LOCUS       NM_001197104           16600 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens lysine methyltransferase 2A (KMT2A), transcript
            variant 1, mRNA.
ACCESSION   NM_001197104
VERSION     NM_001197104.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 16600)
  AUTHORS   Yang,Z., Zhang,G., Zhao,R., Tian,T., Zhi,J., Wei,G., Roeder,R.G.,
            Jing,L. and Yu,M.
  TITLE     MLL-AF9 regulates transcriptional initiation in mixed lineage
            leukemic cells
  JOURNAL   J Biol Chem 300 (8), 107566 (2024)
   PUBMED   39002676
  REMARK    GeneRIF: MLL-AF9 regulates transcriptional initiation in mixed
            lineage leukemic cells.
REFERENCE   2  (bases 1 to 16600)
  AUTHORS   Adriaanse,F.R.S., Schneider,P., Arentsen-Peters,S.T.C.J.M.,
            Fonseca,A.M.N.D., Stutterheim,J., Pieters,R., Zwaan,C.M. and
            Stam,R.W.
  TITLE     Distinct Responses to Menin Inhibition and Synergy with DOT1L
            Inhibition in KMT2A-Rearranged Acute Lymphoblastic and Myeloid
            Leukemia
  JOURNAL   Int J Mol Sci 25 (11), 6020 (2024)
   PUBMED   38892207
  REMARK    GeneRIF: Distinct Responses to Menin Inhibition and Synergy with
            DOT1L Inhibition in KMT2A-Rearranged Acute Lymphoblastic and
            Myeloid Leukemia.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 16600)
  AUTHORS   Cho,U.S.
  TITLE     The Core Complex of Yeast COMPASS and Human Mixed-Lineage Leukemia
            (MLL), Structure, Function, and Recognition of the Nucleosome
  JOURNAL   Subcell Biochem 104, 101-117 (2024)
   PUBMED   38963485
  REMARK    GeneRIF: The Core Complex of Yeast COMPASS and Human Mixed-Lineage
            Leukemia (MLL), Structure, Function, and Recognition of the
            Nucleosome.
            Review article
REFERENCE   4  (bases 1 to 16600)
  AUTHORS   Liu,H., Cheng,E.H. and Hsieh,J.J.
  TITLE     MLL fusions: pathways to leukemia
  JOURNAL   Cancer Biol Ther 8 (13), 1204-1211 (2009)
   PUBMED   19729989
  REMARK    GeneRIF: Stduies indicate that leukemogenic MLL translocations fuse
            the common MLL N-terminus (approximately 1,400 aa) in frame with
            more than 60 translocation partner genes.
            Review article
REFERENCE   5  (bases 1 to 16600)
  AUTHORS   Sheppard,S.E. and Quintero-Rivera,F.
  TITLE     Wiedemann-Steiner Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   35617449
REFERENCE   6  (bases 1 to 16600)
  AUTHORS   Gu,Y., Nakamura,T., Alder,H., Prasad,R., Canaani,O., Cimino,G.,
            Croce,C.M. and Canaani,E.
  TITLE     The t(4;11) chromosome translocation of human acute leukemias fuses
            the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene
  JOURNAL   Cell 71 (4), 701-708 (1992)
   PUBMED   1423625
REFERENCE   7  (bases 1 to 16600)
  AUTHORS   Tkachuk,D.C., Kohler,S. and Cleary,M.L.
  TITLE     Involvement of a homolog of Drosophila trithorax by 11q23
            chromosomal translocations in acute leukemias
  JOURNAL   Cell 71 (4), 691-700 (1992)
   PUBMED   1423624
REFERENCE   8  (bases 1 to 16600)
  AUTHORS   Djabali,M., Selleri,L., Parry,P., Bower,M., Young,B.D. and
            Evans,G.A.
  TITLE     A trithorax-like gene is interrupted by chromosome 11q23
            translocations in acute leukaemias
  JOURNAL   Nat Genet 2 (2), 113-118 (1992)
   PUBMED   1303259
  REMARK    Erratum:[Nat Genet. 1993 Aug;4(4):431. doi: 10.1038/ng0893-431..
            PMID: 8401594]
REFERENCE   9  (bases 1 to 16600)
  AUTHORS   Cimino,G., Moir,D.T., Canaani,O., Williams,K., Crist,W.M.,
            Katzav,S., Cannizzaro,L., Lange,B., Nowell,P.C., Croce,C.M. et al.
  TITLE     Cloning of ALL-1, the locus involved in leukemias with the
            t(4;11)(q21;q23), t(9;11)(p22;q23), and t(11;19)(q23;p13)
            chromosome translocations
  JOURNAL   Cancer Res 51 (24), 6712-6714 (1991)
   PUBMED   1835902
REFERENCE   10 (bases 1 to 16600)
  AUTHORS   Ziemin-van der Poel,S., McCabe,N.R., Gill,H.J., Espinosa,R. 3rd,
            Patel,Y., Harden,A., Rubinelli,P., Smith,S.D., LeBeau,M.M.,
            Rowley,J.D. et al.
  TITLE     Identification of a gene, MLL, that spans the breakpoint in 11q23
            translocations associated with human leukemias
  JOURNAL   Proc Natl Acad Sci U S A 88 (23), 10735-10739 (1991)
   PUBMED   1720549
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1992 May 1;89(9):4220]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from D14540.1, L04731.1, AP001267.4,
            AP000941.6, BC065385.1 and AI500057.1.
            
            On Sep 24, 2019 this sequence version replaced NM_001197104.1.
            
            Summary: This gene encodes a transcriptional coactivator that plays
            an essential role in regulating gene expression during early
            development and hematopoiesis. The encoded protein contains
            multiple conserved functional domains. One of these domains, the
            SET domain, is responsible for its histone H3 lysine 4 (H3K4)
            methyltransferase activity which mediates chromatin modifications
            associated with epigenetic transcriptional activation. This protein
            is processed by the enzyme Taspase 1 into two fragments, MLL-C and
            MLL-N. These fragments reassociate and further assemble into
            different multiprotein complexes that regulate the transcription of
            specific target genes, including many of the HOX genes. Multiple
            chromosomal translocations involving this gene are the cause of
            certain acute lymphoid leukemias and acute myeloid leukemias.
            Alternate splicing results in multiple transcript
            variants.[provided by RefSeq, Oct 2010].
            
            Transcript Variant: This variant (1) lacks an alternate in-frame
            exon compared to variant 3. The resulting isoform (1) has the same
            N- and C-termini but is shorter compared to isoform 3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L04731.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000534358.8/ ENSP00000436786.2
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-207               D14540.1           3-209
            208-1686            L04731.1           1-1479
            1687-1687           AP001267.4         98263-98263
            1688-10697          L04731.1           1481-10490
            10698-10698         AP001267.4         132007-132007
            10699-12344         L04731.1           10492-12137
            12345-14538         AP001267.4         148015-150208
            14539-15545         AP000941.6         1-1007
            15546-16592         BC065385.1         776-1822
            16593-16600         AI500057.1         13-20               c
FEATURES             Location/Qualifiers
     source          1..16600
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q23.3"
     gene            1..16600
                     /gene="KMT2A"
                     /gene_synonym="ALL-1; ALL1; CXXC7; GAS7; HRX; HTRX; HTRX1;
                     MLL; MLL1; MLL1A; TRX1; WDSTS"
                     /note="lysine methyltransferase 2A"
                     /db_xref="GeneID:4297"
                     /db_xref="HGNC:HGNC:7132"
                     /db_xref="MIM:159555"
     exon            1..453
                     /gene="KMT2A"
                     /gene_synonym="ALL-1; ALL1; CXXC7; GAS7; HRX; HTRX; HTRX1;
                     MLL; MLL1; MLL1A; TRX1; WDSTS"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..11940
                     /gene="KMT2A"
                     /gene_synonym="ALL-1; ALL1; CXXC7; GAS7; HRX; HTRX; HTRX1;
                     MLL; MLL1; MLL1A; TRX1; WDSTS"
                     /EC_number="2.1.1.364"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger protein HRX; trithorax-like protein; lysine
                     (K)-specific methyltransferase 2A; lysine
                     N-methyltransferase 2A; CXXC-type zinc finger protein 7;
                     myeloid/lymphoid or mixed-lineage leukemia (trithorax
                     homolog, Drosophila); mixed lineage leukemia 1;
                     histone-lysine N-methyltransferase 2A; Acute lymphocytic
                     1"
                     /codon_start=1
                     /product="histone-lysine N-methyltransferase 2A isoform 1"
                     /protein_id="NP_001184033.1"
                     /db_xref="CCDS:CCDS55791.1"
                     /db_xref="GeneID:4297"
                     /db_xref="HGNC:HGNC:7132"
                     /db_xref="MIM:159555"
                     /translation="MAHSCRWRFPARPGTTGGGGGGGRRGLGGAPRQRVPALLLPPGP
                     PVGGGGPGAPPSPPAVAAAAAAAGSSGAGVPGGAAAASAASSSSASSSSSSSSSASSG
                     PALLRVGPGFDAALQVSAAIGTNLRRFRAVFGESGGGGGSGEDEQFLGFGSDEEVRVR
                     SPTRSPSVKTSPRKPRGRPRSGSDRNSAILSDPSVFSPLNKSETKSGDKIKKKDSKSI
                     EKKRGRPPTFPGVKIKITHGKDISELPKGNKEDSLKKIKRTPSATFQQATKIKKLRAG
                     KLSPLKSKFKTGKLQIGRKGVQIVRRRGRPPSTERIKTPSGLLINSELEKPQKVRKDK
                     EGTPPLTKEDKTVVRQSPRRIKPVRIIPSSKRTDATIAKQLLQRAKKGAQKKIEKEAA
                     QLQGRKVKTQVKNIRQFIMPVVSAISSRIIKTPRRFIEDEDYDPPIKIARLESTPNSR
                     FSAPSCGSSEKSSAASQHSSQMSSDSSRSSSPSVDTSTDSQASEEIQVLPEERSDTPE
                     VHPPLPISQSPENESNDRRSRRYSVSERSFGSRTTKKLSTLQSAPQQQTSSSPPPPLL
                     TPPPPLQPASSISDHTPWLMPPTIPLASPFLPASTAPMQGKRKSILREPTFRWTSLKH
                     SRSEPQYFSSAKYAKEGLIRKPIFDNFRPPPLTPEDVGFASGFSASGTAASARLFSPL
                     HSGTRFDMHKRSPLLRAPRFTPSEAHSRIFESVTLPSNRTSAGTSSSGVSNRKRKRKV
                     FSPIRSEPRSPSHSMRTRSGRLSSSELSPLTPPSSVSSSLSISVSPLATSALNPTFTF
                     PSHSLTQSGESAEKNQRPRKQTSAPAEPFSSSSPTPLFPWFTPGSQTERGRNKDKAPE
                     ELSKDRDADKSVEKDKSRERDREREKENKRESRKEKRKKGSEIQSSSALYPVGRVSKE
                     KVVGEDVATSSSAKKATGRKKSSSHDSGTDITSVTLGDTTAVKTKILIKKGRGNLEKT
                     NLDLGPTAPSLEKEKTLCLSTPSSSTVKHSTSSIGSMLAQADKLPMTDKRVASLLKKA
                     KAQLCKIEKSKSLKQTDQPKAQGQESDSSETSVRGPRIKHVCRRAAVALGRKRAVFPD
                     DMPTLSALPWEEREKILSSMGNDDKSSIAGSEDAEPLAPPIKPIKPVTRNKAPQEPPV
                     KKGRRSRRCGQCPGCQVPEDCGVCTNCLDKPKFGGRNIKKQCCKMRKCQNLQWMPSKA
                     YLQKQAKAVKKKEKKSKTSEKKDSKESSVVKNVVDSSQKPTPSAREDPAPKKSSSEPP
                     PRKPVEEKSEEGNVSAPGPESKQATTPASRKSSKQVSQPALVIPPQPPTTGPPRKEVP
                     KTTPSEPKKKQPPPPESGPEQSKQKKVAPRPSIPVKQKPKEKEKPPPVNKQENAGTLN
                     ILSTLSNGNSSKQKIPADGVHRIRVDFKEDCEAENVWEMGGLGILTSVPITPRVVCFL
                     CASSGHVEFVYCQVCCEPFHKFCLEENERPLEDQLENWCCRRCKFCHVCGRQHQATKQ
                     LLECNKCRNSYHPECLGPNYPTKPTKKKKVWICTKCVRCKSCGSTTPGKGWDAQWSHD
                     FSLCHDCAKLFAKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSGTEDEMY
                     EILSNLPESVAYTCVNCTERHPAEWRLALEKELQISLKQVLTALLNSRTTSHLLRYRQ
                     AAKPPDLNPETEESIPSRSSPEGPDPPVLTEVSKQDDQQPLDLEGVKRKMDQGNYTSV
                     LEFSDDIVKIIQAAINSDGGQPEIKKANSMVKSFFIRQMERVFPWFSVKKSRFWEPNK
                     VSSNSGMLPNAVLPPSLDHNYAQWQEREENSHTEQPPLMKKIIPAPKPKGPGEPDSPT
                     PLHPPTPPILSTDRSREDSPELNPPPGIEDNRQCALCLTYGDDSANDAGRLLYIGQNE
                     WTHVNCALWSAEVFEDDDGSLKNVHMAVIRGKQLRCEFCQKPGATVGCCLTSCTSNYH
                     FMCSRAKNCVFLDDKKVYCQRHRDLIKGEVVPENGFEVFRRVFVDFEGISLRRKFLNG
                     LEPENIHMMIGSMTIDCLGILNDLSDCEDKLFPIGYQCSRVYWSTTDARKRCVYTCKI
                     VECRPPVVEPDINSTVEHDENRTIAHSPTSFTESSSKESQNTAEIISPPSPDRPPHSQ
                     TSGSCYYHVISKVPRIRTPSYSPTQRSPGCRPLPSAGSPTPTTHEIVTVGDPLLSSGL
                     RSIGSRRHSTSSLSPQRSKLRIMSPMRTGNTYSRNNVSSVSTTGTATDLESSAKVVDH
                     VLGPLNSSTSLGQNTSTSSNLQRTVVTVGNKNSHLDGSSSSEMKQSSASDLVSKSSSL
                     KGEKTKVLSSKSSEGSAHNVAYPGIPKLAPQVHNTTSRELNVSKIGSFAEPSSVSFSS
                     KEALSFPHLHLRGQRNDRDQHTDSTQSANSSPDEDTEVKTLKLSGMSNRSSIINEHMG
                     SSSRDRRQKGKKSCKETFKEKHSSKSFLEPGQVTTGEEGNLKPEFMDEVLTPEYMGQR
                     PCNNVSSDKIGDKGLSMPGVPKAPPMQVEGSAKELQAPRKRTVKVTLTPLKMENESQS
                     KNALKESSPASPLQIESTSPTEPISASENPGDGPVAQPSPNNTSCQDSQSNNYQNLPV
                     QDRNLMLPDGPKPQEDGSFKRRYPRRSARARSNMFFGLTPLYGVRSYGEEDIPFYSSS
                     TGKKRGKRSAEGQVDGADDLSTSDEDDLYYYNFTRTVISSGGEERLASHNLFREEEQC
                     DLPKISQLDGVDDGTESDTSVTATTRKSSQIPKRNGKENGTENLKIDRPEDAGEKEHV
                     TKSSVGHKNEPKMDNCHSVSRVKTQGQDSLEAQLSSLESSRRVHTSTPSDKNLLDTYN
                     TELLKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGESPESSSSELLNLGEGLGL
                     DSNREKDMGLFEVFSQQLPTTEPVDSSVSSSISAEEQFELPLELPSDLSVLTTRSPTV
                     PSQNPSRLAVISDSGEKRVTITEKSVASSESDPALLSPGVDPTPEGHMTPDHFIQGHM
                     DADHISSPPCGSVEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNSTDSPGPS
                     QISNAAVQTTPPHLKPATEKLIVVNQNMQPLYVLQTLPNGVTQKIQLTSSVSSTPSVM
                     ETNTSVLGPMGGGLTLTTGLNPSLPTSQSLFPSASKGLLPMSHHQHLHSFPAATQSSF
                     PPNISNPPSGLLIGVQPPPDPQLLVSESSQRTDLSTTVATPSSGLKKRPISRLQTRKN
                     KKLAPSSTPSNIAPSDVVSNMTLINFTPSQLPNHPSLLDLGSLNTSSHRTVPNIIKRS
                     KSSIMYFEPAPLLPQSVGGTAATAAGTSTISQDTSHLTSGSVSGLASSSSVLNVVSMQ
                     TTTTPTSSASVPGHVTLTNPRLLGTPDIGSISNLLIKASQQSLGIQDQPVALPPSSGM
                     FPQLGTSQTPSTAAITAASSICVLPSTQTTGITAASPSGEADEHYQLQHVNQLLASKT
                     GIHSSQRDLDSASGPQVSNFTQTVDAPNSMGLEQNKALSSAVQASPTSPGGSPSSPSS
                     GQRSASPSVPGPTKPKPKTKRFQLPLDKGNGKKHKVSHLRTSSSEAHIPDQETTSLTS
                     GTGTPGAEAEQQDTASVEQSSQKECGQPAGQVAVLPEVQVTQNPANEQESAEPKTVEE
                     EESNFSSPLMLWLQQEQKRKESITEKKPKKGLVFEISSDDGFQICAESIEDAWKSLTD
                     KVQEARSNARLKQLSFAGVNGLRMLGILHDAVVFLIEQLSGAKHCRNYKFRFHKPEEA
                     NEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATS
                     MDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTD
                     KREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIV
                     IFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN"
     exon            454..523
                     /gene="KMT2A"
                     /gene_synonym="ALL-1; ALL1; CXXC7; GAS7; HRX; HTRX; HTRX1;
                     MLL; MLL1; MLL1A; TRX1; WDSTS"
                     /inference="alignment:Splign:2.1.0"
     exon            524..3177
                     /gene="KMT2A"
                     /gene_synonym="ALL-1; ALL1; CXXC7; GAS7; HRX; HTRX; HTRX1;
                     MLL; MLL1; MLL1A; TRX1; WDSTS"
                     /inference="alignment:Splign:2.1.0"
     exon            3178..3355
                     /gene="KMT2A"
                     /gene_synonym="ALL-1; ALL1; CXXC7; GAS7; HRX; HTRX; HTRX1;
                     MLL; MLL1; MLL1A; TRX1; WDSTS"
                     /inference="alignment:Splign:2.1.0"
     exon            3356..3590
                     /gene="KMT2A"
                     /gene_synonym="ALL-1; ALL1; CXXC7; GAS7; HRX; HTRX; HTRX1;
                     MLL; MLL1; MLL1A; TRX1; WDSTS"
                     /inference="alignment:Splign:2.1.0"
     exon            3591..3655
                     /gene="KMT2A"
                     /gene_synonym="ALL-1; ALL1; CXXC7; GAS7; HRX; HTRX; HTRX1;
                     MLL; MLL1; MLL1A; TRX1; WDSTS"
                     /inference="alignment:Splign:2.1.0"
     exon            3656..4033
                     /gene="KMT2A"
                     /gene_synonym="ALL-1; ALL1; CXXC7; GAS7; HRX; HTRX; HTRX1;
                     MLL; MLL1; MLL1A; TRX1; WDSTS"
                     /inference="alignment:Splign:2.1.0"
     exon            4034..4107
                     /gene="KMT2A"
                     /gene_synonym="ALL-1; ALL1; CXXC7; GAS7; HRX; HTRX; HTRX1;
                     MLL; MLL1; MLL1A; TRX1; WDSTS"
                     /inference="alignment:Splign:2.1.0"
     exon            4108..4239
                     /gene="KMT2A"
                     /gene_synonym="ALL-1; ALL1; CXXC7; GAS7; HRX; HTRX; HTRX1;
                     MLL; MLL1; MLL1A; TRX1; WDSTS"
                     /inference="alignment:Splign:2.1.0"
     exon            4240..4353
                     /gene="KMT2A"
                     /gene_synonym="ALL-1; ALL1; CXXC7; GAS7; HRX; HTRX; HTRX1;
                     MLL; MLL1; MLL1A; TRX1; WDSTS"
                     /inference="alignment:Splign:2.1.0"
     exon            4354..4500
                     /gene="KMT2A"
                     /gene_synonym="ALL-1; ALL1; CXXC7; GAS7; HRX; HTRX; HTRX1;
                     MLL; MLL1; MLL1A; TRX1; WDSTS"
                     /inference="alignment:Splign:2.1.0"
     exon            4501..4596
                     /gene="KMT2A"
                     /gene_synonym="ALL-1; ALL1; CXXC7; GAS7; HRX; HTRX; HTRX1;
                     MLL; MLL1; MLL1A; TRX1; WDSTS"
                     /inference="alignment:Splign:2.1.0"
     exon            4597..4717
                     /gene="KMT2A"
                     /gene_synonym="ALL-1; ALL1; CXXC7; GAS7; HRX; HTRX; HTRX1;
                     MLL; MLL1; MLL1A; TRX1; WDSTS"
                     /inference="alignment:Splign:2.1.0"
     exon            4718..4840
                     /gene="KMT2A"
                     /gene_synonym="ALL-1; ALL1; CXXC7; GAS7; HRX; HTRX; HTRX1;
                     MLL; MLL1; MLL1A; TRX1; WDSTS"
                     /inference="alignment:Splign:2.1.0"
     exon            4841..5025
                     /gene="KMT2A"
                     /gene_synonym="ALL-1; ALL1; CXXC7; GAS7; HRX; HTRX; HTRX1;
                     MLL; MLL1; MLL1A; TRX1; WDSTS"
                     /inference="alignment:Splign:2.1.0"
     exon            5026..5199
                     /gene="KMT2A"
                     /gene_synonym="ALL-1; ALL1; CXXC7; GAS7; HRX; HTRX; HTRX1;
                     MLL; MLL1; MLL1A; TRX1; WDSTS"
                     /inference="alignment:Splign:2.1.0"
     exon            5200..5310
                     /gene="KMT2A"
                     /gene_synonym="ALL-1; ALL1; CXXC7; GAS7; HRX; HTRX; HTRX1;
                     MLL; MLL1; MLL1A; TRX1; WDSTS"
                     /inference="alignment:Splign:2.1.0"
     exon            5311..5384
                     /gene="KMT2A"
                     /gene_synonym="ALL-1; ALL1; CXXC7; GAS7; HRX; HTRX; HTRX1;
                     MLL; MLL1; MLL1A; TRX1; WDSTS"
                     /inference="alignment:Splign:2.1.0"
     exon            5385..5578
                     /gene="KMT2A"
                     /gene_synonym="ALL-1; ALL1; CXXC7; GAS7; HRX; HTRX; HTRX1;
                     MLL; MLL1; MLL1A; TRX1; WDSTS"
                     /inference="alignment:Splign:2.1.0"
     exon            5579..5685
                     /gene="KMT2A"
                     /gene_synonym="ALL-1; ALL1; CXXC7; GAS7; HRX; HTRX; HTRX1;
                     MLL; MLL1; MLL1A; TRX1; WDSTS"
                     /inference="alignment:Splign:2.1.0"
     exon            5686..5823
                     /gene="KMT2A"
                     /gene_synonym="ALL-1; ALL1; CXXC7; GAS7; HRX; HTRX; HTRX1;
                     MLL; MLL1; MLL1A; TRX1; WDSTS"
                     /inference="alignment:Splign:2.1.0"
     exon            5824..5982
                     /gene="KMT2A"
                     /gene_synonym="ALL-1; ALL1; CXXC7; GAS7; HRX; HTRX; HTRX1;
                     MLL; MLL1; MLL1A; TRX1; WDSTS"
                     /inference="alignment:Splign:2.1.0"
     exon            5983..6100
                     /gene="KMT2A"
                     /gene_synonym="ALL-1; ALL1; CXXC7; GAS7; HRX; HTRX; HTRX1;
                     MLL; MLL1; MLL1A; TRX1; WDSTS"
                     /inference="alignment:Splign:2.1.0"
     exon            6101..6179
                     /gene="KMT2A"
                     /gene_synonym="ALL-1; ALL1; CXXC7; GAS7; HRX; HTRX; HTRX1;
                     MLL; MLL1; MLL1A; TRX1; WDSTS"
                     /inference="alignment:Splign:2.1.0"
     exon            6180..6340
                     /gene="KMT2A"
                     /gene_synonym="ALL-1; ALL1; CXXC7; GAS7; HRX; HTRX; HTRX1;
                     MLL; MLL1; MLL1A; TRX1; WDSTS"
                     /inference="alignment:Splign:2.1.0"
     exon            6341..6526
                     /gene="KMT2A"
                     /gene_synonym="ALL-1; ALL1; CXXC7; GAS7; HRX; HTRX; HTRX1;
                     MLL; MLL1; MLL1A; TRX1; WDSTS"
                     /inference="alignment:Splign:2.1.0"
     exon            6527..10775
                     /gene="KMT2A"
                     /gene_synonym="ALL-1; ALL1; CXXC7; GAS7; HRX; HTRX; HTRX1;
                     MLL; MLL1; MLL1A; TRX1; WDSTS"
                     /inference="alignment:Splign:2.1.0"
     exon            10776..10856
                     /gene="KMT2A"
                     /gene_synonym="ALL-1; ALL1; CXXC7; GAS7; HRX; HTRX; HTRX1;
                     MLL; MLL1; MLL1A; TRX1; WDSTS"
                     /inference="alignment:Splign:2.1.0"
     exon            10857..10921
                     /gene="KMT2A"
                     /gene_synonym="ALL-1; ALL1; CXXC7; GAS7; HRX; HTRX; HTRX1;
                     MLL; MLL1; MLL1A; TRX1; WDSTS"
                     /inference="alignment:Splign:2.1.0"
     exon            10922..11092
                     /gene="KMT2A"
                     /gene_synonym="ALL-1; ALL1; CXXC7; GAS7; HRX; HTRX; HTRX1;
                     MLL; MLL1; MLL1A; TRX1; WDSTS"
                     /inference="alignment:Splign:2.1.0"
     exon            11093..11167
                     /gene="KMT2A"
                     /gene_synonym="ALL-1; ALL1; CXXC7; GAS7; HRX; HTRX; HTRX1;
                     MLL; MLL1; MLL1A; TRX1; WDSTS"
                     /inference="alignment:Splign:2.1.0"
     exon            11168..11342
                     /gene="KMT2A"
                     /gene_synonym="ALL-1; ALL1; CXXC7; GAS7; HRX; HTRX; HTRX1;
                     MLL; MLL1; MLL1A; TRX1; WDSTS"
                     /inference="alignment:Splign:2.1.0"
     exon            11343..11450
                     /gene="KMT2A"
                     /gene_synonym="ALL-1; ALL1; CXXC7; GAS7; HRX; HTRX; HTRX1;
                     MLL; MLL1; MLL1A; TRX1; WDSTS"
                     /inference="alignment:Splign:2.1.0"
     exon            11451..11534
                     /gene="KMT2A"
                     /gene_synonym="ALL-1; ALL1; CXXC7; GAS7; HRX; HTRX; HTRX1;
                     MLL; MLL1; MLL1A; TRX1; WDSTS"
                     /inference="alignment:Splign:2.1.0"
     exon            11535..11664
                     /gene="KMT2A"
                     /gene_synonym="ALL-1; ALL1; CXXC7; GAS7; HRX; HTRX; HTRX1;
                     MLL; MLL1; MLL1A; TRX1; WDSTS"
                     /inference="alignment:Splign:2.1.0"
     exon            11665..16600
                     /gene="KMT2A"
                     /gene_synonym="ALL-1; ALL1; CXXC7; GAS7; HRX; HTRX; HTRX1;
                     MLL; MLL1; MLL1A; TRX1; WDSTS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      16574..16579
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KMT2A"
                     /gene_synonym="ALL-1; ALL1; CXXC7; GAS7; HRX; HTRX; HTRX1;
                     MLL; MLL1; MLL1A; TRX1; WDSTS"
                     /note="hexamer: AATAAA"
     polyA_site      16600
                     /gene="KMT2A"
                     /gene_synonym="ALL-1; ALL1; CXXC7; GAS7; HRX; HTRX; HTRX1;
                     MLL; MLL1; MLL1A; TRX1; WDSTS"
                     /note="major polyA site"
ORIGIN      
        1 gcttcacttc acggggcgaa catggcgcac agctgtcggt ggcgcttccc cgcccgaccc
       61 gggaccaccg ggggcggcgg cggcgggggg cgccggggcc tagggggcgc cccgcggcaa
      121 cgcgtcccgg ccctgctgct tccccccggg cccccggtcg gcggtggcgg ccccggggcg
      181 cccccctccc ccccggctgt ggcggccgcg gcggcggcgg cgggaagcag cggggctggg
      241 gttccagggg gagcggccgc cgcctcagca gcctcctcgt cgtccgcctc gtcttcgtct
      301 tcgtcatcgt cctcagcctc ttcagggccg gccctgctcc gggtgggccc gggcttcgac
      361 gcggcgctgc aggtctcggc cgccatcggc accaacctgc gccggttccg ggccgtgttt
      421 ggggagagcg gcgggggagg cggcagcgga gaggatgagc aattcttagg ttttggctca
      481 gatgaagaag tcagagtgcg aagtcccaca aggtctcctt cagttaaaac tagtcctcga
      541 aaacctcgtg ggagacctag aagtggctct gaccgaaatt cagctatcct ctcagatcca
      601 tctgtgtttt cccctctaaa taaatcagag accaaatctg gagataagat caagaagaaa
      661 gattctaaaa gtatagaaaa gaagagagga agacctccca ccttccctgg agtaaaaatc
      721 aaaataacac atggaaagga catttcagag ttaccaaagg gaaacaaaga agatagcctg
      781 aaaaaaatta aaaggacacc ttctgctacg tttcagcaag ccacaaagat taaaaaatta
      841 agagcaggta aactctctcc tctcaagtct aagtttaaga cagggaagct tcaaatagga
      901 aggaaggggg tacaaattgt acgacggaga ggaaggcctc catcaacaga aaggataaag
      961 accccttcgg gtctcctcat taattctgaa ctggaaaagc cccagaaagt ccggaaagac
     1021 aaggaaggaa cacctccact tacaaaagaa gataagacag ttgtcagaca aagccctcga
     1081 aggattaagc cagttaggat tattccttct tcaaaaagga cagatgcaac cattgctaag
     1141 caactcttac agagggcaaa aaagggggct caaaagaaaa ttgaaaaaga agcagctcag
     1201 ctgcagggaa gaaaggtgaa gacacaggtc aaaaatattc gacagttcat catgcctgtt
     1261 gtcagtgcta tctcctcgcg gatcattaag acccctcggc ggtttataga ggatgaggat
     1321 tatgaccctc caattaaaat tgcccgatta gagtctacac cgaatagtag attcagtgcc
     1381 ccgtcctgtg gatcttctga aaaatcaagt gcagcttctc agcactcctc tcaaatgtct
     1441 tcagactcct ctcgatctag tagccccagt gttgatacct ccacagactc tcaggcttct
     1501 gaggagattc aggtacttcc tgaggagcgg agcgataccc ctgaagttca tcctccactg
     1561 cccatttccc agtccccaga aaatgagagt aatgatagga gaagcagaag gtattcagtg
     1621 tcggagagaa gttttggatc tagaacgacg aaaaaattat caactctaca aagtgccccc
     1681 cagcagcaga cctcctcgtc tccacctcca cctctgctga ctccaccgcc accactgcag
     1741 ccagcctcca gtatctctga ccacacacct tggcttatgc ctccaacaat ccccttagca
     1801 tcaccatttt tgcctgcttc cactgctcct atgcaaggga agcgaaaatc tattttgcga
     1861 gaaccgacat ttaggtggac ttctttaaag cattctaggt cagagccaca atacttttcc
     1921 tcagcaaagt atgccaaaga aggtcttatt cgcaaaccaa tatttgataa tttccgaccc
     1981 cctccactaa ctcccgagga cgttggcttt gcatctggtt tttctgcatc tggtaccgct
     2041 gcttcagccc gattgttttc gccactccat tctggaacaa ggtttgatat gcacaaaagg
     2101 agccctcttc tgagagctcc aagatttact ccaagtgagg ctcactctag aatatttgag
     2161 tctgtaacct tgcctagtaa tcgaacttct gctggaacat cttcttcagg agtatccaat
     2221 agaaaaagga aaagaaaagt gtttagtcct attcgatctg aaccaagatc tccttctcac
     2281 tccatgagga caagaagtgg aaggcttagt agttctgagc tctcacctct cacccccccg
     2341 tcttctgtct cttcctcgtt aagcatttct gttagtcctc ttgccactag tgccttaaac
     2401 ccaactttta cttttccttc tcattccctg actcagtctg gggaatctgc agagaaaaat
     2461 cagagaccaa ggaagcagac tagtgctccg gcagagccat tttcatcaag tagtcctact
     2521 cctctcttcc cttggtttac cccaggctct cagactgaaa gagggagaaa taaagacaag
     2581 gcccccgagg agctgtccaa agatcgagat gctgacaaga gcgtggagaa ggacaagagt
     2641 agagagagag accgggagag agaaaaggag aataagcggg agtcaaggaa agagaaaagg
     2701 aaaaagggat cagaaattca gagtagttct gctttgtatc ctgtgggtag ggtttccaaa
     2761 gagaaggttg ttggtgaaga tgttgccact tcatcttctg ccaaaaaagc aacagggcgg
     2821 aagaagtctt catcacatga ttctgggact gatattactt ctgtgactct tggggataca
     2881 acagctgtca aaaccaaaat acttataaag aaagggagag gaaatctgga aaaaaccaac
     2941 ttggacctcg gcccaactgc cccatccctg gagaaggaga aaaccctctg cctttccact
     3001 ccttcatcta gcactgttaa acattccact tcctccatag gctccatgtt ggctcaggca
     3061 gacaagcttc caatgactga caagagggtt gccagcctcc taaaaaaggc caaagctcag
     3121 ctctgcaaga ttgagaagag taagagtctt aaacaaaccg accagcccaa agcacagggt
     3181 caagaaagtg actcatcaga gacctctgtg cgaggacccc ggattaaaca tgtctgcaga
     3241 agagcagctg ttgcccttgg ccgaaaacga gctgtgtttc ctgatgacat gcccaccctg
     3301 agtgccttac catgggaaga acgagaaaag attttgtctt ccatggggaa tgatgacaag
     3361 tcatcaattg ctggctcaga agatgctgaa cctcttgctc cacccatcaa accaattaaa
     3421 cctgtcacta gaaacaaggc accccaggaa cctccagtaa agaaaggacg tcgatcgagg
     3481 cggtgtgggc agtgtcccgg ctgccaggtg cctgaggact gtggtgtttg tactaattgc
     3541 ttagataagc ccaagtttgg tggtcgcaat ataaagaagc agtgctgcaa gatgagaaaa
     3601 tgtcagaatc tacaatggat gccttccaaa gcctacctgc agaagcaagc taaagctgtg
     3661 aaaaagaaag agaaaaagtc taagaccagt gaaaagaaag acagcaaaga gagcagtgtt
     3721 gtgaagaacg tggtggactc tagtcagaaa cctaccccat cagcaagaga ggatcctgcc
     3781 ccaaagaaaa gcagtagtga gcctcctcca cgaaagcccg tcgaggaaaa gagtgaagaa
     3841 gggaatgtct cggcccctgg gcctgaatcc aaacaggcca ccactccagc ttccaggaag
     3901 tcaagcaagc aggtctccca gccagcactg gtcatcccgc ctcagccacc tactacagga
     3961 ccgccaagaa aagaagttcc caaaaccact cctagtgagc ccaagaaaaa gcagcctcca
     4021 ccaccagaat caggtccaga gcagagcaaa cagaaaaaag tggctccccg cccaagtatc
     4081 cctgtaaaac aaaaaccaaa agaaaaggaa aaaccacctc cggtcaataa gcaggagaat
     4141 gcaggcactt tgaacatcct cagcactctc tccaatggca atagttctaa gcaaaaaatt
     4201 ccagcagatg gagtccacag gatcagagtg gactttaagg aggattgtga agcagaaaat
     4261 gtgtgggaga tgggaggctt aggaatcttg acttctgttc ctataacacc cagggtggtt
     4321 tgctttctct gtgccagtag tgggcatgta gagtttgtgt attgccaagt ctgttgtgag
     4381 cccttccaca agttttgttt agaggagaac gagcgccctc tggaggacca gctggaaaat
     4441 tggtgttgtc gtcgttgcaa attctgtcac gtttgtggaa ggcaacatca ggctacaaag
     4501 cagctgctgg agtgtaataa gtgccgaaac agctatcacc ctgagtgcct gggaccaaac
     4561 taccccacca aacccacaaa gaagaagaaa gtctggatct gtaccaagtg tgttcgctgt
     4621 aagagctgtg gatccacaac tccaggcaaa gggtgggatg cacagtggtc tcatgatttc
     4681 tcactgtgtc atgattgcgc caagctcttt gctaaaggaa acttctgccc tctctgtgac
     4741 aaatgttatg atgatgatga ctatgagagt aagatgatgc aatgtggaaa gtgtgatcgc
     4801 tgggtccatt ccaaatgtga gaatctttca ggtacagaag atgagatgta tgagattcta
     4861 tctaatctgc cagaaagtgt ggcctacact tgtgtgaact gtactgagcg gcaccctgca
     4921 gagtggcgac tggcccttga aaaagagctg cagatttctc tgaagcaagt tctgacagct
     4981 ttgttgaatt ctcggactac cagccatttg ctacgctacc ggcaggctgc caagcctcca
     5041 gacttaaatc ccgagacaga ggagagtata ccttcccgca gctcccccga aggacctgat
     5101 ccaccagttc ttactgaggt cagcaaacag gatgatcagc agcctttaga tctagaagga
     5161 gtcaagagga agatggacca agggaattac acatctgtgt tggagttcag tgatgatatt
     5221 gtgaagatca ttcaagcagc cattaattca gatggaggac agccagaaat taaaaaagcc
     5281 aacagcatgg tcaagtcctt cttcattcgg caaatggaac gtgtttttcc atggttcagt
     5341 gtcaaaaagt ccaggttttg ggagccaaat aaagtatcaa gcaacagtgg gatgttacca
     5401 aacgcagtgc ttccaccttc acttgaccat aattatgctc agtggcagga gcgagaggaa
     5461 aacagccaca ctgagcagcc tcctttaatg aagaaaatca ttccagctcc caaacccaaa
     5521 ggtcctggag aaccagactc accaactcct ctgcatcctc ctacaccacc aattttgagt
     5581 actgatagga gtcgagaaga cagtccagag ctgaacccac ccccaggcat agaagacaat
     5641 agacagtgtg cgttatgttt gacttatggt gatgacagtg ctaatgatgc tggtcgttta
     5701 ctatatattg gccaaaatga gtggacacat gtaaattgtg ctttgtggtc agcggaagtg
     5761 tttgaagatg atgacggatc actaaagaat gtgcatatgg ctgtgatcag gggcaagcag
     5821 ctgagatgtg aattctgcca aaagccagga gccaccgtgg gttgctgtct cacatcctgc
     5881 accagcaact atcacttcat gtgttcccga gccaagaact gtgtctttct ggatgataaa
     5941 aaagtatatt gccaacgaca tcgggatttg atcaaaggcg aagtggttcc tgagaatgga
     6001 tttgaagttt tcagaagagt gtttgtggac tttgaaggaa tcagcttgag aaggaagttt
     6061 ctcaatggct tggaaccaga aaatatccac atgatgattg ggtctatgac aatcgactgc
     6121 ttaggaattc taaatgatct ctccgactgt gaagataagc tctttcctat tggatatcag
     6181 tgttccaggg tatactggag caccacagat gctcgcaagc gctgtgtata tacatgcaag
     6241 atagtggagt gccgtcctcc agtcgtagag ccggatatca acagcactgt tgaacatgat
     6301 gaaaacagga ccattgccca tagtccaaca tcttttacag aaagttcatc aaaagagagt
     6361 caaaacacag ctgaaattat aagtcctcca tcaccagacc gacctcctca ttcacaaacc
     6421 tctggctcct gttattatca tgtcatctca aaggtcccca ggattcgaac acccagttat
     6481 tctccaacac agagatcccc tggctgtcga ccgttgcctt ctgcaggaag tcctacccca
     6541 accactcatg aaatagtcac agtaggtgat cctttactct cctctggact tcgaagcatt
     6601 ggctccaggc gtcacagtac ctcttcctta tcaccccagc ggtccaaact ccggataatg
     6661 tctccaatga gaactgggaa tacttactct aggaataatg tttcctcagt ctccaccacc
     6721 gggaccgcta ctgatcttga atcaagtgcc aaagtagttg atcatgtctt agggccactg
     6781 aattcaagta ctagtttagg gcaaaacact tccacctctt caaatttgca aaggacagtg
     6841 gttactgtag gcaataaaaa cagtcacttg gatggatctt catcttcaga aatgaagcag
     6901 tccagtgctt cagacttggt gtccaagagc tcctctttaa agggagagaa gaccaaagtg
     6961 ctgagttcca agagctcaga gggatctgca cataatgtgg cttaccctgg aattcctaaa
     7021 ctggccccac aggttcataa cacaacatct agagaactga atgttagtaa aatcggctcc
     7081 tttgctgaac cctcttcagt gtcgttttct tctaaagagg ccctctcctt cccacacctc
     7141 catttgagag ggcaaaggaa tgatcgagac caacacacag attctaccca atcagcaaac
     7201 tcctctccag atgaagatac tgaagtcaaa accttgaagc tatctggaat gagcaacaga
     7261 tcatccatta tcaacgaaca tatgggatct agttccagag ataggagaca gaaagggaaa
     7321 aaatcctgta aagaaacttt caaagaaaag cattccagta aatctttttt ggaacctggt
     7381 caggtgacaa ctggtgagga aggaaacttg aagccagagt ttatggatga ggttttgact
     7441 cctgagtata tgggccaacg accatgtaac aatgtttctt ctgataagat tggtgataaa
     7501 ggcctttcta tgccaggagt ccccaaagct ccacccatgc aagtagaagg atctgccaag
     7561 gaattacagg caccacggaa acgcacagtc aaagtgacac tgacacctct aaaaatggaa
     7621 aatgagagtc aatccaaaaa tgccctgaaa gaaagtagtc ctgcttcccc tttgcaaata
     7681 gagtcaacat ctcccacaga accaatttca gcctctgaaa atccaggaga tggtccagtg
     7741 gcccaaccaa gccccaataa tacctcatgc caggattctc aaagtaacaa ctatcagaat
     7801 cttccagtac aggacagaaa cctaatgctt ccagatggcc ccaaacctca ggaggatggc
     7861 tcttttaaaa ggaggtatcc ccgtcgcagt gcccgtgcac gttctaacat gttttttggg
     7921 cttaccccac tctatggagt aagatcctat ggtgaagaag acattccatt ctacagcagc
     7981 tcaactggga agaagcgagg caagagatca gctgaaggac aggtggatgg ggccgatgac
     8041 ttaagcactt cagatgaaga cgacttatac tattacaact tcactagaac agtgatttct
     8101 tcaggtggag aggaacgact ggcatcccat aatttatttc gggaggagga acagtgtgat
     8161 cttccaaaaa tctcacagtt ggatggtgtt gatgatggga cagagagtga tactagtgtc
     8221 acagccacaa caaggaaaag cagccagatt ccaaaaagaa atggtaaaga aaatggaaca
     8281 gagaacttaa agattgatag acctgaagat gctggggaga aagaacatgt cactaagagt
     8341 tctgttggcc acaaaaatga gccaaagatg gataactgcc attctgtaag cagagttaaa
     8401 acacagggac aagattcctt ggaagctcag ctcagctcat tggagtcaag ccgcagagtc
     8461 cacacaagta ccccctccga caaaaattta ctggacacct ataatactga gctcctgaaa
     8521 tcagattcag acaataacaa cagtgatgac tgtgggaata tcctgccttc agacattatg
     8581 gactttgtac taaagaatac tccatccatg caggctttgg gtgagagccc agagtcatct
     8641 tcatcagaac tcctgaatct tggtgaagga ttgggtcttg acagtaatcg tgaaaaagac
     8701 atgggtcttt ttgaagtatt ttctcagcag ctgcctacaa cagaacctgt ggatagtagt
     8761 gtctcttcct ctatctcagc agaggaacag tttgagttgc ctctagagct accatctgat
     8821 ctgtctgtct tgaccacccg gagtcccact gtccccagcc agaatcccag tagactagct
     8881 gttatctcag actcagggga gaagagagta accatcacag aaaaatctgt agcctcctct
     8941 gaaagtgacc cagcactgct gagcccagga gtagatccaa ctcctgaagg ccacatgact
     9001 cctgatcatt ttatccaagg acacatggat gcagaccaca tctctagccc tccttgtggt
     9061 tcagtagagc aaggtcatgg caacaatcag gatttaacta ggaacagtag cacccctggc
     9121 cttcaggtac ctgtttcccc aactgttccc atccagaacc agaagtatgt gcccaattct
     9181 actgatagtc ctggcccgtc tcagatttcc aatgcagctg tccagaccac tccaccccac
     9241 ctgaagccag ccactgagaa actcatagtt gttaaccaga acatgcagcc actttatgtt
     9301 ctccaaactc ttccaaatgg agtgacccaa aaaatccaat tgacctcttc tgttagttct
     9361 acacccagtg tgatggagac aaatacttca gtattgggac ccatgggagg tggtctcacc
     9421 cttaccacag gactaaatcc aagcttgcca acttctcaat ctttgttccc ttctgctagc
     9481 aaaggattgc tacccatgtc tcatcaccag cacttacatt ccttccctgc agctactcaa
     9541 agtagtttcc caccaaacat cagcaatcct ccttcaggcc tgcttattgg ggttcagcct
     9601 cctccggatc cccaactttt ggtttcagaa tccagccaga ggacagacct cagtaccaca
     9661 gtagccactc catcctctgg actcaagaaa agacccatat ctcgtctaca gacccgaaag
     9721 aataaaaaac ttgctccctc tagtacccct tcaaacattg ccccttctga tgtggtttct
     9781 aatatgacat tgattaactt cacaccctcc cagcttccta atcatccaag tctgttagat
     9841 ttggggtcac ttaatacttc atctcaccga actgtcccca acatcataaa aagatctaaa
     9901 tctagcatca tgtattttga accggcaccc ctgttaccac agagtgtggg aggaactgct
     9961 gccacagcgg caggcacatc aacaataagc caggatacta gccacctcac atcagggtct
    10021 gtgtctggct tggcatccag ttcctctgtc ttgaatgttg tatccatgca aactaccaca
    10081 acccctacaa gtagtgcgtc agttccagga cacgtcacct taaccaaccc aaggttgctt
    10141 ggtaccccag atattggctc aataagcaat cttttaatca aagctagcca gcagagcctg
    10201 gggattcagg accagcctgt ggctttaccg ccaagttcag gaatgtttcc acaactgggg
    10261 acatcacaga ccccctctac tgctgcaata acagcggcat ctagcatctg tgtgctcccc
    10321 tccactcaga ctacgggcat aacagccgct tcaccttctg gggaagcaga cgaacactat
    10381 cagcttcagc atgtgaacca gctccttgcc agcaaaactg ggattcattc ttcccagcgt
    10441 gatcttgatt ctgcttcagg gccccaggta tccaacttta cccagacggt agacgctcct
    10501 aatagcatgg gactggagca gaacaaggct ttatcctcag ctgtgcaagc cagccccacc
    10561 tctcctgggg gttctccatc ctctccatct tctggacagc ggtcagcaag cccttcagtg
    10621 ccgggtccca ctaaacccaa accaaaaacc aaacggtttc agctgcctct agacaaaggg
    10681 aatggcaaga agcacaaagt ttcccatttg cggaccagtt cttctgaagc acacattcca
    10741 gaccaagaaa cgacatccct gacctcaggc acagggactc caggagcaga ggctgagcag
    10801 caggatacag ctagcgtgga gcagtcctcc cagaaggagt gtgggcaacc tgcagggcaa
    10861 gtcgctgttc ttccggaagt tcaggtgacc caaaatccag caaatgaaca agaaagtgca
    10921 gaacctaaaa cagtggaaga agaggaaagt aatttcagct ccccactgat gctttggctt
    10981 cagcaagaac aaaagcggaa ggaaagcatt actgagaaaa aacccaagaa aggacttgtt
    11041 tttgaaattt ccagtgatga tggctttcag atctgtgcag aaagtattga agatgcctgg
    11101 aagtcattga cagataaagt ccaggaagct cgatcaaatg cccgcctaaa gcagctctca
    11161 tttgcaggtg ttaacggttt gaggatgctg gggattctcc atgatgcagt tgtgttcctc
    11221 attgagcagc tgtctggtgc caagcactgt cgaaattaca aattccgttt ccacaagcca
    11281 gaggaggcca atgaaccccc cttgaaccct cacggctcag ccagggctga agtccacctc
    11341 aggaagtcag catttgacat gtttaacttc ctggcttcta aacatcgtca gcctcctgaa
    11401 tacaacccca atgatgaaga agaggaggag gtacagctga agtcagctcg gagggcaact
    11461 agcatggatc tgccaatgcc catgcgcttc cggcacttaa aaaagacttc taaggaggca
    11521 gttggtgtct acaggtctcc catccatggc cggggtcttt tctgtaagag aaacattgat
    11581 gcaggtgaga tggtgattga gtatgccggc aacgtcatcc gctccatcca gactgacaag
    11641 cgggaaaagt attacgacag caagggcatt ggttgctata tgttccgaat tgatgactca
    11701 gaggtagtgg atgccaccat gcatggaaat gctgcacgct tcatcaatca ctcgtgtgag
    11761 cctaactgct attctcgggt catcaatatt gatgggcaga agcacattgt catctttgcc
    11821 atgcgtaaga tctaccgagg agaggaactc acttacgact ataagttccc cattgaggat
    11881 gccagcaaca agctgccctg caactgtggc gccaagaaat gccggaagtt cctaaactaa
    11941 agctgctctt ctcccccagt gttggagtgc aaggaggcgg ggccatccaa agcaacgctg
    12001 aaggcctttt ccagcagctg ggagctcccg gattgcgtgg cacagctgag gggcctctgt
    12061 gatggctgag ctctcttatg tcctatactc acatcagaca tgtgatcata gtcccagaga
    12121 cagagttgag gtctcgaaga aaagatccat gatcggcttt ctcctggggc ccctccaatt
    12181 gtttactgtt agaaagtggg aatggggtcc ctagcagact tgcctggaag gagcctatta
    12241 tagagggttg gttatgttgg gagattgggc ctgaatttct ccacagaaat aagttgccat
    12301 cctcaggttg gccctttccc aagcactgta agtgagtggg tcaggcaaag ccccaaatgg
    12361 agggttggtt agattcctga cagtttgcca gccaggcccc acctacagcg tctgtcgaac
    12421 aaacagaggt ctggtggttt tccctactat cctcccactc gagagttcac ttctggttgg
    12481 gagacaggat tcctagcacc tccggtgtca aaaggctgtc atggggttgt gccaattaat
    12541 taccaaacat tgagcctgca ggctttgagt gggagtgttg cccccaggag ccttatctca
    12601 gccaattacc tttcttgaca gtaggagcgg cttccctctc ccattccctc ttcactccct
    12661 tttcttcctt tcccctgtct tcatgccact gctttcccat gcttctttcg ggttgtaggg
    12721 gagactgact gcctgctcaa ggacactccc tgctgggcat aggatgtgcc tgcaaaaagt
    12781 tccctgagcc tgtaagcact ccaggtgggg aagtggacag gagccattgg tcataaccag
    12841 acagaatttg gaaacatttt cataaagctc catggagagt tttaaagaaa catatgtagc
    12901 atgattttgt aggagaggaa aaagattatt taaataggat ttaaatcatg caacaacgag
    12961 agtatcacag ccaggatgac ccttgggtcc cattcctaag acatggttac tttattttcc
    13021 ccttgttaag acataggaag acttaatttt taaacggtca gtgtccagtt gaaggcagaa
    13081 cactaatcag atttcaaggc ccacaacttg gggactagac caccttatgt tgagggaact
    13141 ctgccacctg cgtgcaaccc acagctaaag taaattcaat gacactactg ccctgattac
    13201 tccttaggat gtggtcaaaa cagcatcaaa tgtttcttct cttcctttcc ccaagacaga
    13261 gtcctgaacc tgttaaatta agtcattgga ttttactctg ttctgtttac agtttactat
    13321 ttaaggtttt ataaatgtaa atatattttg tatatttttc tatgagaagc acttcatagg
    13381 gagaagcact tatgacaagg ctatttttta aaccgcggta ttatcctaat ttaaaagaag
    13441 atcggttttt aataattttt tattttcata ggatgaagtt agagaaaata ttcagctgta
    13501 cacacaaagt ctggtttttc ctgcccaact tccccctgga aggtgtactt tttgttgttt
    13561 aatgtgtagc ttgtttgtgc cctgttgaca taaatgtttc ctgggtttgc tctttgacaa
    13621 taaatggaga aggaaggtca cccaactcca ttgggccact cccctccttc ccctattgaa
    13681 gctcctcaaa aggctacagt aatatcttga tacaacagat tctcttcttt cccgcctctc
    13741 tcctttccgg cgcaacttcc agagtggtgg gagacggcaa tctttacatt tccctcatct
    13801 ttcttacttc agagttagca aacaacaagt tgaatggcaa cttgacattt ttgcatcacc
    13861 atctgcctca taggccactc tttcctttcc ctctgcccac caagtcctca tatctgcaga
    13921 gaacccattg atcaccttgt gccctctttt ggggcagcct gttgaaactg aagcacagtc
    13981 tgaccactca cgataaagca gatttttctc tgcctctgcc acaaggtttc agagtagtgt
    14041 agtccaagta gagggtgggg cacccttttc tcgccgcaag aagcccattc ctatggaagt
    14101 ctagcaaagc aatacgactc agcccagcac tctctgcccc aggactcatg gctctgctgt
    14161 gccttccatc ctgggctccc ttctctcctg tgaccttaag aactttgtct ggtggctttg
    14221 ctggaacatt gtcactgttt tcactgtcat gcagggagcc cagcactgtg gccaggatgg
    14281 cagagacttc cttgtcatca tggagaagtg ccagcagggg actgggaaaa gcactctacc
    14341 cagacctcac ctcccttcct ccttttgccc atgaacaaga tgcagtggcc ctaggggttc
    14401 cactagtgtc tgctttcctt tattattgca ctgtgtgagg tttttttgta aatccttgta
    14461 ttcctatttt ttttaaagaa aaaaaaaaaa ccttaagctg catttgttac tgaaatgatt
    14521 aatgcactga tgggtcctga attcaccttg agaaagaccc aaaggccagt cagggggtgg
    14581 ggggaactca gctaaataga cctagttact gccctgctag gccatgctgt actgtgagcc
    14641 cctcctcact ctctaccaac cctaaaccct gaggacaggg gaggaaccca cagcttcctt
    14701 ctcctgccag ctgcagatgg tttgccttgc ctttccaccc cctaattgtc aaccacaaaa
    14761 atgagaaatt cctcttctag ctcagccttg agtccattgc caaattttca gcacacctgc
    14821 cagcaacttg ggggaataag cgaaggtttc cctacaagag ggaaagaagg caaaaacggc
    14881 acagctatct ccaaacacat ctgagttcat ttcaaaagtg accaagggaa tctccgcaca
    14941 aaagtgcaga ttgaggaatt gtgatgggtc attcccaaga atcccccaag gggcatccca
    15001 aatccctgag gagtaacagc tgcaaacctg gtcagttctc agtgagagcc agctcactta
    15061 tagctttgct gctagaacct gttgtggctg catttcctgg tggccagtga caactgtgta
    15121 accagaatag ctgcatggcg ctgacccttt ggccggaact tggtctcttg gctccctcct
    15181 tggccaccca ccacctctcg cacagcccct ctgtttttac accaataaca agaattaagg
    15241 gggaagccct ggcagctata cgttttcaac cagactcctt tgccgggacc cagcccgcca
    15301 ccctgctcgc ctccgtcaaa cccccggcca atgcagtgag caccatgtag ctcccttgat
    15361 ttaaaaaaaa taaaaaataa aaaaaaaagg aaaaaaaaat acaacacaca cacaaaaata
    15421 aaaaaaatat tctaatgaat gtatctttct aaaggactga cgttcaatca aatatctgaa
    15481 aatactaaag gtcaaaacct tgtcagatgt taacttctaa gttcggtttg ggattttttt
    15541 tttttaatag aaatcaagtt gtttttgttt ttaaggaaaa gcgggtcatt gcaaagggct
    15601 gggtgtaatt ttatgtttca tttccttcat tttaaagcaa tacaaggtta tggagcagat
    15661 ggttttgtgc cgaatcatga atactagtca agtcacacac tctggaaact tgcaactttt
    15721 tgtttgtttt ggttttcaaa taaatataaa tatgatatat ataggaacta atatagtaat
    15781 gcaccatgta acaaagccta gttcagtcca tggcttttaa ttctcttaac actatagata
    15841 aggattgtgt tacagttgct agtagcggca ggaagatgtc aggctcactt tcctctgatt
    15901 cccgaaatgg ggggaacctc taaccataaa ggaatggtag aacagtccat tcctcggatc
    15961 agagaaaaat gcagacatgg tgtcacctgg atttttttct gcccatgaat gttgccagtc
    16021 agtacctgtc ctccttgttt ctctattttt ggttatgaat gttggggtta ccacctgcat
    16081 ttaggggaaa attgtgttct gtgctttcct ggtatcttgt tccgaggtac tctagttctg
    16141 tctttcaacc aagaaaatag aattgtggtg tttcttttat tgaactttta acagtctctt
    16201 tagtaaatac aggtagttga ataattgttt caagagctca acagatgaca agcttctttt
    16261 ctagaaataa gacatttttt gacaacttta tcatgtataa cagatctgtt ttttttcctt
    16321 gtgttcttcc aagcttctgg ttagagaaaa agagaaaaaa aaaaaaggaa aatgtgtcta
    16381 aagtccatca gtgttaactc cctgtgacag ggatgaagga aaatacttta atagttcaaa
    16441 aaataataat gctgaaagct ctctacgaaa gactgaatgt aaaagtaaaa agtgtacata
    16501 gttgtaaaaa aaaggagttt ttaaacatgt ttattttcta tgcacttttt tttatttaag
    16561 tgatagttta attaataaac atgtcaagtt tattgctgca
//
