggcttcatca aggctagtac aaagatggca gtaacagttc caggcagcat
     3301 atcaagaccc tagaacattc cagaggaaga aaagcctttt tgtgtctcaa ggaaacttcc
     3361 agaagcctcc attgctgggc aatgagtcat ctgcccatag ctgcacccgc ccctgtcatg
     3421 ggaaggctgg tgattccctt cagtcaagaa gagtggatgc tggtgaagtg gccatggtgt
     3481 ccacagctgc ccattgggca gaggtgaggc aggcacttca ggcagtttcc ctggctctga
     3541 accctgatcc gcaagcattg gccaggtcaa tagttggaca agtatgtgct acaaggacct
     3601 acttgggcca cttccctcag gacgtgaact tgtcctgcct ttctttcctg gattcaacct
     3661 tgagatacat aatgggagag gccgtggaaa gcccaagagg cagtgttctg gatttgagtg
     3721 agtgccttct gggcacctcc tcctttgatg gagaaacaaa tccctcctga ccttgagcaa
     3781 cactacagga atgtgcctgg tgtaaacagg aaccagccgt tcgtttcttt ttttttgaga
     3841 tggagtctca cggtcgcgca ggctggagtg tggtggcgtg atctcggctc attgtaacct
     3901 ctgcttcctg ggttcaagcg attcttgtgc ctcagtctcc tgagtagctg gaatcggccg
     3961 tttactactc atagttttta tcttgccaag aggtcaccct gacgttggcc tgccttagct
     4021 ctgttaaaaa ggttgtgctc tgccaggtgc ggtgactcac gcctgtaatc ccagcacttt
     4081 gggaggccaa ggtgggcgga tcacgaggtc aagagttcga gaccagcctg accaacatgg
     4141 tgaaaccccg tctctactaa aaatacaaaa attagctggg tgggtgtggt gtcacgggct
     4201 tgtaatcccg gctactcagg aggctgacag gagaatcgct tgaacccggg aggtggaggt
     4261 tgtagtgagc tgggatggtg ccactgcaca ctctagcccc gggcaacaga atgagactct
     4321 gtctcaaaaa caaacaaaaa aaaactgtct ttgggtgatt gtggagaggt gatcatatgt
     4381 ccgctgtgtt gctcccatcc aagccctggt gactggtagc tctcatgagg gtgtgatggt
     4441 caggccttgc ccctggtgta aattctgtct gtaataggct gtgactttct aactcaacat
     4501 caccactggc ttaggagttc catttgcaca gggggagctt tattgctttt ctatatacat
     4561 aagaacttta cgtctcacca gtggaggttg ggcagccaag acaccacaat gctgggtgtc
     4621 ttcagaatgg acttaatctt gtccttttgc tttctgccag tgcagatcac catctctcag
     4681 atgagcagga ccccaccctc tggcagtctt gtcttgggag aatcactctg agctcccatc
     4741 ctttgtaaat taacattggt ttgagcacca ccctccatca cggctgcagt gagccatgat
     4801 tgcaccactg tgttccagcc tgggtgacag agcaagaccc cattccaaaa aaaaaaaaaa
     4861 atttgccaaa tagacacagt cctcacaaaa gaagttggca gaataacacc ccttcctacc
     4921 acatctcctc agaacctgtg tatttgttag gttacgaaac aaaagggaat taagtttgct
     4981 aatcagctga ccttaaaaca ggaagaggat cccgtgtttc tgggtgggcc ggaggaatca
     5041 caaagatccc taaatgtgga agaggaaggc aaaaaagagt ccacatcaaa gagacttaag
     5101 aaagacttga ctagacactg ctggttttga agatgggaag ggaagggtca gaagccaagg
     5161 aatgtgtgtg ctgtctagaa gctggaaaag gcaaggaagt agattctccc ctagagcctc
     5221 ccagaaggag cgtagccctg ctgatgcctt aattttagct cagtgagacc aggcggactt
     5281 aagacctata gaaccgtcag atgacaacat tatgttttaa gccgctacaa ttgtggcaat
     5341 ttgttaaagt aacaatagaa gacctaatgt aagtaagtct catgtggaag ttgccatggt
     5401 tttgtttttc tttctttttt tttttttgag acagtctcac tctcactcca cgcccaggct
     5461 ggagtgcaga ggcgtgatct cagctcactg caacctccac ctccagggtt caagcgattc
     5521 tcctgcctca gcctcctgag aagctgggat tacaggtgag caccaccaca cccagctaat
     5581 ttttttttgt atttttagta gagatggagt ttcaccatgt tggccaggat ggtcttgatc
     5641 tcttggcctc atgatccacc tacctcagcc tcccaaagtg ttggtattac aggcatgagc
     5701 caccgcaccc aggccccatc atttttattt tctacaattc tggctgacat cttattgctc
     5761 catccttgct aatgatagac ttcatctcac atagaccagt gttttcagag accggcttat
     5821 tgattcagta aagggctggg ggaaactgca cacacaagga catataaaat ctaagcctct
     5881 gcctgggcca catgacagga ttcagaagca cctttgatat aatgggtgcc cgacctcatg
     5941 tgaaagtcca agttcaggtg taatgtgaga gcggtaagaa ttcactggcc taggcttggg
     6001 aactaatgct gcccaccacg ttcagcctca gaggagaaga aatgacttga agaacataat
     6061 ttgtgaattt gccaattgtt tttcatttta tagcatcaca cagtaaaagt agataaaata
     6121 attttaatga aaatacttct gtgggccagg tgcggtggct tacgcctgta atcccagcac
     6181 tttgggaggc cgaggcggcg gatcacctga ggtcaggagt tctagaccag cctgaccaac
     6241 atggagaaac cccatctcta ctaaaaatac aaaattagct gggtgtggtg gcgcactcct
     6301 gttatcccag ctactcagga ggctgaggca ggagaattgc ttagactcgg gaggcggagg
     6361 ttggggtgag ccgagatcac gccattgtac tccagcctgg gcaacaagag tgaaactgtc
     6421 tcaaaaaaaa gaaaaaaaaa cagaattttg tgaaataaag gccacttggg agtatctgag
     6481 ccacccca
//
