LOCUS       NP_003670                486 aa            linear   PRI 20-SEP-2024
DEFINITION  kynurenine 3-monooxygenase isoform 1 [Homo sapiens].
ACCESSION   NP_003670
VERSION     NP_003670.2
DBSOURCE    REFSEQ: accession NM_003679.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 486)
  AUTHORS   Liao,F.J., Shen,S.L., Bao,H.L., Li,H., Zhao,Q.W., Chen,L.,
            Gong,C.W., Xiong,C.Z., Liu,W.P., Li,W. and Liu,D.N.
  TITLE     Identification and experimental validation of KMO as a critical
            immune-associated mitochondrial gene in unstable atherosclerotic
            plaque
  JOURNAL   J Transl Med 22 (1), 668 (2024)
   PUBMED   39026250
  REMARK    GeneRIF: Identification and experimental validation of KMO as a
            critical immune-associated mitochondrial gene in unstable
            atherosclerotic plaque.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 486)
  AUTHORS   Babu,H.W.S., Elangovan,A., Iyer,M., Kirola,L., Muthusamy,S.,
            Jeeth,P., Muthukumar,S., Vanlalpeka,H., Gopalakrishnan,A.V.,
            Kadhirvel,S., Kumar,N.S. and Vellingiri,B.
  TITLE     Association Study Between Kynurenine 3-Monooxygenase (KMO) Gene and
            Parkinson's Disease Patients
  JOURNAL   Mol Neurobiol 61 (7), 3867-3881 (2024)
   PUBMED   38040995
  REMARK    GeneRIF: Association Study Between Kynurenine 3-Monooxygenase (KMO)
            Gene and Parkinson's Disease Patients.
REFERENCE   3  (residues 1 to 486)
  AUTHORS   Zhai,Y., Chavez,J.A., D'Aquino,K.E., Meng,R., Nawrocki,A.R.,
            Pocai,A., Wang,L. and Ma,L.J.
  TITLE     Kynurenine 3-monooxygenase limits de novo NAD+ synthesis through
            dietary tryptophan in renal proximal tubule epithelial cell models
  JOURNAL   Am J Physiol Cell Physiol 326 (5), C1423-C1436 (2024)
   PUBMED   38497113
  REMARK    GeneRIF: Kynurenine 3-monooxygenase limits de novo NAD[+] synthesis
            through dietary tryptophan in renal proximal tubule epithelial cell
            models.
REFERENCE   4  (residues 1 to 486)
  AUTHORS   Hughes,T.D., Guner,O.F., Iradukunda,E.C., Phillips,R.S. and
            Bowen,J.P.
  TITLE     The Kynurenine Pathway and Kynurenine 3-Monooxygenase Inhibitors
  JOURNAL   Molecules 27 (1), 273 (2022)
   PUBMED   35011505
  REMARK    GeneRIF: The Kynurenine Pathway and Kynurenine 3-Monooxygenase
            Inhibitors.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 486)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   6  (residues 1 to 486)
  AUTHORS   Magni,G., Amici,A., Emanuelli,M., Orsomando,G., Raffaelli,N. and
            Ruggieri,S.
  TITLE     Enzymology of NAD+ homeostasis in man
  JOURNAL   Cell Mol Life Sci 61 (1), 19-34 (2004)
   PUBMED   14704851
  REMARK    Review article
REFERENCE   7  (residues 1 to 486)
  AUTHORS   Stone,T.W. and Darlington,L.G.
  TITLE     Endogenous kynurenines as targets for drug discovery and
            development
  JOURNAL   Nat Rev Drug Discov 1 (8), 609-620 (2002)
   PUBMED   12402501
  REMARK    Review article
REFERENCE   8  (residues 1 to 486)
  AUTHORS   Halford,S., Freedman,M.S., Bellingham,J., Inglis,S.L.,
            Poopalasundaram,S., Soni,B.G., Foster,R.G. and Hunt,D.M.
  TITLE     Characterization of a novel human opsin gene with wide tissue
            expression and identification of embedded and flanking genes on
            chromosome 1q43
  JOURNAL   Genomics 72 (2), 203-208 (2001)
   PUBMED   11401433
REFERENCE   9  (residues 1 to 486)
  AUTHORS   Breton,J., Avanzi,N., Magagnin,S., Covini,N., Magistrelli,G.,
            Cozzi,L. and Isacchi,A.
  TITLE     Functional characterization and mechanism of action of recombinant
            human kynurenine 3-hydroxylase
  JOURNAL   Eur J Biochem 267 (4), 1092-1099 (2000)
   PUBMED   10672018
REFERENCE   10 (residues 1 to 486)
  AUTHORS   Alberati-Giani,D., Cesura,A.M., Broger,C., Warren,W.D., Rover,S.
            and Malherbe,P.
  TITLE     Cloning and functional expression of human kynurenine
            3-monooxygenase
  JOURNAL   FEBS Lett 410 (2-3), 407-412 (1997)
   PUBMED   9237672
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AU137977.1, Y13153.1,
            AK291558.1, AF056032.1, AL133390.7, CB989076.1, AI262990.1 and
            DB373228.1.
            
            On May 13, 2008 this sequence version replaced NP_003670.1.
            
            Summary: This gene encodes a mitochondrion outer membrane protein
            that catalyzes the hydroxylation of L-tryptophan metabolite,
            L-kynurenine, to form L-3-hydroxykynurenine. Studies in yeast
            identified this gene as a therapeutic target for Huntington
            disease. [provided by RefSeq, Oct 2011].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF056032.1, AK291558.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000366559.9/ ENSP00000355517.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..486
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q43"
     Protein         1..486
                     /product="kynurenine 3-monooxygenase isoform 1"
                     /EC_number="1.14.13.9"
                     /note="kynurenine 3-hydroxylase"
                     /calculated_mol_wt=55679
     Region          7..364
                     /region_name="UbiH"
                     /note="2-polyprenyl-6-methoxyphenol hydroxylase and
                     related FAD-dependent oxidoreductases [Coenzyme transport
                     and metabolism, Energy production and conversion];
                     COG0654"
                     /db_xref="CDD:440419"
     Site            385..404
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O15229.2)"
     Site            425..445
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O15229.2)"
     Site            465
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:29429898; propagated from
                     UniProtKB/Swiss-Prot (O15229.2)"
     CDS             1..486
                     /gene="KMO"
                     /gene_synonym="dJ317G22.1"
                     /coded_by="NM_003679.5:68..1528"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS1618.1"
                     /db_xref="GeneID:8564"
                     /db_xref="HGNC:HGNC:6381"
                     /db_xref="MIM:603538"
ORIGIN      
        1 mdssviqrkk vaviggglvg slqacflakr nfqidvyear edtrvatftr grsinlalsh
       61 rgrqalkavg ledqivsqgi pmrarmihsl sgkksaipyg tksqyilsvs renlnkdllt
      121 aaekypnvkm hfnhrllkcn peegmitvlg sdkvpkdvtc dlivgcdgay stvrshlmkk
      181 prfdysqqyi phgymeltip pkngdyamep nylhiwprnt fmmialpnmn ksftctlfmp
      241 feefekllts ndvvdffqky fpdaiplige kllvqdffll paqpmisvkc ssfhfkshcv
      301 llgdaahaiv pffgqgmnag fedclvfdel mdkfsndlsl clpvfsrlri pddhaisdls
      361 mynyiemrah vnsswfifqk nmerflhaim pstfiplytm vtfsriryhe avqrwhwqkk
      421 vinkglfflg sliaisstyl lihymsprsf lrlrrpwnwi ahfrnttcfp akavdsleqi
      481 snlisr
//
