LOCUS       NM_007360               1576 bp    mRNA    linear   PRI 17-JUN-2024
DEFINITION  Homo sapiens killer cell lectin like receptor K1 (KLRK1), mRNA.
ACCESSION   NM_007360
VERSION     NM_007360.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1576)
  AUTHORS   Hartmann,J.A., Cardoso,M.R., Talarico,M.C.R., Kenney,D.J.,
            Leone,M.R., Reese,D.C., Turcinovic,J., O'Connell,A.K., Gertje,H.P.,
            Marino,C., Ojeda,P.E., De Paula,E.V., Orsi,F.A., Velloso,L.A.,
            Cafiero,T.R., Connor,J.H., Ploss,A., Hoelzemer,A., Carrington,M.,
            Barczak,A.K., Crossland,N.A., Douam,F., Boucau,J. and
            Garcia-Beltran,W.F.
  TITLE     Evasion of NKG2D-mediated cytotoxic immunity by sarbecoviruses
  JOURNAL   Cell 187 (10), 2393-2410 (2024)
   PUBMED   38653235
  REMARK    GeneRIF: Evasion of NKG2D-mediated cytotoxic immunity by
            sarbecoviruses.
REFERENCE   2  (bases 1 to 1576)
  AUTHORS   Ma,Y., Ping,D., Huang,K., Tao,Y., Peng,Y., Sun,X. and Liu,C.
  TITLE     Lower NKG2D expression in hepatic natural killer cells predicts
            poorer prognosis for chronic hepatitis B patients with cirrhosis
  JOURNAL   Hum Immunol 85 (3), 110775 (2024)
   PUBMED   38493049
  REMARK    GeneRIF: Lower NKG2D expression in hepatic natural killer cells
            predicts poorer prognosis for chronic hepatitis B patients with
            cirrhosis.
REFERENCE   3  (bases 1 to 1576)
  AUTHORS   Fernandez-Soto,D., Garcia-Jimenez,A.F., Casasnovas,J.M.,
            Vales-Gomez,M. and Reyburn,H.T.
  TITLE     Elevated levels of cell-free NKG2D-ligands modulate NKG2D surface
            expression and compromise NK cell function in severe COVID-19
            disease
  JOURNAL   Front Immunol 15, 1273942 (2024)
   PUBMED   38410511
  REMARK    GeneRIF: Elevated levels of cell-free NKG2D-ligands modulate NKG2D
            surface expression and compromise NK cell function in severe
            COVID-19 disease.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1576)
  AUTHORS   Raulet,D.H.
  TITLE     Roles of the NKG2D immunoreceptor and its ligands
  JOURNAL   Nat Rev Immunol 3 (10), 781-790 (2003)
   PUBMED   14523385
  REMARK    GeneRIF: NKG2D signalling enhances innate and adaptive immune
            responses (review)
            Review article
REFERENCE   5  (bases 1 to 1576)
  AUTHORS   Wu,J., Song,Y., Bakker,A.B., Bauer,S., Spies,T., Lanier,L.L. and
            Phillips,J.H.
  TITLE     An activating immunoreceptor complex formed by NKG2D and DAP10
  JOURNAL   Science 285 (5428), 730-732 (1999)
   PUBMED   10426994
REFERENCE   6  (bases 1 to 1576)
  AUTHORS   Bauer,S., Groh,V., Wu,J., Steinle,A., Phillips,J.H., Lanier,L.L.
            and Spies,T.
  TITLE     Activation of NK cells and T cells by NKG2D, a receptor for
            stress-inducible MICA
  JOURNAL   Science 285 (5428), 727-729 (1999)
   PUBMED   10426993
REFERENCE   7  (bases 1 to 1576)
  AUTHORS   Glienke,J., Sobanov,Y., Brostjan,C., Steffens,C., Nguyen,C.,
            Lehrach,H., Hofer,E. and Francis,F.
  TITLE     The genomic organization of NKG2C, E, F, and D receptor genes in
            the human natural killer gene complex
  JOURNAL   Immunogenetics 48 (3), 163-173 (1998)
   PUBMED   9683661
REFERENCE   8  (bases 1 to 1576)
  AUTHORS   Plougastel,B. and Trowsdale,J.
  TITLE     Sequence analysis of a 62-kb region overlapping the human KLRC
            cluster of genes
  JOURNAL   Genomics 49 (2), 193-199 (1998)
   PUBMED   9598306
REFERENCE   9  (bases 1 to 1576)
  AUTHORS   Plougastel,B. and Trowsdale,J.
  TITLE     Cloning of NKG2-F, a new member of the NKG2 family of human natural
            killer cell receptor genes
  JOURNAL   Eur J Immunol 27 (11), 2835-2839 (1997)
   PUBMED   9394807
REFERENCE   10 (bases 1 to 1576)
  AUTHORS   Houchins,J.P., Yabe,T., McSherry,C. and Bach,F.H.
  TITLE     DNA sequence analysis of NKG2, a family of related cDNA clones
            encoding type II integral membrane proteins on human natural killer
            cells
  JOURNAL   J Exp Med 173 (4), 1017-1020 (1991)
   PUBMED   2007850
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA933271.1, AK292059.1,
            AC022075.29 and CB241686.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_007360.3.
            
            Summary: Natural killer (NK) cells are lymphocytes that can mediate
            lysis of certain tumor cells and virus-infected cells without
            previous activation. They can also regulate specific humoral and
            cell-mediated immunity. NK cells preferentially express several
            calcium-dependent (C-type) lectins, which have been implicated in
            the regulation of NK cell function. The NKG2 gene family is located
            within the NK complex, a region that contains several C-type lectin
            genes preferentially expressed in NK cells. This gene encodes a
            member of the NKG2 family. The encoded transmembrane protein is
            characterized by a type II membrane orientation (has an
            extracellular C terminus) and the presence of a C-type lectin
            domain. It binds to a diverse family of ligands that include MHC
            class I chain-related A and B proteins and UL-16 binding proteins,
            where ligand-receptor interactions can result in the activation of
            NK and T cells. The surface expression of these ligands is
            important for the recognition of stressed cells by the immune
            system, and thus this protein and its ligands are therapeutic
            targets for the treatment of immune diseases and cancers.
            Read-through transcription exists between this gene and the
            upstream KLRC4 (killer cell lectin-like receptor subfamily C,
            member 4) family member in the same cluster. [provided by RefSeq,
            Dec 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC039836.1, AK292059.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000240618.11/ ENSP00000240618.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 DA933271.1         14-15
            3-947               AK292059.1         2-946
            948-1523            AC022075.29        44843-45418
            1524-1576           CB241686.1         18-70               c
FEATURES             Location/Qualifiers
     source          1..1576
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.2"
     gene            1..1576
                     /gene="KLRK1"
                     /gene_synonym="CD314; D12S2489E; KLR; NKG2-D; NKG2D"
                     /note="killer cell lectin like receptor K1"
                     /db_xref="GeneID:22914"
                     /db_xref="HGNC:HGNC:18788"
                     /db_xref="MIM:611817"
     exon            1..99
                     /gene="KLRK1"
                     /gene_synonym="CD314; D12S2489E; KLR; NKG2-D; NKG2D"
                     /inference="alignment:Splign:2.1.0"
     exon            100..204
                     /gene="KLRK1"
                     /gene_synonym="CD314; D12S2489E; KLR; NKG2-D; NKG2D"
                     /inference="alignment:Splign:2.1.0"
     CDS             165..815
                     /gene="KLRK1"
                     /gene_synonym="CD314; D12S2489E; KLR; NKG2-D; NKG2D"
                     /note="NK cell receptor D; NKG2-D-activating NK receptor;
                     killer cell lectin-like receptor subfamily K, member 1"
                     /codon_start=1
                     /product="NKG2-D type II integral membrane protein"
                     /protein_id="NP_031386.2"
                     /db_xref="GeneID:22914"
                     /db_xref="HGNC:HGNC:18788"
                     /db_xref="MIM:611817"
                     /translation="MGWIRGRRSRHSWEMSEFHNYNLDLKKSDFSTRWQKQRCPVVKS
                     KCRENASPFFFCCFIAVAMGIRFIIMVTIWSAVFLNSLFNQEVQIPLTESYCGPCPKN
                     WICYKNNCYQFFDESKNWYESQASCMSQNASLLKVYSKEDQDLLKLVKSYHWMGLVHI
                     PTNGSWQWEDGSILSPNLLTIIEMQKGDCALYASSFKGYIENCSTPNTYICMQRTV"
     exon            205..312
                     /gene="KLRK1"
                     /gene_synonym="CD314; D12S2489E; KLR; NKG2-D; NKG2D"
                     /inference="alignment:Splign:2.1.0"
     exon            313..405
                     /gene="KLRK1"
                     /gene_synonym="CD314; D12S2489E; KLR; NKG2-D; NKG2D"
                     /inference="alignment:Splign:2.1.0"
     exon            406..441
                     /gene="KLRK1"
                     /gene_synonym="CD314; D12S2489E; KLR; NKG2-D; NKG2D"
                     /inference="alignment:Splign:2.1.0"
     exon            442..593
                     /gene="KLRK1"
                     /gene_synonym="CD314; D12S2489E; KLR; NKG2-D; NKG2D"
                     /inference="alignment:Splign:2.1.0"
     exon            594..697
                     /gene="KLRK1"
                     /gene_synonym="CD314; D12S2489E; KLR; NKG2-D; NKG2D"
                     /inference="alignment:Splign:2.1.0"
     exon            698..1576
                     /gene="KLRK1"
                     /gene_synonym="CD314; D12S2489E; KLR; NKG2-D; NKG2D"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1550..1555
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLRK1"
                     /gene_synonym="CD314; D12S2489E; KLR; NKG2-D; NKG2D"
                     /note="hexamer: AATAAA"
     polyA_site      1576
                     /gene="KLRK1"
                     /gene_synonym="CD314; D12S2489E; KLR; NKG2-D; NKG2D"
                     /note="major polyA site"
ORIGIN      
        1 actttcaatt ctagatcagg aactgaggac atatctaaat tttctagttt tatagaaggc
       61 ttttatccac aagaatcaag atcttccctc tctgagcagg aatcctttgt gcattgaaga
      121 ctttagattc ctctctgcgg tagacgtgca cttataagta tttgatgggg tggattcgtg
      181 gtcggaggtc tcgacacagc tgggagatga gtgaatttca taattataac ttggatctga
      241 agaagagtga tttttcaaca cgatggcaaa agcaaagatg tccagtagtc aaaagcaaat
      301 gtagagaaaa tgcatctcca ttttttttct gctgcttcat cgctgtagcc atgggaatcc
      361 gtttcattat tatggtaaca atatggagtg ctgtattcct aaactcatta ttcaaccaag
      421 aagttcaaat tcccttgacc gaaagttact gtggcccatg tcctaaaaac tggatatgtt
      481 acaaaaataa ctgctaccaa ttttttgatg agagtaaaaa ctggtatgag agccaggctt
      541 cttgtatgtc tcaaaatgcc agccttctga aagtatacag caaagaggac caggatttac
      601 ttaaactggt gaagtcatat cattggatgg gactagtaca cattccaaca aatggatctt
      661 ggcagtggga agatggctcc attctctcac ccaacctact aacaataatt gaaatgcaga
      721 agggagactg tgcactctat gcctcgagct ttaaaggcta tatagaaaac tgttcaactc
      781 caaatacgta catctgcatg caaaggactg tgtaaagatg atcaaccatc tcaataaaag
      841 ccaggaacag agaagagatt acaccagcgg taacactgcc aactgagact aaaggaaaca
      901 aacaaaaaca ggacaaaatg accaaagact gtcagatttc ttagactcca caggaccaaa
      961 ccatagaaca atttcactgc aaacatgcat gattctccaa gacaaaagaa gagagatcct
     1021 aaaggcaatt cagatatccc caaggctgcc tctcccacca caagcccaga gtggatgggc
     1081 tgggggaggg gtgctgtttt aatttctaaa ggtaggacca acacccaggg gatcagtgaa
     1141 ggaagagaag gccagcagat cactgagagt gcaaccccac cctccacagg aaattgcctc
     1201 atgggcaggg ccacagcaga gagacacagc atgggcagtg ccttccctgc ctgtgggggt
     1261 catgctgcca cttttaatgg gtcctccacc caacggggtc agggaggtgg tgctgcccca
     1321 gtgggccatg attatcttaa aggcattatt ctccagcctt aagtaagatc ttaggacgtt
     1381 tcctttgcta tgatttgtac ttgcttgagt cccatgactg tttctcttcc tctctttctt
     1441 ccttttggaa tagtaatatc catcctatgt ttgtcccact attgtatttt ggaagcacat
     1501 aacttgtttg gtttcacagg ttcacagtta agaaggaatt ttgcctctga ataaatagaa
     1561 tcttgagtct catgca
//
