LOCUS       NM_198508               2158 bp    mRNA    linear   PRI 27-JUL-2024
DEFINITION  Homo sapiens killer cell lectin like receptor G2 (KLRG2), mRNA.
ACCESSION   NM_198508 XM_294372
VERSION     NM_198508.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2158)
  AUTHORS   Liu,X., Cheng,I., Plummer,S.J., Suarez,B.K., Casey,G.,
            Catalona,W.J. and Witte,J.S.
  TITLE     Fine-mapping of prostate cancer aggressiveness loci on chromosome
            7q22-35
  JOURNAL   Prostate 71 (7), 682-689 (2011)
   PUBMED   20945404
  REMARK    GeneRIF: Genetic variants in the gene KLRG2 may affect Gleason
            score at diagnosis and hence the aggressiveness of prostate cancer.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC005531.2.
            
            On May 17, 2019 this sequence version replaced NM_198508.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.960492.1,
                                           SRR7346977.776675.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA2142363
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000340940.5/ ENSP00000339356.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-788               AC005531.2         54390-55177         c
            789-890             AC005531.2         51650-51751         c
            891-1036            AC005531.2         51131-51276         c
            1037-1140           AC005531.2         25615-25718         c
            1141-2158           AC005531.2         24194-25211         c
FEATURES             Location/Qualifiers
     source          1..2158
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q34"
     gene            1..2158
                     /gene="KLRG2"
                     /gene_synonym="CLEC15B"
                     /note="killer cell lectin like receptor G2"
                     /db_xref="GeneID:346689"
                     /db_xref="HGNC:HGNC:24778"
     exon            1..788
                     /gene="KLRG2"
                     /gene_synonym="CLEC15B"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..1261
                     /gene="KLRG2"
                     /gene_synonym="CLEC15B"
                     /note="C-type lectin domain family 15 member B; killer
                     cell lectin-like receptor subfamily G, member 2"
                     /codon_start=1
                     /product="killer cell lectin-like receptor subfamily G
                     member 2"
                     /protein_id="NP_940910.1"
                     /db_xref="CCDS:CCDS5854.1"
                     /db_xref="GeneID:346689"
                     /db_xref="HGNC:HGNC:24778"
                     /translation="MEESWEAAPGGQAGAELPMEPVGSLVPTLEQPQVPAKVRQPEGP
                     ESSPSPAGAVEKAAGAGLEPSSKKKPPSPRPGSPRVPPLSLGYGVCPEPPSPGPALVK
                     LPRNGEAPGAEPAPSAWAPMELQVDVRVKPVGAAGGSSTPSPRPSTRFLKVPVPESPA
                     FSRHADPAHQLLLRAPSQGGTWGRRSPLAAARTESGCDAEGRASPAEGSAGSPGSPTC
                     CRCKELGLEKEDAALLPRAGLDGDEKLPRAVTLTGLPMYVKSLYWALAFMAVLLAVSG
                     VVIVVLASRAGARCQQCPPGWVLSEEHCYYFSAEAQAWEASQAFCSAYHATLPLLSHT
                     QDFLGRYPVSRHSWVGAWRGPQGWHWIDEAPLPPQLLPEDGEDNLDINCGALEEGTLV
                     AANCSTPRPWVCAKGTQ"
     exon            789..890
                     /gene="KLRG2"
                     /gene_synonym="CLEC15B"
                     /inference="alignment:Splign:2.1.0"
     exon            891..1036
                     /gene="KLRG2"
                     /gene_synonym="CLEC15B"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1140
                     /gene="KLRG2"
                     /gene_synonym="CLEC15B"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..2158
                     /gene="KLRG2"
                     /gene_synonym="CLEC15B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1558..1563
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLRG2"
                     /gene_synonym="CLEC15B"
                     /note="hexamer: ATTAAA"
     polyA_site      1606
                     /gene="KLRG2"
                     /gene_synonym="CLEC15B"
                     /note="major polyA site"
ORIGIN      
        1 ctcagcgtct ccgggtggcg gggcgcgcgg gatggaggag tcttgggagg ctgcgcccgg
       61 aggccaagcc ggggcagagc tcccaatgga gcccgtggga agcctggtcc ccacgctgga
      121 gcagccgcag gtgcccgcga aggtgcgaca acctgaaggt cccgaaagca gcccaagtcc
      181 ggccggggcc gtggagaagg cggcgggcgc aggcctggag ccctcgagca agaaaaagcc
      241 gccttcgcct cgccccgggt ccccgcgcgt gccgccgctc agcctgggct acggggtctg
      301 ccccgagccg ccgtcaccgg gccctgcctt ggtcaagctg ccccggaatg gcgaggcgcc
      361 cggggctgag cctgcgccca gcgcctgggc gcccatggag ctgcaggtag atgtgcgcgt
      421 gaagcccgtg ggcgcggccg gtggcagcag cacgccatcg cccaggccct ccacgcgctt
      481 cctcaaggtg ccggtgcccg agtcccctgc cttctcccgc cacgcggacc cggcgcacca
      541 gctcctgctg cgcgcaccat cccagggcgg cacgtggggc cgccgctcgc cgctggctgc
      601 agcccggacg gagagcggct gcgacgcaga gggccgggcc agccccgcgg aaggaagcgc
      661 cggctccccg ggctccccca cgtgctgccg ctgcaaggag ctggggctgg agaaggagga
      721 tgcggcgctg ttgccccgcg cggggttgga cggcgacgag aagctgcccc gggccgtaac
      781 gcttacgggg ctacccatgt acgtgaagtc cctgtactgg gccctggcgt tcatggctgt
      841 gctcctggca gtctctgggg ttgtcattgt ggtcctggcc tcaagagcag gagccagatg
      901 ccagcagtgc cccccaggct gggtgttgtc cgaggagcac tgttactact tctctgcaga
      961 agcgcaggcc tgggaagcca gccaggcttt ctgctcagcc taccacgcta ccctccccct
     1021 gctaagccac acccaggact tcctgggcag atacccagtc tccaggcact cctgggtggg
     1081 ggcctggcga ggcccccagg gctggcactg gatcgacgag gccccactcc cgccccagct
     1141 actccctgag gacggcgagg acaatctgga tatcaactgt ggggccctgg aggaaggcac
     1201 gctggtggct gcaaactgca gcactccaag accctgggtc tgtgccaagg ggacccagtg
     1261 atctgggctc tgcctggtcc tcagcctgcc aggcagatgc agcaccccct acaggggagg
     1321 ccagttgaga gcttgggcag cctcttcctg gacccagtta tccaggtctt catgctctgc
     1381 tcaagggggc cacatgagcg agcctaggag ctggacttca acccaggaag atgcatccga
     1441 gggaaaggag attttctatg gcctcaggcc tgagtgccaa tattagtctc cagcttctgt
     1501 ggatgatcgg tttgatgaca ttgggatggt tgtttagcat ttctgtgcct tggtttcatt
     1561 aaaatgacaa tttcccccta gaggaaaaag acagggttaa caaccacagc ggattccaat
     1621 ctgggttctc attccggctc atggaaatga gtctgccgtt gttcagtggc agtgggactt
     1681 ggcagggata acgtcattgc tgtgaattct acttcaggca gctgggtgta catcggacac
     1741 agcctaccgg cagcctctgg aaaattaacc aaggaaaagg agcggtcagc cctggaaaga
     1801 ggggagagca aggttttcct tccccaccct gagagttggc aaagggttgg cagacaggaa
     1861 ggttctgggt ggagatcccg catgtgggct ggccagcccc tggcacgctg atgcccaagg
     1921 gtgagacaag gcagagagga cagggccacc tggcaggaga agccaggaga gcaccccagc
     1981 ttggtaggtg gaagctgagg agtctgagtg aaaaaggaaa tcagagaaat gcaggcacgt
     2041 tccaggcagc tcttctaccc acagctgcag agacgaccaa cctgaagatg tctccatgct
     2101 ggggtgcagt gaagaccttc aggctggagg atgtggctga cagagttgtg tagttcct
//
