LOCUS       NM_182931               7782 bp    mRNA    linear   PRI 10-OCT-2024
DEFINITION  Homo sapiens lysine methyltransferase 2E (inactive) (KMT2E),
            transcript variant 1, mRNA.
ACCESSION   NM_182931
VERSION     NM_182931.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7782)
  AUTHORS   Pereira-Martins,D.A., Weinhauser,I., Coelho-Silva,J.L.,
            Franca-Neto,P.L., Almeida,L.Y., Bianco,T.M., Silva,C.L.,
            Franca,R.F., Traina,F., Rego,E.M., Schuringa,J.J. and
            Lucena-Araujo,A.R.
  TITLE     MLL5 improves ATRA driven differentiation and promotes
            xenotransplant engraftment in acute promyelocytic leukemia model
  JOURNAL   Cell Death Dis 12 (4), 371 (2021)
   PUBMED   33824267
  REMARK    GeneRIF: MLL5 improves ATRA driven differentiation and promotes
            xenotransplant engraftment in acute promyelocytic leukemia model.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7782)
  AUTHORS   Sharawat,I.K., Panda,P.K. and Dawman,L.
  TITLE     Clinical Characteristics and Genotype-Phenotype Correlation in
            Children with KMT2E Gene-Related Neurodevelopmental Disorders:
            Report of Two New Cases and Review of Published Literature
  JOURNAL   Neuropediatrics 52 (2), 98-104 (2021)
   PUBMED   33111303
  REMARK    GeneRIF: Clinical Characteristics and Genotype-Phenotype
            Correlation in Children with KMT2E Gene-Related Neurodevelopmental
            Disorders: Report of Two New Cases and Review of Published
            Literature.
            Review article
REFERENCE   3  (bases 1 to 7782)
  AUTHORS   Conforti,R., Iovine,S., Santangelo,G., Capasso,R., Cirillo,M.,
            Fratta,M. and Caranci,F.
  TITLE     ODLURO syndrome: personal experience and review of the literature
  JOURNAL   Radiol Med 126 (2), 316-322 (2021)
   PUBMED   32691224
  REMARK    GeneRIF: ODLURO syndrome: personal experience and review of the
            literature.
            Review article
REFERENCE   4  (bases 1 to 7782)
  AUTHORS   Lee,K.H., Kim,B.C., Jeong,C.W., Ku,J.H., Kim,H.H. and Kwak,C.
  TITLE     MLL5, a histone modifying enzyme, regulates androgen receptor
            activity in prostate cancer cells by recruiting co-regulators, HCF1
            and SET1
  JOURNAL   BMB Rep 53 (12), 634-639 (2020)
   PUBMED   33050986
  REMARK    GeneRIF: MLL5, a histone modifying enzyme, regulates androgen
            receptor activity in prostate cancer cells by recruiting
            co-regulators, HCF1 and SET1.
REFERENCE   5  (bases 1 to 7782)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 7782)
  AUTHORS   Sun,X.J., Xu,P.F., Zhou,T., Hu,M., Fu,C.T., Zhang,Y., Jin,Y.,
            Chen,Y., Chen,S.J., Huang,Q.H., Liu,T.X. and Chen,Z.
  TITLE     Genome-wide survey and developmental expression mapping of
            zebrafish SET domain-containing genes
  JOURNAL   PLoS One 3 (1), e1499 (2008)
   PUBMED   18231586
  REMARK    GeneRIF: MLL5 protein has been classified into a distinct subfamily
            with SETD5, because its SET domain and domain architecture show
            high homology with SETD5 rather than the members in MLL subfamily
            (i.e. MLL, MLL2, MLL3 and MLL4)
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 7782)
  AUTHORS   Deng,L.W., Chiu,I. and Strominger,J.L.
  TITLE     MLL 5 protein forms intranuclear foci, and overexpression inhibits
            cell cycle progression
  JOURNAL   Proc Natl Acad Sci U S A 101 (3), 757-762 (2004)
   PUBMED   14718661
  REMARK    GeneRIF: MLL5 forms intranuclear protein complexes that may play an
            important role in chromatin remodeling and cellular growth
            suppression.
REFERENCE   8  (bases 1 to 7782)
  AUTHORS   Emerling,B.M., Bonifas,J., Kratz,C.P., Donovan,S., Taylor,B.R.,
            Green,E.D., Le Beau,M.M. and Shannon,K.M.
  TITLE     MLL5, a homolog of Drosophila trithorax located within a segment of
            chromosome band 7q22 implicated in myeloid leukemia
  JOURNAL   Oncogene 21 (31), 4849-4854 (2002)
   PUBMED   12101424
  REMARK    GeneRIF: MLL5 is a homolog of Drosophila trithorax located within a
            segment of chromosome band 7q22 implicated in myeloid leukemia.
REFERENCE   9  (bases 1 to 7782)
  AUTHORS   Johnson,E. and Cotter,F.E.
  TITLE     Monosomy 7 and 7q--associated with myeloid malignancy
  JOURNAL   Blood Rev 11 (1), 46-55 (1997)
   PUBMED   9218106
  REMARK    Review article
REFERENCE   10 (bases 1 to 7782)
  AUTHORS   Pais,L., Rodan,L. and O'Donnell-Luria,A.
  TITLE     KMT2E-Related Neurodevelopmental Disorder
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   38648332
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY147037.1, AF519459.1 and
            AC005070.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_182931.2.
            
            Summary: This gene is a member of the myeloid/lymphoid or
            mixed-lineage leukemia (MLL) family and encodes a protein with an
            N-terminal PHD zinc finger and a central SET domain. Overexpression
            of the protein inhibits cell cycle progression. Alternate
            transcriptional splice variants have been characterized. [provided
            by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY147037.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000311117.8/ ENSP00000312379.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6844              AY147037.1         16-6859
            6845-6848           AF519459.1         6527-6530
            6849-7782           AC005070.1         13225-14158
FEATURES             Location/Qualifiers
     source          1..7782
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.3"
     gene            1..7782
                     /gene="KMT2E"
                     /gene_synonym="HDCMC04P; MLL5; NKp44L; ODLURO; SETD5B"
                     /note="lysine methyltransferase 2E (inactive)"
                     /db_xref="GeneID:55904"
                     /db_xref="HGNC:HGNC:18541"
                     /db_xref="MIM:608444"
     exon            1..331
                     /gene="KMT2E"
                     /gene_synonym="HDCMC04P; MLL5; NKp44L; ODLURO; SETD5B"
                     /inference="alignment:Splign:2.1.0"
     exon            332..405
                     /gene="KMT2E"
                     /gene_synonym="HDCMC04P; MLL5; NKp44L; ODLURO; SETD5B"
                     /inference="alignment:Splign:2.1.0"
     exon            406..590
                     /gene="KMT2E"
                     /gene_synonym="HDCMC04P; MLL5; NKp44L; ODLURO; SETD5B"
                     /inference="alignment:Splign:2.1.0"
     CDS             520..6096
                     /gene="KMT2E"
                     /gene_synonym="HDCMC04P; MLL5; NKp44L; ODLURO; SETD5B"
                     /EC_number="2.1.1.354"
                     /note="isoform a is encoded by transcript variant 1;
                     histone-lysine N-methyltransferase MLL5; myeloid/lymphoid
                     or mixed-lineage leukemia protein 5; myeloid/lymphoid or
                     mixed-lineage leukemia 5 (trithorax homolog, Drosophila);
                     histone-lysine N-methyltransferase 2E; lysine (K)-specific
                     methyltransferase 2E; inactive lysine N-methyltransferase
                     2E; inactive histone-lysine N-methyltransferase 2E"
                     /codon_start=1
                     /product="inactive histone-lysine N-methyltransferase 2E
                     isoform a"
                     /protein_id="NP_891847.1"
                     /db_xref="CCDS:CCDS34723.1"
                     /db_xref="GeneID:55904"
                     /db_xref="HGNC:HGNC:18541"
                     /db_xref="MIM:608444"
                     /translation="MSIVIPLGVDTAETSYLEMAAGSEPESVEASPVVVEKSNSYPHQ
                     LYTSSSHHSHSYIGLPYADHNYGARPPPTPPASPPPSVLISKNEVGIFTTPNFDETSS
                     ATTISTSEDGSYGTDVTRCICGFTHDDGYMICCDKCSVWQHIDCMGIDRQHIPDTYLC
                     ERCQPRNLDKERAVLLQRRKRENMSDGDTSATESGDEVPVELYTAFQHTPTSITLTAS
                     RVSKVNDKRRKKSGEKEQHISKCKKAFREGSRKSSRVKGSAPEIDPSSDGSNFGWETK
                     IKAWMDRYEEANNNQYSEGVQREAQRIALRLGNGNDKKEMNKSDLNTNNLLFKPPVES
                     HIQKNKKILKSAKDLPPDALIIEYRGKFMLREQFEANGYFFKRPYPFVLFYSKFHGLE
                     MCVDARTFGNEARFIRRSCTPNAEVRHEIQDGTIHLYIYSIHSIPKGTEITIAFDFDY
                     GNCKYKVDCACLKENPECPVLKRSSESMENINSGYETRRKKGKKDKDISKEKDTQNQN
                     ITLDCEGTTNKMKSPETKQRKLSPLRLSVSNNQEPDFIDDIEEKTPISNEVEMESEEQ
                     IAERKRKMTREERKMEAILQAFARLEKREKRREQALERISTAKTEVKTECKDTQIVSD
                     AEVIQEQAKEENASKPTPAKVNRTKQRKSFSRSRTHIGQQRRRHRTVSMCSDIQPSSP
                     DIEVTSQQNDIENTVLTIEPETETALAEIITETEVPALNKCPTKYPKTKKHLVNEWLS
                     EKNEKTGKPSDGLSERPLRITTDPEVLATQLNSLPGLTYSPHVYSTPKHYIRFTSPFL
                     SEKRRRKEPTENISGSCKKRWLKQALEEENSAILHRFNSPCQERSRSPAVNGENKSPL
                     LLNDSCSLPDLTTPLKKRRFYQLLDSVYSETSTPTPSPYATPTHTDITPMDPSFATPP
                     RIKSDDETCRNGYKPIYSPVTPVTPGTPGNTMHFENISSPESSPEIKRRTYSQEGYDR
                     SSTMLTLGPFRNSNLTELGLQEIKTIGYTSPRSRTEVNRQCPGEKEPVSDLQLGLDAV
                     EPTALHKTLETPAHDRAEPNSQLDSTHSGRGTMYSSWVKSPDRTGVNFSVNSNLRDLT
                     PSHQLEVGGGFRISESKCLMQDDTRGMFMETTVFCTSEDGLVSGFGRTVNDNLIDGNC
                     TPQNPPQKKKVSLLEYRKRQREARKSGSKTENFPLISVSPHASGSLSNNGDGCASSND
                     NGEQVDHTASLPLPTPATVYNATSEETSNNCPVKDATASEKNEPEVQWTASTSVEQVR
                     ERSYQRALLLSDHRKDKDSGGESPCVSCSPSHVQSSPSSHSNHIPQLQAKGPVPSFSE
                     LMEDPDPENPEPTTTNECPSPDTSQNTCKSPPKMSKPGSPGSVIPAQAHGKIFTKPDP
                     QWDSTVSASEAENGVHLKTELQQKQLSNNNQALSKNHPPQTHVRNSSEQLSQKLPSVP
                     TKLHCPPSPHLENPPKSSTPHTPVQHGYLSPKPPSQQLGSPYRPHHSQSPQVGTPQRE
                     PQRNFYPAAQNLPANTQQATSGTLFTQTPSGQSSATYSQFNQQSLNSTAPPPPPPPPP
                     SSSYYQNQQPSANFQNYNQLKGSLSQQTVFTSGPNQALPGTTSQQTVPGHHVTPGHFL
                     PSQNPTIHHQTAAAVVPPPPPPPPAPGPHLVQQPNSHQQHSVAHVVGPVHAVTPGSHI
                     HSQTAGHHLPPPPPPPGPAPHHHPPPHPSTGLQGLQAQHQHVVNSAPPPPPPPPPSSV
                     LASGHHTTSAQALHHPPHQGPPLFPSSAHPTVPPYPSQATHHTTLGPGPQHQPSGTGP
                     HCPLPVTGPHLQPQGPNSIPTPTASGFCPHPGSVALPHGVQGPQQASPVPGQIPIHRA
                     QVPPTFQNNYHGSGWH"
     exon            591..705
                     /gene="KMT2E"
                     /gene_synonym="HDCMC04P; MLL5; NKp44L; ODLURO; SETD5B"
                     /inference="alignment:Splign:2.1.0"
     exon            706..935
                     /gene="KMT2E"
                     /gene_synonym="HDCMC04P; MLL5; NKp44L; ODLURO; SETD5B"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1016
                     /gene="KMT2E"
                     /gene_synonym="HDCMC04P; MLL5; NKp44L; ODLURO; SETD5B"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1075
                     /gene="KMT2E"
                     /gene_synonym="HDCMC04P; MLL5; NKp44L; ODLURO; SETD5B"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1248
                     /gene="KMT2E"
                     /gene_synonym="HDCMC04P; MLL5; NKp44L; ODLURO; SETD5B"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1287
                     /gene="KMT2E"
                     /gene_synonym="HDCMC04P; MLL5; NKp44L; ODLURO; SETD5B"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1518
                     /gene="KMT2E"
                     /gene_synonym="HDCMC04P; MLL5; NKp44L; ODLURO; SETD5B"
                     /inference="alignment:Splign:2.1.0"
     exon            1519..1649
                     /gene="KMT2E"
                     /gene_synonym="HDCMC04P; MLL5; NKp44L; ODLURO; SETD5B"
                     /inference="alignment:Splign:2.1.0"
     exon            1650..1767
                     /gene="KMT2E"
                     /gene_synonym="HDCMC04P; MLL5; NKp44L; ODLURO; SETD5B"
                     /inference="alignment:Splign:2.1.0"
     exon            1768..1877
                     /gene="KMT2E"
                     /gene_synonym="HDCMC04P; MLL5; NKp44L; ODLURO; SETD5B"
                     /inference="alignment:Splign:2.1.0"
     exon            1878..2142
                     /gene="KMT2E"
                     /gene_synonym="HDCMC04P; MLL5; NKp44L; ODLURO; SETD5B"
                     /inference="alignment:Splign:2.1.0"
     exon            2143..2241
                     /gene="KMT2E"
                     /gene_synonym="HDCMC04P; MLL5; NKp44L; ODLURO; SETD5B"
                     /inference="alignment:Splign:2.1.0"
     exon            2242..2406
                     /gene="KMT2E"
                     /gene_synonym="HDCMC04P; MLL5; NKp44L; ODLURO; SETD5B"
                     /inference="alignment:Splign:2.1.0"
     exon            2407..2715
                     /gene="KMT2E"
                     /gene_synonym="HDCMC04P; MLL5; NKp44L; ODLURO; SETD5B"
                     /inference="alignment:Splign:2.1.0"
     exon            2716..2970
                     /gene="KMT2E"
                     /gene_synonym="HDCMC04P; MLL5; NKp44L; ODLURO; SETD5B"
                     /inference="alignment:Splign:2.1.0"
     exon            2971..3115
                     /gene="KMT2E"
                     /gene_synonym="HDCMC04P; MLL5; NKp44L; ODLURO; SETD5B"
                     /inference="alignment:Splign:2.1.0"
     exon            3116..3366
                     /gene="KMT2E"
                     /gene_synonym="HDCMC04P; MLL5; NKp44L; ODLURO; SETD5B"
                     /inference="alignment:Splign:2.1.0"
     exon            3367..3423
                     /gene="KMT2E"
                     /gene_synonym="HDCMC04P; MLL5; NKp44L; ODLURO; SETD5B"
                     /inference="alignment:Splign:2.1.0"
     exon            3424..3987
                     /gene="KMT2E"
                     /gene_synonym="HDCMC04P; MLL5; NKp44L; ODLURO; SETD5B"
                     /inference="alignment:Splign:2.1.0"
     exon            3988..4274
                     /gene="KMT2E"
                     /gene_synonym="HDCMC04P; MLL5; NKp44L; ODLURO; SETD5B"
                     /inference="alignment:Splign:2.1.0"
     exon            4275..4363
                     /gene="KMT2E"
                     /gene_synonym="HDCMC04P; MLL5; NKp44L; ODLURO; SETD5B"
                     /inference="alignment:Splign:2.1.0"
     exon            4364..4489
                     /gene="KMT2E"
                     /gene_synonym="HDCMC04P; MLL5; NKp44L; ODLURO; SETD5B"
                     /inference="alignment:Splign:2.1.0"
     exon            4490..4587
                     /gene="KMT2E"
                     /gene_synonym="HDCMC04P; MLL5; NKp44L; ODLURO; SETD5B"
                     /inference="alignment:Splign:2.1.0"
     exon            4588..7782
                     /gene="KMT2E"
                     /gene_synonym="HDCMC04P; MLL5; NKp44L; ODLURO; SETD5B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6823..6828
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KMT2E"
                     /gene_synonym="HDCMC04P; MLL5; NKp44L; ODLURO; SETD5B"
                     /note="hexamer: AATAAA"
     polyA_site      6848
                     /gene="KMT2E"
                     /gene_synonym="HDCMC04P; MLL5; NKp44L; ODLURO; SETD5B"
                     /note="major polyA site"
     regulatory      7761..7766
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KMT2E"
                     /gene_synonym="HDCMC04P; MLL5; NKp44L; ODLURO; SETD5B"
                     /note="hexamer: AATAAA"
     polyA_site      7782
                     /gene="KMT2E"
                     /gene_synonym="HDCMC04P; MLL5; NKp44L; ODLURO; SETD5B"
ORIGIN      
        1 agagcgagag gcagtgacac tgagcgggcg cagggggccg agtcggagac cgtgccggag
       61 ttcgggagcg gcaacagagt gggcatagac actccgagca gcctcgccgt cgtctctgcg
      121 ttcctgttga ctgcctggct gccccctccc ctactcctcg gttcctggtg aagaggctgc
      181 gcgctgctgt ttggggaggg ggtgtgtgga gccgggtcct gtgtccgcag tggctgctgt
      241 cggggggtcg cctgttcgcg gaggtgcgga gagactcctt gggggtcgag cacataacgg
      301 ggttcgggtg tctcgtgtgt gaacatcaca ggtctattct ggataagcag gttttgtgaa
      361 gacatttatt ctttcttgga cctcagattt accagacatc tcatgggttt gtggatgcac
      421 ttagatgttt gcaatgagca ctgtggctgg catgccccag tgttttggat accaatgcat
      481 aggactccat agtaatcgaa tttaccagag gcgaacgtca tgagcatagt gatcccattg
      541 ggggttgata cagcagagac gtcatacttg gaaatggctg caggttcaga accagaatcc
      601 gtagaagcta gccctgtggt agttgagaaa tccaacagtt atccccacca gttatatacc
      661 agcagctcac atcattcaca cagttacatt ggtttgccct atgcggacca taattatggt
      721 gctcgtcctc ctccgacacc tccggcttcc cctcctccat cagtccttat tagcaaaaat
      781 gaagtaggca tatttaccac tcctaatttt gatgaaactt ccagtgctac tacaatcagc
      841 acatctgagg atggaagtta tggtactgat gtaaccaggt gcatatgtgg ttttacacat
      901 gatgatggat acatgatctg ttgtgacaaa tgcagcgttt ggcaacatat tgactgcatg
      961 gggattgata ggcagcatat tcctgataca tatctatgtg aacgttgtca gcctaggaat
     1021 ttggataaag agagggcagt gctactacaa cgccggaaaa gggaaaatat gtcagatggt
     1081 gataccagtg caactgagag tggtgatgag gttcctgtgg aattatatac tgcatttcag
     1141 catactccaa catcaattac tttaactgct tcaagagttt ccaaagttaa tgataaaaga
     1201 aggaaaaaaa gcggggagaa agaacaacac atttcaaaat gtaaaaaggc atttcgtgaa
     1261 ggatctagga agtcatcaag agttaagggt tcagctccag agattgatcc ttcatctgat
     1321 ggttcaaatt ttggatggga gacaaagatc aaagcatgga tggatcgata tgaagaagca
     1381 aataacaacc agtacagtga gggtgttcag agggaggcac aaagaatagc tctgagatta
     1441 ggcaatggaa atgacaaaaa agagatgaat aaatccgatt tgaataccaa caatttgctc
     1501 ttcaaacctc ctgtagagag ccatatacaa aagaataaga aaattcttaa atctgcaaaa
     1561 gatttgcctc ctgatgcact tatcattgaa tacagaggga agtttatgct gagagaacag
     1621 tttgaagcaa atgggtattt ctttaaaaga ccataccctt ttgtgttatt ctactctaaa
     1681 tttcatgggc tagaaatgtg tgttgatgca aggacttttg ggaatgaggc tcgattcatc
     1741 aggcggtctt gtacacccaa tgcagaggtg aggcatgaaa ttcaagatgg aaccatacat
     1801 ctttatattt attctataca cagtattcca aagggaactg aaattactat tgcctttgat
     1861 tttgactatg gaaattgtaa gtacaaggtg gactgtgcat gcctcaaaga aaacccagag
     1921 tgccctgttc taaaacgtag ttctgaatcc atggaaaata tcaatagtgg ttatgagacc
     1981 agacggaaaa aaggaaaaaa agacaaagat atttcaaaag aaaaagatac acaaaatcag
     2041 aatattactt tggattgtga aggaacgacc aacaaaatga agagcccaga aactaaacaa
     2101 agaaagcttt ctccactgag actatcagta tcaaataatc aggaaccaga ttttattgat
     2161 gatatagaag aaaaaactcc tattagtaat gaagtagaaa tggaatcaga ggagcagatt
     2221 gcagaaagga aaaggaagat gacaagagaa gaaagaaaaa tggaagcaat tttgcaagct
     2281 tttgccagac ttgaaaagag agagaaaaga agagaacaag ctttggaaag gatcagcaca
     2341 gccaaaactg aagttaaaac tgaatgtaaa gatacacaga ttgtcagtga tgctgaagtt
     2401 attcaggaac aagcaaaaga agaaaatgct agcaagccaa cccctgccaa agtaaataga
     2461 actaaacaga gaaaaagttt ttctcggagt aggactcaca ttggacagca gcgtcggaga
     2521 cacagaactg tcagcatgtg ttcagatatc cagccatctt ctcctgatat agaagttact
     2581 tcacaacaaa atgatattga aaatactgta cttacaatag aaccagaaac tgaaactgca
     2641 ctagcagaaa taattactga aactgaagtt ccagcactta ataaatgtcc taccaagtac
     2701 cccaaaacaa agaagcactt ggttaatgaa tggttaagtg agaagaatga gaagacagga
     2761 aaaccttcag atggcctttc agaaaggcct ctacgcataa ctacagatcc tgaagtgtta
     2821 gctacacaac tcaattcttt accaggtctc acttacagcc cccatgtata ctccactcct
     2881 aagcattata ttagatttac ttcaccattc ctttcagaaa aaaggagaag aaaagaacct
     2941 actgaaaaca tttctggttc atgcaagaag cgatggttga aacaagctct ggaagaagaa
     3001 aattcagcaa ttttacatag atttaattca ccctgtcaag aaagatccag aagtcctgca
     3061 gtcaatggtg aaaataaaag tccactacta ttaaatgaca gctgttccct tccagattta
     3121 actacaccac taaaaaaacg aagattttat cagttgctag attcggttta ctcagaaacc
     3181 tccacaccta ctccttcccc gtatgctaca ccaactcaca ccgatattac tcctatggac
     3241 ccatcttttg ccacgcctcc acggataaaa tcagatgatg aaacttgtag aaatggttat
     3301 aaacccatat attcaccagt taccccagta actcctggta caccaggaaa taccatgcac
     3361 tttgagaata tttcttcccc agaaagttct ccagaaataa agagacgcac ttatagtcaa
     3421 gagggatatg acagatcttc aaccatgtta acattggggc cttttagaaa ttctaattta
     3481 actgaactgg gtctgcaaga aataaagact attggttata cgagccctag gagtaggact
     3541 gaagtcaaca ggcagtgtcc tggagaaaag gaacctgtgt cagaccttca gctaggactc
     3601 gatgcagttg agccaactgc cctacataaa accctggaaa cgcctgcaca tgacagggct
     3661 gagcccaaca gccaactgga ctcgactcac tctggacggg gcacaatgta ttcttcctgg
     3721 gtaaagagcc ctgacagaac aggagttaac ttctcagtga actccaactt gagggacctg
     3781 acaccctcgc atcagttgga ggttggagga ggcttccgaa taagtgagtc aaagtgcctg
     3841 atgcaggatg atactagagg catgtttatg gaaacaactg tgttttgtac ttccgaagat
     3901 gggcttgtat ctggtttcgg acggactgtt aatgacaatt tgatcgacgg gaattgcaca
     3961 ccccagaatc caccacaaaa gaaaaaggtt tctctattag aataccgtaa gagacaacgt
     4021 gaagctagga aaagtggctc taagacagag aactttccac tcattagtgt atcaccccat
     4081 gcaagtggaa gcttgagcaa caatggtgat ggctgtgcca gcagtaatga caatggggag
     4141 caggtggacc acactgctag cctaccttta ccaacaccag ctacagttta taatgccact
     4201 tctgaagaaa ctagcaataa ctgccctgtt aaggatgcta ctgctagtga gaagaatgaa
     4261 ccagaagttc aatggactgc ctcaacttca gtggaacaag tcagagaaag gagttatcag
     4321 agagctttac ttctcagtga tcaccgaaaa gataaagata gtgggggaga atcaccatgt
     4381 gtctcatgtt caccgagtca tgttcagtct tcaccttcat ctcattcaaa tcacataccc
     4441 cagttgcaag ctaagggccc agtcccttct ttcagtgaac ttatggaaga ccctgatcct
     4501 gaaaatccag aacccacaac tacgaatgaa tgtccatccc cagatacttc tcaaaatact
     4561 tgtaaaagtc ctccaaaaat gagcaagcct ggttcacctg gatctgtaat tcctgctcaa
     4621 gcacacggga aaatattcac aaaaccagat ccccaatggg actccacagt tagtgcatcc
     4681 gaagctgaaa atggtgttca cctaaaaaca gagctccaac aaaaacagct atcaaataac
     4741 aaccaagcac tttcaaagaa tcatcctcct cagacacacg ttcgtaattc atctgagcaa
     4801 ctttcacaaa agctgccttc tgtgccaaca aagttgcact gtcctccatc acctcaccta
     4861 gaaaatcctc caaagtcatc cacgcctcac acacctgtac agcatggtta tctttcacca
     4921 aagcctcctt cacagcagtt aggatctccc tacaggcctc atcattcaca gtcacctcaa
     4981 gttggaacac ctcagcgaga gcctcaaaga aacttttatc cagcagcaca gaaccttcca
     5041 gccaatactc agcaggcaac ttctggaaca ttatttacac agacaccctc aggacaatct
     5101 tcagcaacat acagtcagtt taaccaacaa agtctgaaca gcacggcacc accccctcca
     5161 cctcctccac ctccttcttc gtcttactat caaaaccagc agccctctgc aaactttcag
     5221 aattataatc agctcaaagg tagtctttct caacaaactg tgtttacatc aggaccaaat
     5281 caagcacttc ctggcaccac aagccagcaa acagttccag gacaccacgt gactccaggg
     5341 cattttttgc cctctcagaa ccctaccatt caccatcaaa ctgctgctgc cgtagtcccc
     5401 cctcctcctc caccaccacc tgctccagga ccgcaccttg tacaacagcc gaattcccat
     5461 cagcaacact ctgtagcaca tgtagtaggg cctgttcatg cggtcacccc tgggtcgcat
     5521 attcattctc aaactgctgg acaccactta cccccacccc caccccctcc tggtcctgcc
     5581 cctcatcacc atccaccacc ccatccatcc acaggactcc aaggtctaca agcacaacac
     5641 cagcatgttg taaattcagc acccccacca ccccctccgc cgccaccttc cagtgttttg
     5701 gcttctgggc atcataccac atcagctcaa gccttacacc acccacctca tcaaggacct
     5761 ccactttttc cttcgagtgc tcatccaact gtaccaccgt atccctcaca agctacacat
     5821 cataccactt tgggaccggg accccagcac cagccttctg gaacagggcc acattgtcca
     5881 ttacctgtca caggtcctca tctccagccc caaggaccaa acagtattcc aacacctact
     5941 gcttcagggt tctgtcctca tcctggctct gtggccctgc cacatggggt tcaaggacct
     6001 cagcaggcat ctccagtgcc tggacagatt ccaattcaca gagcacaggt gccaccaaca
     6061 tttcaaaaca attaccatgg gtcagggtgg cattaaaatg gactccaaaa acattttttt
     6121 aaatgttctg taagataaac tgtatatttc atatgtacct gttaaggtac tttttaaagc
     6181 ttgtacatga acctttgtat aaaaaacacc agtgctcttt cgttgtattt ttctcatttt
     6241 tgctttttaa aattccttta aaaaatgtgc tgttaagcca gtattaggta tctttatttt
     6301 gtaagtgaac attccagctg tttttttctg gcagatctga tgctgatttg atgctgtatg
     6361 atcttttttt tttttttagt taaattcatt tagtgaatgt tctattattt tatacataca
     6421 cattaagtac tcagctaagt aatggcacta tgaggatttt ttttttcttt cctgtcagca
     6481 gcagttctgt gaatgcatct taggtataaa aatgcaatac agatttttat attttggtgt
     6541 ggacatggct cattttgttt taccagttat ttgcaagcaa aatgtaattt aatgtataga
     6601 tgatttctaa tgtctcctga caaactgtaa atactgcatt tcttttgcgt atataattgc
     6661 ttacagcttt tctcatttga tatatagcat tgtacatatg acaagtcttt tgcaaaactg
     6721 tgtgatcttt gtgaaagtag tacagtatat gacctttaat ttctttttta ttttaaatat
     6781 actgtcacac tgaagcactg gttgggcatt ttaattcatg ttaataaatc acaattatgt
     6841 cagttttacc agattgtcct gtacaacttc taagatcggg atctgtgtgt ttctacagaa
     6901 gttctagttt tcaaatatag attgtaagga gccttcaatt ttctttagcg actactacct
     6961 cagcaacagg aggcagcaag gggctgttcc tgtggtggtt tctgtttgca tttttgcagg
     7021 agccatagga aactactgaa atgattgtgc tgggtaaatt aaggatctgg catcatacaa
     7081 aatgaagcca gaccactaat gcattacagt agttcttgaa tacaaggtac aacaactgtt
     7141 tgaaaatatg ggtagtttgc ccaaaacagg aaaatttgtc ttgggtgtaa aaactaaaga
     7201 aaaaaggcat tattcctaga tctctcagtg aaatgaaaat ggcctcttaa gtgaacgttt
     7261 ttattgctaa aatataaaat gctagttagt tattaattat taatcttcaa aaaattaaaa
     7321 atttcccagc ctttgtcttc tacctctgag gattcagtaa gtacatccaa taataatgat
     7381 actgttttat caatcaacat atttttcatc atccaattac ctgacataat ttggcacagg
     7441 atacaaattc tgtgcatcag agaaagtaaa cactaaaatg actgcgtgac ctcattcagt
     7501 catgttttta cactttgaac ctctatttat ttccttttga aaattagcta atgatggtac
     7561 attaacgcag ctcacttagg gctcaatcct aatcacagct tcaaatttta gaagaacata
     7621 taggccaagt ttgccatcct caatttgtcc aacaaaattc tatttatggt atttagtaaa
     7681 gaaacatttg tctgagaaga aatggtttta catcatctat cctgatagtt tcaaacagaa
     7741 taaaggtaac tagcatgtga aataaaaata ttcttcttaa aa
//
