LOCUS       NM_014727               8485 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens lysine methyltransferase 2B (KMT2B), mRNA.
ACCESSION   NM_014727
VERSION     NM_014727.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8485)
  AUTHORS   Becht,D.C., Mohid,S.A., Lee,J.E., Zandian,M., Benz,C., Biswas,S.,
            Sinha,V.K., Ivarsson,Y., Ge,K., Zhang,Y. and Kutateladze,T.G.
  TITLE     MLL4 binds TET3
  JOURNAL   Structure 32 (6), 706-714 (2024)
   PUBMED   38579707
  REMARK    GeneRIF: MLL4 binds TET3.
REFERENCE   2  (bases 1 to 8485)
  AUTHORS   Ramon-Gomez,J.L., Bernal-Pacheco,O., Zarante-Bahamon,A.M.,
            Martinez-Cordoba,N. and Lince-Rivera,I.
  TITLE     [Phenotypic and genotypic spectrum of KMT2B dystonia. Description
            of three Colombian patients]
  JOURNAL   Rev Neurol 78 (10), 285-291 (2024)
   PUBMED   38743022
  REMARK    GeneRIF: [Phenotypic and genotypic spectrum of KMT2B dystonia.
            Description of three Colombian patients].
REFERENCE   3  (bases 1 to 8485)
  AUTHORS   Chen,D., Chen,Z., Wang,Z., Hong,C., Wang,Q., Yang,P., Huang,Z.,
            Lian,W., Huang,Y., Fu,W., Li,J. and Hong,Z.
  TITLE     LncRNA SEMA3B-AS1 suppresses the tumor-initiating characteristics
            of triple negative breast cancer via engaging in MLL4-mediated H3K4
            trimethylation
  JOURNAL   Mol Carcinog 63 (3), 371-383 (2024)
   PUBMED   37975495
  REMARK    GeneRIF: LncRNA SEMA3B-AS1 suppresses the tumor-initiating
            characteristics of triple negative breast cancer via engaging in
            MLL4-mediated H3K4 trimethylation.
REFERENCE   4  (bases 1 to 8485)
  AUTHORS   Chen,Y., Su,H., Zhao,J., Na,Z., Jiang,K., Bacchiocchi,A., Loh,K.H.,
            Halaban,R., Wang,Z., Cao,X. and Slavoff,S.A.
  TITLE     Unannotated microprotein EMBOW regulates the interactome and
            chromatin and mitotic functions of WDR5
  JOURNAL   Cell Rep 42 (9), 113145 (2023)
   PUBMED   37725512
REFERENCE   5  (bases 1 to 8485)
  AUTHORS   Lee,S., Lee,D.K., Dou,Y., Lee,J., Lee,B., Kwak,E., Kong,Y.Y.,
            Lee,S.K., Roeder,R.G. and Lee,J.W.
  TITLE     Coactivator as a target gene specificity determinant for histone H3
            lysine 4 methyltransferases
  JOURNAL   Proc Natl Acad Sci U S A 103 (42), 15392-15397 (2006)
   PUBMED   17021013
REFERENCE   6  (bases 1 to 8485)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   7  (bases 1 to 8485)
  AUTHORS   Milne,T.A., Dou,Y., Martin,M.E., Brock,H.W., Roeder,R.G. and
            Hess,J.L.
  TITLE     MLL associates specifically with a subset of transcriptionally
            active target genes
  JOURNAL   Proc Natl Acad Sci U S A 102 (41), 14765-14770 (2005)
   PUBMED   16199523
REFERENCE   8  (bases 1 to 8485)
  AUTHORS   Huntsman,D.G., Chin,S.F., Muleris,M., Batley,S.J., Collins,V.P.,
            Wiedemann,L.M., Aparicio,S. and Caldas,C.
  TITLE     MLL2, the second human homolog of the Drosophila trithorax gene,
            maps to 19q13.1 and is amplified in solid tumor cell lines
  JOURNAL   Oncogene 18 (56), 7975-7984 (1999)
   PUBMED   10637508
REFERENCE   9  (bases 1 to 8485)
  AUTHORS   FitzGerald,K.T. and Diaz,M.O.
  TITLE     MLL2: A new mammalian member of the trx/MLL family of genes
  JOURNAL   Genomics 59 (2), 187-192 (1999)
   PUBMED   10409430
REFERENCE   10 (bases 1 to 8485)
  AUTHORS   Abela,L. and Kurian,M.A.
  TITLE     KMT2B-Related Dystonia
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   29697234
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AD000671.1 and AJ007041.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 30, 2019 this sequence version replaced NM_014727.2.
            
            Summary: This gene encodes a protein which contains multiple
            domains including a CXXC zinc finger, three PHD zinc fingers, two
            FY-rich domains, and a SET (suppressor of variegation, enhancer of
            zeste, and trithorax) domain. The SET domain is a conserved
            C-terminal domain that characterizes proteins of the MLL
            (mixed-lineage leukemia) family. This gene is ubiquitously
            expressed in adult tissues. It is also amplified in solid tumor
            cell lines, and may be involved in human cancer. Two alternatively
            spliced transcript variants encoding distinct isoforms have been
            reported for this gene, however, the full length nature of the
            shorter transcript is not known. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ007041.1, AF186605.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000420124.4/ ENSP00000398837.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                AD000671.1         13514-13529
            17-8485             AJ007041.1         1-8469
FEATURES             Location/Qualifiers
     source          1..8485
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.12"
     gene            1..8485
                     /gene="KMT2B"
                     /gene_synonym="CXXC10; DYT28; HRX2; MLL1B; MLL2; MLL4;
                     MRD68; TRX2; WBP-7; WBP7"
                     /note="lysine methyltransferase 2B"
                     /db_xref="GeneID:9757"
                     /db_xref="HGNC:HGNC:15840"
                     /db_xref="MIM:606834"
     exon            1..379
                     /gene="KMT2B"
                     /gene_synonym="CXXC10; DYT28; HRX2; MLL1B; MLL2; MLL4;
                     MRD68; TRX2; WBP-7; WBP7"
                     /inference="alignment:Splign:2.1.0"
     CDS             17..8164
                     /gene="KMT2B"
                     /gene_synonym="CXXC10; DYT28; HRX2; MLL1B; MLL2; MLL4;
                     MRD68; TRX2; WBP-7; WBP7"
                     /EC_number="2.1.1.364"
                     /note="histone-lysine N-methyltransferase MLL4; trithorax
                     homologue 2; WW domain binding protein 7; myeloid/lymphoid
                     or mixed-lineage leukemia (trithorax homolog, Drosophila)
                     4; mixed lineage leukemia gene homolog 2; myeloid/lymphoid
                     or mixed-lineage leukemia protein 4; lysine (K)-specific
                     methyltransferase 2B"
                     /codon_start=1
                     /product="histone-lysine N-methyltransferase 2B"
                     /protein_id="NP_055542.1"
                     /db_xref="CCDS:CCDS46055.1"
                     /db_xref="GeneID:9757"
                     /db_xref="HGNC:HGNC:15840"
                     /db_xref="MIM:606834"
                     /translation="MAAAAGGGSCPGPGSARGRFPGRPRGAGGGGGRGGRGNGAERVR
                     VALRRGGGATGPGGAEPGEDTALLRLLGLRRGLRRLRRLWAGPRVQRGRGRGRGRGWG
                     PSRGCVPEEESSDGESDEEEFQGFHSDEDVAPSSLRSALRSQRGRAPRGRGRKHKTTP
                     LPPPRLADVAPTPPKTPARKRGEEGTERMVQALTELLRRAQAPQAPRSRACEPSTPRR
                     SRGRPPGRPAGPCRRKQQAVVVAEAAVTIPKPEPPPPVVPVKHQTGSWKCKEGPGPGP
                     GTPRRGGQSSRGGRGGRGRGRGGGLPFVIKFVSRAKKVKMGQLSLGLESGQGQGQHEE
                     SWQDVPQRRVGSGQGGSPCWKKQEQKLDDEEEEKKEEEEKDKEGEEKEERAVAEEMMP
                     AAEKEEAKLPPPPLTPPAPSPPPPLPPPSTSPPPPLCPPPPPPVSPPPLPSPPPPPAQ
                     EEQEESPPPVVPATCSRKRGRPPLTPSQRAEREAARAGPEGTSPPTPTPSTATGGPPE
                     DSPTVAPKSTTFLKNIRQFIMPVVSARSSRVIKTPRRFMDEDPPKPPKVEVSPVLRPP
                     ITTSPPVPQEPAPVPSPPRAPTPPSTPVPLPEKRRSILREPTFRWTSLTRELPPPPPA
                     PPPPPAPSPPPAPATSSRRPLLLRAPQFTPSEAHLKIYESVLTPPPLGAPEAPEPEPP
                     PADDSPAEPEPRAVGRTNHLSLPRFAPVVTTPVKAEVSPHGAPALSNGPQTQAQLLQP
                     LQALQTQLLPQALPPPQPQLQPPPSPQQMPPLEKARIAGVGSLPLSGVEEKMFSLLKR
                     AKVQLFKIDQQQQQKVAASMPLSPGGQMEEVAGAVKQISDRGPVRSEDESVEAKRERP
                     SGPESPVQGPRIKHVCRHAAVALGQARAMVPEDVPRLSALPLRDRQDLATEDTSSASE
                     TESVPSRSRRGKVEAAGPGGESEPTGSGGTLAHTPRRSLPSHHGKKMRMARCGHCRGC
                     LRVQDCGSCVNCLDKPKFGGPNTKKQCCVYRKCDKIEARKMERLAKKGRTIVKTLLPW
                     DSDESPEASPGPPGPRRGAGAGGPREEVVAHPGPEEQDSLLQRKSARRCVKQRPSYDI
                     FEDSDDSEPGGPPAPRRRTPRENELPLPEPEEQSRPRKPTLQPVLQLKARRRLDKDAL
                     APGPFASFPNGWTGKQKSPDGVHRVRVDFKEDCDLENVWLMGGLSVLTSVPGGPPMVC
                     LLCASKGLHELVFCQVCCDPFHPFCLEEAERPLPQHHDTWCCRRCKFCHVCGRKGRGS
                     KHLLECERCRHAYHPACLGPSYPTRATRKRRHWICSACVRCKSCGATPGKNWDVEWSG
                     DYSLCPRCTQLYEKGNYCPICTRCYEDNDYESKMMQCAQCDHWVHAKCEGLSDEDYEI
                     LSGLPDSVLYTCGPCAGAAQPRWREALSGALQGGLRQVLQGLLSSKVVGPLLLCTQCG
                     PDGKQLHPGPCGLQAVSQRFEDGHYKSVHSFMEDMVGILMRHSEEGETPDRRAGGQMK
                     GLLLKLLESAFGWFDAHDPKYWRRSTRLPNGVLPNAVLPPSLDHVYAQWRQQEPETPE
                     SGQPPGDPSAAFQGKDPAAFSHLEDPRQCALCLKYGDADSKEAGRLLYIGQNEWTHVN
                     CAIWSAEVFEENDGSLKNVHAAVARGRQMRCELCLKPGATVGCCLSSCLSNFHFMCAR
                     ASYCIFQDDKKVFCQKHTDLLDGKEIVNPDGFDVLRRVYVDFEGINFKRKFLTGLEPD
                     AINVLIGSIRIDSLGTLSDLSDCEGRLFPIGYQCSRLYWSTVDARRRCWYRCRILEYR
                     PWGPREEPAHLEAAEENQTIVHSPAPSSEPPGGEDPPLDTDVLVPGAPERHSPIQNLD
                     PPLRPDSGSAPPPAPRSFSGARIKVPNYSPSRRPLGGVSFGPLPSPGSPSSLTHHIPT
                     VGDPDFPAPPRRSRRPSPLAPRPPPSRWASPPLKTSPQLRVPPPTSVVTALTPTSGEL
                     APPGPAPSPPPPEDLGPDFEDMEVVSGLSAADLDFAASLLGTEPFQEEIVAAGAMGSS
                     HGGPGDSSEEESSPTSRYIHFPVTVVSAPGLAPSATPGAPRIEQLDGVDDGTDSEAEA
                     VQQPRGQGTPPSGPGVVRAGVLGAAGDRARPPEDLPSEIVDFVLKNLGGPGDGGAGPR
                     EESLPPAPPLANGSQPSQGLTASPADPTRTFAWLPGAPGVRVLSLGPAPEPPKPATSK
                     IILVNKLGQVFVKMAGEGEPVPPPVKQPPLPPTISPTAPTSWTLPPGPLLGVLPVVGV
                     VRPAPPPPPPPLTLVLSSGPASPPRQAIRVKRVSTFSGRSPPAPPPYKAPRLDEDGEA
                     SEDTPQVPGLGSGGFSRVRMKTPTVRGVLDLDRPGEPAGEESPGPLQERSPLLPLPED
                     GPPQVPDGPPDLLLESQWHHYSGEASSSEEEPPSPDDKENQAPKRTGPHLRFEISSED
                     GFSVEAESLEGAWRTLIEKVQEARGHARLRHLSFSGMSGARLLGIHHDAVIFLAEQLP
                     GAQRCQHYKFRYHQQGEGQEEPPLNPHGAARAEVYLRKCTFDMFNFLASQHRVLPEGA
                     TCDEEEDEVQLRSTRRATSLELPMAMRFRHLKKTSKEAVGVYRSAIHGRGLFCKRNID
                     AGEMVIEYSGIVIRSVLTDKREKFYDGKGIGCYMFRMDDFDVVDATMHGNAARFINHS
                     CEPNCFSRVIHVEGQKHIVIFALRRILRGEELTYDYKFPIEDASNKLPCNCGAKRCRR
                     FLN"
     exon            380..452
                     /gene="KMT2B"
                     /gene_synonym="CXXC10; DYT28; HRX2; MLL1B; MLL2; MLL4;
                     MRD68; TRX2; WBP-7; WBP7"
                     /inference="alignment:Splign:2.1.0"
     exon            453..2473
                     /gene="KMT2B"
                     /gene_synonym="CXXC10; DYT28; HRX2; MLL1B; MLL2; MLL4;
                     MRD68; TRX2; WBP-7; WBP7"
                     /inference="alignment:Splign:2.1.0"
     exon            2474..2587
                     /gene="KMT2B"
                     /gene_synonym="CXXC10; DYT28; HRX2; MLL1B; MLL2; MLL4;
                     MRD68; TRX2; WBP-7; WBP7"
                     /inference="alignment:Splign:2.1.0"
     exon            2588..2738
                     /gene="KMT2B"
                     /gene_synonym="CXXC10; DYT28; HRX2; MLL1B; MLL2; MLL4;
                     MRD68; TRX2; WBP-7; WBP7"
                     /inference="alignment:Splign:2.1.0"
     exon            2739..3018
                     /gene="KMT2B"
                     /gene_synonym="CXXC10; DYT28; HRX2; MLL1B; MLL2; MLL4;
                     MRD68; TRX2; WBP-7; WBP7"
                     /inference="alignment:Splign:2.1.0"
     exon            3019..3074
                     /gene="KMT2B"
                     /gene_synonym="CXXC10; DYT28; HRX2; MLL1B; MLL2; MLL4;
                     MRD68; TRX2; WBP-7; WBP7"
                     /inference="alignment:Splign:2.1.0"
     exon            3075..3350
                     /gene="KMT2B"
                     /gene_synonym="CXXC10; DYT28; HRX2; MLL1B; MLL2; MLL4;
                     MRD68; TRX2; WBP-7; WBP7"
                     /inference="alignment:Splign:2.1.0"
     exon            3351..3445
                     /gene="KMT2B"
                     /gene_synonym="CXXC10; DYT28; HRX2; MLL1B; MLL2; MLL4;
                     MRD68; TRX2; WBP-7; WBP7"
                     /inference="alignment:Splign:2.1.0"
     exon            3446..3544
                     /gene="KMT2B"
                     /gene_synonym="CXXC10; DYT28; HRX2; MLL1B; MLL2; MLL4;
                     MRD68; TRX2; WBP-7; WBP7"
                     /inference="alignment:Splign:2.1.0"
     exon            3545..3658
                     /gene="KMT2B"
                     /gene_synonym="CXXC10; DYT28; HRX2; MLL1B; MLL2; MLL4;
                     MRD68; TRX2; WBP-7; WBP7"
                     /inference="alignment:Splign:2.1.0"
     exon            3659..3805
                     /gene="KMT2B"
                     /gene_synonym="CXXC10; DYT28; HRX2; MLL1B; MLL2; MLL4;
                     MRD68; TRX2; WBP-7; WBP7"
                     /inference="alignment:Splign:2.1.0"
     exon            3806..3901
                     /gene="KMT2B"
                     /gene_synonym="CXXC10; DYT28; HRX2; MLL1B; MLL2; MLL4;
                     MRD68; TRX2; WBP-7; WBP7"
                     /inference="alignment:Splign:2.1.0"
     exon            3902..4019
                     /gene="KMT2B"
                     /gene_synonym="CXXC10; DYT28; HRX2; MLL1B; MLL2; MLL4;
                     MRD68; TRX2; WBP-7; WBP7"
                     /inference="alignment:Splign:2.1.0"
     exon            4020..4133
                     /gene="KMT2B"
                     /gene_synonym="CXXC10; DYT28; HRX2; MLL1B; MLL2; MLL4;
                     MRD68; TRX2; WBP-7; WBP7"
                     /inference="alignment:Splign:2.1.0"
     exon            4134..4318
                     /gene="KMT2B"
                     /gene_synonym="CXXC10; DYT28; HRX2; MLL1B; MLL2; MLL4;
                     MRD68; TRX2; WBP-7; WBP7"
                     /inference="alignment:Splign:2.1.0"
     exon            4319..4408
                     /gene="KMT2B"
                     /gene_synonym="CXXC10; DYT28; HRX2; MLL1B; MLL2; MLL4;
                     MRD68; TRX2; WBP-7; WBP7"
                     /inference="alignment:Splign:2.1.0"
     exon            4409..4513
                     /gene="KMT2B"
                     /gene_synonym="CXXC10; DYT28; HRX2; MLL1B; MLL2; MLL4;
                     MRD68; TRX2; WBP-7; WBP7"
                     /inference="alignment:Splign:2.1.0"
     exon            4514..4587
                     /gene="KMT2B"
                     /gene_synonym="CXXC10; DYT28; HRX2; MLL1B; MLL2; MLL4;
                     MRD68; TRX2; WBP-7; WBP7"
                     /inference="alignment:Splign:2.1.0"
     exon            4588..4703
                     /gene="KMT2B"
                     /gene_synonym="CXXC10; DYT28; HRX2; MLL1B; MLL2; MLL4;
                     MRD68; TRX2; WBP-7; WBP7"
                     /inference="alignment:Splign:2.1.0"
     exon            4704..4795
                     /gene="KMT2B"
                     /gene_synonym="CXXC10; DYT28; HRX2; MLL1B; MLL2; MLL4;
                     MRD68; TRX2; WBP-7; WBP7"
                     /inference="alignment:Splign:2.1.0"
     exon            4796..4933
                     /gene="KMT2B"
                     /gene_synonym="CXXC10; DYT28; HRX2; MLL1B; MLL2; MLL4;
                     MRD68; TRX2; WBP-7; WBP7"
                     /inference="alignment:Splign:2.1.0"
     exon            4934..5092
                     /gene="KMT2B"
                     /gene_synonym="CXXC10; DYT28; HRX2; MLL1B; MLL2; MLL4;
                     MRD68; TRX2; WBP-7; WBP7"
                     /inference="alignment:Splign:2.1.0"
     exon            5093..5213
                     /gene="KMT2B"
                     /gene_synonym="CXXC10; DYT28; HRX2; MLL1B; MLL2; MLL4;
                     MRD68; TRX2; WBP-7; WBP7"
                     /inference="alignment:Splign:2.1.0"
     exon            5214..5292
                     /gene="KMT2B"
                     /gene_synonym="CXXC10; DYT28; HRX2; MLL1B; MLL2; MLL4;
                     MRD68; TRX2; WBP-7; WBP7"
                     /inference="alignment:Splign:2.1.0"
     exon            5293..5453
                     /gene="KMT2B"
                     /gene_synonym="CXXC10; DYT28; HRX2; MLL1B; MLL2; MLL4;
                     MRD68; TRX2; WBP-7; WBP7"
                     /inference="alignment:Splign:2.1.0"
     exon            5454..5681
                     /gene="KMT2B"
                     /gene_synonym="CXXC10; DYT28; HRX2; MLL1B; MLL2; MLL4;
                     MRD68; TRX2; WBP-7; WBP7"
                     /inference="alignment:Splign:2.1.0"
     exon            5682..6975
                     /gene="KMT2B"
                     /gene_synonym="CXXC10; DYT28; HRX2; MLL1B; MLL2; MLL4;
                     MRD68; TRX2; WBP-7; WBP7"
                     /inference="alignment:Splign:2.1.0"
     exon            6976..7065
                     /gene="KMT2B"
                     /gene_synonym="CXXC10; DYT28; HRX2; MLL1B; MLL2; MLL4;
                     MRD68; TRX2; WBP-7; WBP7"
                     /inference="alignment:Splign:2.1.0"
     exon            7066..7175
                     /gene="KMT2B"
                     /gene_synonym="CXXC10; DYT28; HRX2; MLL1B; MLL2; MLL4;
                     MRD68; TRX2; WBP-7; WBP7"
                     /inference="alignment:Splign:2.1.0"
     exon            7176..7313
                     /gene="KMT2B"
                     /gene_synonym="CXXC10; DYT28; HRX2; MLL1B; MLL2; MLL4;
                     MRD68; TRX2; WBP-7; WBP7"
                     /inference="alignment:Splign:2.1.0"
     exon            7314..7388
                     /gene="KMT2B"
                     /gene_synonym="CXXC10; DYT28; HRX2; MLL1B; MLL2; MLL4;
                     MRD68; TRX2; WBP-7; WBP7"
                     /inference="alignment:Splign:2.1.0"
     exon            7389..7566
                     /gene="KMT2B"
                     /gene_synonym="CXXC10; DYT28; HRX2; MLL1B; MLL2; MLL4;
                     MRD68; TRX2; WBP-7; WBP7"
                     /inference="alignment:Splign:2.1.0"
     exon            7567..7674
                     /gene="KMT2B"
                     /gene_synonym="CXXC10; DYT28; HRX2; MLL1B; MLL2; MLL4;
                     MRD68; TRX2; WBP-7; WBP7"
                     /inference="alignment:Splign:2.1.0"
     exon            7675..7758
                     /gene="KMT2B"
                     /gene_synonym="CXXC10; DYT28; HRX2; MLL1B; MLL2; MLL4;
                     MRD68; TRX2; WBP-7; WBP7"
                     /inference="alignment:Splign:2.1.0"
     exon            7759..7888
                     /gene="KMT2B"
                     /gene_synonym="CXXC10; DYT28; HRX2; MLL1B; MLL2; MLL4;
                     MRD68; TRX2; WBP-7; WBP7"
                     /inference="alignment:Splign:2.1.0"
     exon            7889..8485
                     /gene="KMT2B"
                     /gene_synonym="CXXC10; DYT28; HRX2; MLL1B; MLL2; MLL4;
                     MRD68; TRX2; WBP-7; WBP7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8463..8468
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KMT2B"
                     /gene_synonym="CXXC10; DYT28; HRX2; MLL1B; MLL2; MLL4;
                     MRD68; TRX2; WBP-7; WBP7"
                     /note="hexamer: AATAAA"
     polyA_site      8485
                     /gene="KMT2B"
                     /gene_synonym="CXXC10; DYT28; HRX2; MLL1B; MLL2; MLL4;
                     MRD68; TRX2; WBP-7; WBP7"
                     /note="major polyA site"
ORIGIN      
        1 ctctcacggt gccaagatgg cggcggcggc gggcggcggc agttgccccg ggcctggctc
       61 cgcgcggggc cgcttcccgg gccggccgcg gggcgccggc gggggcgggg gccgcggcgg
      121 acggggcaac ggggccgaaa gagtgcgggt agctctgcgg cgcggcggtg gcgcgacggg
      181 gccgggcgga gccgagcccg gggaggacac ggccctgctc cgtttgctgg ggctccgccg
      241 gggcctgcgc cggctccgcc gcctgtgggc cggcccgcgg gtccagcggg gccggggacg
      301 gggtcggggc cggggctggg gcccgagtcg aggctgcgtg ccggaggagg agagcagtga
      361 cggggaatcc gacgaggagg agtttcaggg ttttcattca gatgaagatg tggcccccag
      421 ttccctgcgc tctgcgctcc gatcccagcg aggtcgagcg ccccgaggtc ggggtcgcaa
      481 gcataagacg accccccttc ctcctcctcg cctagcagat gtggctccta cccccccaaa
      541 gacccctgcc cggaaacggg gtgaggaagg cacagaacgg atggtgcagg cactgactga
      601 acttctccgg cgggcccagg caccccaagc accccggagc cgggcatgtg agccctccac
      661 cccccggcgg tctcggggac ggcccccagg acggccagca ggcccctgca ggaggaagca
      721 gcaagcagta gtggtggcag aagcagctgt gacaatcccc aaacctgagc ccccacctcc
      781 tgtggttcca gtgaaacatc agactggcag ctggaaatgc aaggaggggc ccggtccagg
      841 acctgggacc cccaggcgtg gaggacagtc aagccgtgga ggccgtggag gcaggggccg
      901 cggccgaggt ggtgggctcc cctttgtgat caagtttgtt tcaagggcca aaaaagtaaa
      961 gatgggacaa ttgtccttgg gactcgaatc aggtcaaggt caaggtcaac atgaggaaag
     1021 ttggcaggat gtcccccaaa gaagagttgg atctggacag ggagggagcc cttgctggaa
     1081 aaagcaggaa cagaagctgg atgacgagga agaagagaag aaagaagaag aagaaaaaga
     1141 caaggaggga gaagagaagg aagaaagagc tgtagctgag gagatgatgc cagctgcgga
     1201 aaaggaagag gcaaagctgc caccaccgcc tctgactcct ccagcccctt cacctcctcc
     1261 acccctccca cccccttcga catctcctcc acccccactc tgccctccac caccaccccc
     1321 agtgtcccca ccacctctac catcccctcc accgcctcct gcccaagagg agcaggagga
     1381 atcccctcct cctgtggtcc cagctacgtg ctccaggaag aggggccggc ctcccctgac
     1441 tcccagccag cgggcggagc gggaagctgc tcgggcaggg ccagagggca cctctcctcc
     1501 cactccaacc cccagcaccg ccacgggagg ccctccggaa gacagtccca ccgtggcccc
     1561 caaaagcacc accttcctga agaatatccg gcagtttatt atgcctgtgg tgagtgcccg
     1621 ctcctcccgt gtcatcaaga caccccggcg atttatggat gaagaccccc ccaaaccccc
     1681 aaaggtggag gtctcacctg tcctgcgacc tcccattacc acctccccac ctgttcccca
     1741 ggagccagca ccagtcccct ctccaccacg tgccccaact cctccatcta ccccagttcc
     1801 actccctgag aagagacggt ccatcctaag ggaacccaca tttcgctgga cctcactgac
     1861 ccgggagctg ccccctcctc ccccagcccc tccacctccc ccggccccct ccccaccccc
     1921 tgctcctgcc acctcctccc ggaggcccct actccttcgg gcccctcagt ttaccccaag
     1981 cgaagcccac ctgaagatct acgaatcggt gcttactcct cctcctcttg gggctcctga
     2041 agcccctgag ccagagcctc ctcctgccga tgactctcca gctgagcctg agcctcgggc
     2101 agtgggccgc accaaccacc tcagcctgcc tcgattcgcc cctgtggtca ccactcctgt
     2161 taaggccgag gtgtcccctc acggggctcc agctctgagc aacgggccac agacacaggc
     2221 tcagctactg cagcccctgc aggccttgca aacccagctc ctgccccagg cactaccgcc
     2281 accacagcca cagctgcagc caccgccgtc accacagcag atgcctcccc tggaaaaagc
     2341 ccggattgcg ggcgtgggtt ccttgccgct gtctggggta gaggagaaga tgttcagcct
     2401 cctcaagaga gccaaagtgc agctattcaa gatcgatcag cagcagcagc agaaggtggc
     2461 agcttccatg ccgctgagcc ctggagggca gatggaggag gtggccgggg ctgtcaagca
     2521 gatctccgac agaggccctg tccggtctga agatgagtcg gtggaagcta agagagagcg
     2581 gccctcaggt cccgagtccc ctgtgcaagg tccccgcatc aaacatgtct gccgtcatgc
     2641 tgctgtggcc ctgggtcagg cccgggccat ggtgcctgaa gatgtccctc gcctcagtgc
     2701 cctccctctc cgggatcggc aggacctcgc cacagaggat acatcatcgg cgtccgagac
     2761 tgagagtgtc ccgtcacggt cccggcgggg aaaggtggag gcagcaggcc ctgggggaga
     2821 atcagagccc acaggttctg gagggaccct ggcccacaca ccccggcgct cactgccctc
     2881 ccatcacggc aagaagatgc gcatggctcg atgtggacac tgtcggggct gcctacgtgt
     2941 gcaggactgt gggtcctgtg tcaactgcct agacaagccc aagtttgggg gccctaacac
     3001 caagaagcag tgctgtgtat accggaagtg tgacaaaata gaggctcgga agatggaacg
     3061 actggctaaa aaaggccgga cgatagtgaa gacgctgttg ccctgggatt ccgatgaatc
     3121 tcctgaggcc tcccctggtc ctccaggccc acgccggggg gcgggagctg gggggccccg
     3181 ggaggaggtg gtggcccacc cagggcccga ggagcaggac tccctcctgc agcgcaagtc
     3241 agctcggcgc tgcgtcaaac agcgaccctc ctatgatatc ttcgaggatt cggatgactc
     3301 ggagcccggg ggcccccctg ctcctcggcg tcggaccccc cgagaaaatg agctgccact
     3361 gccagaacct gaggagcaga gccggccccg caaacctacc ctgcagcctg tgttgcagct
     3421 caaggcccga aggcgcctgg acaaggatgc tttggcccct ggcccctttg cttcttttcc
     3481 caatggctgg actggaaagc agaagtctcc cgatggtgtg caccgcgtcc gtgtggattt
     3541 taaggaggat tgtgatttag agaacgtgtg gctgatgggg ggcctgagtg tgctcacctc
     3601 tgtgccaggg ggccccccga tggtgtgctt gctgtgtgcc agcaaaggac tccacgagct
     3661 ggtgttctgt caagtctgct gtgacccatt ccacccattc tgcctggagg aggccgagcg
     3721 gcccctgccc cagcatcacg acacctggtg ctgccgtcgc tgcaaattct gccacgtctg
     3781 tggacgcaaa ggtcgtggat ccaagcacct cctggagtgc gagcgctgcc gccatgcata
     3841 ccacccggcc tgtctggggc ccagctatcc aacccgggcc acgcgcaaac ggcgccactg
     3901 gatctgttca gcctgtgtgc gctgtaagag ctgtggggca actccaggca agaactggga
     3961 cgtcgagtgg tctggagatt acagcctctg ccccaggtgc acccagctat atgagaaagg
     4021 aaactactgc ccgatctgta cacgctgcta tgaagacaac gactatgaga gcaagatgat
     4081 gcagtgcgca cagtgcgatc actgggtgca tgccaagtgc gaggggctct cagatgaaga
     4141 ctacgagatc ctttcaggac tgccagactc ggtgctgtac acctgcggac cgtgtgctgg
     4201 ggcagcgcag ccccgctggc gagaggccct gagcggggcc ctccaggggg gcctgcgcca
     4261 ggtgctccag ggcctgctga gctccaaggt ggtgggccca ctgctgctct gcacccagtg
     4321 tgggccagat gggaagcaac tgcacccagg accctgcggc ctgcaagctg tgagtcagcg
     4381 cttcgaggat ggccactaca agtctgtgca cagcttcatg gaggacatgg tgggcatcct
     4441 catgcggcac tcggaggagg gagagacccc ggaccgccgg gctggaggcc agatgaaggg
     4501 gctcctgctg aagctgctag aatctgcgtt cggctggttc gacgcccacg accccaagta
     4561 ctggcgacgg agtacccggc tgccaaacgg agtccttccc aatgcggtgt tgcccccatc
     4621 cctggatcat gtctatgcgc agtggagaca gcaggaacca gagaccccag aatcagggca
     4681 gcctccaggg gatccctcag cagcattcca gggcaaggat ccggctgcct tctcacacct
     4741 ggaggacccc cgtcagtgtg cactctgcct caaatacggg gatgcagact ccaaggaggc
     4801 ggggcggctc ttgtacatcg ggcagaacga gtggacacac gtcaactgtg ccatctggtc
     4861 ggcggaagtc ttcgaggaga acgacggctc cctcaagaat gtgcatgctg ctgtggcccg
     4921 agggaggcag atgcgctgcg agctctgcct gaagcctggc gccacggtgg gctgctgcct
     4981 gtcctcctgc ctcagcaact tccacttcat gtgtgcccgg gccagctact gcatcttcca
     5041 ggatgacaag aaagtcttct gccagaaaca cactgatctc ctggatggca aggaaattgt
     5101 gaaccccgat ggttttgatg ttctccgccg agtctatgtg gacttcgagg gcatcaactt
     5161 caagcggaag ttcttgacgg ggcttgaacc cgatgccatc aacgtgctca ttggttccat
     5221 ccgcattgac tccctgggta ctctgtctga tctctcggac tgcgagggac ggctcttccc
     5281 cattggctac cagtgctccc gtctgtactg gagcacagtg gatgctcgga ggcgctgctg
     5341 gtatcggtgc cgaattctgg agtatcggcc atgggggccg agggaagagc cagctcacct
     5401 ggaggctgca gaggagaacc agaccattgt gcacagcccc gccccttcct cagagccccc
     5461 aggtggtgag gaccccccac tggacacaga tgttcttgtc cctggagctc ctgagcgcca
     5521 ctcgcccatt cagaacctgg accctccact gcggccagat tcaggcagcg cccctcctcc
     5581 agccccccgt tctttttcgg gggctcgaat caaagtgccc aactactcgc catcccggag
     5641 gcccttgggg ggtgtctcct ttggccccct gccctcccct ggaagtccat cttcactgac
     5701 ccaccacatc cccacagtgg gagacccgga cttcccagct ccccccagac gttcccgtcg
     5761 tcccagccct ttggctccca ggccgcctcc atcacggtgg gcctcccctc ctctaaaaac
     5821 ctcccctcag ctcagggtgc cccctcctac ctcagtcgtc acagccctca cacctacctc
     5881 aggggagctg gctccccctg gcccggcccc atctccacca ccccctgaag acctgggccc
     5941 agacttcgag gacatggagg tggtgtcagg actgagtgct gctgacctgg acttcgcggc
     6001 cagcctgctg gggactgagc ccttccagga agagattgta gccgctgggg ccatggggag
     6061 cagccacggg ggcccggggg acagctccga ggaggagtcc agccccacct cccgctacat
     6121 ccacttccct gtgactgtgg tgtccgcccc tggtctggcc cccagcgcta cccctggagc
     6181 cccccgcatt gaacagctgg acggcgtgga cgacggcact gacagtgagg ctgaggcggt
     6241 gcagcagcct cggggccagg gcacgcctcc ttcggggcca ggagtagtcc gggcaggggt
     6301 ccttggggct gcaggggaca gggcccggcc tcctgaggac ctgccatcgg aaattgtgga
     6361 ttttgtgttg aagaacctag ggggtcctgg ggatggaggt gctggcccta gagaggagtc
     6421 actccccccg gcgcctcccc tggctaatgg cagccagccc tcccaaggcc tgaccgccag
     6481 cccagctgac cccacccgca catttgcctg gctcccaggg gccccagggg tccgggtgtt
     6541 aagccttggc cctgcccctg agccccccaa acccgccaca tccaaaatca tacttgtcaa
     6601 caagctgggg caagtatttg tgaagatggc tggggagggt gaacctgtcc cacccccagt
     6661 gaagcagcca cctttgcccc ccaccatttc ccccacggct cccacctcct ggactctgcc
     6721 cccaggcccc ctcctcggcg tgctgcccgt ggtcggagtg gtccgccctg ccccgccccc
     6781 gccaccccct cccctgacgc tggtgctgag cagtgggcca gccagcccgc cccgccaggc
     6841 catccgcgtc aagagggtgt ccactttctc cggccggtcc ccgccagcac ctcccccata
     6901 caaagccccc cggctggatg aagatggaga ggcctcagag gatacccctc aggttccagg
     6961 gcttggcagt ggcgggttta gccgtgtgag gatgaaaacc cccacagtgc gtggggtcct
     7021 tgacctggat cggcctgggg agcccgctgg ggaagaaagt cctgggcccc tccaggaacg
     7081 gtcccctttg ctgccacttc cggaagatgg tcctccccag gtccccgatg gtcccccaga
     7141 cctgctgctt gagtcccagt ggcaccacta ttcaggtgag gcttcgagct ctgaggaaga
     7201 gcctccatcc ccagatgata aagagaacca ggccccaaaa cggactggcc cacatctgcg
     7261 cttcgagatc agcagtgagg atgggttcag cgttgaggca gagagcttgg agggggcgtg
     7321 gagaactctg atcgagaaag tgcaagaggc ccgagggcat gcccgactca gacatctctc
     7381 ctttagtgga atgagtgggg cgagactcct gggcatccac catgatgctg tcatcttcct
     7441 ggccgagcag ctccccggag cccagcgttg ccagcactat aagttccgtt accaccagca
     7501 gggagagggc caggaggagc cgcccctgaa tccccatggg gctgctcggg cagaggtcta
     7561 tctccggaag tgcacctttg acatgttcaa cttcctggcc tcccagcacc gggtgctccc
     7621 tgagggggcc acctgtgatg aggaagagga tgaggtgcag ctcaggtcaa ccagacgtgc
     7681 caccagcctg gagctgccca tggccatgcg ttttcgtcac cttaagaaga cgtccaaaga
     7741 agctgtgggt gtctacagat cagccatcca cgggcgaggc ctgttctgta agcgcaacat
     7801 cgacgcgggg gagatggtca tcgagtactc tggcattgtc atccgctcgg tgttgactga
     7861 caagcgggag aagttctacg atgggaaggg catcgggtgc tatatgttcc gcatggatga
     7921 ctttgatgta gtggacgcca cgatgcatgg caatgccgcc cgcttcatca accactcctg
     7981 tgagcccaac tgcttctctc gggtcatcca cgtggagggc cagaaacaca ttgttatctt
     8041 cgccctgcgc cgcatcctgc gtggtgagga gctcacctac gactacaagt tccccatcga
     8101 ggatgccagc aacaagctgc cctgcaactg tggcgccaag cgctgccgtc ggttccttaa
     8161 ctgaggccgt ggctgcccac cacgacccct cacacctcct gctgccgtcg ctgccatctt
     8221 gcccctagcc tgggggctcc ctagcccctc ccagagcatc tcacccccac cctcatgttc
     8281 agggtggatg tgggcatgca ggtgacaagg gccctgcctc cacccctcca gcccatccag
     8341 caatcgcccc ctttctgccc tgggggccca ggatgtagat attgtacaaa ggtttctaaa
     8401 tcccttcttt tctatgcact tttttattta agaggtgggg tcccaggtgg gaaccccccc
     8461 acaataaagt ctgtcaatgt ttgga
//
