LOCUS       NM_032701               2286 bp    mRNA    linear   PRI 17-MAR-2024
DEFINITION  Homo sapiens lysine methyltransferase 5C (KMT5C), mRNA.
ACCESSION   NM_032701
VERSION     NM_032701.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2286)
  AUTHORS   Zeng,B., Wan,R., Chang,K., Li,J., Zhang,X., Shi,G., Ye,D. and Xu,F.
  TITLE     Lysine methyltransferase 5C increases the proliferation and
            metastatic abilities of clear cell renal cell carcinoma via aerobic
            glycolysis
  JOURNAL   Int J Oncol 64 (4) (2024)
   PUBMED   38426605
  REMARK    GeneRIF: Lysine methyltransferase 5C increases the proliferation
            and metastatic abilities of clear cell renal cell carcinoma via
            aerobic glycolysis.
REFERENCE   2  (bases 1 to 2286)
  AUTHORS   Papadaki,S. and Piperi,C.
  TITLE     Impact of Histone Lysine Methyltransferase SUV4-20H2 on Cancer
            Onset and Progression with Therapeutic Potential
  JOURNAL   Int J Mol Sci 25 (5), 2498 (2024)
   PUBMED   38473745
  REMARK    GeneRIF: Impact of Histone Lysine Methyltransferase SUV4-20H2 on
            Cancer Onset and Progression with Therapeutic Potential.
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2286)
  AUTHORS   Ryu,T.Y., Lee,J., Kang,Y., Son,M.Y., Kim,D.S., Lee,Y.S., Kim,M.Y.
            and Cho,H.S.
  TITLE     Epigenetic regulation of DHRS2 by SUV420H2 inhibits cell apoptosis
            in renal cell carcinoma
  JOURNAL   Biochem Biophys Res Commun 663, 41-46 (2023)
   PUBMED   37119764
  REMARK    GeneRIF: Epigenetic regulation of DHRS2 by SUV420H2 inhibits cell
            apoptosis in renal cell carcinoma.
REFERENCE   4  (bases 1 to 2286)
  AUTHORS   Boonsanay,V., Mosa,M.H., Looso,M., Weichenhan,D., Ceteci,F.,
            Pudelko,L., Lechel,A., Michel,C.S., Kunne,C., Farin,H.F., Plass,C.
            and Greten,F.R.
  TITLE     Loss of SUV420H2-Dependent Chromatin Compaction Drives Right-Sided
            Colon Cancer Progression
  JOURNAL   Gastroenterology 164 (2), 214-227 (2023)
   PUBMED   36402192
  REMARK    GeneRIF: Loss of SUV420H2-Dependent Chromatin Compaction Drives
            Right-Sided Colon Cancer Progression.
REFERENCE   5  (bases 1 to 2286)
  AUTHORS   Pal,A.S., Agredo,A., Lanman,N.A., Son,J., Sohal,I.S., Bains,M.,
            Li,C., Clingerman,J., Gates,K. and Kasinski,A.L.
  TITLE     Loss of KMT5C Promotes EGFR Inhibitor Resistance in NSCLC via
            LINC01510-Mediated Upregulation of MET
  JOURNAL   Cancer Res 82 (8), 1534-1547 (2022)
   PUBMED   35404406
  REMARK    GeneRIF: Loss of KMT5C Promotes EGFR Inhibitor Resistance in NSCLC
            via LINC01510-Mediated Upregulation of MET.
REFERENCE   6  (bases 1 to 2286)
  AUTHORS   Allis,C.D., Berger,S.L., Cote,J., Dent,S., Jenuwien,T.,
            Kouzarides,T., Pillus,L., Reinberg,D., Shi,Y., Shiekhattar,R.,
            Shilatifard,A., Workman,J. and Zhang,Y.
  TITLE     New nomenclature for chromatin-modifying enzymes
  JOURNAL   Cell 131 (4), 633-636 (2007)
   PUBMED   18022353
REFERENCE   7  (bases 1 to 2286)
  AUTHORS   Szafranski,K., Schindler,S., Taudien,S., Hiller,M., Huse,K.,
            Jahn,N., Schreiber,S., Backofen,R. and Platzer,M.
  TITLE     Violating the splicing rules: TG dinucleotides function as
            alternative 3' splice sites in U2-dependent introns
  JOURNAL   Genome Biol 8 (8), R154 (2007)
   PUBMED   17672918
  REMARK    GeneRIF: occurrence of an unusual TG 3' splice site in intron 5
REFERENCE   8  (bases 1 to 2286)
  AUTHORS   Tryndyak,V.P., Kovalchuk,O. and Pogribny,I.P.
  TITLE     Loss of DNA methylation and histone H4 lysine 20 trimethylation in
            human breast cancer cells is associated with aberrant expression of
            DNA methyltransferase 1, Suv4-20h2 histone methyltransferase and
            methyl-binding proteins
  JOURNAL   Cancer Biol Ther 5 (1), 65-70 (2006)
   PUBMED   16322686
  REMARK    GeneRIF: The decrease in trimethylation of lysine 20 of histone H4
            in breast cancer cells was accompanied by diminished expression of
            Suv4-20h2 histone methyltransferase.
REFERENCE   9  (bases 1 to 2286)
  AUTHORS   Wan,D., Gong,Y., Qin,W., Zhang,P., Li,J., Wei,L., Zhou,X., Li,H.,
            Qiu,X., Zhong,F., He,L., Yu,J., Yao,G., Jiang,H., Qian,L., Yu,Y.,
            Shu,H., Chen,X., Xu,H., Guo,M., Pan,Z., Chen,Y., Ge,C., Yang,S. and
            Gu,J.
  TITLE     Large-scale cDNA transfection screening for genes related to cancer
            development and progression
  JOURNAL   Proc Natl Acad Sci U S A 101 (44), 15724-15729 (2004)
   PUBMED   15498874
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 Dec 14:101(50):17565]
REFERENCE   10 (bases 1 to 2286)
  AUTHORS   Schotta,G., Lachner,M., Sarma,K., Ebert,A., Sengupta,R., Reuter,G.,
            Reinberg,D. and Jenuwein,T.
  TITLE     A silencing pathway to induce H3-K9 and H4-K20 trimethylation at
            constitutive heterochromatin
  JOURNAL   Genes Dev 18 (11), 1251-1262 (2004)
   PUBMED   15145825
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK308586.1, BC044889.1 and AW248704.1.
            
            On Nov 22, 2018 this sequence version replaced NM_032701.3.
            
            Summary: SUV420H2 and the related enzyme SUV420H1 (MIM 610881)
            function as histone methyltransferases that specifically
            trimethylate nucleosomal histone H4 (see MIM 602822) on lysine-20
            (K20) (Schotta et al., 2004 [PubMed 15145825]).[supplied by OMIM,
            Dec 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC044889.1, SRR3476690.629103.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000255613.8/ ENSP00000255613.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                AK308586.1         24-43
            21-2194             BC044889.1         1-2174
            2195-2286           AW248704.1         10-101              c
FEATURES             Location/Qualifiers
     source          1..2286
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.42"
     gene            1..2286
                     /gene="KMT5C"
                     /gene_synonym="Suv4-20h2; SUV420H2"
                     /note="lysine methyltransferase 5C"
                     /db_xref="GeneID:84787"
                     /db_xref="HGNC:HGNC:28405"
                     /db_xref="MIM:613198"
     exon            1..82
                     /gene="KMT5C"
                     /gene_synonym="Suv4-20h2; SUV420H2"
                     /inference="alignment:Splign:2.1.0"
     exon            83..335
                     /gene="KMT5C"
                     /gene_synonym="Suv4-20h2; SUV420H2"
                     /inference="alignment:Splign:2.1.0"
     CDS             226..1614
                     /gene="KMT5C"
                     /gene_synonym="Suv4-20h2; SUV420H2"
                     /EC_number="2.1.1.361"
                     /EC_number="2.1.1.362"
                     /note="histone-lysine N-methyltransferase SUV420H2;
                     su(var)4-20 homolog 2; lysine N-methyltransferase 5C;
                     suppressor of variegation 4-20 homolog 2; lysine
                     (K)-specific methyltransferase 5C; lysine-specific
                     methyltransferase 5C; [histone H4]-lysine20
                     N-methyltransferase KMT5B; [histone
                     H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B"
                     /codon_start=1
                     /product="histone-lysine N-methyltransferase KMT5C"
                     /protein_id="NP_116090.2"
                     /db_xref="CCDS:CCDS12922.1"
                     /db_xref="GeneID:84787"
                     /db_xref="HGNC:HGNC:28405"
                     /db_xref="MIM:613198"
                     /translation="MGPDRVTARELCENDDLATSLVLDPYLGFRTHKMNVSPVPPLRR
                     QQHLRSALETFLRQRDLEAAYRALTLGGWTARYFQSRGPRQEAALKTHVYRYLRAFLP
                     ESGFTILPCTRYSMETNGAKIVSTRAWKKNEKLELLVGCIAELREADEGLLRAGENDF
                     SIMYSTRKRSAQLWLGPAAFINHDCKPNCKFVPADGNAACVKVLRDIEPGDEVTCFYG
                     EGFFGEKNEHCECHTCERKGEGAFRTRPREPALPPRPLDKYQLRETKRRLQQGLDSGS
                     RQGLLGPRACVHPSPLRRDPFCAACQPLRLPACSARPDTSPLWLQWLPQPQPRVRPRK
                     RRRPRPRRAPVLSTHHAARVSLHRWGGCGPHCRLRGEALVALGQPPHARWAPQQDWHW
                     ARRYGLPYVVRVDLRRLAPAPPATPAPAGTPGPILIPKQALAFAPFSPPKRLRLVVSH
                     GSIDLDVGGEEL"
     exon            336..501
                     /gene="KMT5C"
                     /gene_synonym="Suv4-20h2; SUV420H2"
                     /inference="alignment:Splign:2.1.0"
     exon            502..611
                     /gene="KMT5C"
                     /gene_synonym="Suv4-20h2; SUV420H2"
                     /inference="alignment:Splign:2.1.0"
     exon            612..775
                     /gene="KMT5C"
                     /gene_synonym="Suv4-20h2; SUV420H2"
                     /inference="alignment:Splign:2.1.0"
     exon            776..795
                     /gene="KMT5C"
                     /gene_synonym="Suv4-20h2; SUV420H2"
                     /inference="alignment:Splign:2.1.0"
     exon            796..932
                     /gene="KMT5C"
                     /gene_synonym="Suv4-20h2; SUV420H2"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1120
                     /gene="KMT5C"
                     /gene_synonym="Suv4-20h2; SUV420H2"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..2286
                     /gene="KMT5C"
                     /gene_synonym="Suv4-20h2; SUV420H2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2263..2268
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KMT5C"
                     /gene_synonym="Suv4-20h2; SUV420H2"
                     /note="hexamer: ATTAAA"
     polyA_site      2286
                     /gene="KMT5C"
                     /gene_synonym="Suv4-20h2; SUV420H2"
                     /note="major polyA site"
ORIGIN      
        1 agtgtttgac gagagccgaa ggaggctgtg ggaggtgttg gcggcggcgg cgcgggcgcc
       61 tgaggaggag gaggagaagc ggatgagatc gtggggctca ccagcgtccc ccatggcttc
      121 tgagtagcgt gggagtggag tcagcaccaa gccaggctcc ccgcgcctgc cttgccctca
      181 cctgctcctg ctctctgcca gaggcagcat ggtccgcagg gcaccatggg gcccgacaga
      241 gtgacagcac gagaactgtg cgagaacgac gacctggcca ccagcctcgt cctggacccc
      301 tacctcggtt tccgcaccca taagatgaac gtcagccctg tgccccccct gcggcgacag
      361 cagcacctgc gctcagcgct ggaaactttc ctgaggcagc gggacctgga ggctgcgtac
      421 cgggccctga cgctgggagg ctggacggcc cgctacttcc agagccgggg cccgcggcag
      481 gaggctgccc tcaagaccca cgtctatcgc tacctccgtg ccttcctgcc ggaaagtggc
      541 tttaccatcc tgccctgcac gcgctactcc atggagacca acggggccaa gatcgtgtcc
      601 actcgtgctt ggaaaaagaa tgagaagctg gagctgctgg tgggctgcat tgcagagctg
      661 cgggaggcag atgaggggct gctgagggcc ggtgagaatg acttcagcat catgtactca
      721 acccgcaagc ggagtgctca gctgtggctg ggcccagccg ccttcatcaa ccatgactgc
      781 aaacccaact gcaagtttgt gcctgcagat gggaacgcag cctgcgtgaa ggtgctccgg
      841 gacattgagc ctggggacga ggtgacatgc ttctacggcg agggcttctt cggcgagaag
      901 aatgagcact gtgaatgcca cacctgtgag aggaaaggtg aaggagcttt ccgaaccagg
      961 cctagggagc ccgcgttgcc accacggccc ctggacaagt accagctgcg tgagaccaag
     1021 cggcggctgc agcaaggcct ggacagtggc agccgacagg gcctgctggg ccctcgggcc
     1081 tgcgtgcacc catccccgct gcgccgggac ccattctgcg ccgcctgcca gcccctgcgc
     1141 ctgccagcct gcagcgcccg cccagacacc tcacccctct ggctccagtg gctgcctcag
     1201 ccccagcccc gagtgcggcc ccggaagcgc cgacgccccc ggccccggag ggccccagtg
     1261 ctctccaccc accacgctgc ccgcgtctcc ctgcaccgat ggggaggctg tggcccccac
     1321 tgccgcctgc gaggagaggc cctggtggcc ctgggccagc ccccccacgc ccgctgggcc
     1381 cctcagcagg actggcactg ggcccggcgc tatgggctgc cttacgtggt gcgtgtggac
     1441 cttcgtcgcc tggccccagc cccaccagct accccagccc ctgctgggac cccaggcccc
     1501 atcctgatcc cgaagcaggc cctcgccttc gcccccttct ccccacccaa gcgcctacgg
     1561 ctggtggtca gccacggctc catcgacctg gatgtcggcg gtgaagagct gtgacaggcc
     1621 ggacggggag gcccagcagg gagagagggt ctctctccta gctgctaccc aggacctcca
     1681 gaaggagccc ttggacctct gggagggagc tgacccttga ctccagcata gctctgaccc
     1741 tggaatgggg ttggtttgga cacccccagg gatctgagcc ctgacccttt gtgactgctg
     1801 acccctgagc cacccccact cccacaggga gccccggcca tttgctgccc tccccacccc
     1861 tgccccagcc tcaggactgc aggagccatc cgcccccctc agccccttcc tccccaggga
     1921 gcaaagccat aaggggcagg ggccacccca cggcatctcc ccagaagtac aggcctcagg
     1981 aggaggtgga actgatgtag ggggtggcac tccccagaga ctgccctcac gaggggactg
     2041 ggttcgctct cagctctgca gctgtctgcg gtggggggaa ggttgggggg tgtctggagg
     2101 catgttcccc tcaccacccc ccgtgggtct cagggaggcc gggtgtgacc tcatctttct
     2161 catggtgcta tcctggtgct attggggtgg ggagctccct cccctccccc acaccagaaa
     2221 ggggtatgtt gggggcttgg aagcacttga actttttatt ttattaaaac cttgttataa
     2281 gcagca
//
