LOCUS       NM_001322255            2896 bp    mRNA    linear   PRI 15-FEB-2024
DEFINITION  Homo sapiens kinocilin (KNCN), transcript variant 1, mRNA.
ACCESSION   NM_001322255 XM_011540784
VERSION     NM_001322255.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2896)
  AUTHORS   Leibovici,M., Verpy,E., Goodyear,R.J., Zwaenepoel,I., Blanchard,S.,
            Laine,S., Richardson,G.P. and Petit,C.
  TITLE     Initial characterization of kinocilin, a protein of the hair cell
            kinocilium
  JOURNAL   Hear Res 203 (1-2), 144-153 (2005)
   PUBMED   15855039
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL136373.21.
            
            On Nov 27, 2019 this sequence version replaced NM_001322255.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.278999.1,
                                           SRR1803617.27878.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000481882.7/ ENSP00000419705.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-583               AL136373.21        23872-24454         c
            584-652             AL136373.21        22741-22809         c
            653-727             AL136373.21        22000-22074         c
            728-2896            AL136373.21        18448-20616         c
FEATURES             Location/Qualifiers
     source          1..2896
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p33"
     gene            1..2896
                     /gene="KNCN"
                     /gene_synonym="Kino; L5"
                     /note="kinocilin"
                     /db_xref="GeneID:148930"
                     /db_xref="HGNC:HGNC:26488"
                     /db_xref="MIM:611455"
     exon            1..583
                     /gene="KNCN"
                     /gene_synonym="Kino; L5"
                     /inference="alignment:Splign:2.1.0"
     CDS             433..807
                     /gene="KNCN"
                     /gene_synonym="Kino; L5"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="kinocilin isoform 1"
                     /protein_id="NP_001309184.1"
                     /db_xref="CCDS:CCDS81316.1"
                     /db_xref="GeneID:148930"
                     /db_xref="HGNC:HGNC:26488"
                     /db_xref="MIM:611455"
                     /translation="MDIPISSRDFRGLQLACVALGLVAGSIIIGISVSKAAAAMGGVF
                     IGAAVLGLLILAYPFLKARFNLDHILPTIGSLRIHPHPGADHGEGRSSTNGNKEGARS
                     SLSTVSRTLEKLKPGTRGAEEC"
     exon            584..652
                     /gene="KNCN"
                     /gene_synonym="Kino; L5"
                     /inference="alignment:Splign:2.1.0"
     exon            653..727
                     /gene="KNCN"
                     /gene_synonym="Kino; L5"
                     /inference="alignment:Splign:2.1.0"
     exon            728..2896
                     /gene="KNCN"
                     /gene_synonym="Kino; L5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1756..1761
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KNCN"
                     /gene_synonym="Kino; L5"
                     /note="hexamer: ATTAAA"
     polyA_site      1775
                     /gene="KNCN"
                     /gene_synonym="Kino; L5"
                     /note="major polyA site"
     regulatory      1825..1830
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KNCN"
                     /gene_synonym="Kino; L5"
                     /note="hexamer: AATAAA"
     polyA_site      1845
                     /gene="KNCN"
                     /gene_synonym="Kino; L5"
     regulatory      2873..2878
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KNCN"
                     /gene_synonym="Kino; L5"
                     /note="hexamer: AATAAA"
     polyA_site      2896
                     /gene="KNCN"
                     /gene_synonym="Kino; L5"
ORIGIN      
        1 agtaagtggc tctaggaagc tggggcagga tgtcctgggc aggggagctt gaactctcct
       61 gggtggaggc tggcagggaa ggatcctatg gaacaggccc agctccctag aactctggca
      121 gccaaagcag aaatgtagcc agacaggagt cccaagggtg ggcttcagct tcagagggct
      181 ttgagagagg aagagtaagc tgggtgacct cgtacagatc cctggtcaag gtgggactgg
      241 ggggcccgta gtggagcagt ggaataggac tgcagataaa tcccagggtt ccccacctat
      301 catcttactg cccagaaact cctaccctga agttggagcg ccaacaagga gacatccaag
      361 agcccagaaa cttccaggac ttttctgggg ccagactgca ccggctggag gcagtgcccc
      421 gggtgggcct gcatggacat ccccatcagc agcagagact tccgcggcct gcagctggcc
      481 tgcgtggctc tcgggctggt ggctggcagc atcattatcg gcatctccgt atccaaggct
      541 gcagctgcca tgggcggtgt ctttattggc gctgctgttc tggggctcct catcttggcc
      601 taccccttcc tgaaggctcg gttcaacctg gaccacatcc tgcctaccat agggagccta
      661 agaatccatc cccatccagg ggcagaccac ggggaaggaa gatccagcac caatggcaac
      721 aaggaaggag cccgcagcag cctgtccacc gtgagcagga ccctggagaa gctgaagccg
      781 gggacccggg gggctgagga atgctgaggc aaagtctgag cggctgccca tgccctgccc
      841 tcccatcctg cctgctgccc ctatgtcagt gccctcctgg gttaggagac ccggaccgga
      901 gacaagccag gccctgcaga ccccagagcg gctgggaaca gtgtctggaa tggggccttt
      961 tgcactcgcc cggccaagcc tctccaaaat ggattccact ggtgtgggct gggacctgga
     1021 gcaaggtgtc gccggacgcc cccacagggt tcccatgttt caggctcctg ccctggcctt
     1081 tctttctgga ctgcagctca gctttgttgc ctgttcaatc tactgatttg tttctctgga
     1141 atttggggtc caaggccctg actatgacca ggatgcccca gtcccttgct ctaacccggc
     1201 tacagaagtg aaccacaggc ccacaagaac cacagacagg gaccctccac ccccacggtc
     1261 tagcccaggg gctctagagc tcactagccc aatagagggg ctagacaaga ttcttttcca
     1321 aatatcaaaa ctcctggcag ttcctcaggg acaggctctg agcagcagtg aatcagatgg
     1381 gggaatttgg ggggctcaca aagggacagg tacaaacaac ttcgcctggg ggtcagagga
     1441 ggcaacttct cagctgagcc caggcctgag acccttggtg tcttaactcc accactcaag
     1501 gctttttgtg atctgacttc tctcttcctc ccatcttctc actgctccct gaacaagcaa
     1561 aacacattcc tgtctccaag ctttgccctg tgttctccag caccctccct gcttctgtct
     1621 gcctatcaaa caccccactt ttaaagtccc cgttcaaaaa atctcctacc cacgtggttt
     1681 cctcattctc ttccaccaac ctctgtcttg ccacctttca ggcagggctg aagtcttcct
     1741 tttcacaaaa caattattaa accatcttaa gtctactgaa cgttgcccct gctctagtgt
     1801 ctagcaccag accagtaggt gcttaataaa tgttaatgga ttcaatttaa tgtaaaaaca
     1861 attccctagg ctttccctgg gaagccactt caaagtccca tctaccgtgg gtagagcaag
     1921 gaggcccagg tgtggcctca cagaaaacat tgttcctccc tccacacctg caccctccag
     1981 gcagagttgt ttgacctcta cagagatacc ctctccatac ggcctctggc ctggtttagt
     2041 gagcagaaga caagctagaa atcacgtcct tcttccagga tcaatggaga cggcacttcc
     2101 tcttagaagc ctcccctgac ttcactgtgc ttcccagccc cagggtttcc ctccttcaca
     2161 gaccaatctg agtggccttt gtctatttcc cctcttgaga gtgggagcag agggccaggc
     2221 acccagacga caccccagtg gatgttggaa aaaccaaagt tttctgaagc acagagtcca
     2281 tctcagatgg gaaagctgag gccccactgg aaaaaggact catcgagtcc catggtgaaa
     2341 gatcacgggg ccaggcctgc agccaggtct cctatctctc cctatccaag gctctatctt
     2401 ctgctgtcct ctgcacaagt ggcagggatc agttctctga caacagtgcg acagacctcc
     2461 atgaaggggc tgccttccac aaatgctggc taggtgtaga gacttcgttt ccttcagctg
     2521 agagaagcaa cttcctctct ttgaactgcc ctcctctcca cccagctgct gcctattccc
     2581 tgccccttct cctttccttc attatcatca acaatatctc aggctgctgg tccctcctca
     2641 atcaatgagg agacccttcc tcctatccat cttcgatcct cacctcagtg ccccagagat
     2701 gccccagggt ggagggggtg ggaatggggg atgtggagac tgagctgtgg agagtgtggt
     2761 tccctccccc ctgcccatca acccctctca gccatgctct ccccagggtg gggctatgga
     2821 atccccgatg cctggcaggg ccaggcagag agagatgctg gggaccaggt ggaataaatc
     2881 aaggaatgaa agcata
//
