LOCUS       NM_170606              16860 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens lysine methyltransferase 2C (KMT2C), mRNA.
ACCESSION   NM_170606
VERSION     NM_170606.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 16860)
  AUTHORS   Rots,D., Choufani,S., Faundes,V., Dingemans,A.J.M., Joss,S.,
            Foulds,N., Jones,E.A., Stewart,S., Vasudevan,P., Dabir,T.,
            Park,S.M., Jewell,R., Brown,N., Pais,L., Jacquemont,S., Jizi,K.,
            Ravenswaaij-Arts,C.M.A.V., Kroes,H.Y., Stumpel,C.T.R.M.,
            Ockeloen,C.W., Diets,I.J., Nizon,M., Vincent,M., Cogne,B.,
            Besnard,T., Kambouris,M., Anderson,E., Zackai,E.H., McDougall,C.,
            Donoghue,S., O'Donnell-Luria,A., Valivullah,Z., O'Leary,M.,
            Srivastava,S., Byers,H., Leslie,N., Mazzola,S., Tiller,G.E.,
            Vera,M., Shen,J.J., Boles,R., Jain,V., Brischoux-Boucher,E.,
            Kinning,E., Simpson,B.N., Giltay,J.C., Harris,J., Keren,B.,
            Guimier,A., Marijon,P., Vries,B.B.A., Motter,C.S., Mendelsohn,B.A.,
            Coffino,S., Gerkes,E.H., Afenjar,A., Visconti,P., Bacchelli,E.,
            Maestrini,E., Delahaye-Duriez,A., Gooch,C., Hendriks,Y., Adams,H.,
            Thauvin-Robinet,C., Josephi-Taylor,S., Bertoli,M., Parker,M.J.,
            Rutten,J.W., Caluseriu,O., Vernon,H.J., Kaziyev,J., Zhu,J.,
            Kremen,J., Frazier,Z., Osika,H., Breault,D., Nair,S., Lewis,S.M.E.,
            Ceroni,F., Viggiano,M., Posar,A., Brittain,H., Giovanna,T.,
            Giulia,G., Quteineh,L., Ha-Vinh Leuchter,R.,
            Zonneveld-Huijssoon,E., Mellado,C., Marey,I., Coudert,A., Aracena
            Alvarez,M.I., Kennis,M.G.P., Bouman,A., Roifman,M., Amoros
            Rodriguez,M.I., Ortigoza-Escobar,J.D., Vernimmen,V., Sinnema,M.,
            Pfundt,R., Brunner,H.G., Vissers,L.E.L.M., Kleefstra,T.,
            Weksberg,R. and Banka,S.
  TITLE     Pathogenic variants in KMT2C result in a neurodevelopmental
            disorder distinct from Kleefstra and Kabuki syndromes
  JOURNAL   Am J Hum Genet 111 (8), 1626-1642 (2024)
   PUBMED   39013459
  REMARK    GeneRIF: Pathogenic variants in KMT2C result in a
            neurodevelopmental disorder distinct from Kleefstra and Kabuki
            syndromes.
REFERENCE   2  (bases 1 to 16860)
  AUTHORS   Jiao,Y., Lv,Y., Liu,M., Liu,Y., Han,M., Xiong,X., Zhou,H.,
            Zhong,J., Kang,X. and Su,W.
  TITLE     The modification role and tumor association with a
            methyltransferase: KMT2C
  JOURNAL   Front Immunol 15, 1444923 (2024)
   PUBMED   39165358
  REMARK    GeneRIF: The modification role and tumor association with a
            methyltransferase: KMT2C.
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 16860)
  AUTHORS   Whitford,W., Taylor,J., Hayes,I., Smith,W., Snell,R.G., Lehnert,K.
            and Jacobsen,J.C.
  TITLE     A novel 11 base pair deletion in KMT2C resulting in Kleefstra
            syndrome 2
  JOURNAL   Mol Genet Genomic Med 12 (1), e2350 (2024)
   PUBMED   38146907
  REMARK    GeneRIF: A novel 11 base pair deletion in KMT2C resulting in
            Kleefstra syndrome 2.
REFERENCE   4  (bases 1 to 16860)
  AUTHORS   Chen,Y., Su,H., Zhao,J., Na,Z., Jiang,K., Bacchiocchi,A., Loh,K.H.,
            Halaban,R., Wang,Z., Cao,X. and Slavoff,S.A.
  TITLE     Unannotated microprotein EMBOW regulates the interactome and
            chromatin and mitotic functions of WDR5
  JOURNAL   Cell Rep 42 (9), 113145 (2023)
   PUBMED   37725512
REFERENCE   5  (bases 1 to 16860)
  AUTHORS   Zhu,S., Xu,N., Liang,J., Zhao,F., Wang,Z., Ni,Y., Dai,J., Zhao,J.,
            Zhang,X., Chen,J., Sun,G., Shen,P. and Zeng,H.
  TITLE     Mutations in epigenetic regulator KMT2C detected by liquid biopsy
            are associated with worse survival in prostate cancer patients
  JOURNAL   Oncol Res 31 (4), 605-614 (2023)
   PUBMED   37415738
  REMARK    GeneRIF: Mutations in epigenetic regulator KMT2C detected by liquid
            biopsy are associated with worse survival in prostate cancer
            patients.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 16860)
  AUTHORS   Goo,Y.H., Sohn,Y.C., Kim,D.H., Kim,S.W., Kang,M.J., Jung,D.J.,
            Kwak,E., Barlev,N.A., Berger,S.L., Chow,V.T., Roeder,R.G.,
            Azorsa,D.O., Meltzer,P.S., Suh,P.G., Song,E.J., Lee,K.J., Lee,Y.C.
            and Lee,J.W.
  TITLE     Activating signal cointegrator 2 belongs to a novel steady-state
            complex that contains a subset of trithorax group proteins
  JOURNAL   Mol Cell Biol 23 (1), 140-149 (2003)
   PUBMED   12482968
REFERENCE   7  (bases 1 to 16860)
  AUTHORS   Ruault,M., van der Bruggen,P., Brun,M.E., Boyle,S., Roizes,G. and
            De Sario,A.
  TITLE     New BAGE (B melanoma antigen) genes mapping to the juxtacentromeric
            regions of human chromosomes 13 and 21 have a cancer/testis
            expression profile
  JOURNAL   Eur J Hum Genet 10 (12), 833-840 (2002)
   PUBMED   12461691
REFERENCE   8  (bases 1 to 16860)
  AUTHORS   Ruault,M., Brun,M.E., Ventura,M., Roizes,G. and De Sario,A.
  TITLE     MLL3, a new human member of the TRX/MLL gene family, maps to 7q36,
            a chromosome region frequently deleted in myeloid leukaemia
  JOURNAL   Gene 284 (1-2), 73-81 (2002)
   PUBMED   11891048
REFERENCE   9  (bases 1 to 16860)
  AUTHORS   Tan,Y.C. and Chow,V.T.
  TITLE     Novel human HALR (MLL3) gene encodes a protein homologous to ALR
            and to ALL-1 involved in leukemia, and maps to chromosome 7q36
            associated with leukemia and developmental defects
  JOURNAL   Cancer Detect Prev 25 (5), 454-469 (2001)
   PUBMED   11718452
REFERENCE   10 (bases 1 to 16860)
  AUTHORS   Boel,P., Wildmann,C., Sensi,M.L., Brasseur,R., Renauld,J.C.,
            Coulie,P., Boon,T. and van der Bruggen,P.
  TITLE     BAGE: a new gene encoding an antigen recognized on human melanomas
            by cytolytic T lymphocytes
  JOURNAL   Immunity 2 (2), 167-175 (1995)
   PUBMED   7895173
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP281562.1, AY024361.1,
            AK025911.1, AF264750.2, CD513584.1, BU623509.1 and BU685177.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_170606.2.
            
            Summary: This gene is a member of the myeloid/lymphoid or
            mixed-lineage leukemia (MLL) family and encodes a nuclear protein
            with an AT hook DNA-binding domain, a DHHC-type zinc finger, six
            PHD-type zinc fingers, a SET domain, a post-SET domain and a
            RING-type zinc finger. This protein is a member of the ASC-2/NCOA6
            complex (ASCOM), which possesses histone methylation activity and
            is involved in transcriptional coactivation. [provided by RefSeq,
            Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY024361.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262189.11/ ENSP00000262189.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                BP281562.1         3-39
            38-1793             AY024361.1         1-1756
            1794-2051           AK025911.1         22-279
            2052-4072           AY024361.1         2015-4035
            4073-11887          AF264750.2         1402-9216
            11888-12099         AY024361.1         11851-12062
            12100-14379         AF264750.2         9600-11879
            14380-15014         AY024361.1         14343-14977
            15015-15816         CD513584.1         14-815
            15817-16398         BU623509.1         19-600              c
            16399-16860         BU685177.1         15-476              c
FEATURES             Location/Qualifiers
     source          1..16860
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q36.1"
     gene            1..16860
                     /gene="KMT2C"
                     /gene_synonym="HALR; KLEFS2; MLL3"
                     /note="lysine methyltransferase 2C"
                     /db_xref="GeneID:58508"
                     /db_xref="HGNC:HGNC:13726"
                     /db_xref="MIM:606833"
     exon            1..378
                     /gene="KMT2C"
                     /gene_synonym="HALR; KLEFS2; MLL3"
                     /inference="alignment:Splign:2.1.0"
     CDS             218..14953
                     /gene="KMT2C"
                     /gene_synonym="HALR; KLEFS2; MLL3"
                     /EC_number="2.1.1.364"
                     /note="ALR-like protein; histone-lysine
                     N-methyltransferase MLL3; histone-lysine
                     N-methyltransferase, H3 lysine-4 specific; homologous to
                     ALR protein; myeloid/lymphoid or mixed-lineage leukemia
                     protein 3; lysine (K)-specific methyltransferase 2C"
                     /codon_start=1
                     /product="histone-lysine N-methyltransferase 2C"
                     /protein_id="NP_733751.2"
                     /db_xref="CCDS:CCDS5931.1"
                     /db_xref="GeneID:58508"
                     /db_xref="HGNC:HGNC:13726"
                     /db_xref="MIM:606833"
                     /translation="MSSEEDKSVEQPQPPPPPPEEPGAPAPSPAAADKRPRGRPRKDG
                     ASPFQRARKKPRSRGKTAVEDEDSMDGLETTETETIVETEIKEQSAEEDAEAEVDNSK
                     QLIPTLQRSVSEESANSLVSVGVEAKISEQLCAFCYCGEKSSLGQGDLKQFRITPGFI
                     LPWRNQPSNKKDIDDNSNGTYEKMQNSAPRKQRGQRKERSPQQNIVSCVSVSTQTASD
                     DQAGKLWDELSLVGLPDAIDIQALFDSTGTCWAHHRCVEWSLGVCQMEEPLLVNVDKA
                     VVSGSTERCAFCKHLGATIKCCEEKCTQMYHYPCAAGAGTFQDFSHIFLLCPEHIDQA
                     PERSKEDANCAVCDSPGDLLDQFFCTTCGQHYHGMCLDIAVTPLKRAGWQCPECKVCQ
                     NCKQSGEDSKMLVCDTCDKGYHTFCLQPVMKSVPTNGWKCKNCRICIECGTRSSSQWH
                     HNCLICDNCYQQQDNLCPFCGKCYHPELQKDMLHCNMCKRWVHLECDKPTDHELDTQL
                     KEEYICMYCKHLGAEMDRLQPGEEVEIAELTTDYNNEMEVEGPEDQMVFSEQAANKDV
                     NGQESTPGIVPDAVQVHTEEQQKSHPSESLDTDSLLIAVSSQHTVNTELEKQISNEVD
                     SEDLKMSSEVKHICGEDQIEDKMEVTENIEVVTHQITVQQEQLQLLEEPETVVSREES
                     RPPKLVMESVTLPLETLVSPHEESISLCPEEQLVIERLQGEKEQKENSELSTGLMDSE
                     MTPTIEGCVKDVSYQGGKSIKLSSETESSFSSSADISKADVSSSPTPSSDLPSHDMLH
                     NYPSALSSSAGNIMPTTYISVTPKIGMGKPAITKRKFSPGRPRSKQGAWSTHNTVSPP
                     SWSPDISEGREIFKPRQLPGSAIWSIKVGRGSGFPGKRRPRGAGLSGRGGRGRSKLKS
                     GIGAVVLPGVSTADISSNKDDEENSMHNTVVLFSSSDKFTLNQDMCVVCGSFGQGAEG
                     RLLACSQCGQCYHPYCVSIKITKVVLSKGWRCLECTVCEACGKATDPGRLLLCDDCDI
                     SYHTYCLDPPLQTVPKGGWKCKWCVWCRHCGATSAGLRCEWQNNYTQCAPCASLSSCP
                     VCYRNYREEDLILQCRQCDRWMHAVCQNLNTEEEVENVADIGFDCSMCRPYMPASNVP
                     SSDCCESSLVAQIVTKVKELDPPKTYTQDGVCLTESGMTQLQSLTVTVPRRKRSKPKL
                     KLKIINQNSVAVLQTPPDIQSEHSRDGEMDDSREGELMDCDGKSESSPEREAVDDETK
                     GVEGTDGVKKRKRKPYRPGIGGFMVRQRSRTGQGKTKRSVIRKDSSGSISEQLPCRDD
                     GWSEQLPDTLVDESVSVTESTEKIKKRYRKRKNKLEETFPAYLQEAFFGKDLLDTSRQ
                     SKISLDNLSEDGAQLLYKTNMNTGFLDPSLDPLLSSSSAPTKSGTHGPADDPLADISE
                     VLNTDDDILGIISDDLAKSVDHSDIGPVTDDPSSLPQPNVNQSSRPLSEEQLDGILSP
                     ELDKMVTDGAILGKLYKIPELGGKDVEDLFTAVLSPANTQPTPLPQPPPPTQLLPIHN
                     QDAFSRMPLMNGLIGSSPHLPHNSLPPGSGLGTFSAIAQSSYPDARDKNSAFNPMASD
                     PNNSWTSSAPTVEGENDTMSNAQRSTLKWEKEEALGEMATVAPVLYTNINFPNLKEEF
                     PDWTTRVKQIAKLWRKASSQERAPYVQKARDNRAALRINKVQMSNDSMKRQQQQDSID
                     PSSRIDSELFKDPLKQRESEHEQEWKFRQQMRQKSKQQAKIEATQKLEQVKNEQQQQQ
                     QQQFGSQHLLVQSGSDTPSSGIQSPLTPQPGNGNMSPAQSFHKELFTKQPPSTPTSTS
                     SDDVFVKPQAPPPPPAPSRIPIQDSLSQAQTSQPPSPQVFSPGSSNSRPPSPMDPYAK
                     MVGTPRPPPVGHSFSRRNSAAPVENCTPLSSVSRPLQMNETTANRPSPVRDLCSSSTT
                     NNDPYAKPPDTPRPVMTDQFPKSLGLSRSPVVSEQTAKGPIAAGTSDHFTKPSPRADV
                     FQRQRIPDSYARPLLTPAPLDSGPGPFKTPMQPPPSSQDPYGSVSQASRRLSVDPYER
                     PALTPRPIDNFSHNQSNDPYSQPPLTPHPAVNESFAHPSRAFSQPGTISRPTSQDPYS
                     QPPGTPRPVVDSYSQSSGTARSNTDPYSQPPGTPRPTTVDPYSQQPQTPRPSTQTDLF
                     VTPVTNQRHSDPYAHPPGTPRPGISVPYSQPPATPRPRISEGFTRSSMTRPVLMPNQD
                     PFLQAAQNRGPALPGPLVRPPDTCSQTPRPPGPGLSDTFSRVSPSAARDPYDQSPMTP
                     RSQSDSFGTSQTAHDVADQPRPGSEGSFCASSNSPMHSQGQQFSGVSQLPGPVPTSGV
                     TDTQNTVNMAQADTEKLRQRQKLREIILQQQQQKKIAGRQEKGSQDSPAVPHPGPLQH
                     WQPENVNQAFTRPPPPYPGNIRSPVAPPLGPRYAVFPKDQRGPYPPDVASMGMRPHGF
                     RFGFPGGSHGTMPSQERFLVPPQQIQGSGVSPQLRRSVSVDMPRPLNNSQMNNPVGLP
                     QHFSPQSLPVQQHNILGQAYIELRHRAPDGRQRLPFSAPPGSVVEASSNLRHGNFIPR
                     PDFPGPRHTDPMRRPPQGLPNQLPVHPDLEQVPPSQQEQGHSVHSSSMVMRTLNHPLG
                     GEFSEAPLSTSVPSETTSDNLQITTQPSDGLEEKLDSDDPSVKELDVKDLEGVEVKDL
                     DDEDLENLNLDTEDGKVVELDTLDNLETNDPNLDDLLRSGEFDIIAYTDPELDMGDKK
                     SMFNEELDLPIDDKLDNQCVSVEPKKKEQENKTLVLSDKHSPQKKSTVTNEVKTEVLS
                     PNSKVESKCETEKNDENKDNVDTPCSQASAHSDLNDGEKTSLHPCDPDLFEKRTNRET
                     AGPSANVIQASTQLPAQDVINSCGITGSTPVLSSLLANEKSDNSDIRPSGSPPPPTLP
                     ASPSNHVSSLPPFIAPPGRVLDNAMNSNVTVVSRVNHVFSQGVQVNPGLIPGQSTVNH
                     SLGTGKPATQTGPQTSQSGTSSMSGPQQLMIPQTLAQQNRERPLLLEEQPLLLQDLLD
                     QERQEQQQQRQMQAMIRQRSEPFFPNIDFDAITDPIMKAKMVALKGINKVMAQNNLGM
                     PPMVMSRFPFMGQVVTGTQNSEGQNLGPQAIPQDGSITHQISRPNPPNFGPGFVNDSQ
                     RKQYEEWLQETQQLLQMQQKYLEEQIGAHRKSKKALSAKQRTAKKAGREFPEEDAEQL
                     KHVTEQQSMVQKQLEQIRKQQKEHAELIEDYRIKQQQQCAMAPPTMMPSVQPQPPLIP
                     GATPPTMSQPTFPMVPQQLQHQQHTTVISGHTSPVRMPSLPGWQPNSAPAHLPLNPPR
                     IQPPIAQLPIKTCTPAPGTVSNANPQSGPPPRVEFDDNNPFSESFQERERKERLREQQ
                     ERQRIQLMQEVDRQRALQQRMEMEQHGMVGSEISSSRTSVSQIPFYSSDLPCDFMQPL
                     GPLQQSPQHQQQMGQVLQQQNIQQGSINSPSTQTFMQTNERRQVGPPSFVPDSPSIPV
                     GSPNFSSVKQGHGNLSGTSFQQSPVRPSFTPALPAAPPVANSSLPCGQDSTITHGHSY
                     PGSTQSLIQLYSDIIPEEKGKKKRTRKKKRDDDAESTKAPSTPHSDITAPPTPGISET
                     TSTPAVSTPSELPQQADQESVEPVGPSTPNMAAGQLCTELENKLPNSDFSQATPNQQT
                     YANSEVDKLSMETPAKTEEIKLEKAETESCPGQEEPKLEEQNGSKVEGNAVACPVSSA
                     QSPPHSAGAPAAKGDSGNELLKHLLKNKKSSSLLNQKPEGSICSEDDCTKDNKLVEKQ
                     NPAEGLQTLGAQMQGGFGCGNQLPKTDGGSETKKQRSKRTQRTGEKAAPRSKKRKKDE
                     EEKQAMYSSTDTFTHLKQQNNLSNPPTPPASLPPTPPPMACQKMANGFATTEELAGKA
                     GVLVSHEVTKTLGPKPFQLPFRPQDDLLARALAQGPKTVDVPASLPTPPHNNQEELRI
                     QDHCGDRDTPDSFVPSSSPESVVGVEVSRYPDLSLVKEEPPEPVPSPIIPILPSTAGK
                     SSESRRNDIKTEPGTLYFASPFGPSPNGPRSGLISVAITLHPTAAENISSVVAAFSDL
                     LHVRIPNSYEVSSAPDVPSMGLVSSHRINPGLEYRQHLLLRGPPPGSANPPRLVSSYR
                     LKQPNVPFPPTSNGLSGYKDSSHGIAESAALRPQWCCHCKVVILGSGVRKSFKDLTLL
                     NKDSRESTKRVEKDIVFCSNNCFILYSSTAQAKNSENKESIPSLPQSPMRETPSKAFH
                     QYSNNISTLDVHCLPQLPEKASPPASPPIAFPPAFEAAQVEAKPDELKVTVKLKPRLR
                     AVHGGFEDCRPLNKKWRGMKWKKWSIHIVIPKGTFKPPCEDEIDEFLKKLGTSLKPDP
                     VPKDYRKCCFCHEEGDGLTDGPARLLNLDLDLWVHLNCALWSTEVYETQAGALINVEL
                     ALRRGLQMKCVFCHKTGATSGCHRFRCTNIYHFTCAIKAQCMFFKDKTMLCPMHKPKG
                     IHEQELSYFAVFRRVYVQRDEVRQIASIVQRGERDHTFRVGSLIFHTIGQLLPQQMQA
                     FHSPKALFPVGYEASRLYWSTRYANRRCRYLCSIEEKDGRPVFVIRIVEQGHEDLVLS
                     DISPKGVWDKILEPVACVRKKSEMLQLFPAYLKGEDLFGLTVSAVARIAESLPGVEAC
                     ENYTFRYGRNPLMELPLAVNPTGCARSEPKMSAHVKRFVLRPHTLNSTSTSKSFQSTV
                     TGELNAPYSKQFVHSKSSQYRKMKTEWKSNVYLARSRIQGLGLYAARDIEKHTMVIEY
                     IGTIIRNEVANRKEKLYESQNRGVYMFRMDNDHVIDATLTGGPARYINHSCAPNCVAE
                     VVTFERGHKIIISSSRRIQKGEELCYDYKFDFEDDQHKIPCHCGAVNCRKWMN"
     exon            379..467
                     /gene="KMT2C"
                     /gene_synonym="HALR; KLEFS2; MLL3"
                     /inference="alignment:Splign:2.1.0"
     exon            468..606
                     /gene="KMT2C"
                     /gene_synonym="HALR; KLEFS2; MLL3"
                     /inference="alignment:Splign:2.1.0"
     exon            607..807
                     /gene="KMT2C"
                     /gene_synonym="HALR; KLEFS2; MLL3"
                     /inference="alignment:Splign:2.1.0"
     exon            808..956
                     /gene="KMT2C"
                     /gene_synonym="HALR; KLEFS2; MLL3"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1066
                     /gene="KMT2C"
                     /gene_synonym="HALR; KLEFS2; MLL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1229
                     /gene="KMT2C"
                     /gene_synonym="HALR; KLEFS2; MLL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1401
                     /gene="KMT2C"
                     /gene_synonym="HALR; KLEFS2; MLL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..1516
                     /gene="KMT2C"
                     /gene_synonym="HALR; KLEFS2; MLL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1686
                     /gene="KMT2C"
                     /gene_synonym="HALR; KLEFS2; MLL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..1838
                     /gene="KMT2C"
                     /gene_synonym="HALR; KLEFS2; MLL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1839..1952
                     /gene="KMT2C"
                     /gene_synonym="HALR; KLEFS2; MLL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1953..2030
                     /gene="KMT2C"
                     /gene_synonym="HALR; KLEFS2; MLL3"
                     /inference="alignment:Splign:2.1.0"
     exon            2031..2749
                     /gene="KMT2C"
                     /gene_synonym="HALR; KLEFS2; MLL3"
                     /inference="alignment:Splign:2.1.0"
     exon            2750..2869
                     /gene="KMT2C"
                     /gene_synonym="HALR; KLEFS2; MLL3"
                     /inference="alignment:Splign:2.1.0"
     exon            2870..2986
                     /gene="KMT2C"
                     /gene_synonym="HALR; KLEFS2; MLL3"
                     /inference="alignment:Splign:2.1.0"
     exon            2987..3088
                     /gene="KMT2C"
                     /gene_synonym="HALR; KLEFS2; MLL3"
                     /inference="alignment:Splign:2.1.0"
     exon            3089..3193
                     /gene="KMT2C"
                     /gene_synonym="HALR; KLEFS2; MLL3"
                     /inference="alignment:Splign:2.1.0"
     exon            3194..3375
                     /gene="KMT2C"
                     /gene_synonym="HALR; KLEFS2; MLL3"
                     /inference="alignment:Splign:2.1.0"
     exon            3376..3540
                     /gene="KMT2C"
                     /gene_synonym="HALR; KLEFS2; MLL3"
                     /inference="alignment:Splign:2.1.0"
     exon            3541..3650
                     /gene="KMT2C"
                     /gene_synonym="HALR; KLEFS2; MLL3"
                     /inference="alignment:Splign:2.1.0"
     exon            3651..3716
                     /gene="KMT2C"
                     /gene_synonym="HALR; KLEFS2; MLL3"
                     /inference="alignment:Splign:2.1.0"
     exon            3717..3929
                     /gene="KMT2C"
                     /gene_synonym="HALR; KLEFS2; MLL3"
                     /inference="alignment:Splign:2.1.0"
     exon            3930..4058
                     /gene="KMT2C"
                     /gene_synonym="HALR; KLEFS2; MLL3"
                     /inference="alignment:Splign:2.1.0"
     exon            4059..4178
                     /gene="KMT2C"
                     /gene_synonym="HALR; KLEFS2; MLL3"
                     /inference="alignment:Splign:2.1.0"
     exon            4179..4309
                     /gene="KMT2C"
                     /gene_synonym="HALR; KLEFS2; MLL3"
                     /inference="alignment:Splign:2.1.0"
     exon            4310..4490
                     /gene="KMT2C"
                     /gene_synonym="HALR; KLEFS2; MLL3"
                     /inference="alignment:Splign:2.1.0"
     exon            4491..4595
                     /gene="KMT2C"
                     /gene_synonym="HALR; KLEFS2; MLL3"
                     /inference="alignment:Splign:2.1.0"
     exon            4596..4724
                     /gene="KMT2C"
                     /gene_synonym="HALR; KLEFS2; MLL3"
                     /inference="alignment:Splign:2.1.0"
     exon            4725..4757
                     /gene="KMT2C"
                     /gene_synonym="HALR; KLEFS2; MLL3"
                     /inference="alignment:Splign:2.1.0"
     exon            4758..4877
                     /gene="KMT2C"
                     /gene_synonym="HALR; KLEFS2; MLL3"
                     /inference="alignment:Splign:2.1.0"
     exon            4878..5010
                     /gene="KMT2C"
                     /gene_synonym="HALR; KLEFS2; MLL3"
                     /inference="alignment:Splign:2.1.0"
     exon            5011..5225
                     /gene="KMT2C"
                     /gene_synonym="HALR; KLEFS2; MLL3"
                     /inference="alignment:Splign:2.1.0"
     exon            5226..5299
                     /gene="KMT2C"
                     /gene_synonym="HALR; KLEFS2; MLL3"
                     /inference="alignment:Splign:2.1.0"
     exon            5300..5482
                     /gene="KMT2C"
                     /gene_synonym="HALR; KLEFS2; MLL3"
                     /inference="alignment:Splign:2.1.0"
     exon            5483..7366
                     /gene="KMT2C"
                     /gene_synonym="HALR; KLEFS2; MLL3"
                     /inference="alignment:Splign:2.1.0"
     exon            7367..7659
                     /gene="KMT2C"
                     /gene_synonym="HALR; KLEFS2; MLL3"
                     /inference="alignment:Splign:2.1.0"
     exon            7660..9479
                     /gene="KMT2C"
                     /gene_synonym="HALR; KLEFS2; MLL3"
                     /inference="alignment:Splign:2.1.0"
     exon            9480..9591
                     /gene="KMT2C"
                     /gene_synonym="HALR; KLEFS2; MLL3"
                     /inference="alignment:Splign:2.1.0"
     exon            9592..9670
                     /gene="KMT2C"
                     /gene_synonym="HALR; KLEFS2; MLL3"
                     /inference="alignment:Splign:2.1.0"
     exon            9671..9734
                     /gene="KMT2C"
                     /gene_synonym="HALR; KLEFS2; MLL3"
                     /inference="alignment:Splign:2.1.0"
     exon            9735..9967
                     /gene="KMT2C"
                     /gene_synonym="HALR; KLEFS2; MLL3"
                     /inference="alignment:Splign:2.1.0"
     exon            9968..11677
                     /gene="KMT2C"
                     /gene_synonym="HALR; KLEFS2; MLL3"
                     /inference="alignment:Splign:2.1.0"
     exon            11678..11887
                     /gene="KMT2C"
                     /gene_synonym="HALR; KLEFS2; MLL3"
                     /inference="alignment:Splign:2.1.0"
     exon            11888..12029
                     /gene="KMT2C"
                     /gene_synonym="HALR; KLEFS2; MLL3"
                     /inference="alignment:Splign:2.1.0"
     exon            12030..12177
                     /gene="KMT2C"
                     /gene_synonym="HALR; KLEFS2; MLL3"
                     /inference="alignment:Splign:2.1.0"
     exon            12178..12356
                     /gene="KMT2C"
                     /gene_synonym="HALR; KLEFS2; MLL3"
                     /inference="alignment:Splign:2.1.0"
     exon            12357..12493
                     /gene="KMT2C"
                     /gene_synonym="HALR; KLEFS2; MLL3"
                     /inference="alignment:Splign:2.1.0"
     exon            12494..12743
                     /gene="KMT2C"
                     /gene_synonym="HALR; KLEFS2; MLL3"
                     /inference="alignment:Splign:2.1.0"
     exon            12744..12883
                     /gene="KMT2C"
                     /gene_synonym="HALR; KLEFS2; MLL3"
                     /inference="alignment:Splign:2.1.0"
     exon            12884..12991
                     /gene="KMT2C"
                     /gene_synonym="HALR; KLEFS2; MLL3"
                     /inference="alignment:Splign:2.1.0"
     exon            12992..14111
                     /gene="KMT2C"
                     /gene_synonym="HALR; KLEFS2; MLL3"
                     /inference="alignment:Splign:2.1.0"
     exon            14112..14248
                     /gene="KMT2C"
                     /gene_synonym="HALR; KLEFS2; MLL3"
                     /inference="alignment:Splign:2.1.0"
     exon            14249..14391
                     /gene="KMT2C"
                     /gene_synonym="HALR; KLEFS2; MLL3"
                     /inference="alignment:Splign:2.1.0"
     exon            14392..14560
                     /gene="KMT2C"
                     /gene_synonym="HALR; KLEFS2; MLL3"
                     /inference="alignment:Splign:2.1.0"
     exon            14561..14677
                     /gene="KMT2C"
                     /gene_synonym="HALR; KLEFS2; MLL3"
                     /inference="alignment:Splign:2.1.0"
     exon            14678..14751
                     /gene="KMT2C"
                     /gene_synonym="HALR; KLEFS2; MLL3"
                     /inference="alignment:Splign:2.1.0"
     exon            14752..14860
                     /gene="KMT2C"
                     /gene_synonym="HALR; KLEFS2; MLL3"
                     /inference="alignment:Splign:2.1.0"
     exon            14861..16860
                     /gene="KMT2C"
                     /gene_synonym="HALR; KLEFS2; MLL3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      16597..16602
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KMT2C"
                     /gene_synonym="HALR; KLEFS2; MLL3"
                     /note="hexamer: AATAAA"
     polyA_site      16631
                     /gene="KMT2C"
                     /gene_synonym="HALR; KLEFS2; MLL3"
     regulatory      16838..16843
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KMT2C"
                     /gene_synonym="HALR; KLEFS2; MLL3"
                     /note="hexamer: AATAAA"
     polyA_site      16860
                     /gene="KMT2C"
                     /gene_synonym="HALR; KLEFS2; MLL3"
                     /note="major polyA site"
ORIGIN      
        1 ggtgcgcgcg cccgcgccga tgtgtgtgag tgcgtgtcct gctcgctcca tgttgccgcc
       61 tctcccggta cctgctgctg ctcccggggc tgcgggaaat gcgagaggct gagccgggga
      121 ggaggaaccc gagcagcagc ggcggcggcg gcggccgcgg cggcgggagc cccccaggag
      181 gaggaccggg atccatgtgt ctttcctggt gactaggatg tcgtcggagg aggacaagag
      241 cgtggagcag ccgcagccgc cgccaccacc ccccgaggag cctggagccc cggccccgag
      301 ccccgcagcc gcagacaaaa gacctcgggg ccggcctcgc aaagatggcg cttccccttt
      361 ccagagagcc agaaagaaac ctcgaagtag ggggaaaact gcagtggaag atgaggacag
      421 catggatggg ctggagacaa cagaaacaga aacgattgtg gaaacagaaa tcaaagaaca
      481 atctgcagaa gaggatgctg aagcagaagt ggataacagc aaacagctaa ttccaactct
      541 tcagcgatct gtgtctgagg aatcggcaaa ctccctggtc tctgttggtg tagaagccaa
      601 aatcagtgaa cagctctgcg ctttttgtta ctgtggggaa aaaagttcct taggacaagg
      661 agacttaaaa caattcagaa taacgcctgg atttatcttg ccatggagaa accaaccttc
      721 taacaagaag gacattgatg acaacagcaa tggaacctat gagaaaatgc aaaactcagc
      781 accacgaaaa caaagaggac agagaaaaga acgatctcct cagcagaata tagtatcttg
      841 tgtaagtgta agcacccaga cagcttcaga tgatcaagct ggtaaactgt gggatgaact
      901 cagtctggtt gggcttccag atgccattga tatccaagcc ttatttgatt ctacaggcac
      961 ttgttgggct catcaccgtt gtgtggagtg gtcactagga gtatgccaga tggaagaacc
     1021 attgttagtg aacgtggaca aagctgttgt ctcagggagc acagaacgat gtgcattttg
     1081 taagcacctt ggagccacta tcaaatgctg tgaagagaaa tgtacccaga tgtatcatta
     1141 tccttgtgct gcaggagccg gcacctttca ggatttcagt cacatcttcc tgctttgtcc
     1201 agaacacatt gaccaagctc ctgaaagatc gaaggaagat gcaaactgtg cagtgtgcga
     1261 cagcccggga gacctcttag atcagttctt ttgtactact tgtggtcagc actatcatgg
     1321 aatgtgcctg gatatagcgg ttactccatt aaaacgtgca ggttggcaat gtcctgagtg
     1381 caaagtgtgc cagaactgca aacaatcggg agaagatagc aagatgctag tgtgtgatac
     1441 gtgtgacaaa gggtatcata ctttttgtct tcaaccagtt atgaaatcag taccaaccaa
     1501 tggctggaaa tgcaaaaatt gcagaatatg tatagagtgt ggcacacggt ctagttctca
     1561 gtggcaccac aattgcctga tatgtgacaa ttgttaccaa cagcaggata acttatgtcc
     1621 cttctgtggg aagtgttatc atccagaatt gcagaaagac atgcttcatt gtaatatgtg
     1681 caaaaggtgg gttcacctag agtgtgacaa accaacagat catgaactgg atactcagct
     1741 caaagaagag tatatctgca tgtattgtaa acacctggga gctgagatgg atcgtttaca
     1801 gccaggtgag gaagtggaga tagctgagct cactacagat tataacaatg aaatggaagt
     1861 tgaaggccct gaagatcaaa tggtattctc agagcaggca gctaataaag atgtcaacgg
     1921 tcaggagtcc actcctggaa ttgttccaga tgcggttcaa gtccacactg aagagcaaca
     1981 gaagagtcat ccctcagaaa gtcttgacac agatagtctt cttattgctg tatcatccca
     2041 acatacagtg aatactgaat tggaaaaaca gatttctaat gaagttgata gtgaagacct
     2101 gaaaatgtct tctgaagtga agcatatttg tggcgaagat caaattgaag ataaaatgga
     2161 agtgacagaa aacattgaag tcgttacaca ccagatcact gtgcagcaag aacaactgca
     2221 gttgttagag gaacctgaaa cagtggtatc cagagaagaa tcaaggcctc caaaattagt
     2281 catggaatct gtcactcttc cactagaaac cttagtgtcc ccacatgagg aaagtatttc
     2341 attatgtcct gaggaacagt tggttataga aaggctacaa ggagaaaagg aacagaaaga
     2401 aaattctgaa ctttctactg gattgatgga ctctgaaatg actcctacaa ttgagggttg
     2461 tgtgaaagat gtttcatacc aaggaggcaa atctataaag ttatcatctg agacagagtc
     2521 atcattttca tcatcagcag acataagcaa ggcagatgtg tcttcctccc caacaccttc
     2581 ttcagacttg ccttcgcatg acatgctgca taattaccct tcagctctta gttcctctgc
     2641 tggaaacatc atgccaacaa cttacatctc agtcactcca aaaattggca tgggtaaacc
     2701 agctattact aagagaaaat tttctcctgg tagacctcgg tccaaacagg gggcttggag
     2761 tacccataat acagtgagcc caccttcctg gtccccagac atttcagaag gtcgggaaat
     2821 ttttaaaccc aggcagcttc ctggcagtgc catttggagc atcaaagtgg gccgtgggtc
     2881 tggatttcca ggaaagcgga gacctcgagg tgcaggactg tcggggcgag gtggccgagg
     2941 caggtcaaag ctgaaaagtg gaatcggagc tgttgtatta cctggggtgt ctactgcaga
     3001 tatttcatca aataaggatg atgaagaaaa ctctatgcac aatacagttg tgttgttttc
     3061 tagcagtgac aagttcactt tgaatcagga tatgtgtgta gtttgtggca gttttggcca
     3121 aggagcagaa ggaagattac ttgcctgttc tcagtgtggt cagtgttacc atccatactg
     3181 tgtcagtatt aagatcacta aagtggttct tagcaaaggt tggaggtgtc ttgagtgcac
     3241 tgtgtgtgag gcctgtggga aggcaactga cccaggaaga ctcctgctgt gtgatgactg
     3301 tgacataagt tatcacacct actgcctaga ccctccattg cagacagttc ccaaaggagg
     3361 ctggaagtgc aaatggtgtg tttggtgcag acactgtgga gcaacatctg caggtctaag
     3421 atgtgaatgg cagaacaatt acacacagtg cgctccttgt gcaagcttat cttcctgtcc
     3481 agtctgctat cgaaactata gagaagaaga tcttattctg caatgtagac aatgtgatag
     3541 atggatgcat gcagtttgtc agaacttaaa tactgaggaa gaagtggaaa atgtagcaga
     3601 cattggtttt gattgtagca tgtgcagacc ctatatgcct gcgtctaatg tgccttcctc
     3661 agactgctgt gaatcttcac ttgtagcaca aattgtcaca aaagtaaaag agctagaccc
     3721 acccaagact tatacccagg atggtgtgtg tttgactgaa tcagggatga ctcagttaca
     3781 gagcctcaca gttacagttc caagaagaaa acggtcaaaa ccaaaattga aattgaagat
     3841 tataaatcag aatagcgtgg ccgtccttca gacccctcca gacatccaat cagagcattc
     3901 aagggatggt gaaatggatg atagtcgaga aggagaactt atggattgtg atggaaaatc
     3961 agaatctagt cctgagcggg aagctgtgga tgatgaaact aagggagtgg aaggaacaga
     4021 tggtgtcaaa aagagaaaaa ggaaaccata cagaccaggt attggtggat ttatggtgcg
     4081 gcaaagaagt cgaactgggc aagggaaaac caaaagatct gtgatcagaa aagattcctc
     4141 aggctctatt tccgagcagt taccttgcag agatgatggc tggagtgagc agttaccaga
     4201 tactttagtt gatgaatctg tttctgttac tgaaagcact gaaaaaataa agaagagata
     4261 ccgaaaaagg aaaaataagc ttgaagaaac tttccctgcc tatttacaag aagctttctt
     4321 tggaaaagat cttctagata caagtagaca aagcaagata agtttagata atctgtcaga
     4381 agatggagct cagcttttat ataaaacaaa catgaacaca ggtttcttgg atccttcctt
     4441 agatccacta cttagttcat cctcggctcc aacaaaatct ggaactcacg gtcctgctga
     4501 tgacccatta gctgatattt ctgaagtttt aaacacagat gatgacattc ttggaataat
     4561 ttcagatgat ctagcaaaat cagttgatca ttcagatatt ggtcctgtca ctgatgatcc
     4621 ttcctctttg cctcagccaa atgtcaatca gagttcacga ccattaagtg aagaacagct
     4681 agatgggatc ctcagtcctg aactagacaa aatggtcaca gatggagcaa ttcttggaaa
     4741 attatataaa attccagagc ttggcggaaa agatgttgaa gacttattta cagctgtact
     4801 tagtcctgcg aacactcagc caactccatt gccacagcct cccccaccaa cacagctgtt
     4861 gccaatacac aatcaggatg ctttttcacg gatgcctctc atgaatggcc ttattggatc
     4921 cagtcctcat ctcccacata attctttgcc acctggaagc ggactgggaa ctttctctgc
     4981 aattgcacaa tcctcttatc ctgatgccag ggataaaaat tcagccttta atccaatggc
     5041 aagtgatcct aacaactctt ggacatcatc agctcccact gtggaaggag aaaatgacac
     5101 aatgtcgaat gcccagagaa gcacgcttaa gtgggagaaa gaggaggctc tgggtgaaat
     5161 ggcaactgtt gccccagttc tctacaccaa tattaatttc cccaacttaa aggaagaatt
     5221 ccctgattgg actactagag tgaagcaaat tgccaaattg tggagaaaag caagctcaca
     5281 agaaagagca ccatatgtgc aaaaagccag agataacaga gctgctttac gcattaataa
     5341 agtacagatg tcaaatgatt ccatgaaaag gcagcaacag caagatagca ttgatcccag
     5401 ctctcgtatt gattcggagc tttttaaaga tcctttaaag caaagagaat cagaacatga
     5461 acaggaatgg aaatttagac agcaaatgcg tcagaaaagt aagcagcaag ctaaaattga
     5521 agccacacag aaacttgaac aggtgaaaaa tgagcagcag cagcagcaac aacagcaatt
     5581 tggttctcag catcttctgg tgcagtctgg ttcagataca ccaagtagtg ggatacagag
     5641 tcccttgaca cctcagcctg gcaatggaaa tatgtctcct gcacagtcat tccataaaga
     5701 actgtttaca aaacagccac ccagtacccc tacgtctaca tcttcagatg atgtgtttgt
     5761 aaagccacaa gctccacctc ctcctccagc cccatcccgg attcccatcc aggatagtct
     5821 ttctcaggct cagacttctc agccaccctc accgcaagtg ttttcacctg ggtcctctaa
     5881 ctcacgacca ccatctccaa tggatccata tgcaaaaatg gttggtaccc ctcgaccacc
     5941 tcctgtgggc catagttttt ccagaagaaa ttctgctgca ccagtggaaa actgtacacc
     6001 tttatcatcg gtatctaggc cccttcaaat gaatgagaca acagcaaata ggccatcccc
     6061 tgtcagagat ttatgttctt cttccacgac aaataatgac ccctatgcaa aacctccaga
     6121 cacacctagg cctgtgatga cagatcaatt tcccaaatcc ttgggcctat cccggtctcc
     6181 tgtagtttca gaacaaactg caaaaggccc tatagcagct ggaaccagtg atcactttac
     6241 taaaccatct cctagggcag atgtgtttca aagacaaagg atacctgact catatgcacg
     6301 acccttgttg acacctgcac ctcttgatag tggtcctgga ccttttaaga ctccaatgca
     6361 acctcctcca tcctctcagg atccttatgg atcagtgtca caggcatcaa ggcgattgtc
     6421 tgttgaccct tatgaaaggc ctgctttgac accaagacct atagataatt tttctcataa
     6481 tcagtcaaat gatccatata gtcagcctcc ccttacccca catccagcag tgaatgaatc
     6541 ttttgcccat ccttcaaggg ctttttccca gcctggaacc atatcaaggc caacatctca
     6601 ggacccatac tcccaacccc caggaactcc acgacctgtt gtagattctt attcccaatc
     6661 ttcaggaaca gctaggtcca atacagaccc ttactctcaa cctcctggaa ctccccggcc
     6721 tactactgtt gacccatata gtcagcagcc ccaaacccca agaccatcta cacaaactga
     6781 cttgtttgtt acacctgtaa caaatcagag gcattctgat ccatatgctc atcctcctgg
     6841 aacaccaaga cctggaattt ctgtccctta ctctcagcca ccagcaacac caaggccaag
     6901 gatttcagag ggttttacta ggtcctcaat gacaagacca gtcctcatgc caaatcagga
     6961 tcctttcctg caagcagcac aaaaccgagg accagcttta cctggcccgt tggtaaggcc
     7021 acctgataca tgttcccaga cacctaggcc ccctggacct ggtctttcag acacatttag
     7081 ccgtgtttcc ccatctgctg cccgtgatcc ctatgatcag tctccaatga ctccaagatc
     7141 tcagtctgac tcttttggaa caagtcaaac tgcccatgat gttgctgatc agccaaggcc
     7201 tggatcagag gggagcttct gtgcatcttc aaactctcca atgcactccc aaggccagca
     7261 gttctctggt gtctcccaac ttcctggacc tgtgccaact tcaggagtaa ctgatacaca
     7321 gaatactgta aatatggccc aagcagatac agagaaattg agacagcggc agaagttacg
     7381 tgaaatcatt ctccagcagc aacagcagaa gaagattgca ggtcgacagg agaaggggtc
     7441 acaggactca cccgcagtgc ctcatccagg gcctcttcaa cactggcaac cagagaatgt
     7501 taaccaggct ttcaccagac ccccacctcc ctatcctggg aacattaggt ctcctgttgc
     7561 ccctccttta ggacctagat atgctgtttt cccaaaagat cagcgtggac cctatcctcc
     7621 tgatgttgct agtatgggga tgagacctca tggatttaga tttggatttc caggaggtag
     7681 tcatggtacc atgccgagtc aagagcgctt ccttgtgcct cctcagcaaa tacagggatc
     7741 tggagtttct ccacagctaa gaagatcagt atctgtagat atgcctaggc ctttaaataa
     7801 ctcacaaatg aataatccag ttggacttcc tcagcatttt tcaccacaga gcttgccagt
     7861 tcagcagcac aacatactgg gccaagcata tattgaactg agacataggg ctcctgacgg
     7921 aaggcaacgg ctgcctttca gtgctccacc tggcagcgtt gtagaggcat cttctaatct
     7981 gagacatgga aacttcattc cccggccaga ctttccgggc cctagacaca cagaccccat
     8041 gcgacgacct ccccagggtc tacctaatca gctacctgtg cacccagatt tggaacaagt
     8101 gccaccatct caacaagagc aaggtcattc tgtccattca tcttctatgg tcatgaggac
     8161 tctgaaccat ccactaggtg gtgaattttc agaagctcct ttgtcaacat ctgtaccgtc
     8221 tgaaacaacg tctgataatt tacagataac cacccagcct tctgatggtc tagaggaaaa
     8281 acttgattct gatgaccctt ctgtgaagga actggatgtt aaagaccttg agggggttga
     8341 agtcaaagac ttagatgatg aagatcttga aaacttaaat ttagatacag aggatggcaa
     8401 ggtagttgaa ttggatactt tagataattt ggaaactaat gatcccaacc tggatgacct
     8461 cttaaggtca ggagagtttg atatcattgc atatacagat ccagaacttg acatgggaga
     8521 taagaaaagc atgtttaatg aggaactaga ccttccaatt gatgataagt tagataatca
     8581 gtgtgtatct gttgaaccaa aaaaaaagga acaagaaaac aaaactctgg ttctctctga
     8641 taaacattca ccacagaaaa aatccactgt taccaatgag gtaaaaacgg aagtactgtc
     8701 tccaaattct aaggtggaat ccaaatgtga aactgaaaaa aatgatgaga ataaagataa
     8761 tgttgacact ccttgctcac aggcttctgc tcactcagac ctaaatgatg gagaaaagac
     8821 ttctttgcat ccttgtgatc cagatctatt tgagaaaaga accaatcgag aaactgctgg
     8881 ccccagtgca aatgtcattc aggcatccac tcaactacct gctcaagatg taataaactc
     8941 ttgtggcata actggatcaa ctccagttct ctcaagttta cttgctaatg agaaatctga
     9001 taattcagac attaggccat cggggtctcc accaccacca actctgccgg cctccccatc
     9061 caatcatgtg tcaagtttgc ctcctttcat agcaccgcct ggccgtgttt tggataatgc
     9121 catgaattct aatgtgacag tagtctctag ggtaaaccat gttttttctc agggtgtgca
     9181 ggtaaaccca gggctcattc caggtcaatc aacagttaac cacagtctgg ggacaggaaa
     9241 acctgcaact caaactgggc ctcaaacaag tcagtctggt accagtagca tgtctggacc
     9301 ccaacagcta atgattcctc aaacattagc acagcagaat agagagaggc cccttcttct
     9361 agaagaacag cctctacttc tacaggatct tttggatcaa gaaaggcaag aacagcagca
     9421 gcaaagacag atgcaagcca tgattcgtca gcgatcagaa ccgttcttcc ctaatattga
     9481 ttttgatgca attacagatc ctataatgaa agccaaaatg gtggccctta aaggtataaa
     9541 taaagtgatg gcacaaaaca atctgggcat gccaccaatg gtgatgagca ggttcccttt
     9601 tatgggccag gtggtaactg gaacacagaa cagtgaagga cagaaccttg gaccacaggc
     9661 cattcctcag gatggcagta taacacatca gatttctagg cctaatcctc caaattttgg
     9721 tccaggcttt gtcaatgatt cacagcgtaa gcagtatgaa gagtggctcc aggagaccca
     9781 acagctgctt caaatgcagc agaagtatct tgaagaacaa attggtgctc acagaaaatc
     9841 taagaaggcc ctttcagcta aacaacgtac tgccaagaaa gctgggcgtg aatttccaga
     9901 ggaagatgca gaacaactca agcatgttac tgaacagcaa agcatggttc agaaacagct
     9961 agaacagatt cgtaaacaac agaaagaaca tgctgaattg attgaagatt atcggatcaa
    10021 acagcagcag caatgtgcaa tggccccacc taccatgatg cccagtgtcc agccccagcc
    10081 acccctaatt ccaggtgcca ctccacccac catgagccaa cccacctttc ccatggtgcc
    10141 acagcagctt cagcaccagc agcacacaac agttatttct ggccatacta gccctgttag
    10201 aatgcccagt ttacctggat ggcaacccaa cagtgctcct gcccacctgc ccctcaatcc
    10261 tcctagaatt cagcccccaa ttgcccagtt accaataaaa acttgtacac cagccccagg
    10321 gacagtctca aatgcaaatc cacagagtgg accaccacct cgggtagaat ttgatgacaa
    10381 caatcccttt agtgaaagtt ttcaagaacg ggaacgtaag gaacgtttac gagaacagca
    10441 agagagacaa cggatccaac tcatgcagga ggtagataga caaagagctt tgcagcagag
    10501 gatggaaatg gagcagcatg gtatggtggg ctctgagata agtagtagta ggacatctgt
    10561 gtcccagatt cccttctaca gttccgactt accttgtgat tttatgcaac ctctaggacc
    10621 ccttcagcag tctccacaac accaacagca aatggggcag gttttacagc agcagaatat
    10681 acaacaagga tcaattaatt caccctccac ccaaactttc atgcagacta atgagcgaag
    10741 gcaggtaggc cctccttcat ttgttcctga ttcaccatca atccctgttg gaagcccaaa
    10801 tttttcttct gtgaagcagg gacatggaaa tctttctggg accagcttcc agcagtcccc
    10861 agtgaggcct tcttttacac ctgctttacc agcagcacct ccagtagcta atagcagtct
    10921 cccatgtggc caagattcta ctataaccca tggacacagt tatccgggat caacccaatc
    10981 gctcattcag ttgtattctg atataatccc agaggaaaaa gggaaaaaga aaagaacaag
    11041 aaagaagaaa agagatgatg atgcagaatc caccaaggct ccatcaactc cccattcaga
    11101 tataactgcc ccaccgactc caggcatctc agaaactacc tctactcctg cagtgagcac
    11161 acccagtgag cttcctcaac aagccgacca agagtcggtg gaaccagtcg gcccatccac
    11221 tcccaatatg gcagcaggcc agctatgtac agaattagag aacaaactgc ccaatagtga
    11281 tttctcacaa gcaactccaa atcaacagac gtatgcaaat tcagaagtag acaagctctc
    11341 catggaaacc cctgccaaaa cagaagagat aaaactggaa aaggctgaga cagagtcctg
    11401 cccaggccaa gaggagccta aattggagga acagaatggt agtaaggtag aaggaaacgc
    11461 tgtagcctgt cctgtctcct cagcacagag tcctccccat tctgctgggg cccctgctgc
    11521 caaaggagac tcagggaatg aacttctgaa acacttgttg aaaaataaaa agtcatcttc
    11581 tcttttgaat caaaaacctg agggcagtat ttgttcagaa gatgactgta caaaggataa
    11641 taaactagtt gagaagcaga acccagctga aggactgcaa actttggggg ctcaaatgca
    11701 aggtggtttt ggatgtggca accagttgcc aaaaacagat ggaggaagtg aaaccaagaa
    11761 acagcgaagc aaacggactc agaggacggg tgagaaagca gcacctcgct caaagaaaag
    11821 gaaaaaggac gaagaggaga aacaagctat gtactctagc actgacacgt ttacccactt
    11881 gaaacagcag aataatttaa gtaatcctcc aacaccccct gcctctcttc ctcctacacc
    11941 acctcctatg gcttgtcaga agatggccaa tggttttgca acaactgaag aacttgctgg
    12001 aaaagccgga gtgttagtga gccatgaagt taccaaaact ctaggaccta aaccatttca
    12061 gctgcccttc agaccccagg acgacttgtt ggcccgagct cttgctcagg gccccaagac
    12121 agttgatgtg ccagcctccc tcccaacacc acctcataac aatcaggaag aattaaggat
    12181 acaggatcac tgtggtgatc gagatactcc tgacagtttt gttccctcat cctctcctga
    12241 gagtgtggtt ggggtagaag tgagcaggta tccagatctg tcattggtca aggaggagcc
    12301 tccagaaccg gtgccgtccc ccatcattcc aattcttcct agcactgctg ggaaaagttc
    12361 agaatcaaga aggaatgaca tcaaaactga gccaggcact ttatattttg cgtcaccttt
    12421 tggtccttcc ccaaatggtc ccagatcagg tcttatatct gtagcaatta ctctgcatcc
    12481 tacagctgct gagaacatta gcagtgttgt ggctgcattt tccgaccttc ttcacgtccg
    12541 aatccctaac agctatgagg ttagcagtgc tccagatgtc ccatccatgg gtttggtcag
    12601 tagccacaga atcaacccgg gtttggagta tcgacagcat ttacttctcc gtgggcctcc
    12661 gccaggatct gcaaaccctc ccagattagt gagctcttac cggctgaagc agcctaatgt
    12721 accatttcct ccaacaagca atggtctttc tggatataag gattctagtc atggtattgc
    12781 agaaagcgca gcactcagac cacagtggtg ttgtcattgt aaagtggtta ttcttggaag
    12841 tggtgtgcgg aaatctttca aagatctgac ccttttgaac aaggattccc gagaaagcac
    12901 caagagggta gagaaggaca ttgtcttctg tagtaataac tgctttattc tttattcatc
    12961 aactgcacaa gcgaaaaact cagaaaacaa ggaatccatt ccttcattgc cacaatcacc
    13021 tatgagagaa acgccttcca aagcatttca tcagtacagc aacaacatct ccactttgga
    13081 tgtgcactgt ctcccccagc tcccagagaa agcttctccc cctgcctcac cacccatcgc
    13141 cttccctcct gcttttgaag cagcccaagt cgaggccaag ccagatgagc tgaaggtgac
    13201 agtcaagctg aagcctcggc taagagctgt ccatggtggg tttgaagatt gcaggccgct
    13261 caataaaaaa tggagaggaa tgaaatggaa gaagtggagc attcatattg taatccctaa
    13321 ggggacattt aaaccacctt gtgaggatga aatagatgaa tttctaaaga aattgggcac
    13381 ttcccttaaa cctgatcctg tgcccaaaga ctatcggaaa tgttgctttt gtcatgaaga
    13441 aggtgatgga ttgacagatg gaccagcaag gctactcaac cttgacttgg atctgtgggt
    13501 ccacttgaac tgcgctctgt ggtccacgga ggtctatgag actcaggctg gtgccttaat
    13561 aaatgtggag ctagctctga ggagaggcct acaaatgaaa tgtgtcttct gtcacaagac
    13621 gggtgccact agtggatgcc acagatttcg atgcaccaac atttatcact tcacttgcgc
    13681 cattaaagca caatgcatgt tttttaagga caaaactatg ctttgcccca tgcacaaacc
    13741 aaagggaatt catgagcaag aattaagtta ctttgcagtc ttcaggaggg tctatgttca
    13801 gcgtgatgag gtgcgacaga ttgctagcat cgtgcaacga ggagaacggg accatacctt
    13861 tcgcgtgggt agcctcatct tccacacaat tggtcagctg cttccacagc agatgcaagc
    13921 attccattct cctaaagcac tcttccctgt gggctatgaa gccagccggc tgtactggag
    13981 cactcgctat gccaataggc gctgccgcta cctgtgctcc attgaggaga aggatgggcg
    14041 cccagtgttt gtcatcagga ttgtggaaca aggccatgaa gacctggttc taagtgacat
    14101 ctcacctaaa ggtgtctggg ataagatttt ggagcctgtg gcatgtgtga gaaaaaagtc
    14161 tgaaatgctc cagcttttcc cagcgtattt aaaaggagag gatctgtttg gcctgaccgt
    14221 ctctgcagtg gcacgcatag cggaatcact tcctggggtt gaggcatgtg aaaattatac
    14281 cttccgatac ggccgaaatc ctctcatgga acttcctctt gccgttaacc ccacaggttg
    14341 tgcccgttct gaacctaaaa tgagtgccca tgtcaagagg tttgtgttaa ggcctcacac
    14401 cttaaacagc accagcacct caaagtcatt tcagagcaca gtcactggag aactgaacgc
    14461 accttatagt aaacagtttg ttcactccaa gtcatcgcag taccggaaga tgaaaactga
    14521 atggaaatcc aatgtgtatc tggcacggtc tcggattcag gggctgggcc tgtatgctgc
    14581 tcgagacatt gagaaacaca ccatggtcat tgagtacatc gggactatca ttcgaaacga
    14641 agtagccaac aggaaagaga agctttatga gtctcagaac cgtggtgtgt acatgttccg
    14701 catggataac gaccatgtga ttgacgcgac gctcacagga gggcccgcaa ggtatatcaa
    14761 ccattcgtgt gcacctaatt gtgtggctga agtggtgact tttgagagag gacacaaaat
    14821 tatcatcagc tccagtcgga gaatccagaa aggagaagag ctctgctatg actataagtt
    14881 tgactttgaa gatgaccagc acaagattcc gtgtcactgt ggagctgtga actgccggaa
    14941 gtggatgaac tgaaatgcat tccttgctag ctcagcgggc ggcttgtccc taggaagagg
    15001 cgattcaaca caccattgga attttgcaga cagaaagaga tttttgtttt ctgttttatg
    15061 actttttgaa aaagcttctg ggagttctga tttcctcagt cctttaggtt aaagcagcgc
    15121 caggaggaag ctgacagaag cagcgttcct gaagtggccg aggttaaacg gaatcacaga
    15181 atggtccagc acttttgctt ttttttcttt tccttttctt ttttttttgt ttgttttttg
    15241 ttttgttttt cccttgtggg tgggtttcat tgttttggtt ttctagtctc actaaggaga
    15301 aacttttact ggggcaaaga gccgatggct gccctgcccc gggcaggggc cttcctatga
    15361 atgtaagact gaaatcacca gcgaggggga cagagagtgc tggccacggc cttattaaaa
    15421 aggggcaggc cctctaactt caaaatgttt ttaaataaag tagacaccac tgaacaagga
    15481 atgtactgaa atgacttcct tagggataga gctaagggat aataacttgc actaaataca
    15541 tttaaatact tgattccatg agtcagttta ttgtagtttt tgatttctgt aaaataagag
    15601 aaacttttgt atttattatt gaataagtga atgaagctat ttttaaataa agttagaaga
    15661 aagccaagct gctgctgtta cctgcagaac taacaaaccc tgttactttg tacagatatg
    15721 taaatatttt gagaaaaaat acagtataaa aatagttatt gaccaaatgc taccaggctc
    15781 tgcagcagct cgggggctta taaaatgttc atagggatgt tacaatataa ttttgtgtta
    15841 taaaatatgc cattataatt atgtaataac caaaatttca acctagagtg ttgggggttt
    15901 tttggaaacc gcagtctatt agtactcaat ggttttatac accttacttc tgacagagcg
    15961 gggcgtatgc tacgactaca acttttatag ctgttttggt aatttaaact aattttttca
    16021 tattatattg ttgcatccct acttcttcag tcaggttttt ttgtgcttac aatttgtgat
    16081 aactgtgaat aactgcttaa aaatacaccc aaatggaggc tgaatttttt cttcagcaaa
    16141 agtagttttg attagaactt tgtttcagcc acagagaatc atgtaaacgt aataggatca
    16201 tgtagcagaa acttaaatct aaccctttag ccttctattt aacacaaaaa tttgaaaaag
    16261 ttaaaaaaaa aaaggagatg tgattatgct tacagctgca ggactctggc aatagggttt
    16321 ttggaagatg taattttaaa atgtgtttgt atgaactgtt tgtttacatt tctttaataa
    16381 aaaaaacact gttttgtgtt tgcttgtaga aacttaatca gcattttgaa ccaggttagc
    16441 tttttatttt gtacttaaaa ttctggtact gacacttcac aggctaagta taaaatgaag
    16501 ttttgtgtgc acaattcaag tggactgtaa actgttggta tattcagtga tgcagttctg
    16561 aacttgtata tggcatgatg tatttttatc ttacagaata aatcaattgt atatattttt
    16621 ctcttgataa atagctgtat gaaatttgtt tcctgaatat ttttcttctc ttgtacaata
    16681 tcctgacatc ctaccagtat ttgtcctacc gggtttttgt tgttttctgt tctgtataat
    16741 agtatctaat gttggcaaaa attgaatttt ttgaagtata cagagtgtta tgggttttgg
    16801 aatttgtgga cacagattta gaagatcacc atttacaaat aaaatatttt acatctataa
//
