LOCUS       NM_005810               1874 bp    mRNA    linear   PRI 24-JUN-2024
DEFINITION  Homo sapiens killer cell lectin like receptor G1 (KLRG1),
            transcript variant 2, mRNA.
ACCESSION   NM_005810
VERSION     NM_005810.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1874)
  AUTHORS   Yang,Y., Shi,H., Zhou,Y. and Zhou,Y.
  TITLE     Expression of HLA-DR and KLRG1 enhances the cytotoxic potential and
            cytokine secretion capacity of CD3+ T cells in tuberculosis
            patients
  JOURNAL   Int Immunopharmacol 133, 112115 (2024)
   PUBMED   38652959
  REMARK    GeneRIF: Expression of HLA-DR and KLRG1 enhances the cytotoxic
            potential and cytokine secretion capacity of CD3[+] T cells in
            tuberculosis patients.
REFERENCE   2  (bases 1 to 1874)
  AUTHORS   Wang,L., Liao,F., Yang,L., Jiang,L., Duan,L., Wang,B., Mu,D.,
            Chen,J., Huang,Y., Hu,Q. and Chen,W.
  TITLE     KLRG1-expressing CD8+ T cells are exhausted and polyfunctional in
            patients with chronic hepatitis B
  JOURNAL   PLoS One 19 (5), e0303945 (2024)
   PUBMED   38776335
  REMARK    GeneRIF: KLRG1-expressing CD8+ T cells are exhausted and
            polyfunctional in patients with chronic hepatitis B.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1874)
  AUTHORS   Astorga-Gamaza,A., Perea,D., Sanchez-Gaona,N., Calvet-Mirabent,M.,
            Gallego-Cortes,A., Grau-Exposito,J., Sanchez-Cerrillo,I., Rey,J.,
            Castellvi,J., Curran,A., Burgos,J., Navarro,J., Suanzes,P.,
            Falco,V., Genesca,M., Martin-Gayo,E. and Buzon,M.J.
  TITLE     KLRG1 expression on natural killer cells is associated with HIV
            persistence, and its targeting promotes the reduction of the viral
            reservoir
  JOURNAL   Cell Rep Med 4 (10), 101202 (2023)
   PUBMED   37741278
  REMARK    GeneRIF: KLRG1 expression on natural killer cells is associated
            with HIV persistence, and its targeting promotes the reduction of
            the viral reservoir.
REFERENCE   4  (bases 1 to 1874)
  AUTHORS   Novelli,L., Barbati,C., Capuano,C., Recalchi,S., Ceccarelli,F.,
            Vomero,M., Alessandri,C., Morrone,S. and Conti,F.
  TITLE     KLRG1 is reduced on NK cells in SLE patients, inversely correlates
            with disease activity and is modulated by hydroxychloroquine in
            vitro
  JOURNAL   Lupus 32 (4), 549-559 (2023)
   PUBMED   36876466
  REMARK    GeneRIF: KLRG1 is reduced on NK cells in SLE patients, inversely
            correlates with disease activity and is modulated by
            hydroxychloroquine in vitro.
REFERENCE   5  (bases 1 to 1874)
  AUTHORS   Lou,C., Wu,K., Shi,J., Dai,Z. and Xu,Q.
  TITLE     N-cadherin protects oral cancer cells from NK cell killing in the
            circulation by inducing NK cell functional exhaustion via the KLRG1
            receptor
  JOURNAL   J Immunother Cancer 10 (9) (2022)
   PUBMED   36096526
  REMARK    GeneRIF: N-cadherin protects oral cancer cells from NK cell killing
            in the circulation by inducing NK cell functional exhaustion via
            the KLRG1 receptor.
REFERENCE   6  (bases 1 to 1874)
  AUTHORS   Voehringer,D., Koschella,M. and Pircher,H.
  TITLE     Lack of proliferative capacity of human effector and memory T cells
            expressing killer cell lectinlike receptor G1 (KLRG1)
  JOURNAL   Blood 100 (10), 3698-3702 (2002)
   PUBMED   12393723
  REMARK    GeneRIF: human effector and memory T cells expressing KLRG1 lack
            proliferative capacity
REFERENCE   7  (bases 1 to 1874)
  AUTHORS   Hanke,T., Corral,L., Vance,R.E. and Raulet,D.H.
  TITLE     2F1 antigen, the mouse homolog of the rat 'mast cell
            function-associated antigen', is a lectin-like type II
            transmembrane receptor expressed by natural killer cells
  JOURNAL   Eur J Immunol 28 (12), 4409-4417 (1998)
   PUBMED   9862378
REFERENCE   8  (bases 1 to 1874)
  AUTHORS   Butcher,S., Arney,K.L. and Cook,G.P.
  TITLE     MAFA-L, an ITIM-containing receptor encoded by the human NK cell
            gene complex and expressed by basophils and NK cells
  JOURNAL   Eur J Immunol 28 (11), 3755-3762 (1998)
   PUBMED   9842918
REFERENCE   9  (bases 1 to 1874)
  AUTHORS   Lamers,M.B., Lamont,A.G. and Williams,D.H.
  TITLE     Human MAFA has alternatively spliced variants
  JOURNAL   Biochim Biophys Acta 1399 (2-3), 209-212 (1998)
   PUBMED   9765598
REFERENCE   10 (bases 1 to 1874)
  AUTHORS   Ortega,E., Schneider,H. and Pecht,I.
  TITLE     Possible interactions between the Fc epsilon receptor and a novel
            mast cell function-associated antigen
  JOURNAL   Int Immunol 3 (4), 333-342 (1991)
   PUBMED   1831652
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC006581.16, AF097358.1,
            AI433079.1 and BC012621.1.
            
            On Nov 23, 2018 this sequence version replaced NM_005810.3.
            
            Summary: Natural killer (NK) cells are lymphocytes that can mediate
            lysis of certain tumor cells and virus-infected cells without
            previous activation. They can also regulate specific humoral and
            cell-mediated immunity. The protein encoded by this gene belongs to
            the killer cell lectin-like receptor (KLR) family, which is a group
            of transmembrane proteins preferentially expressed in NK cells.
            Studies in mice suggested that the expression of this gene may be
            regulated by MHC class I molecules. [provided by RefSeq, Jun 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189664.54335.1, AK301367.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000356986.8/ ENSP00000349477.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-79                AC006581.16        138503-138581
            80-966              AF097358.1         7-893
            967-1314            AI433079.1         1-348               c
            1315-1870           BC012621.1         771-1326
            1871-1874           AC006581.16        159705-159708
FEATURES             Location/Qualifiers
     source          1..1874
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.31"
     gene            1..1874
                     /gene="KLRG1"
                     /gene_synonym="2F1; CLEC15A; MAFA; MAFA-2F1; MAFA-L;
                     MAFA-LIKE"
                     /note="killer cell lectin like receptor G1"
                     /db_xref="GeneID:10219"
                     /db_xref="HGNC:HGNC:6380"
                     /db_xref="MIM:604874"
     exon            1..172
                     /gene="KLRG1"
                     /gene_synonym="2F1; CLEC15A; MAFA; MAFA-2F1; MAFA-L;
                     MAFA-LIKE"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..660
                     /gene="KLRG1"
                     /gene_synonym="2F1; CLEC15A; MAFA; MAFA-2F1; MAFA-L;
                     MAFA-LIKE"
                     /note="isoform b is encoded by transcript variant 2; mast
                     cell function-associated antigen (ITIM-containing);
                     MAFA-like receptor; ITIM-containing receptor MAFA-L;
                     C-type lectin domain family 15 member A; killer cell
                     lectin-like receptor subfamily G, member 1"
                     /codon_start=1
                     /product="killer cell lectin-like receptor subfamily G
                     member 1 isoform b"
                     /protein_id="NP_005801.3"
                     /db_xref="CCDS:CCDS8599.1"
                     /db_xref="GeneID:10219"
                     /db_xref="HGNC:HGNC:6380"
                     /db_xref="MIM:604874"
                     /translation="MTDSVIYSMLELPTATQAQNDYGPQQKSSSSRPSCSCLVAIALG
                     LLTAVLLSVLLYQWILCQGSNYSTCASCPSCPDRWMKYGNHCYYFSVEEKDWNSSLEF
                     CLARDSHLLVITDNQEMSLLQVFLSEAFCWIGLRNNSGWRWEDGSPLNFSRISSNSFV
                     QTCGAINKNGLQASSCEVPLHWVCKKVRL"
     exon            173..277
                     /gene="KLRG1"
                     /gene_synonym="2F1; CLEC15A; MAFA; MAFA-2F1; MAFA-L;
                     MAFA-LIKE"
                     /inference="alignment:Splign:2.1.0"
     exon            278..447
                     /gene="KLRG1"
                     /gene_synonym="2F1; CLEC15A; MAFA; MAFA-2F1; MAFA-L;
                     MAFA-LIKE"
                     /inference="alignment:Splign:2.1.0"
     exon            448..548
                     /gene="KLRG1"
                     /gene_synonym="2F1; CLEC15A; MAFA; MAFA-2F1; MAFA-L;
                     MAFA-LIKE"
                     /inference="alignment:Splign:2.1.0"
     exon            549..1874
                     /gene="KLRG1"
                     /gene_synonym="2F1; CLEC15A; MAFA; MAFA-2F1; MAFA-L;
                     MAFA-LIKE"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1850..1855
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLRG1"
                     /gene_synonym="2F1; CLEC15A; MAFA; MAFA-2F1; MAFA-L;
                     MAFA-LIKE"
                     /note="hexamer: AATAAA"
     polyA_site      1874
                     /gene="KLRG1"
                     /gene_synonym="2F1; CLEC15A; MAFA; MAFA-2F1; MAFA-L;
                     MAFA-LIKE"
                     /note="major polyA site"
ORIGIN      
        1 agagattggg ctgtttcctc actgatacat atcccttcac acttctataa tttaactctc
       61 tcaactgcat gtgaaagatc ttagctgaag atgactgaca gtgttattta ttccatgtta
      121 gagttgccta cggcaaccca agcccagaat gactatggac cacagcaaaa atcttcctct
      181 tccaggcctt cttgttcttg ccttgtggca atagctttgg ggcttctgac tgcagttctt
      241 ctgagtgtgc tgctatacca gtggatcctg tgccagggct ccaactactc cacttgtgcc
      301 agctgtccta gctgcccaga ccgctggatg aaatatggta accattgtta ttatttctca
      361 gtggaggaaa aggactggaa ttctagtctg gaattctgcc tagccagaga ctcacacctc
      421 cttgtgataa cggacaatca ggaaatgagc ctgctccaag ttttcctcag tgaggccttt
      481 tgctggattg gtctgaggaa caattctggc tggaggtggg aagatggatc acctctaaac
      541 ttctcaagga tttcttctaa tagctttgtg cagacatgcg gtgccatcaa caaaaatggt
      601 cttcaagcct caagctgtga agttccttta cactgggtgt gtaagaaggt cagactttga
      661 tagatgacca ctctgtcctg accctcagat ctgtcatgta tccctaaaag gagggagctg
      721 gccactggct gttgggaaag ccatgagtat atagttagca aatactgaac tttctcagat
      781 atggcattag atgcaagaca acctcctagg gattgatgcc taactgatgg attctctttg
      841 agactattta gatattatgt gagcaattta aagaccagat ctaagcaaat tttgaaatag
      901 atgtttgttt tttgtatttc tcagtatgga aactaatgct gccactctca tccccgtccc
      961 aaccatctct gtcaaaaata tacctttttc atatgatatt ctgagctaat ctgataaaat
     1021 ctatgccaat atatactatt gcttgtgtac tagagaagta cattattgct gtactcctct
     1081 gtacattact gatccctgat ggtatatttc tatcctaaca gtgtcccttt gcagatcaag
     1141 ctttattctg aagaataaac ctagctggca tgctggtgtg tacctgtagt cctagctatt
     1201 tgggaagctg aggtgggagg gtcgcttgag cccaggagtt tgaggctgca gtgagctatg
     1261 attgtgccac tgtactccag cctgggagat agagcaagac tccatctcta aaaaaaaaaa
     1321 aaaatgctaa tgtgagaata taaattgtgg gaaatgagtg agggcaaggt ggtacttcct
     1381 ccttctgagc tcttcacacg taatgcaaaa acccggtctt aactgatttt gttttttttc
     1441 tgagtatgca tatatgtggt tgaatgaacc aatgtgtgat tgtatctttt ccattatgtg
     1501 actgtttgac ctgcatatta atttcaagat agcagtcaat tcgataaggc attttcatag
     1561 aggaaagttt acagaaacag tttatgtggt tggatcacca aattatctta ggtactaagg
     1621 cctcaaaaat aagaaaaact ttattatttc tcctcagtag agtttggaca tacataagga
     1681 gagaaggtac agtgatgaag gagaccataa ttctgtagtg ttgatgatcc tggattataa
     1741 tctttttctc tttatctttc atagtttttt taaaaacatg gactgtatct tatctaccac
     1801 tatatcccaa atacctaaga tagtgcttac gttcagtgac tattaaataa ataaatggat
     1861 gaattaaaaa gtaa
//
