LOCUS       NM_016523               1239 bp    mRNA    linear   PRI 27-JUL-2024
DEFINITION  Homo sapiens killer cell lectin like receptor F1 (KLRF1),
            transcript variant 1, mRNA.
ACCESSION   NM_016523
VERSION     NM_016523.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1239)
  AUTHORS   Zhang,J., Dunk,C.E., Kwan,M., Jones,R.L., Harris,L.K., Keating,S.
            and Lye,S.J.
  TITLE     Human dNK cell function is differentially regulated by extrinsic
            cellular engagement and intrinsic activating receptors in first and
            second trimester pregnancy
  JOURNAL   Cell Mol Immunol 14 (2), 203-213 (2017)
   PUBMED   26277900
  REMARK    GeneRIF: In the second trimester, functional markers of Decidual
            natural killer activation, i.e., angiogenic factor production
            (e.g., vascular endothelial growth factor, interleukin-8,
            interferon-gamma), remained stable despite an increase in NKp80 or
            NKG2D surface expression.
REFERENCE   2  (bases 1 to 1239)
  AUTHORS   Freud,A.G., Keller,K.A., Scoville,S.D., Mundy-Bosse,B.L., Cheng,S.,
            Youssef,Y., Hughes,T., Zhang,X., Mo,X., Porcu,P., Baiocchi,R.A.,
            Yu,J., Carson,W.E. 3rd and Caligiuri,M.A.
  TITLE     NKp80 Defines a Critical Step during Human Natural Killer Cell
            Development
  JOURNAL   Cell Rep 16 (2), 379-391 (2016)
   PUBMED   27373165
  REMARK    GeneRIF: NKp80 is a marker of natural killer (NK) cell maturity in
            secondary lymphoid tissues and supports NK cell development through
            a stage 4a intermediate with ILC3-associated features.
REFERENCE   3  (bases 1 to 1239)
  AUTHORS   Klimosch,S.N., Bartel,Y., Wiemann,S. and Steinle,A.
  TITLE     Genetically coupled receptor-ligand pair NKp80-AICL enables
            autonomous control of human NK cell responses
  JOURNAL   Blood 122 (14), 2380-2389 (2013)
   PUBMED   23929856
  REMARK    GeneRIF: our data report a previously unrecognized regulatory
            circuit enabling autonomous control of human NK cell responses via
            the NKp80-AICL axis.
REFERENCE   4  (bases 1 to 1239)
  AUTHORS   Ruckrich,T. and Steinle,A.
  TITLE     Attenuated natural killer (NK) cell activation through C-type
            lectin-like receptor NKp80 is due to an anomalous
            hemi-immunoreceptor tyrosine-based activation motif (HemITAM) with
            impaired Syk kinase recruitment capacity
  JOURNAL   J Biol Chem 288 (24), 17725-17733 (2013)
   PUBMED   23609447
  REMARK    GeneRIF: Two non-consensus amino acids of NKp80, in particular
            arginine 6, critically impair both hemi-immunoreceptor
            tyrosine-based activation motif phosphorylation and Syk
            recruitment.
REFERENCE   5  (bases 1 to 1239)
  AUTHORS   Davila,S., Froeling,F.E., Tan,A., Bonnard,C., Boland,G.J.,
            Snippe,H., Hibberd,M.L. and Seielstad,M.
  TITLE     New genetic associations detected in a host response study to
            hepatitis B vaccine
  JOURNAL   Genes Immun 11 (3), 232-238 (2010)
   PUBMED   20237496
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 1239)
  AUTHORS   Kuttruff,S., Koch,S., Kelp,A., Pawelec,G., Rammensee,H.G. and
            Steinle,A.
  TITLE     NKp80 defines and stimulates a reactive subset of CD8 T cells
  JOURNAL   Blood 113 (2), 358-369 (2009)
   PUBMED   18922855
  REMARK    GeneRIF: NKp80 is expressed on a highly responsive subset of
            effector memory CD8 T cells with an inflammatory NK-like phenotype
            and promotes T-cell responses toward AICL-expressing cells.
REFERENCE   7  (bases 1 to 1239)
  AUTHORS   Welte,S., Kuttruff,S., Waldhauer,I. and Steinle,A.
  TITLE     Mutual activation of natural killer cells and monocytes mediated by
            NKp80-AICL interaction
  JOURNAL   Nat Immunol 7 (12), 1334-1342 (2006)
   PUBMED   17057721
REFERENCE   8  (bases 1 to 1239)
  AUTHORS   Roda-Navarro,P., Hernanz-Falcon,P., Arce,I. and Fernandez-Ruiz,E.
  TITLE     Molecular characterization of two novel alternative spliced
            variants of the KLRF1 gene and subcellular distribution of KLRF1
            isoforms
  JOURNAL   Biochim Biophys Acta 1520 (2), 141-146 (2001)
   PUBMED   11513955
REFERENCE   9  (bases 1 to 1239)
  AUTHORS   Vitale,M., Falco,M., Castriconi,R., Parolini,S., Zambello,R.,
            Semenzato,G., Biassoni,R., Bottino,C., Moretta,L. and Moretta,A.
  TITLE     Identification of NKp80, a novel triggering molecule expressed by
            human NK cells
  JOURNAL   Eur J Immunol 31 (1), 233-242 (2001)
   PUBMED   11265639
REFERENCE   10 (bases 1 to 1239)
  AUTHORS   Roda-Navarro,P., Arce,I., Renedo,M., Montgomery,K., Kucherlapati,R.
            and Fernandez-Ruiz,E.
  TITLE     Human KLRF1, a novel member of the killer cell lectin-like receptor
            gene family: molecular characterization, genomic structure,
            physical mapping to the NK gene complex and expression analysis
  JOURNAL   Eur J Immunol 30 (2), 568-576 (2000)
   PUBMED   10671213
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF175206.1 and AJ305370.1.
            
            On Nov 22, 2018 this sequence version replaced NM_016523.2.
            
            Summary: KLRF1, an activating homodimeric C-type lectin-like
            receptor (CTLR), is expressed on nearly all natural killer (NK)
            cells and stimulates their cytoxicity and cytokine release
            (Kuttruff et al., 2009 [PubMed 18922855]).[supplied by OMIM, Oct
            2009].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF175206.1, AJ305370.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000617889.5/ ENSP00000483713.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                AF175206.1         1-17
            18-1239             AJ305370.1         1-1222
FEATURES             Location/Qualifiers
     source          1..1239
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.31"
     gene            1..1239
                     /gene="KLRF1"
                     /gene_synonym="CLEC5C; NKp80"
                     /note="killer cell lectin like receptor F1"
                     /db_xref="GeneID:51348"
                     /db_xref="HGNC:HGNC:13342"
                     /db_xref="MIM:605029"
     exon            1..149
                     /gene="KLRF1"
                     /gene_synonym="CLEC5C; NKp80"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..760
                     /gene="KLRF1"
                     /gene_synonym="CLEC5C; NKp80"
                     /note="isoform 1 is encoded by transcript variant 1;
                     lectin-like receptor F1; activating coreceptor NKp80;
                     C-type lectin domain family 5 member C; killer cell
                     lectin-like receptor subfamily F, member 1"
                     /codon_start=1
                     /product="killer cell lectin-like receptor subfamily F
                     member 1 isoform 1"
                     /protein_id="NP_057607.1"
                     /db_xref="CCDS:CCDS41750.1"
                     /db_xref="GeneID:51348"
                     /db_xref="HGNC:HGNC:13342"
                     /db_xref="MIM:605029"
                     /translation="MQDEERYMTLNVQSKKRSSAQTSQLTFKDYSVTLHWYKILLGIS
                     GTVNGILTLTLISLILLVSQGVLLKCQKGSCSNATQYEDTGDLKVNNGTRRNISNKDL
                     CASRSADQTVLCQSEWLKYQGKCYWFSNEMKSWSDSYVYCLERKSHLLIIHDQLEMAF
                     IQKNLRQLNYVWIGLNFTSLKMTWTWVDGSPIDSKIFFIKGPAKENSCAAIKESKIFS
                     ETCSSVFKWICQY"
     exon            150..248
                     /gene="KLRF1"
                     /gene_synonym="CLEC5C; NKp80"
                     /inference="alignment:Splign:2.1.0"
     exon            249..398
                     /gene="KLRF1"
                     /gene_synonym="CLEC5C; NKp80"
                     /inference="alignment:Splign:2.1.0"
     exon            399..538
                     /gene="KLRF1"
                     /gene_synonym="CLEC5C; NKp80"
                     /inference="alignment:Splign:2.1.0"
     exon            539..651
                     /gene="KLRF1"
                     /gene_synonym="CLEC5C; NKp80"
                     /inference="alignment:Splign:2.1.0"
     exon            652..1239
                     /gene="KLRF1"
                     /gene_synonym="CLEC5C; NKp80"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1213..1218
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLRF1"
                     /gene_synonym="CLEC5C; NKp80"
                     /note="hexamer: AATAAA"
     polyA_site      1239
                     /gene="KLRF1"
                     /gene_synonym="CLEC5C; NKp80"
                     /note="major polyA site"
ORIGIN      
        1 atttcatgtt atacttaata aaacaaaaca tacctgtata cacacacatt cactcacatt
       61 gaagatgcaa gatgaagaaa gatacatgac attgaatgta cagtcaaaga aaaggagttc
      121 tgcccaaaca tctcaactta catttaaaga ttattcagtg acgttgcact ggtataaaat
      181 cttactggga atatctggaa ccgtgaatgg tattctcact ttgactttga tctccttgat
      241 cctgttggtt tctcagggag tattgctaaa atgccaaaaa ggaagttgtt caaatgccac
      301 tcagtatgag gacactggag atctaaaagt gaataatggc acaagaagaa atataagtaa
      361 taaggacctt tgtgcttcga gatctgcaga ccagacagta ctatgccaat cagaatggct
      421 caaataccaa gggaagtgtt attggttctc taatgagatg aaaagctgga gtgacagtta
      481 tgtgtattgt ttggaaagaa aatctcatct actaatcata catgaccaac ttgaaatggc
      541 ttttatacag aaaaacctaa gacaattaaa ctacgtatgg attgggctta actttacctc
      601 cttgaaaatg acatggactt gggtggatgg ttctccaata gattcaaaga tattcttcat
      661 aaagggacca gctaaagaaa acagctgtgc tgccattaag gaaagcaaaa ttttctctga
      721 aacctgcagc agtgttttca aatggatttg tcagtattag agtttgacaa aattcacagt
      781 gaaataatca atgatcacta tttttggcct attagtttct aatattaatc tccaggtgta
      841 agattttaaa gtgcaattaa atgccaaaat ctcttctccc ttctccctcc atcatcgaca
      901 ctggtctagc ctcagagtaa cccctgttaa caaactaaaa tgtacacttc aaaattttta
      961 cgtgatagta taaaccaatg tgacttcatg tgatcatatc caggattttt attcgtcgct
     1021 tattttatgc caaatgtgat caaattatgc ctgtttttct gtatcttgcg ttttaaattc
     1081 ttaataaggt cctaaacaaa atttcttata tttctaatgg ttgaattata atgtgggttt
     1141 atacattttt tacccttttg tcaaagagaa ttaactttgt ttccaggctt ttgctactct
     1201 tcactcagct acaataaaca tcctgaatgt tttcttaaa
//
