LOCUS       NM_152643               7021 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens kinase non-catalytic C-lobe domain containing 1
            (KNDC1), transcript variant 1, mRNA.
ACCESSION   NM_152643 NM_033404 XM_113594
VERSION     NM_152643.8
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7021)
  AUTHORS   Ji,J., Hao,Z., Liu,H., Liu,Y., Liu,J., Lin,B., Ma,C. and Lin,Y.
  TITLE     Effect of KNDC1 overexpression on the senescence of human umbilical
            vein endothelial cells
  JOURNAL   Mol Med Rep 17 (5), 7037-7044 (2018)
   PUBMED   29568929
  REMARK    GeneRIF: The results demonstrated that KNDC1 overexpression
            possibly inhibited HUVEC activity and function and promoted HUVEC
            senescence. Mechanistic studies demonstrated that KNDC1 triggered a
            p53ROS positive feedback loop, which serves a crucial role in
            regulating senescence.
REFERENCE   2  (bases 1 to 7021)
  AUTHORS   Hayashi,K., Furuya,A., Sakamaki,Y., Akagi,T., Shinoda,Y.,
            Sadakata,T., Hashikawa,T., Shimizu,K., Minami,H., Sano,Y.,
            Nakayama,M. and Furuichi,T.
  TITLE     The brain-specific RasGEF very-KIND is required for normal
            dendritic growth in cerebellar granule cells and proper motor
            coordination
  JOURNAL   PLoS One 12 (3), e0173175 (2017)
   PUBMED   28264072
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7021)
  AUTHORS   Zhang,C., Zhen,Y.Z., Lin,Y.J., Liu,J., Wei,J., Xu,R. and Hu,G.
  TITLE     KNDC1 knockdown protects human umbilical vein endothelial cells
            from senescence
  JOURNAL   Mol Med Rep 10 (1), 82-88 (2014)
   PUBMED   24788352
  REMARK    GeneRIF: KNDC1 knockdown promoted HUVEC proliferation via the
            extracellular signal-regulated kinase signaling pathway and delayed
            HUVEC senescence by inhibiting the p53-p21-p16 transduction
            cascade.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL445199.37.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_152643.7.
            
            Summary: The protein encoded by this gene is a Ras guanine
            nucleotide exchange factor that appears to negatively regulate
            dendritic growth in the brain. Knockdown of this gene in senescent
            umbilical vein endothelial cells partially reversed the senescence,
            showing that this gene could potentially be targeted by anti-aging
            therapies. [provided by RefSeq, Dec 2016].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2145245,
                              SAMEA2145743 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000304613.8/ ENSP00000304437.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-351               AL445199.37        129302-129652
            352-550             AL445199.37        136464-136662
            551-609             AL445199.37        137337-137395
            610-756             AL445199.37        152427-152573
            757-874             AL445199.37        152955-153072
            875-1575            AL445199.37        155057-155757
            1576-1690           AL445199.37        157622-157736
            1691-1762           AL445199.37        158681-158752
            1763-1824           AL445199.37        158835-158896
            1825-1983           AL445199.37        164746-164904
            1984-2061           AL445199.37        166141-166218
            2062-2155           AL445199.37        166758-166851
            2156-2318           AL445199.37        167420-167582
            2319-3007           AL445199.37        167661-168349
            3008-3152           AL445199.37        168541-168685
            3153-3238           AL445199.37        169458-169543
            3239-3636           AL445199.37        170584-170981
            3637-3730           AL445199.37        175768-175861
            3731-3828           AL445199.37        175939-176036
            3829-4043           AL445199.37        176220-176434
            4044-4157           AL445199.37        179694-179807
            4158-4305           AL445199.37        180505-180652
            4306-4485           AL445199.37        180762-180941
            4486-4692           AL445199.37        181799-182005
            4693-4775           AL445199.37        182728-182810
            4776-4926           AL445199.37        183055-183205
            4927-5049           AL445199.37        187914-188036
            5050-5109           AL445199.37        188114-188173
            5110-5267           AL445199.37        189038-189195
            5268-7021           AL445199.37        193742-195495
FEATURES             Location/Qualifiers
     source          1..7021
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q26.3"
     gene            1..7021
                     /gene="KNDC1"
                     /gene_synonym="bB439H18.3; C10orf23; RASGEF2; v-KIND;
                     Very-KIND"
                     /note="kinase non-catalytic C-lobe domain containing 1"
                     /db_xref="GeneID:85442"
                     /db_xref="HGNC:HGNC:29374"
                     /db_xref="MIM:616237"
     exon            1..351
                     /gene="KNDC1"
                     /gene_synonym="bB439H18.3; C10orf23; RASGEF2; v-KIND;
                     Very-KIND"
                     /inference="alignment:Splign:2.1.0"
     CDS             250..5499
                     /gene="KNDC1"
                     /gene_synonym="bB439H18.3; C10orf23; RASGEF2; v-KIND;
                     Very-KIND"
                     /note="isoform 1 is encoded by transcript variant 1;
                     RasGEF domain family, member 2; protein very KIND;
                     cerebral protein 9; KIND domain-containing protein 1;
                     ras-GEF domain-containing family member 2; kinase
                     non-catalytic C-lobe domain-containing protein 1; kinase
                     non-catalytic C-lobe domain (KIND) containing 1"
                     /codon_start=1
                     /product="kinase non-catalytic C-lobe domain-containing
                     protein 1 isoform 1"
                     /protein_id="NP_689856.6"
                     /db_xref="CCDS:CCDS7674.1"
                     /db_xref="GeneID:85442"
                     /db_xref="HGNC:HGNC:29374"
                     /db_xref="MIM:616237"
                     /translation="MQAMDPAAADLYEEDGKDLDFYDFEPLPTLPEDEENVSLADILS
                     LRDRGLSEQEAWAVCLECSLSMRSVAHAAIFQSLCITPDTLAFNTSGNVCFMEQLSDD
                     PEGAFVPPEFDVTGNTFEAHIYSLGATLKAALEYVAEPTLEPRLSQDLEALLSRMQAE
                     DPGDRPDLESIIALCEEKLQLTSSCRVCRSLSAVGRRVLSIESFGALQDVSESSWRER
                     PAPGNAGPRRPPGDPSTDPEVLPTPEGPESETSRGPRASPTKALLSTPVRNGESHSRE
                     GLAGLVLDAERTLGELDRDALRRSRLRKVQTFPRLLSDSPEATLCLPLTRGKSQLPIS
                     ELFSPDPRKAFLDRKNGLSSFQAQPKCRLWPEQEPEHQLGRVPCAGRSTDRGPGVPGS
                     PGQPETSHPSQGPAEAPADPRDASGEAQTPRDDERIPEGARQLESAAAEQWVSLQDLL
                     SQLGRPFREYELWALCLACLRALQTRPEHPAYLCLDSVLVAEDGAVLFQPPPANGSYD
                     SFFLAPELAEERLVTEKASVYCVAAVLWTAAKFSVPRNHKLALPRRLKTLLLDMARRS
                     APERPSAAEAIKVCGSYLLQRGMDSRKILAHLRASICQVYQEEETISLQNAFSVVELK
                     PSVAPAPEPSPGFLPVNSDTGLVAVPGPVPGQHPCGEEATQLPAAFTSEATHFKPIVL
                     AQNASVARDQPALAQEESEERGGQREGEGEEKLSLEAHAGSPSLKTPDGPVPGPGPQG
                     AAPEPLGASVQRDSAQGRPCPPPQAPANQPEGASSAAPGSPVPAPPTKASALPVEQGP
                     AEPIPPGVASGGLRPDALGPTTAHHGPRHPPKPPRSKATERPGQEPEGPGATPAGERD
                     DQSPDSVPERPRPADRRLCLPCVDASPLPGRTACPSLQEATRLIQEEFAFDGYLDNGL
                     EALIMGEYIFALKDLTFATFCGAISEKFCDLYWDEKLLQNLFKVVNGQASPSPSTAEE
                     AGSQLEGSQSPRSPSSKRPSLHRLGKEKPAMARTSSRAPCSPTSVSDVDSDALSRGNF
                     EVGFRPQRSVKAERAQQPEAGEDRRPAGGASDVEAVTRLARSKGVGPALSPGPAGFQS
                     CSPGWCSAFYEADCFGADVHNYVKDLGRQQADGALPDAQSPELEQQLMMEKRNYRKTL
                     KFYQKLLQKEKRNKGSDVKTMLSKLKGQLEEMKSRVQFLSLVKKYLQVMYAERWGLEP
                     CTLPVIVNIAAAPCDTLDFSPLDESSSLIFYNVNKHPGGRQKARILQAGTPLGLMAYL
                     YSSDAFLEGYVQQFLYTFRYFCTPHDFLHFLLDRINSTLTRAHQDPTSTFTKIYRRSL
                     CVLQAWVEDCYAVDFPRNSGLLGKLEDFISSKILPLDGSAKHLLGLLEVGMDRRAEGN
                     PRGTDLENPREAEEDARPFNALCKRLSEDGISRKSFPWRLPRGNGLVLPPHKERPYTI
                     AAALPKPCFLEDFYGPCAKTSEKGPYFLTEYSTHQLFSQLTLLQQELFQKCHPVHFLN
                     SRALGVMDKSTAIPKASSSESLSAKTCSLFLPNYVQDKYLLQLLRNADDVSTWVAAEI
                     VTSHTSKLQVNLLSKFLLIAKSCYEQRNFATAMQILSGLEHLAVRQSPAWRILPAKIA
                     EVMEELKAVEVFLKSDSLCLMEGRRFRAQPTLPSAHLLAMHIQQLETGGFTMTNGAHR
                     WSKLRNIAKVVSQVHAFQENPYTFSPDPKLQSYLKQRIARFSGADISTLAADSRANFH
                     QVSSEKHSRKIQDKLRRMKATFQ"
     exon            352..550
                     /gene="KNDC1"
                     /gene_synonym="bB439H18.3; C10orf23; RASGEF2; v-KIND;
                     Very-KIND"
                     /inference="alignment:Splign:2.1.0"
     exon            551..609
                     /gene="KNDC1"
                     /gene_synonym="bB439H18.3; C10orf23; RASGEF2; v-KIND;
                     Very-KIND"
                     /inference="alignment:Splign:2.1.0"
     exon            610..756
                     /gene="KNDC1"
                     /gene_synonym="bB439H18.3; C10orf23; RASGEF2; v-KIND;
                     Very-KIND"
                     /inference="alignment:Splign:2.1.0"
     exon            757..874
                     /gene="KNDC1"
                     /gene_synonym="bB439H18.3; C10orf23; RASGEF2; v-KIND;
                     Very-KIND"
                     /inference="alignment:Splign:2.1.0"
     exon            875..1575
                     /gene="KNDC1"
                     /gene_synonym="bB439H18.3; C10orf23; RASGEF2; v-KIND;
                     Very-KIND"
                     /inference="alignment:Splign:2.1.0"
     exon            1576..1690
                     /gene="KNDC1"
                     /gene_synonym="bB439H18.3; C10orf23; RASGEF2; v-KIND;
                     Very-KIND"
                     /inference="alignment:Splign:2.1.0"
     exon            1691..1762
                     /gene="KNDC1"
                     /gene_synonym="bB439H18.3; C10orf23; RASGEF2; v-KIND;
                     Very-KIND"
                     /inference="alignment:Splign:2.1.0"
     exon            1763..1824
                     /gene="KNDC1"
                     /gene_synonym="bB439H18.3; C10orf23; RASGEF2; v-KIND;
                     Very-KIND"
                     /inference="alignment:Splign:2.1.0"
     exon            1825..1983
                     /gene="KNDC1"
                     /gene_synonym="bB439H18.3; C10orf23; RASGEF2; v-KIND;
                     Very-KIND"
                     /inference="alignment:Splign:2.1.0"
     exon            1984..2061
                     /gene="KNDC1"
                     /gene_synonym="bB439H18.3; C10orf23; RASGEF2; v-KIND;
                     Very-KIND"
                     /inference="alignment:Splign:2.1.0"
     exon            2062..2155
                     /gene="KNDC1"
                     /gene_synonym="bB439H18.3; C10orf23; RASGEF2; v-KIND;
                     Very-KIND"
                     /inference="alignment:Splign:2.1.0"
     exon            2156..2318
                     /gene="KNDC1"
                     /gene_synonym="bB439H18.3; C10orf23; RASGEF2; v-KIND;
                     Very-KIND"
                     /inference="alignment:Splign:2.1.0"
     exon            2319..3007
                     /gene="KNDC1"
                     /gene_synonym="bB439H18.3; C10orf23; RASGEF2; v-KIND;
                     Very-KIND"
                     /inference="alignment:Splign:2.1.0"
     exon            3008..3152
                     /gene="KNDC1"
                     /gene_synonym="bB439H18.3; C10orf23; RASGEF2; v-KIND;
                     Very-KIND"
                     /inference="alignment:Splign:2.1.0"
     exon            3153..3238
                     /gene="KNDC1"
                     /gene_synonym="bB439H18.3; C10orf23; RASGEF2; v-KIND;
                     Very-KIND"
                     /inference="alignment:Splign:2.1.0"
     exon            3239..3636
                     /gene="KNDC1"
                     /gene_synonym="bB439H18.3; C10orf23; RASGEF2; v-KIND;
                     Very-KIND"
                     /inference="alignment:Splign:2.1.0"
     exon            3637..3730
                     /gene="KNDC1"
                     /gene_synonym="bB439H18.3; C10orf23; RASGEF2; v-KIND;
                     Very-KIND"
                     /inference="alignment:Splign:2.1.0"
     exon            3731..3828
                     /gene="KNDC1"
                     /gene_synonym="bB439H18.3; C10orf23; RASGEF2; v-KIND;
                     Very-KIND"
                     /inference="alignment:Splign:2.1.0"
     exon            3829..4043
                     /gene="KNDC1"
                     /gene_synonym="bB439H18.3; C10orf23; RASGEF2; v-KIND;
                     Very-KIND"
                     /inference="alignment:Splign:2.1.0"
     exon            4044..4157
                     /gene="KNDC1"
                     /gene_synonym="bB439H18.3; C10orf23; RASGEF2; v-KIND;
                     Very-KIND"
                     /inference="alignment:Splign:2.1.0"
     exon            4158..4305
                     /gene="KNDC1"
                     /gene_synonym="bB439H18.3; C10orf23; RASGEF2; v-KIND;
                     Very-KIND"
                     /inference="alignment:Splign:2.1.0"
     exon            4306..4485
                     /gene="KNDC1"
                     /gene_synonym="bB439H18.3; C10orf23; RASGEF2; v-KIND;
                     Very-KIND"
                     /inference="alignment:Splign:2.1.0"
     exon            4486..4692
                     /gene="KNDC1"
                     /gene_synonym="bB439H18.3; C10orf23; RASGEF2; v-KIND;
                     Very-KIND"
                     /inference="alignment:Splign:2.1.0"
     exon            4693..4775
                     /gene="KNDC1"
                     /gene_synonym="bB439H18.3; C10orf23; RASGEF2; v-KIND;
                     Very-KIND"
                     /inference="alignment:Splign:2.1.0"
     exon            4776..4926
                     /gene="KNDC1"
                     /gene_synonym="bB439H18.3; C10orf23; RASGEF2; v-KIND;
                     Very-KIND"
                     /inference="alignment:Splign:2.1.0"
     exon            4927..5049
                     /gene="KNDC1"
                     /gene_synonym="bB439H18.3; C10orf23; RASGEF2; v-KIND;
                     Very-KIND"
                     /inference="alignment:Splign:2.1.0"
     exon            5050..5109
                     /gene="KNDC1"
                     /gene_synonym="bB439H18.3; C10orf23; RASGEF2; v-KIND;
                     Very-KIND"
                     /inference="alignment:Splign:2.1.0"
     exon            5110..5267
                     /gene="KNDC1"
                     /gene_synonym="bB439H18.3; C10orf23; RASGEF2; v-KIND;
                     Very-KIND"
                     /inference="alignment:Splign:2.1.0"
     exon            5268..7021
                     /gene="KNDC1"
                     /gene_synonym="bB439H18.3; C10orf23; RASGEF2; v-KIND;
                     Very-KIND"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5742..5747
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KNDC1"
                     /gene_synonym="bB439H18.3; C10orf23; RASGEF2; v-KIND;
                     Very-KIND"
                     /note="hexamer: ATTAAA"
     polyA_site      5774
                     /gene="KNDC1"
                     /gene_synonym="bB439H18.3; C10orf23; RASGEF2; v-KIND;
                     Very-KIND"
                     /note="major polyA site"
     regulatory      7001..7006
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KNDC1"
                     /gene_synonym="bB439H18.3; C10orf23; RASGEF2; v-KIND;
                     Very-KIND"
                     /note="hexamer: AATAAA"
     polyA_site      7021
                     /gene="KNDC1"
                     /gene_synonym="bB439H18.3; C10orf23; RASGEF2; v-KIND;
                     Very-KIND"
                     /note="major polyA site"
ORIGIN      
        1 aggaaggagc gacgttccct aggcgccggg tccggacagc gccgcgcagc ccccgcgcac
       61 cccgcgcccc ccgcgccccc cgggcccgcc ccgtatccct gaccgcgtcc cctggagaca
      121 ctgcggcagc ggcgggcggg cgggggcggg cgagggccgg gcgcgtctcc atggagccag
      181 ggcgcgcgta gccgagccca gcccagccca gccggaggcc ccgggggcgg tgcgcggcgc
      241 ggccgcagga tgcaggccat ggacccggcc gcggcggatc tttacgagga ggacggcaaa
      301 gacctggact tctacgactt cgagccgctg cccaccctcc ccgaggacga ggagaacgtg
      361 tctctggctg acatcctctc cctgcgggac cgcggcctca gcgagcagga agcctgggcc
      421 gtgtgcctgg agtgcagcct gtccatgcgg agcgtggccc acgccgccat cttccagagc
      481 ctgtgcatca cgcccgacac cctggccttc aacaccagcg ggaacgtgtg tttcatggag
      541 cagctcagcg acgaccctga gggtgccttc gttccccccg agttcgacgt gaccgggaac
      601 acctttgagg cgcacatcta ctctctgggg gccacgctga aggccgccct cgagtacgtg
      661 gcagagccca cactggaacc caggctgagc caagacctcg aggcgctgct gagccggatg
      721 caggcggagg accccgggga ccggccggac cttgagagca tcatcgcgct gtgtgaagag
      781 aagctgcagc tcacatcctc ctgtcgcgtg tgccggagcc tctctgctgt ggggaggagg
      841 gtcctctcca tcgagtcctt cggagcgctg caggatgtca gcgagagcag ctggcgggag
      901 agacctgccc caggaaacgc tgggcccagg aggccgcccg gggaccccag cactgacccg
      961 gaggttctgc cgacccccga aggcccggag tctgagacga gccggggccc cagagcctcc
     1021 ccaaccaagg ctctgctgtc caccccggtg agaaatggcg agagccacag ccgggagggg
     1081 ctggccggcc tcgtcctgga tgccgagcgc accctcgggg agctggacag agacgccctc
     1141 aggagaagcc gcctgcggaa ggtgcagacg ttccctaggc tgctgtccga cagccccgag
     1201 gccaccctct gcctgccgct gacccgcggg aaaagccagc tgcccatatc ggaattattc
     1261 tctccggacc ccaggaaggc ctttctggac aggaaaaatg gcctttctag cttccaggct
     1321 cagcccaaat gcaggctgtg gccggagcag gagccggaac accagctggg acgggttccc
     1381 tgtgcaggcc gcagcacgga caggggccct ggggtgcccg gcagtccagg acagcccgag
     1441 acttcacacc ccagccaggg gccagcagag gcccctgcag accctcgaga tgctagcggt
     1501 gaagcccaga ctcccaggga cgatgagaga attccagaag gagctaggca gctggaaagt
     1561 gcagccgcgg agcagtgggt gtccctgcag gacctcctgt cccagctggg ccggcccttc
     1621 cgggagtacg agctgtgggc cctgtgcctg gcctgcctcc gcgcactgca gacacgccct
     1681 gagcacccag cctacctgtg tctggactcc gtgctggttg ctgaggacgg ggctgtgctc
     1741 ttccagccac cccctgccaa cggttcctat gactcgttct ttctggctcc cgagctggca
     1801 gaggagaggc tggtaactga aaaggcctct gtgtactgtg tggccgccgt tctgtggacc
     1861 gcagccaagt tcagcgtccc ccgcaaccac aagctggccc tgccacgcag gctcaagacc
     1921 ctcctcctgg acatggccag gcgcagtgcc ccggagcggc cgtccgcggc tgaggccatc
     1981 aaggtgtgcg gcagctacct cctccagcga ggcatggaca gccggaaaat ccttgcccac
     2041 ctcagagctt ccatctgcca ggtgtaccag gaggaagaga ccatcagcct ccaaaacgcc
     2101 ttctcagtgg ttgaactgaa gcccagtgtg gcaccagccc cagagcccag cccaggcttc
     2161 ctgccggtga acagcgacac cgggcttgtg gctgtgccag ggcccgtgcc cggccagcac
     2221 ccctgcggtg aagaagccac ccagctgcct gcagcgttca cctccgaggc cacgcacttc
     2281 aagcccattg tcctcgcgca gaacgcaagt gtggccaggg accagcctgc cttggcccag
     2341 gaggagtccg aggagagggg cggccagagg gagggagaag gtgaggagaa gctctccctg
     2401 gaggcccacg ctgggtcccc cagcctgaag acgcctgacg ggccggtgcc tggtccgggg
     2461 ccacagggag cagccccaga gcctcttggg gcgtcagtgc agcgtgactc agcccagggc
     2521 cgcccctgcc ctccacccca ggccccagca aaccagccag agggggcctc atcggcagct
     2581 cccggctctc cagtccccgc cccgcccacg aaggcatctg cgctgcccgt agagcaaggg
     2641 ccggctgagc cgatcccacc tggagttgct tccgggggcc tcaggcccga cgccctgggg
     2701 cccaccacgg cccaccacgg cccacgccac ccgcccaagc ccccacgaag caaggccacc
     2761 gagcgcccgg gccaggagcc agagggcccc ggggccaccc ctgccgggga acgtgatgac
     2821 cagagtccag acagtgtccc agagaggccg cggcccgcag accggaggct ctgtctgccc
     2881 tgcgtggatg cctcgccact cccagggagg acggcctgcc cgtcgctgca ggaggccacg
     2941 cgcctcatcc aggaggaatt tgccttcgat ggctacctgg acaatgggct ggaggctctg
     3001 atcatggggg agtacatctt cgccttgaaa gatctcacct ttgccacttt ctgtggcgcc
     3061 atttccgaga agttctgtga cctgtactgg gatgagaagt tgctgcagaa cctctttaag
     3121 gtggtcaacg ggcaggcgtc accctcccca agcacggccg aggaggctgg gtcacagctc
     3181 gagggcagcc aaagcccccg ctccccgtcc agcaagaggc cgtcgctgca ccgcctggga
     3241 aaagagaagc cagccatggc caggaccagc agcagggccc cctgctcacc cacctcggtg
     3301 tcggatgtgg actcggacgc actgtcacgg ggaaacttcg aggtggggtt tcggcctcag
     3361 aggtccgtaa aagccgagag agcgcagcag cctgaggctg gcgaggacag acggccagct
     3421 ggcggggcct cagacgtgga ggcagtgacc cgactggcca ggtccaaagg ggtcggccca
     3481 gccttgtccc ccggcccagc cggattccag agctgcagcc ccggctggtg cagcgccttc
     3541 tacgaggccg actgcttcgg ggccgacgtc cacaactacg tgaaggacct ggggcggcag
     3601 caggcggacg gggccctgcc cgacgcccag agcccggagc tggaacagca gctcatgatg
     3661 gagaaaagaa actaccgcaa gaccctgaag ttctaccaga aactcttaca gaaggaaaag
     3721 aggaacaaag gttccgacgt caagaccatg ctgtccaagc tgaaagggca gctagaagaa
     3781 atgaaatcca gggtgcaatt cctcagcttg gtcaagaagt atctgcaggt catgtacgcg
     3841 gaacgctggg gcctggagcc ctgcaccctc ccagtgatcg tgaacatcgc ggccgcaccc
     3901 tgcgacacgc tggacttcag ccccctggac gagtcctcct cgctcatctt ctacaacgtc
     3961 aacaagcacc cgggcggccg gcagaaggcc cgcatcctgc aggccggcac gccgctgggg
     4021 ctcatggcct acctgtactc cagtgatgcc ttcctggagg gttatgtgca gcaattcctc
     4081 tacaccttcc gctacttctg cacaccccac gacttcctgc acttcctcct cgaccgcatc
     4141 aacagcacgc tgaccagggc ccaccaggac cccacctcga ccttcaccaa gatctacagg
     4201 cggagcctct gcgtcctgca ggcctgggtg gaggactgct acgctgtgga cttccctcgg
     4261 aacagcgggc tgctggggaa gctagaggac ttcatctcct ccaagatcct acccctggac
     4321 ggctctgcca agcacctgct gggcctcctg gaggtgggca tggaccggcg ggccgagggc
     4381 aaccctcgcg gcacagacct ggagaacccc agggaggccg aggaggatgc cagacccttc
     4441 aacgccctct gtaagaggct ctcagaggac ggcatctcca ggaagagctt cccctggagg
     4501 ctgccccgag gcaacgggct ggtgctgccg ccacacaagg agcgccccta caccattgct
     4561 gccgccctgc ccaagccctg cttcctcgag gacttctacg gcccctgcgc caagaccagt
     4621 gagaaggggc cctacttcct gacggagtac agcactcacc agctcttcag ccagctcacg
     4681 ctgctacagc aggagttgtt tcaaaagtgc cacccggtcc acttcctgaa ctcacgggcc
     4741 ctgggcgtca tggacaagag cactgccatc cccaaagcca gctcttctga gtctctttcg
     4801 gccaaaacct gcagcttatt tctgcccaat tacgttcagg acaagtatct gttacagctt
     4861 ctaagaaacg cagatgacgt cagcacctgg gtggctgcag agattgtgac cagccacacc
     4921 tccaagctgc aggtgaactt gctgtccaaa tttttgctga ttgcaaaatc ttgctatgag
     4981 cagagaaact tcgcgacagc catgcagatc ctgagcgggc tggagcacct ggccgtgagg
     5041 cagtcccctg cctggagaat tctgcctgca aagatagcag aggtcatgga ggagctgaaa
     5101 gccgtggagg tcttcctgaa gagcgacagc ctgtgtctga tggaagggcg gcgcttccgg
     5161 gcgcagccca ccctgccctc ggcccacctc ctggccatgc acatccagca gctggagaca
     5221 ggcggcttca ccatgaccaa cggggcccac aggtggagca agctcaggaa catcgcaaag
     5281 gtggtgagcc aggtgcacgc gttccaggag aacccttaca ccttcagccc cgaccccaag
     5341 ctccagtcgt acctcaagca gaggattgcc cgcttcagcg gtgccgacat ttccacactc
     5401 gccgcagata gcagggccaa cttccaccag gtctccagcg agaagcactc acggaagatt
     5461 caggacaagc tacggaggat gaaggctaca ttccagtagc cgagctcggg cctggtgtgg
     5521 aattccagat ccgaatccga ctgtgggggg cgggctggga ggtgggagcc gcgtctcagg
     5581 cccggccgtt atcaaggccc ctccgccccc gaaccctggg gagctggacc aggaggtgga
     5641 ggctcagggg accccatggg gacaggcaga gctggtctcc tcccagcaga cggagccagg
     5701 acgggcacaa gagtcttgga ggtttgcgtg tttctgctag aattaaaaag ttaaatttaa
     5761 aaatgaaaat gaaagacagc ttcccaggag ttttgtgcct gtctgcgcct ctcacacaca
     5821 gataagtggc tcttacccag ctctcagtga ctcccccaca aaacagcaac agcctccacc
     5881 gccaactcaa caaacttcag agtagctcct ccctgagcag gtttctgagc cagcctgggt
     5941 tggctgagca acgaagggcc aaagctgacc tctgagtggc caactgcagc tcccagggac
     6001 tccgagacct ccggtccgag accctgcctg ggttcacccc ccacaaccca gacccagaac
     6061 cgctctcccc ttccctgccc agtgcccctc ctccccagcc cagaccccca ggtgcccaag
     6121 gcctgctgct ggagcaggca ccttgggctg ggcctgctcc cccagggccc agggcccccc
     6181 agcttagaac agcccttggt gaggtggtca tgcccgggca aaggccctgc ttcctggaaa
     6241 ggacactcag agcagctcca agacagaggc tctgtggcgg gggtccctga gagtgccccc
     6301 acccatctca tgccccaggg accgccactg cccaccgcct ccagcagcca tgcatgtgcg
     6361 cccgcagccc tgcctccaca gctcgccaca cactcacgct tcgccagaga caggaagtgc
     6421 gctgcctcca cggccccttg cccttgctca ggttcttgga ccccaggcag ctggtgtgga
     6481 gccccttggc cagggccatg ggagtcccgc gcagtcagct ccacattggc ctctgcagct
     6541 gggtgaccag agccccgggc acggccccag ctccgtgggg ctctcacggt gccaatcaca
     6601 agacccaggg ttgtgctttt gagttttaga attagtcatt ctttagagca gccagctagt
     6661 ggcatttcta ggaaaactgt gacctgtgac aaatcgctgc atttttaatg tcaagatgtg
     6721 ttttcccaca taaattcacc ggagacatcc gggccccgct tcgatgtaac atgagaggaa
     6781 gtcggcgtcc tggccacgaa atgcagttca ctttttttta ggcttttata tggattatgt
     6841 tttgctgacc cacgcccgca ttttcagatt ttgtatctaa cagacagtgc tcagtgcaaa
     6901 tcaacattcc agcggtcagg actgaccccg gggcagcact gggctcaggc ttcagcgcga
     6961 ctgtccgcat ggctccctcc cgtcctggca ccaatttctg aataaagtcc tttctaccag
     7021 c
//
