LOCUS       NM_017635               5718 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens lysine methyltransferase 5B (KMT5B), transcript
            variant 1, mRNA.
ACCESSION   NM_017635
VERSION     NM_017635.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5718)
  AUTHORS   Kato,H., Hayami,S., Ueno,M., Suzaki,N., Nakamura,M., Yoshimura,T.,
            Miyamoto,A., Shigekawa,Y., Okada,K.I., Miyazawa,M., Kitahata,Y.,
            Ehata,S., Hamamoto,R., Yamaue,H. and Kawai,M.
  TITLE     Histone methyltransferase SUV420H1/KMT5B contributes to poor
            prognosis in hepatocellular carcinoma
  JOURNAL   Cancer Sci 115 (2), 385-400 (2024)
   PUBMED   38082550
  REMARK    GeneRIF: Histone methyltransferase SUV420H1/KMT5B contributes to
            poor prognosis in hepatocellular carcinoma.
REFERENCE   2  (bases 1 to 5718)
  AUTHORS   Abini-Agbomson,S., Gretarsson,K., Shih,R.M., Hsieh,L., Lou,T., De
            Ioannes,P., Vasilyev,N., Lee,R., Wang,M., Simon,M.D., Armache,J.P.,
            Nudler,E., Narlikar,G., Liu,S., Lu,C. and Armache,K.J.
  TITLE     Catalytic and non-catalytic mechanisms of histone H4 lysine 20
            methyltransferase SUV420H1
  JOURNAL   Mol Cell 83 (16), 2872-2883 (2023)
   PUBMED   37595555
  REMARK    GeneRIF: Catalytic and non-catalytic mechanisms of histone H4
            lysine 20 methyltransferase SUV420H1.
REFERENCE   3  (bases 1 to 5718)
  AUTHORS   Sheppard,S.E., Bryant,L., Wickramasekara,R.N., Vaccaro,C.,
            Robertson,B., Hallgren,J., Hulen,J., Watson,C.J., Faundes,V.,
            Duffourd,Y., Lee,P., Simon,M.C., de la Cruz,X., Padilla,N.,
            Flores-Mendez,M., Akizu,N., Smiler,J., Pellegrino Da Silva,R.,
            Li,D., March,M., Diaz-Rosado,A., Peixoto de Barcelos,I., Choa,Z.X.,
            Lim,C.Y., Dubourg,C., Journel,H., Demurger,F., Mulhern,M.,
            Akman,C., Lippa,N., Andrews,M., Baldridge,D., Constantino,J., van
            Haeringen,A., Snoeck-Streef,I., Chow,P., Hing,A., Graham,J.M. Jr.,
            Au,M., Faivre,L., Shen,W., Mao,R., Palumbos,J., Viskochil,D.,
            Gahl,W., Tifft,C., Macnamara,E., Hauser,N., Miller,R., Maffeo,J.,
            Afenjar,A., Doummar,D., Keren,B., Arn,P., Macklin-Mantia,S.,
            Meerschaut,I., Callewaert,B., Reis,A., Zweier,C., Brewer,C.,
            Saggar,A., Smeland,M.F., Kumar,A., Elmslie,F., Deshpande,C.,
            Nizon,M., Cogne,B., van Ierland,Y., Wilke,M., van Slegtenhorst,M.,
            Koudijs,S., Chen,J.Y., Dredge,D., Pier,D., Wortmann,S.,
            Kamsteeg,E.J., Koch,J., Haynes,D., Pollack,L., Titheradge,H.,
            Ranguin,K., Denomme-Pichon,A.S., Weber,S., Perez de la Fuente,R.,
            Sanchez Del Pozo,J., Lezana Rosales,J.M., Joset,P., Steindl,K.,
            Rauch,A., Mei,D., Mari,F., Guerrini,R., Lespinasse,J., Tran
            Mau-Them,F., Philippe,C., Dauriat,B., Raymond,L., Moutton,S.,
            Cueto-Gonzalez,A.M., Tan,T.Y., Mignot,C., Grotto,S., Renaldo,F.,
            Drivas,T.G., Hennessy,L., Raper,A., Parenti,I., Kaiser,F.J.,
            Kuechler,A., Busk,O.L., Islam,L., Siedlik,J.A., Henderson,L.B.,
            Juusola,J., Person,R., Schnur,R.E., Vitobello,A., Banka,S.,
            Bhoj,E.J. and Stessman,H.A.F.
  TITLE     Mechanism of KMT5B haploinsufficiency in neurodevelopment in humans
            and mice
  JOURNAL   Sci Adv 9 (10), eade1463 (2023)
   PUBMED   36897941
  REMARK    GeneRIF: Mechanism of KMT5B haploinsufficiency in neurodevelopment
            in humans and mice.
REFERENCE   4  (bases 1 to 5718)
  AUTHORS   Chen,G., Han,L., Tan,S., Jia,X., Wu,H., Quan,Y., Zhang,Q., Yu,B.,
            Hu,Z., Xia,K. and Guo,H.
  TITLE     Loss-of-function of KMT5B leads to neurodevelopmental disorder and
            impairs neuronal development and neurogenesis
  JOURNAL   J Genet Genomics 49 (9), 881-890 (2022)
   PUBMED   35331928
  REMARK    GeneRIF: Loss-of-function of KMT5B leads to neurodevelopmental
            disorder and impairs neuronal development and neurogenesis.
REFERENCE   5  (bases 1 to 5718)
  AUTHORS   Lin,W.Y., Fordham,S.E., Hungate,E., Sunter,N.J., Elstob,C., Xu,Y.,
            Park,C., Quante,A., Strauch,K., Gieger,C., Skol,A., Rahman,T.,
            Sucheston-Campbell,L., Wang,J., Hahn,T., Clay-Gilmour,A.I.,
            Jones,G.L., Marr,H.J., Jackson,G.H., Menne,T., Collin,M., Ivey,A.,
            Hills,R.K., Burnett,A.K., Russell,N.H., Fitzgibbon,J., Larson,R.A.,
            Le Beau,M.M., Stock,W., Heidenreich,O., Alharbi,A., Allsup,D.J.,
            Houlston,R.S., Norden,J., Dickinson,A.M., Douglas,E., Lendrem,C.,
            Daly,A.K., Palm,L., Piechocki,K., Jeffries,S., Bornhauser,M.,
            Rollig,C., Altmann,H., Ruhnke,L., Kunadt,D., Wagenfuhr,L.,
            Cordell,H.J., Darlay,R., Andersen,M.K., Fontana,M.C.,
            Martinelli,G., Marconi,G., Sanz,M.A., Cervera,J., Gomez-Segui,I.,
            Cluzeau,T., Moreilhon,C., Raynaud,S., Sill,H., Voso,M.T.,
            Lo-Coco,F., Dombret,H., Cheok,M., Preudhomme,C., Gale,R.E.,
            Linch,D., Gaal-Wesinger,J., Masszi,A., Nowak,D., Hofmann,W.K.,
            Gilkes,A., Porkka,K., Milosevic Feenstra,J.D., Kralovics,R.,
            Grimwade,D., Meggendorfer,M., Haferlach,T., Krizsan,S., Bodor,C.,
            Stolzel,F., Onel,K. and Allan,J.M.
  TITLE     Genome-wide association study identifies susceptibility loci for
            acute myeloid leukemia
  JOURNAL   Nat Commun 12 (1), 6233 (2021)
   PUBMED   34716350
  REMARK    GeneRIF: Genome-wide association study identifies susceptibility
            loci for acute myeloid leukemia.
            Erratum:[Nat Commun. 2022 Jan 4;13(1):2. doi:
            10.1038/s41467-021-27679-6.. PMID: 34983928]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5718)
  AUTHORS   Yang,H., Pesavento,J.J., Starnes,T.W., Cryderman,D.E.,
            Wallrath,L.L., Kelleher,N.L. and Mizzen,C.A.
  TITLE     Preferential dimethylation of histone H4 lysine 20 by Suv4-20
  JOURNAL   J Biol Chem 283 (18), 12085-12092 (2008)
   PUBMED   18296440
  REMARK    GeneRIF: The data indicate that Suv4-20 generates nearly ubiquitous
            dimethylation that facilitates the DNA damage response and
            selective trimethylation that is involved in heterochromatin
            formation.[Suv4-20]
REFERENCE   7  (bases 1 to 5718)
  AUTHORS   Allis,C.D., Berger,S.L., Cote,J., Dent,S., Jenuwien,T.,
            Kouzarides,T., Pillus,L., Reinberg,D., Shi,Y., Shiekhattar,R.,
            Shilatifard,A., Workman,J. and Zhang,Y.
  TITLE     New nomenclature for chromatin-modifying enzymes
  JOURNAL   Cell 131 (4), 633-636 (2007)
   PUBMED   18022353
REFERENCE   8  (bases 1 to 5718)
  AUTHORS   Shi,X., Kachirskaia,I., Yamaguchi,H., West,L.E., Wen,H., Wang,E.W.,
            Dutta,S., Appella,E. and Gozani,O.
  TITLE     Modulation of p53 function by SET8-mediated methylation at lysine
            382
  JOURNAL   Mol Cell 27 (4), 636-646 (2007)
   PUBMED   17707234
REFERENCE   9  (bases 1 to 5718)
  AUTHORS   Tryndyak,V.P., Kovalchuk,O. and Pogribny,I.P.
  TITLE     Loss of DNA methylation and histone H4 lysine 20 trimethylation in
            human breast cancer cells is associated with aberrant expression of
            DNA methyltransferase 1, Suv4-20h2 histone methyltransferase and
            methyl-binding proteins
  JOURNAL   Cancer Biol Ther 5 (1), 65-70 (2006)
   PUBMED   16322686
REFERENCE   10 (bases 1 to 5718)
  AUTHORS   Twells,R.C., Metzker,M.L., Brown,S.D., Cox,R., Garey,C.,
            Hammond,H., Hey,P.J., Levy,E., Nakagawa,Y., Philips,M.S., Todd,J.A.
            and Hess,J.F.
  TITLE     The sequence and gene characterization of a 400-kb candidate region
            for IDDM4 on chromosome 11q13
  JOURNAL   Genomics 72 (3), 231-242 (2001)
   PUBMED   11401438
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC108304.1, BC099714.1 and
            AP002992.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_017635.4.
            
            Summary: This gene encodes a protein that contains a SET domain.
            SET domains appear to be protein-protein interaction domains that
            mediate interactions with a family of proteins that display
            similarity with dual-specificity phosphatases (dsPTPases). The
            function of this gene has not been determined. Several
            alternatively spliced transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Jul
            2014].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.17916.1,
                                           SRR1660807.115891.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000304363.9/ ENSP00000305899.4
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-230               BC108304.1         122-351
            231-3001            BC099714.1         1-2771
            3002-5718           AP002992.4         83096-85812         c
FEATURES             Location/Qualifiers
     source          1..5718
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.2"
     gene            1..5718
                     /gene="KMT5B"
                     /gene_synonym="CGI-85; CGI85; MRD51; SUV420H1"
                     /note="lysine methyltransferase 5B"
                     /db_xref="GeneID:51111"
                     /db_xref="HGNC:HGNC:24283"
                     /db_xref="MIM:610881"
     exon            1..159
                     /gene="KMT5B"
                     /gene_synonym="CGI-85; CGI85; MRD51; SUV420H1"
                     /inference="alignment:Splign:2.1.0"
     exon            160..395
                     /gene="KMT5B"
                     /gene_synonym="CGI-85; CGI85; MRD51; SUV420H1"
                     /inference="alignment:Splign:2.1.0"
     CDS             236..2893
                     /gene="KMT5B"
                     /gene_synonym="CGI-85; CGI85; MRD51; SUV420H1"
                     /EC_number="2.1.1.361"
                     /EC_number="2.1.1.362"
                     /note="isoform 1 is encoded by transcript variant 1;
                     histone-lysine N-methyltransferase SUV420H1; [histone
                     H4]-lysine20 N-methyltransferase KMT5B; [histone
                     H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B;
                     su(var)4-20 homolog 1; lysine N-methyltransferase 5B;
                     suppressor of variegation 4-20 homolog 1; lysine
                     (K)-specific methyltransferase 5B; lysine-specific
                     methyltransferase 5B; histone-lysine N-methyltransferase
                     KMT5B"
                     /codon_start=1
                     /product="histone-lysine N-methyltransferase KMT5B isoform
                     1"
                     /protein_id="NP_060105.3"
                     /db_xref="CCDS:CCDS31623.1"
                     /db_xref="GeneID:51111"
                     /db_xref="HGNC:HGNC:24283"
                     /db_xref="MIM:610881"
                     /translation="MKWLGESKNMVVNGRRNGGKLSNDHQQNQSKLQHTGKDTLKAGK
                     NAVERRSNRCNGNSGFEGQSRYVPSSGMSAKELCENDDLATSLVLDPYLGFQTHKMNT
                     SAFPSRSSRHFSKSDSFSHNNPVRFRPIKGRQEELKEVIERFKKDEHLEKAFKCLTSG
                     EWARHYFLNKNKMQEKLFKEHVFIYLRMFATDSGFEILPCNRYSSEQNGAKIVATKEW
                     KRNDKIELLVGCIAELSEIEENMLLRHGENDFSVMYSTRKNCAQLWLGPAAFINHDCR
                     PNCKFVSTGRDTACVKALRDIEPGEEISCYYGDGFFGENNEFCECYTCERRGTGAFKS
                     RVGLPAPAPVINSKYGLRETDKRLNRLKKLGDSSKNSDSQSVSSNTDADTTQEKNNAT
                     SNRKSSVGVKKNSKSRTLTRQSMSRIPASSNSTSSKLTHINNSRVPKKLKKPAKPLLS
                     KIKLRNHCKRLEQKNASRKLEMGNLVLKEPKVVLYKNLPIKKDKEPEGPAQAAVASGC
                     LTRHAAREHRQNPVRGAHSQGESSPCTYITRRSVRTRTNLKEASDIKLEPNTLNGYKS
                     SVTEPCPDSGEQLQPAPVLQEEELAHETAQKGEAKCHKSDTGMSKKKSRQGKLVKQFA
                     KIEESTPVHDSPGKDDAVPDLMGPHSDQGEHSGTVGVPVSYTDCAPSPVGCSVVTSDS
                     FKTKDSFRTAKSKKKRRITRYDAQLILENNSGIPKLTLRRRHDSSSKTNDQENDGMNS
                     SKISIKLSKDHDNDNNLYVAKLNNGFNSGSGSSSTKLKIQLKRDEENRGSYTEGLHEN
                     GVCCSDPLSLLESRMEVDDYSQYEEESTDDSSSSEGDEEEDDYDDDFEDDFIPLPPAK
                     RLRLIVGKDSIDIDISSRRREDQSLRLNA"
     exon            396..543
                     /gene="KMT5B"
                     /gene_synonym="CGI-85; CGI85; MRD51; SUV420H1"
                     /inference="alignment:Splign:2.1.0"
     exon            544..612
                     /gene="KMT5B"
                     /gene_synonym="CGI-85; CGI85; MRD51; SUV420H1"
                     /inference="alignment:Splign:2.1.0"
     exon            613..778
                     /gene="KMT5B"
                     /gene_synonym="CGI-85; CGI85; MRD51; SUV420H1"
                     /inference="alignment:Splign:2.1.0"
     exon            779..888
                     /gene="KMT5B"
                     /gene_synonym="CGI-85; CGI85; MRD51; SUV420H1"
                     /inference="alignment:Splign:2.1.0"
     exon            889..1055
                     /gene="KMT5B"
                     /gene_synonym="CGI-85; CGI85; MRD51; SUV420H1"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1075
                     /gene="KMT5B"
                     /gene_synonym="CGI-85; CGI85; MRD51; SUV420H1"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1212
                     /gene="KMT5B"
                     /gene_synonym="CGI-85; CGI85; MRD51; SUV420H1"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1409
                     /gene="KMT5B"
                     /gene_synonym="CGI-85; CGI85; MRD51; SUV420H1"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..5718
                     /gene="KMT5B"
                     /gene_synonym="CGI-85; CGI85; MRD51; SUV420H1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5696..5701
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KMT5B"
                     /gene_synonym="CGI-85; CGI85; MRD51; SUV420H1"
                     /note="hexamer: AATAAA"
     polyA_site      5718
                     /gene="KMT5B"
                     /gene_synonym="CGI-85; CGI85; MRD51; SUV420H1"
                     /note="major polyA site"
ORIGIN      
        1 atcttggatt ttactctcca tttttctctg gaattatttt tggtgattaa ttttctgggg
       61 gggactggga cgcggggccc ggcggcgcgg ccccgcatcg cagcggccgg gcagcggggc
      121 ctgggacgcg ccccgaggag gagcggggcg gcgcaggcgg agagaacatt gaaagtattc
      181 tctaagctat ttgaagagag tgactaaatg cacctgggtc aggctgtctg tgggtatgaa
      241 gtggttggga gaatccaaga acatggtggt gaatggcagg agaaatggag gcaagttgtc
      301 taatgaccat cagcagaatc aatcaaaatt acagcacacg gggaaggaca ccctgaaggc
      361 tggcaaaaat gcagtcgaga ggaggtcgaa cagatgtaat ggtaactcgg gatttgaagg
      421 acagagtcgc tatgtaccat cctctggaat gtccgccaag gaactctgtg aaaatgatga
      481 cctagcaacc agtttggttc ttgatcccta tttaggtttt caaacacaca aaatgaatac
      541 tagcgccttt ccttcgagga gctcaaggca tttttcaaaa tctgacagtt tttctcacaa
      601 caaccctgtg agatttaggc ctattaaagg aaggcaggaa gaactaaagg aagtaattga
      661 acgttttaag aaagatgaac acttggagaa agccttcaaa tgtttgactt caggcgaatg
      721 ggcacggcac tattttctca acaagaataa aatgcaggag aaattattca aagaacatgt
      781 atttatttat ttgcgaatgt ttgcaactga cagtggattt gaaatattgc catgtaatag
      841 atactcatca gaacaaaatg gagccaaaat agttgcaaca aaagagtgga aacgaaatga
      901 caaaatagaa ttactggtgg gttgtattgc cgaactttca gaaattgagg agaacatgct
      961 acttagacat ggagaaaacg acttcagtgt catgtactcc acaaggaaaa actgtgctca
     1021 actctggctg ggtcctgctg cgtttataaa ccatgattgc agacctaatt gtaagtttgt
     1081 gtcaactggt cgagatacag catgtgtgaa ggctctaaga gacattgaac ctggagaaga
     1141 aatttcttgt tattatggag atgggttctt tggagaaaat aatgagttct gcgagtgtta
     1201 cacttgcgaa agacggggca ctggtgcttt taaatccaga gtgggactgc ctgcgcctgc
     1261 tcctgttatc aatagcaaat atggactcag agaaacagat aaacgtttaa ataggcttaa
     1321 aaagttaggt gacagcagca aaaattcaga cagtcaatct gtcagctcta acactgatgc
     1381 agataccact caggaaaaaa acaatgcaac ttctaaccga aaatcttcag ttggcgtaaa
     1441 aaagaatagc aagagcagaa cgttaacgag gcaatctatg tcaagaattc cagcttcttc
     1501 caactctacc tcatctaagc taactcatat aaataattcc agggtaccaa agaaactgaa
     1561 gaagcctgca aagcctttac tttcaaagat aaaattgaga aatcattgca agcggctgga
     1621 gcaaaagaat gcttcaagaa aactcgaaat gggaaactta gtactgaaag agcctaaagt
     1681 agttctgtat aaaaatttgc ccattaaaaa agataaggag ccagagggac cagcccaagc
     1741 cgcagttgcc agcgggtgct tgactagaca cgcggcgaga gaacacagac agaatcctgt
     1801 gagaggtgct cattcgcagg gggagagctc gccctgcacc tacataactc ggcggtcagt
     1861 gaggacaaga acaaatctga aggaggcctc tgacatcaag cttgaaccaa atacgttgaa
     1921 tggctataaa agcagtgtga cggaaccttg ccccgacagt ggtgaacagc tgcagccagc
     1981 tcctgtgctg caggaggaag aactggctca tgagactgca caaaaagggg aggcaaagtg
     2041 tcataagagt gacacaggca tgtccaaaaa gaagtcacga caaggaaaac ttgtgaaaca
     2101 gtttgcaaaa atagaggaat ctactccagt gcacgattct cctggaaaag acgacgcggt
     2161 accagatttg atgggtcccc attctgacca gggtgagcac agtggcactg tgggcgtgcc
     2221 tgtgagctac acagactgtg ctccttcacc cgtcggttgt tcagttgtga catcagatag
     2281 cttcaaaaca aaagacagct ttagaactgc aaaaagtaaa aagaagaggc gaatcacaag
     2341 gtatgatgca cagttaatcc tagaaaataa ctctgggatt cccaaattga ctcttcgtag
     2401 gcgtcatgat agcagcagca aaacaaatga ccaagagaat gatggaatga actcttccaa
     2461 aataagcatc aagttaagca aagaccatga caacgataac aatctctatg tagcaaagct
     2521 taataatgga tttaactcag gatcaggcag tagttctaca aaattaaaaa tccagctaaa
     2581 acgagatgag gaaaataggg ggtcttatac agaggggctt catgaaaatg gggtgtgctg
     2641 cagtgatcct ctttctctct tggagtctcg aatggaggtg gatgactata gtcagtatga
     2701 ggaagaaagt acagatgatt cctcctcttc tgagggcgat gaagaggagg atgactatga
     2761 tgatgacttt gaagacgatt ttattcctct tcctccagct aagcgcttga ggttaatagt
     2821 tggaaaagac tctatagata ttgacatttc ttcaaggaga agagaagatc agtctttaag
     2881 gcttaatgcc taagctcttg gtcttaactt gacctgggat aactacttta aagaaataaa
     2941 aaattccagt caattattcc tcaactgaaa gtttagtggc agcacttcta ttgtcccttc
     3001 acttatcagc atactattgt agaaagtgta cagcatactg actcaattct taagtctgat
     3061 ttgtgcaaat ttttatcgta ctttttaaat agccttctta cgtgcaattc tgagttagag
     3121 gtaaagccct gttgtaaaat aaaggctcaa gcaaaattgt acagtgatag caactttcca
     3181 cacaggacgt tgaaaacagt aatgtggcta cacagttttt ttaactgtaa gagcatcagc
     3241 tggctcttta atatatgact aaacaataat ttaaaacaaa tcatagtagc agcatattaa
     3301 gggtttctag tatgctaata tcaccagcaa tgatctttgg ctttttgatt tatttgctag
     3361 atgtttcccc cttggagttt tgtcagtttc acactgtttg ctggcccagg tgtactgttt
     3421 gtggcctttg ttaatatcgc aaaccattgg ttgggagtca gattggtttc ttaaaaaaaa
     3481 aaaaaaaatg acatacgtga cagctcactt ttcagttcat tatatgtacg agggtagcag
     3541 tgtgtgggat gaggttcgat acagcgtatt tattgcttgt catgtaaatt aaaaaccttg
     3601 tatttaactc ttttcaatcc ttttagataa aattgttctt tgcaagaatg attggtgctt
     3661 attttttcaa aaatttgctg tgaacaacgt gatgacaaca agcaacattt atctaatgaa
     3721 ctacagctat cttaatttgg ttcttcaagt tttctgttgc acttgtaaaa tgctacaagg
     3781 aatattaaaa aaatctattc actttaactt ataatagttt atgaaataaa aacatgagtc
     3841 acagcttttg ttctgtggta acctataaaa aaagtttgtc tttgagattc aatgtaaaga
     3901 actgaaaaca atgtatatgt tgtaaatatt tgtgtgttgt gagaaatttt tgtcataaga
     3961 aattaaaaga acttaccagg aaggttttta agtttagaaa tattcatgcc aataaaatag
     4021 gaaattataa atatatagtt ttaagcactg catcagtggg agttcttggc ttatgttagt
     4081 ttatgttagt ttattatgaa aacatcaaag atttttttga ctatattatc agttaaacaa
     4141 aaaggagtca gatttaattt gttttttgaa gcactttgag aaattaattt taattaactt
     4201 aatgagcaaa tttttattac tactttatgt tcaataccag gttcttttca tttctctgga
     4261 ttattttgca aatcattgga cagagaattt gggaatataa atctgtaaca ggtgtttgac
     4321 accagtaggt ctctttattt ctgggaaatg tgtacctgta ctttctgata tacagtgttc
     4381 ctaagtaaaa atcaattcag gggatttgta tagtgtctat aggaaagtag cccatgtctt
     4441 gaaatatgaa aaggaatctg aaggtcatga aaagtccagt ggagaaaatc tcaatgctta
     4501 ctgttactac taattgattc ctactagttt ccaggtttgg ggggatattg tttcaatgac
     4561 gctccttaag actgttgatt gcccataggt tccaaataga aattaagact catgaacatt
     4621 tttagaaagt agattgtttt ctcctggttc tctaaggaac tacttctgca gtcttacata
     4681 gtctcatcct tgtttgttgt ggtgcagtcg aactcctcag gcgtttggaa agcatgtggt
     4741 agaccttctt ccacacccac ccataccccc gttcactgcg tctggaggtc ttcaacagtg
     4801 aagtagggca gcccacacag cctctcagga gcacctgtcc gaggcacccg gagcactttg
     4861 cagagcacgt ccagccctca tggggtccct gcatagaaat gtgaacccct gccactgagg
     4921 aagatgaagg tagaccctgt gtctggaggt gctggagggc agcgggtcac ctcttgtatt
     4981 cccaccttag tttggggtgt tttgaagagg ttcagagact aaatcttaaa ccttatttga
     5041 ataccaacga tagctatttt gggaatttcg atcttaaaaa gtgacaaaac acatttccca
     5101 ttttcatttt tcagctgaat tttagtaact tatttttgat gttttaattt tatcatggcc
     5161 tcctctttgg aggccaacct tcccatgggt ctcaaagcag tgacatttgg tagtaaatca
     5221 ctgcctctca ggagtcggta tgcacaagca ctcagcagcc actgttgatg ccttctaggg
     5281 aaacctaatt tccgttggta aaggtagggg cctcggaact gttccggatc tgctgtagaa
     5341 cttcaccgtg tggaatggtg acagccacac accgttgacc agtttagaag aggttgcatt
     5401 caataaaact cttagcttga gcttatgcaa tgattggtta agattttggc attgtaagaa
     5461 ttaggagatg atcatagaaa tatatgtaaa gtattcaatt ttcaatcatt ttcaaattac
     5521 tgttataaat tgtttttgct gagttgtaat acttttgaga tacaatgtat tccttgtact
     5581 gaaagaatga aaaaggactt tttcagcatt tgaggtaagt tctttaacgt ttcattaaaa
     5641 acatttttta caaatatttt gtacatgcac ttgcagtatt gaggttaatc attttaataa
     5701 attcggaaat taaaacaa
//
