LOCUS       NM_001190765             731 bp    mRNA    linear   PRI 27-JUL-2024
DEFINITION  Homo sapiens killer cell lectin like receptor F2 (KLRF2), mRNA.
ACCESSION   NM_001190765
VERSION     NM_001190765.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 731)
  AUTHORS   Kuhnel,I., Vogler,I., Spreu,J., Bonig,H., Doring,C. and Steinle,A.
  TITLE     The activating receptor NKp65 is selectively expressed by human
            ILC3 and demarcates ILC3 from mature NK cells
  JOURNAL   Eur J Immunol 54 (4), e2250318 (2024)
   PUBMED   38072999
  REMARK    GeneRIF: The activating receptor NKp65 is selectively expressed by
            human ILC3 and demarcates ILC3 from mature NK cells.
REFERENCE   2  (bases 1 to 731)
  AUTHORS   Bauer,B., Wotapek,T., Zoller,T., Rutkowski,E. and Steinle,A.
  TITLE     The Activating C-type Lectin-like Receptor NKp65 Signals through a
            Hemi-immunoreceptor Tyrosine-based Activation Motif (hemITAM) and
            Spleen Tyrosine Kinase (Syk)
  JOURNAL   J Biol Chem 292 (8), 3213-3223 (2017)
   PUBMED   28082678
  REMARK    GeneRIF: NKp65 utilizes a hemi-immunoreceptor tyrosine-based
            activation motif -like motif for cellular activation that requires
            Syk, although Syk appears not to be recruited to NKp65.
REFERENCE   3  (bases 1 to 731)
  AUTHORS   Bauer,B., Spreu,J., Rohe,C., Vogler,I. and Steinle,A.
  TITLE     Key residues at the membrane-distal surface of KACL, but not
            glycosylation, determine the functional interaction of the
            keratinocyte-specific C-type lectin-like receptor KACL with its
            high-affinity receptor NKp65
  JOURNAL   Immunology 145 (1), 114-123 (2015)
   PUBMED   25510854
  REMARK    GeneRIF: Key residues at the membrane-distal surface of KACL, but
            not glycosylation, determine the functional interaction of the
            keratinocyte-specific C-type lectin-like receptor KACL with its
            high-affinity receptor NKp65
REFERENCE   4  (bases 1 to 731)
  AUTHORS   Li,Y., Wang,Q., Chen,S., Brown,P.H. and Mariuzza,R.A.
  TITLE     Structure of NKp65 bound to its keratinocyte ligand reveals basis
            for genetically linked recognition in natural killer gene complex
  JOURNAL   Proc Natl Acad Sci U S A 110 (28), 11505-11510 (2013)
   PUBMED   23803857
  REMARK    GeneRIF: structure explains the exceptionally high affinity of the
            NKp65-KACL interaction compared with other cell-cell interaction
            pairs, which may compensate for the monomeric nature of NKp65 to
            achieve cell activation
REFERENCE   5  (bases 1 to 731)
  AUTHORS   Spreu,J., Kuttruff,S., Stejfova,V., Dennehy,K.M., Schittek,B. and
            Steinle,A.
  TITLE     Interaction of C-type lectin-like receptors NKp65 and KACL
            facilitates dedicated immune recognition of human keratinocytes
  JOURNAL   Proc Natl Acad Sci U S A 107 (11), 5100-5105 (2010)
   PUBMED   20194751
  REMARK    GeneRIF: Keratinocytes express KACL and are capable of stimulating
            NKp65-expressing cells in a KACL-dependent manner.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            GQ398770.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: GQ398770.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2163459 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000535540.1/ ENSP00000438244.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-71                GQ398770.1         1-71
            72-731              GQ398770.1         73-732
FEATURES             Location/Qualifiers
     source          1..731
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.31"
     gene            1..731
                     /gene="KLRF2"
                     /gene_synonym="NKp65"
                     /note="killer cell lectin like receptor F2"
                     /db_xref="GeneID:100431172"
                     /db_xref="HGNC:HGNC:37646"
                     /db_xref="MIM:618814"
     exon            1..177
                     /gene="KLRF2"
                     /gene_synonym="NKp65"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..731
                     /gene="KLRF2"
                     /gene_synonym="NKp65"
                     /note="lectin-like receptor F2; activating coreceptor
                     NKp65; killer cell lectin-like receptor subfamily F,
                     member 2"
                     /codon_start=1
                     /product="killer cell lectin-like receptor subfamily F
                     member 2"
                     /protein_id="NP_001177694.1"
                     /db_xref="CCDS:CCDS53743.1"
                     /db_xref="GeneID:100431172"
                     /db_xref="HGNC:HGNC:37646"
                     /db_xref="MIM:618814"
                     /translation="MENEDGYMTLSFKNRCKSKQKSKDFSLYPQYYCLLLIFGCIVIL
                     IFIMTGIDLKFWHKKMDFSQNVNVSSLSGHNYLCPNDWLLNEGKCYWFSTSFKTWKES
                     QRDCTQLQAHLLVIQNLDELEFIQNSLKPGHFGWIGLYVTFQGNLWMWIDEHFLVPEL
                     FSVIGPTDDRSCAVITGNWVYSEDCSSTFKGICQRDAILTHNGTSGV"
     exon            178..276
                     /gene="KLRF2"
                     /gene_synonym="NKp65"
                     /inference="alignment:Splign:2.1.0"
     exon            277..324
                     /gene="KLRF2"
                     /gene_synonym="NKp65"
                     /inference="alignment:Splign:2.1.0"
     exon            325..473
                     /gene="KLRF2"
                     /gene_synonym="NKp65"
                     /inference="alignment:Splign:2.1.0"
     exon            474..586
                     /gene="KLRF2"
                     /gene_synonym="NKp65"
                     /inference="alignment:Splign:2.1.0"
     exon            587..731
                     /gene="KLRF2"
                     /gene_synonym="NKp65"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agttttcttt tagtaccttg tgccaaagag acatatccaa ggttgagatt agtttccatt
       61 ttctttgtac tattttctgg ataataagac attagacatt tgaagagatg gagaatgaag
      121 atgggtatat gacgctgagt ttcaagaatc gttgtaaatc gaagcagaaa tctaaagatt
      181 tctccctata tccacaatat tattgtcttc tgctcatatt tggatgcatt gtgatcctta
      241 tattcattat gacagggatt gacctgaagt tctggcataa aaaaatggat ttctcccaga
      301 atgtaaacgt cagcagtcta tcaggacaca attacttgtg cccaaatgac tggctgttga
      361 acgaagggaa atgttactgg ttttcaactt cttttaaaac gtggaaagag agtcaacgtg
      421 attgtacaca gctacaggca catttactgg tgattcaaaa tttggatgag ctggagttca
      481 tacagaacag tttaaaacct ggacattttg gttggattgg actatatgtt acattccaag
      541 ggaacctatg gatgtggata gatgaacact ttttagttcc agaattgttt tcagtgattg
      601 gaccaactga tgacaggagc tgtgccgtta tcacaggaaa ctgggtgtat tctgaagact
      661 gtagctccac atttaagggc atttgccaga gagatgcgat cttgacgcac aatggaacca
      721 gtggtgtgta a
//
