LOCUS       NM_001012991            6422 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens lysine rich nucleolar protein 1 (KNOP1), transcript
            variant 2, mRNA.
ACCESSION   NM_001012991 XM_001126237 XM_001132285
VERSION     NM_001012991.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6422)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 6422)
  AUTHORS   Mattheisen,M., Samuels,J.F., Wang,Y., Greenberg,B.D., Fyer,A.J.,
            McCracken,J.T., Geller,D.A., Murphy,D.L., Knowles,J.A.,
            Grados,M.A., Riddle,M.A., Rasmussen,S.A., McLaughlin,N.C.,
            Nurmi,E.L., Askland,K.D., Qin,H.D., Cullen,B.A., Piacentini,J.,
            Pauls,D.L., Bienvenu,O.J., Stewart,S.E., Liang,K.Y., Goes,F.S.,
            Maher,B., Pulver,A.E., Shugart,Y.Y., Valle,D., Lange,C. and
            Nestadt,G.
  TITLE     Genome-wide association study in obsessive-compulsive disorder:
            results from the OCGAS
  JOURNAL   Mol Psychiatry 20 (3), 337-344 (2015)
   PUBMED   24821223
REFERENCE   3  (bases 1 to 6422)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 6422)
  AUTHORS   Grasberger,H. and Bell,G.I.
  TITLE     Subcellular recruitment by TSG118 and TSPYL implicates a role for
            zinc finger protein 106 in a novel developmental pathway
  JOURNAL   Int J Biochem Cell Biol 37 (7), 1421-1437 (2005)
   PUBMED   15833274
REFERENCE   5  (bases 1 to 6422)
  AUTHORS   Loftus,B.J., Kim,U.J., Sneddon,V.P., Kalush,F., Brandon,R.,
            Fuhrmann,J., Mason,T., Crosby,M.L., Barnstead,M., Cronin,L.,
            Deslattes Mays,A., Cao,Y., Xu,R.X., Kang,H.L., Mitchell,S.,
            Eichler,E.E., Harris,P.C., Venter,J.C. and Adams,M.D.
  TITLE     Genome duplications and other features in 12 Mb of DNA sequence
            from human chromosome 16p and 16q
  JOURNAL   Genomics 60 (3), 295-308 (1999)
   PUBMED   10493829
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC002550.1 and BC117562.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001012991.2.
            
            Summary: The protein encoded by this gene is a nucleolar protein
            that interacts with zinc finger 106 protein. The encoded protein
            has several of the same characteristics as nucleostemin and may be
            involved in testis development. [provided by RefSeq, Feb 2017].
            
            Transcript Variant: This variant (2) differs in the 5' UTR and
            coding sequence compared to variant 1. The resulting isoform (b) is
            shorter at the N-terminus compared to isoform a. Variants 2-6 all
            encode the same isoform (b).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.131926.1,
                                           SRR1803613.254425.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000219837.12/ ENSP00000219837.7
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-57                AC002550.1         25905-25961
            58-2007             BC117562.1         1-1950
            2008-6422           AC002550.1         37781-42195
FEATURES             Location/Qualifiers
     source          1..6422
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p12.3"
     gene            1..6422
                     /gene="KNOP1"
                     /gene_synonym="101F10.1; C16orf88; FAM191A; TSG118"
                     /note="lysine rich nucleolar protein 1"
                     /db_xref="GeneID:400506"
                     /db_xref="HGNC:HGNC:34404"
     exon            1..70
                     /gene="KNOP1"
                     /gene_synonym="101F10.1; C16orf88; FAM191A; TSG118"
                     /inference="alignment:Splign:2.1.0"
     exon            71..990
                     /gene="KNOP1"
                     /gene_synonym="101F10.1; C16orf88; FAM191A; TSG118"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..1449
                     /gene="KNOP1"
                     /gene_synonym="101F10.1; C16orf88; FAM191A; TSG118"
                     /note="isoform b is encoded by transcript variant 2;
                     family with sequence similarity 191, member A; protein
                     C16orf88; testis-specific gene 118 protein"
                     /codon_start=1
                     /product="lysine-rich nucleolar protein 1 isoform b"
                     /protein_id="NP_001013009.2"
                     /db_xref="CCDS:CCDS42127.1"
                     /db_xref="GeneID:400506"
                     /db_xref="HGNC:HGNC:34404"
                     /translation="MITKTHKVDLGLPEKKKKKKVVKEPETRYSVLNNDDYFADVSPL
                     RATSPSKSVAHGQAPEMPLVKKKKKKKKGVSTLCEEHVEPETTLPARRTEKSPSLRKQ
                     VFGHLEFLSGEKKNKKSPLAMSHASGVKTSPDPRQGEEETRVGKKLKKHKKEKKGAQD
                     PTAFSVQDPWFCEAREARDVGDTCSVGKKDEEQAALGQKRKRKSPREHNGKVKKKKKI
                     HQEGDALPGHSKPSRSMESSPRKGSKKKPVKVEAPEYIPISDDPKASAKKKMKSKKKV
                     EQPVIEEPALKRKKKKKRKESGVAGDPWKEETDTDLEVVLEKKGNMDEAHIDQVRRKA
                     LQEEIDRESGKTEASETRKWTGTQFGQWDTAGFENEDQKLKFLRLMGGFKNLSPSFSR
                     PASTIARPNMALGKKAADSLQQNLQRDYDRAMSWKYSRGAGLGFSTAPNKIFYIDRNA
                     SKSVKLED"
     exon            991..1059
                     /gene="KNOP1"
                     /gene_synonym="101F10.1; C16orf88; FAM191A; TSG118"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1137
                     /gene="KNOP1"
                     /gene_synonym="101F10.1; C16orf88; FAM191A; TSG118"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..6422
                     /gene="KNOP1"
                     /gene_synonym="101F10.1; C16orf88; FAM191A; TSG118"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1976..1981
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KNOP1"
                     /gene_synonym="101F10.1; C16orf88; FAM191A; TSG118"
                     /note="hexamer: AATAAA"
     polyA_site      2007
                     /gene="KNOP1"
                     /gene_synonym="101F10.1; C16orf88; FAM191A; TSG118"
                     /note="major polyA site"
     regulatory      6388..6393
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KNOP1"
                     /gene_synonym="101F10.1; C16orf88; FAM191A; TSG118"
                     /note="hexamer: AATAAA"
     polyA_site      6422
                     /gene="KNOP1"
                     /gene_synonym="101F10.1; C16orf88; FAM191A; TSG118"
ORIGIN      
        1 gactcgaagt ggacttccgg gtcacggcgg agctggctct cacgtggagg cggggaaatt
       61 tcgcccaccg gaatgatcac caagacacac aaagtagacc ttgggctccc agagaagaaa
      121 aagaagaaga aagtggtcaa agaaccagag actcgatact cagttttaaa caatgatgat
      181 tactttgctg atgtttctcc tttaagagct acatccccct ctaagagtgt ggcccatggg
      241 caggcacctg agatgcctct agtgaagaaa aagaagaaga aaaagaaggg tgtcagcacc
      301 ctttgcgagg agcatgtaga acctgagacc acgctgcctg ctagacggac agagaagtca
      361 cccagcctca ggaagcaggt gtttggccac ttggagttcc tcagtgggga aaagaaaaat
      421 aagaagtcac ctctagccat gtcccatgcc tctggggtga aaacctcccc agaccctaga
      481 cagggtgagg aggaaaccag agttggcaag aagctcaaaa aacacaagaa ggaaaaaaag
      541 ggggcccagg accccacagc cttctcggtc caggaccctt ggttctgtga ggccagggag
      601 gccagggatg ttggggacac ttgctcagtg gggaagaagg atgaggaaca ggcagccttg
      661 gggcagaaac ggaagcggaa gagccccaga gaacacaatg ggaaggtgaa gaagaaaaaa
      721 aaaatccacc aggagggaga tgccctccca ggccactcca agccctccag gtccatggag
      781 agcagcccta ggaaaggaag taaaaagaag ccagtcaaag ttgaggctcc ggaatacatc
      841 cccataagtg atgaccctaa ggcctccgca aagaaaaaga tgaagtccaa aaagaaggta
      901 gagcagccag tcatcgagga gccagctctg aaaaggaaga aaaagaagaa gaggaaagag
      961 agtggggtag caggagaccc ttggaaggag gaaacagaca cggacttaga ggtggtgttg
     1021 gaaaaaaaag gcaacatgga tgaggcgcac atagaccagg tgaggcgaaa ggccttgcaa
     1081 gaagagatcg atcgcgagtc aggcaaaacg gaagcttctg aaaccaggaa gtggacggga
     1141 acccagtttg gccagtggga tactgctggt tttgagaacg aggaccaaaa actgaaattt
     1201 ctcagactta tgggtggctt caaaaacctg tccccttcgt tcagccgccc cgccagcacg
     1261 attgcaaggc ccaacatggc cctcggcaag aaggcggctg acagcctgca gcagaatctg
     1321 cagcgggact acgaccgggc catgagctgg aagtacagcc ggggagccgg cctcggcttc
     1381 tccaccgccc ccaacaagat cttttacatt gacaggaacg cttccaagtc agtcaagctg
     1441 gaagattaaa ctctagagtt ttgtcccccc aaaactgcca caattgcttt gattattcca
     1501 tttatgctgg agattacaaa ttttttttgt gaaaaaatca gatcttggtg aggacctcga
     1561 gcagtaagat ataaataact cccataagct tagcgttcca gtaatggaac actaggcata
     1621 aatggtttat tcagttgtgc aaatgaaagc catctgacag ttggctcaca ttgaacacct
     1681 gtggagatta aggacgagga caactatatt gatgggcttg gatgaactgg ggcagggcag
     1741 ctcatatttc gggagccagg agaacgagtg agtgctaaaa cctcctgttt tctgtgttaa
     1801 acattccgtc cctgtttgag acatcagtat gtacagttaa cttttgttga gtgtttagca
     1861 ggtactaggg acatactagt gttttcctta atgtatttaa tcttcataat tatgaaatgg
     1921 gtgctattat tagccccatc ttatagatga ggcaactgag gttcagggat aaagtaataa
     1981 aattgcctgg ggtcacccag ccactaagtg cagggtgttg tacttttgta cccgaagccc
     2041 taagttcact attcgccact ctgaatgtcc cctttaggga atttccacca gaatcctcgt
     2101 tggggattga aatgtcttta gatggaggaa aaagttttat gacaagtctg catctctgat
     2161 aaaaagtgga gtgaatgagg aacggagaat cgcaaactcc ttttccttcc ttttcctttc
     2221 ccctgtcata gagcagctgt aggcagagag gtgtctgagt tgttaccaaa cacatgtgac
     2281 tgagctgctg ctgctgggaa atgtgcctct aaaccagtcc tgccttttcc actggtgtcc
     2341 cttcggccct aagtgctgag gtaggatttt tgtgctttga ctggattctg aacaaggcat
     2401 tttaggaaga gtggttagtc ccgcaaatga atcaatggca gatcccaggg acgtgtgtgt
     2461 gtgttttgag ataggctctc actctgtcac ccaggctgga gtgtagtggc atatcacggc
     2521 ttgttgcaac cactacctat ccagcttaag tgatcctccc acctcagcct cccaagtagc
     2581 tgggactgtg ggtgtgcacc acaacaacca gctagtgttt aaaatttttt gtagagatgg
     2641 ggtctcacta tattgtccag gctagtccca aactcctgga ctcaactcat gctcctgcct
     2701 cagcccccaa gagctgggat cacaggtgtg agccactgtg cccagcccca gggatgtgtc
     2761 tgatgagatt cttttttatc acaaggaaga gaatcccagg tgacttctgt aggtggatat
     2821 tgaatgccag gaggagatga acgtgtggag atgacacggg aagttgcctc atcggctgtg
     2881 gggacagcgt ttccaagcct ggactctaca gcaagcctca aagagctcca ggtccagtgg
     2941 cccaagtcgc atgtgaccat ctgtgaccac cttctttcca ctcacctagc tttttgcatc
     3001 ccaaaataca ggttctgact gggacatttt cacgatcgtt tggcctgaac atgcctccta
     3061 cagacatccc agcccaggca ggcctcgatg gccagaaagt tcagtctcac gtggcaggaa
     3121 ggcctgatta gggcctggtt caacagctcg ccaaggaagc attctctcca tcatctccag
     3181 tgttggcttc atcaaggcta gtacaaagat ggcagtaaca gttccaggca gcatatcaag
     3241 accctagaac attccagagg aagaaaagcc tttttgtgtc tcaaggaaac ttccagaagc
     3301 ctccattgct gggcaatgag tcatctgccc atagctgcac ccgcccctgt catgggaagg
     3361 ctggtgattc ccttcagtca agaagagtgg atgctggtga agtggccatg gtgtccacag
     3421 ctgcccattg ggcagaggtg aggcaggcac ttcaggcagt ttccctggct ctgaaccctg
     3481 atccgcaagc attggccagg tcaatagttg gacaagtatg tgctacaagg acctacttgg
     3541 gccacttccc tcaggacgtg aacttgtcct gcctttcttt cctggattca accttgagat
     3601 acataatggg agaggccgtg gaaagcccaa gaggcagtgt tctggatttg agtgagtgcc
     3661 ttctgggcac ctcctccttt gatggagaaa caaatccctc ctgaccttga gcaacactac
     3721 aggaatgtgc ctggtgtaaa caggaaccag ccgttcgttt cttttttttt gagatggagt
     3781 ctcacggtcg cgcaggctgg agtgtggtgg cgtgatctcg gctcattgta acctctgctt
     3841 cctgggttca agcgattctt gtgcctcagt ctcctgagta gctggaatcg gccgtttact
     3901 actcatagtt tttatcttgc caagaggtca ccctgacgtt ggcctgcctt agctctgtta
     3961 aaaaggttgt gctctgccag gtgcggtgac tcacgcctgt aatcccagca ctttgggagg
     4021 ccaaggtggg cggatcacga ggtcaagagt tcgagaccag cctgaccaac atggtgaaac
     4081 cccgtctcta ctaaaaatac aaaaattagc tgggtgggtg tggtgtcacg ggcttgtaat
     4141 cccggctact caggaggctg acaggagaat cgcttgaacc cgggaggtgg aggttgtagt
     4201 gagctgggat ggtgccactg cacactctag ccccgggcaa cagaatgaga ctctgtctca
     4261 aaaacaaaca aaaaaaaact gtctttgggt gattgtggag aggtgatcat atgtccgctg
     4321 tgttgctccc atccaagccc tggtgactgg tagctctcat gagggtgtga tggtcaggcc
     4381 ttgcccctgg tgtaaattct gtctgtaata ggctgtgact ttctaactca acatcaccac
     4441 tggcttagga gttccatttg cacaggggga gctttattgc ttttctatat acataagaac
     4501 tttacgtctc accagtggag gttgggcagc caagacacca caatgctggg tgtcttcaga
     4561 atggacttaa tcttgtcctt ttgctttctg ccagtgcaga tcaccatctc tcagatgagc
     4621 aggaccccac cctctggcag tcttgtcttg ggagaatcac tctgagctcc catcctttgt
     4681 aaattaacat tggtttgagc accaccctcc atcacggctg cagtgagcca tgattgcacc
     4741 actgtgttcc agcctgggtg acagagcaag accccattcc aaaaaaaaaa aaaaatttgc
     4801 caaatagaca cagtcctcac aaaagaagtt ggcagaataa caccccttcc taccacatct
     4861 cctcagaacc tgtgtatttg ttaggttacg aaacaaaagg gaattaagtt tgctaatcag
     4921 ctgaccttaa aacaggaaga ggatcccgtg tttctgggtg ggccggagga atcacaaaga
     4981 tccctaaatg tggaagagga aggcaaaaaa gagtccacat caaagagact taagaaagac
     5041 ttgactagac actgctggtt ttgaagatgg gaagggaagg gtcagaagcc aaggaatgtg
     5101 tgtgctgtct agaagctgga aaaggcaagg aagtagattc tcccctagag cctcccagaa
     5161 ggagcgtagc cctgctgatg ccttaatttt agctcagtga gaccaggcgg acttaagacc
     5221 tatagaaccg tcagatgaca acattatgtt ttaagccgct acaattgtgg caatttgtta
     5281 aagtaacaat agaagaccta atgtaagtaa gtctcatgtg gaagttgcca tggttttgtt
     5341 tttctttctt tttttttttt tgagacagtc tcactctcac tccacgccca ggctggagtg
     5401 cagaggcgtg atctcagctc actgcaacct ccacctccag ggttcaagcg attctcctgc
     5461 ctcagcctcc tgagaagctg ggattacagg tgagcaccac cacacccagc taattttttt
     5521 ttgtattttt agtagagatg gagtttcacc atgttggcca ggatggtctt gatctcttgg
     5581 cctcatgatc cacctacctc agcctcccaa agtgttggta ttacaggcat gagccaccgc
     5641 acccaggccc catcattttt attttctaca attctggctg acatcttatt gctccatcct
     5701 tgctaatgat agacttcatc tcacatagac cagtgttttc agagaccggc ttattgattc
     5761 agtaaagggc tgggggaaac tgcacacaca aggacatata aaatctaagc ctctgcctgg
     5821 gccacatgac aggattcaga agcacctttg atataatggg tgcccgacct catgtgaaag
     5881 tccaagttca ggtgtaatgt gagagcggta agaattcact ggcctaggct tgggaactaa
     5941 tgctgcccac cacgttcagc ctcagaggag aagaaatgac ttgaagaaca taatttgtga
     6001 atttgccaat tgtttttcat tttatagcat cacacagtaa aagtagataa aataatttta
     6061 atgaaaatac ttctgtgggc caggtgcggt ggcttacgcc tgtaatccca gcactttggg
     6121 aggccgaggc ggcggatcac ctgaggtcag gagttctaga ccagcctgac caacatggag
     6181 aaaccccatc tctactaaaa atacaaaatt agctgggtgt ggtggcgcac tcctgttatc
     6241 ccagctactc aggaggctga ggcaggagaa ttgcttagac tcgggaggcg gaggttgggg
     6301 tgagccgaga tcacgccatt gtactccagc ctgggcaaca agagtgaaac tgtctcaaaa
     6361 aaaagaaaaa aaaacagaat tttgtgaaat aaaggccact tgggagtatc tgagccaccc
     6421 ca
//
