LOCUS       NM_002262              15563 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens killer cell lectin like receptor D1 (KLRD1),
            transcript variant 1, mRNA.
ACCESSION   NM_002262
VERSION     NM_002262.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 15563)
  AUTHORS   Verma,K., Croft,W., Pearce,H., Zuo,J., Stephens,C., Nunnick,J.,
            Kinsella,F.A., Malladi,R. and Moss,P.
  TITLE     Early expression of CD94 and loss of CD96 on CD8+ T cells after
            allogeneic stem cell tranplantation is predictive of subsequent
            relapse and survival
  JOURNAL   Haematologica 108 (2), 433-443 (2023)
   PUBMED   35924575
  REMARK    GeneRIF: Early expression of CD94 and loss of CD96 on CD8+ T cells
            after allogeneic stem cell tranplantation is predictive of
            subsequent relapse and survival.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 15563)
  AUTHORS   Puiggros,A., Blanco,G., Muntasell,A., Rodriguez-Rivera,M.,
            Nonell,L., Altadill,M., Puigdecanet,E., Arnal,M., Calvo,X.,
            Gimeno,E., Abella,E., Abrisqueta,P., Bosch,F., Yelamos,J.,
            Ferrer,A., Lopez-Botet,M. and Espinet,B.
  TITLE     Reduced expansion of CD94/NKG2C+ NK cells in chronic lymphocytic
            leukemia and CLL-like monoclonal B-cell lymphocytosis is not
            related to increased human cytomegalovirus seronegativity or NKG2C
            deletions
  JOURNAL   Int J Lab Hematol 43 (5), 1032-1040 (2021)
   PUBMED   33615729
  REMARK    GeneRIF: Reduced expansion of CD94/NKG2C(+) NK cells in chronic
            lymphocytic leukemia and CLL-like monoclonal B-cell lymphocytosis
            is not related to increased human cytomegalovirus seronegativity or
            NKG2C deletions.
REFERENCE   3  (bases 1 to 15563)
  AUTHORS   Fang,H., Wang,W., Kadia,T.M., El Hussein,S., Wang,S.A. and
            Khoury,J.D.
  TITLE     CD94 expression patterns in reactive and neoplastic T-cell and
            NK-cell proliferations
  JOURNAL   Leuk Res 108, 106614 (2021)
   PUBMED   33990003
  REMARK    GeneRIF: CD94 expression patterns in reactive and neoplastic T-cell
            and NK-cell proliferations.
REFERENCE   4  (bases 1 to 15563)
  AUTHORS   Zhang,Q., Zheng,Y., Ning,M. and Li,T.
  TITLE     KLRD1, FOSL2 and LILRB3 as potential biomarkers for plaques
            progression in acute myocardial infarction and stable coronary
            artery disease
  JOURNAL   BMC Cardiovasc Disord 21 (1), 344 (2021)
   PUBMED   34271875
  REMARK    GeneRIF: KLRD1, FOSL2 and LILRB3 as potential biomarkers for
            plaques progression in acute myocardial infarction and stable
            coronary artery disease.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 15563)
  AUTHORS   Shreeve,N., Depierreux,D., Hawkes,D., Traherne,J.A., Sovio,U.,
            Huhn,O., Jayaraman,J., Horowitz,A., Ghadially,H., Perry,J.R.B.,
            Moffett,A., Sled,J.G., Sharkey,A.M. and Colucci,F.
  TITLE     The CD94/NKG2A inhibitory receptor educates uterine NK cells to
            optimize pregnancy outcomes in humans and mice
  JOURNAL   Immunity 54 (6), 1231-1244 (2021)
   PUBMED   33887202
  REMARK    GeneRIF: The CD94/NKG2A inhibitory receptor educates uterine NK
            cells to optimize pregnancy outcomes in humans and mice.
REFERENCE   6  (bases 1 to 15563)
  AUTHORS   Brooks,A.G., Posch,P.E., Scorzelli,C.J., Borrego,F. and
            Coligan,J.E.
  TITLE     NKG2A complexed with CD94 defines a novel inhibitory natural killer
            cell receptor
  JOURNAL   J Exp Med 185 (4), 795-800 (1997)
   PUBMED   9034158
REFERENCE   7  (bases 1 to 15563)
  AUTHORS   Lazetic,S., Chang,C., Houchins,J.P., Lanier,L.L. and Phillips,J.H.
  TITLE     Human natural killer cell receptors involved in MHC class I
            recognition are disulfide-linked heterodimers of CD94 and NKG2
            subunits
  JOURNAL   J Immunol 157 (11), 4741-4745 (1996)
   PUBMED   8943374
REFERENCE   8  (bases 1 to 15563)
  AUTHORS   Phillips,J.H., Chang,C., Mattson,J., Gumperz,J.E., Parham,P. and
            Lanier,L.L.
  TITLE     CD94 and a novel associated protein (94AP) form a NK cell receptor
            involved in the recognition of HLA-A, HLA-B, and HLA-C allotypes
  JOURNAL   Immunity 5 (2), 163-172 (1996)
   PUBMED   8769479
REFERENCE   9  (bases 1 to 15563)
  AUTHORS   Chang,C., Rodriguez,A., Carretero,M., Lopez-Botet,M., Phillips,J.H.
            and Lanier,L.L.
  TITLE     Molecular characterization of human CD94: a type II membrane
            glycoprotein related to the C-type lectin superfamily
  JOURNAL   Eur J Immunol 25 (9), 2433-2437 (1995)
   PUBMED   7589107
REFERENCE   10 (bases 1 to 15563)
  AUTHORS   Moretta,A., Vitale,M., Sivori,S., Bottino,C., Morelli,L.,
            Augugliaro,R., Barbaresi,M., Pende,D., Ciccone,E., Lopez-Botet,M.
            and Moretta,L.
  TITLE     Human natural killer cell receptors for HLA-class I molecules.
            Evidence that the Kp43 (CD94) molecule functions as receptor for
            HLA-B alleles
  JOURNAL   J Exp Med 180 (2), 545-555 (1994)
   PUBMED   8046333
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC022075.29 and U30610.1.
            
            On Nov 22, 2018 this sequence version replaced NM_002262.4.
            
            Summary: Natural killer (NK) cells are a distinct lineage of
            lymphocytes that mediate cytotoxic activity and secrete cytokines
            upon immune stimulation. Several genes of the C-type lectin
            superfamily, including members of the NKG2 family, are expressed by
            NK cells and may be involved in the regulation of NK cell function.
            KLRD1 (CD94) is an antigen preferentially expressed on NK cells and
            is classified as a type II membrane protein because it has an
            external C terminus. Several transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, May
            2017].
            
            Transcript Variant: This variant (1) , as well as variants 3 and 5,
            encodes isoform 1.
            
            Sequence Note: This record represents a predicted microRNA
            stem-loop as defined by miRBase. Some sequence at the 5' and 3'
            ends may not be included in the intermediate precursor miRNA
            produced by Drosha cleavage.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR279864.3612.1, BC028009.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000336164.9/ ENSP00000338130.4
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-128               AC022075.29        109827-109954       c
            129-280             U30610.1           5-156
            281-281             AC022075.29        108371-108371       c
            282-958             U30610.1           158-834
            959-15563           AC022075.29        88216-102820        c
FEATURES             Location/Qualifiers
     source          1..15563
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.2"
     gene            1..15563
                     /gene="KLRD1"
                     /gene_synonym="CD94"
                     /note="killer cell lectin like receptor D1"
                     /db_xref="GeneID:3824"
                     /db_xref="HGNC:HGNC:6378"
                     /db_xref="MIM:602894"
     exon            1..215
                     /gene="KLRD1"
                     /gene_synonym="CD94"
                     /inference="alignment:Splign:2.1.0"
     exon            216..308
                     /gene="KLRD1"
                     /gene_synonym="CD94"
                     /inference="alignment:Splign:2.1.0"
     exon            309..371
                     /gene="KLRD1"
                     /gene_synonym="CD94"
                     /inference="alignment:Splign:2.1.0"
     exon            372..523
                     /gene="KLRD1"
                     /gene_synonym="CD94"
                     /inference="alignment:Splign:2.1.0"
     exon            524..627
                     /gene="KLRD1"
                     /gene_synonym="CD94"
                     /inference="alignment:Splign:2.1.0"
     exon            628..15563
                     /gene="KLRD1"
                     /gene_synonym="CD94"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3189..3194
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLRD1"
                     /gene_synonym="CD94"
                     /note="hexamer: AATAAA"
     polyA_site      3211
                     /gene="KLRD1"
                     /gene_synonym="CD94"
                     /note="major polyA site"
     regulatory      8383..8388
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLRD1"
                     /gene_synonym="CD94"
                     /note="hexamer: AATAAA"
     polyA_site      8405
                     /gene="KLRD1"
                     /gene_synonym="CD94"
                     /note="major polyA site"
     regulatory      10905..10910
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLRD1"
                     /gene_synonym="CD94"
                     /note="hexamer: AATAAA"
     polyA_site      10938
                     /gene="KLRD1"
                     /gene_synonym="CD94"
                     /note="major polyA site"
     regulatory      15539..15544
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLRD1"
                     /gene_synonym="CD94"
                     /note="hexamer: ATTAAA"
     polyA_site      15563
                     /gene="KLRD1"
                     /gene_synonym="CD94"
ORIGIN      
        1 attcacacta taatacatgt ctcaccaata gatgattcaa gaacatcatt taaatacaca
       61 atttttcatt ctctattttt gctaaatttc ttcatactca actttcagat tctttaatct
      121 ccagctcagc ttcaacaatt caacgctgtt ctttctgaaa aagtacacat cgtgccttct
      181 ctacttcgct cttggaacat aatttctcat ggcagtgttt aagaccactc tgtggaggtt
      241 aatttctggg accttaggga taatatgcct ttcgttgatg tctacgttgg gaattttgtt
      301 gaaaaattct tttactaaac tgagtattga gccagcattt actccaggac ccaacataga
      361 actccagaaa gactctgact gctgttcttg ccaagaaaaa tgggttgggt accggtgcaa
      421 ctgttacttc atttccagtg aacagaaaac ttggaacgaa agtcggcatc tctgtgcttc
      481 tcagaaatcc agcctgcttc agcttcaaaa cacagatgaa ctggatttta tgagctccag
      541 tcaacaattt tactggattg gactctctta cagtgaggag cacaccgcct ggttgtggga
      601 gaatggctct gcactctccc agtatctatt tccatcattt gaaactttta atacaaagaa
      661 ctgcatagcg tataatccaa atggaaatgc tttagatgaa tcctgtgaag ataaaaatcg
      721 ttatatctgt aagcaacagc tcatttaaat gtttcttggg gcagagaagg tggagagtaa
      781 agacccaaca ttactaacaa tgatacagtt gcatgttata ttattactaa ttgtctactt
      841 ctggagtcta taaaatgttt ttaaacagtg tcatatacaa ttgtcatgta tgtgaaacaa
      901 tgtgttttaa aattgatgaa attcgttcac ctacatttga gaattataaa attaacataa
      961 agaattttgt attttcattt aatgtatata tttaatgtta aattcaatgt agttttatta
     1021 cacatttatg taattttatt tacattcttg ctaattctca gcagaaattt aaataagatt
     1081 taattcacat caaataaaat ttagaaaata aaatttaact cacactgccc aggctggagc
     1141 atagtggcaa gatcatagct cattgcaagc tcaagtgatc ctcctgactc agcctcccaa
     1201 gtagctagga ctgcaggcac catgtcacta tgcccgacta atttttaatt tttaattttt
     1261 tgtcaagaca aggtcttgct atgttgccca ggctggtctt gaactcctgg cctcaaggga
     1321 ttctcccacc ttggattccc aaagtgctgg gattataggt gtgaaccacc atccctggcc
     1381 ctcttcacat tcttgtatga agattgattt gggaaaaatg catttcaggt aactgacaaa
     1441 agatatagga tgaaaaataa tatctttcaa atgtttaatt tgaactaaga gagcttatgc
     1501 attgcacttt ctggagattt gtaatgtttt ggttttgttg tccatgtgac tacaaaataa
     1561 tatatttttt aattaaaaaa tttaaaataa tacaggcaag catgtaatga ttatcaatat
     1621 ttttttccac caactatcct atacccctga cctcctttca ttaggcatta tcttctgttt
     1681 tgattttaac acttagagtg gttttctctg ttatgaatca aagctgatct attttcatca
     1741 tttttgtgat gaaaaaatta attttgattg acttaggatg gaaggatttg gactgggtgt
     1801 ggtggtttat gcctgtaatc gcagcacttt gggaggccaa ggcgggtgga tcacttgagg
     1861 tcaggagttt gagaccagcc tggccaacat ggtgaaaccc tgtctctact aaaaatacaa
     1921 aaattggctg ggtgtggtag tgcacacctg taatcccagc tatttgggag gctgagtcga
     1981 gaggatcgct tgaacctagg aggtggaggt tgcagtgagt cgagattgca ccactgcact
     2041 ccagcctggg tgacagagcc agactcctct ccaaaaaaaa aaaaaaaaaa aaaagatgaa
     2101 aggatttgga accttaattg catctgaaaa actgcctcac ctttgttatt tagtgtactc
     2161 caaccacgga gtaacatccc atcataatcc caaatcctac tcaaacaaaa ggggaaggga
     2221 ttatgcaggt gtacactagg ccactggtgt accaattaga aaccacttta gagttatgcc
     2281 tactgtaccc acataatcct aaaaatatgt tacaactgct acttcatagt ttatgccact
     2341 tattttattt tttactttta ttattttttt ttctgagaca cggtttcatt cccattgccc
     2401 aggctgtagt gcaatgatgc aatcatggtt cactgcagct tcaacttccc aggctcaagg
     2461 gatcctccca cctcagcctt ctgagtactt gggactcagg tgcgagccat catgctcagc
     2521 taattttttg tatcatttgt agaaatgggg ttttgtattg ttgcccaggc tgatcttgaa
     2581 ctcctggggt caaggattct gcccgccttg gcctcctaaa gggctggaat tacaggcata
     2641 agccactgtg cccggccagt ttatataatt taaacactgc cttttggttc cttgattccc
     2701 atatgctagg acaagtaatt attattttat tttattttac tttaagttct gggttacatg
     2761 tgcagaacct gcaggtttgt tacataggta tacatgttcc aaggtggttt gctgcaccta
     2821 ttgacccatc atctaggttt taagtcccac atgcattagg tatttgtcct aatgctcttc
     2881 ctccccttgc cccccacccc ccgacaggcc ttggtctgtg atgttcacct ccctgtgtcc
     2941 atgtgttctc attgttcaac tcccacttat tagtaagaac atgtggtgtt tggttttctg
     3001 ttcctgtgtt agtttgctga gaatgatggt ttccagcttc atccatgtcg ctgcaaagga
     3061 catgaactca ttctttttat ggctgcatag tattccatgg tgtatatgtg ccatattttc
     3121 tttatccagt ctatcactga tgggcatttg ggttggttcc aagtctttgc tatggtaaat
     3181 agtgctgcaa taaacatacg tgtgcatgtg aggacaagta attattttct gtttttctca
     3241 atacattaat tattagttcc tccgttagtt gtgaagtcct aattagggaa aaggagttag
     3301 gctggcggga gcagggaaaa gcagaaagag aaagcagata agctatgagt ctgcctttct
     3361 tcatggtcca ggatatgggc catgtgctaa actattacca gacacctgca agttacctca
     3421 ccgcaacctt ggcattatca gtactggaca aagccctctg cagcatacag cataaacact
     3481 attccataaa atcctaagca agcctttgtt tctttgcagt cagcttttct tctgctgatg
     3541 ctgcctgttg cctccctgga aacatatttt cctacttttc tttaataaat ctgccttcct
     3601 ttacctacag ctgtcttggt aaattctttt acctcaatgc caccggccca ggtagccgtt
     3661 gctcacccac aacattagtg tattagtccg ttcttatgct gctactaaag atatacccaa
     3721 gactgggaaa tttataaaat aaagacattt aattgactca cagttctgca gggttggaga
     3781 agcctcagga aacttacagt aatgacagaa gggaaagcaa acacatccct ctacgcatgg
     3841 cagcagaaag gagacgtgct gagcaaaagg aaaaataccc tcttattaaa tcatcagatc
     3901 tagtgagaac tcactcacta tcatgagaac agcaaagagg taactacccc catgattaaa
     3961 ttacctccta ccagttccct cacatgatac gtgaggatta ggggcactac aattcaagat
     4021 gagatttggg tggggacaca gccaagccat atcagttagt gacatctgta ttctcatatt
     4081 gcatgcataa gaaagtgagt tattttacag ctgaactggg acagctcttt gcttatttcc
     4141 agagatgcct aggtgtctgt ttttgactct tggccatgat atgggtagta ggctaactaa
     4201 ctagctaaca aatggtttat ggtgagttct ttaaagttca aaatccctca gtggaatcca
     4261 gggtcaattt gtttattgat agcttccata tgagataatt acagatcttg tctctgctgt
     4321 gtgaccagac acagataaaa gactgcaaga aatttcagtt tcagctctca tgaaaccaag
     4381 tttcatctca caaatatcag gtttcatcca gagatgaatg gtgtctttgc gcaaatatct
     4441 cttggtccca cactgcttgt ttgaattctc tttctcatac ggtatcatat tcctttcact
     4501 tattaaaaag tttttcatgg ctgggcgcgg tggctcaagc ctgtaatccc agcactttgg
     4561 gaggctgagg cgggtggatc acgaggtcag gagattgaga ccatcctggc taacacggtg
     4621 aaaccccgtg tgtactacaa gtacaaaaaa attagccagg cgtggtgaca ggcacctgta
     4681 gtcccagcta ctcgggaggc tgaggcagga gaatggcgag aacccgggag acggagttta
     4741 cagtgagctg agatcgcgcc actgcactcc agcctgggtg acagaggaga ctccgtctcc
     4801 aaaaaaaaaa aaaaaaaaaa agcttttcat aagtatgctc attagaacct tataattcat
     4861 ttcagttatc tacacctgga aatgttagtt ctataatttt ggactttctg aaacttttct
     4921 ctttatatcc taacgcaggg gttgaaaaac ttttctcaaa aagctctata gcatatattt
     4981 tcaactttgt ggaccagtct ctgttgaaac ttctcaacct tgccatggtg gtgctaaaga
     5041 agacataaat aatacaaaaa tgaatggttt gactgtgtta caaaagaatt ttattgacaa
     5101 aacatatggt gagacagatt tggtccacag gccatagttt gccaacatgt gcccaagtat
     5161 gtaagatgag aatataaggc cataaattct actctctgct ttattctttt ccaggtcact
     5221 tcttaccagt tgtaaatgta cttacaaatt ttgctatatg aaaacagtta tgtctgttac
     5281 tatcaatctg tgttcatttt aaagggtgac aatctacaaa ttatgtgtta tagacaagtt
     5341 gcaagatgtt caccaatgat tcccaccttg tgctatacat gccttggtgg aatttctttc
     5401 cacattgtat caaggttgct ctgtgtgacc aatgaaataa agtggaaatg atgatatttc
     5461 atttctgaga ataggtcatc aaagatagta tgacttcctt tttcctctct cccagattac
     5521 ttgatctggg gaaaaccagt tataatgtca tgagcagccc tgttgaaagg accatgcggc
     5581 aaggaactga agactcttac acacagccag caaggaactg aagtctattt ccaatagcca
     5641 tgctatgagc cttctttgct tgtataggct ccagtcttag tcaagccttc agatgattac
     5701 agcccccagc caacaccttg acggcaacct catgagagac cctgagctag gtccatcgtg
     5761 ctatgctgtt cgaggattcc tcactctcag aagctgtgtg aaatagtaaa gtgtttattc
     5821 tttttttttt tttttttttt gacagagtct cactctgtca cctgggctgg agtgcagtgg
     5881 ggccatgtcg gctcactgca acttctgcct cctggattca agcaattctc ctgcctcagc
     5941 ctcctgagca gctgggatta caggtgtgca ccaccactcc tggctaattt ttttgtattt
     6001 ttagtacaga cggggtttca ccatgttggt caggctggtc ttgaactcct gacctcaggt
     6061 gatctgccta cctcaccctc ccaaagtgct gggattacag gcgtgagcca ctgcgcccag
     6121 acataacttt tattctttta agtcactaaa tattaacgtg tcacatagca ataatcaata
     6181 catattttgg taccaagaat gaagttacta ttataaagaa aaaaaaaaac cactaaaatt
     6241 ttggagtgct tgaaaacagg cagtggatgg aggccaaaag gacaggaaag actgaaacct
     6301 tctagtatgg gcttatagta gggaagtgaa aacatattag aaactggaga aagtaaaaat
     6361 ctttctattt agtaccagaa agtttagcaa cacttttgtc tgtagcattg tggaaagtag
     6421 aaaatgtact taatgattta agagaatgct ctaaacttat ttccaactag agtgttgaat
     6481 atcttgtctg atttcttcct actacttata ttacaatgct atagaacaca cataagctaa
     6541 tggaagggct gttgagcaaa agaagacaga acttgatagt tttgagattc ctggactctc
     6601 aaatgttagc atgtcaaaaa tgctaaaatt gagaaataga ttctgagcaa agatccaatc
     6661 tagagtgctc tcaggaaagc atgattctaa acaagaaggt gtgggtgtga ctgaaatttc
     6721 ctgtaaatat catagaaaga acacaagtag tgcctcaatt cagtcagatg aagatctata
     6781 aaggtcaaat aatagggctt ctaggaagcc ccagggtatt gtccctcagg tatctcagca
     6841 gaagctccag gtagagagaa gattgaagag atttatgtgt gcggttttta caaatagagt
     6901 tcatagaaaa cctcaaaaca cttttgagat gactatgtca gtagaaaatt gacaatgaat
     6961 tgctaccttt tattcaaaag taagaataat tcaaaggaca gaactaagag cctgtaaggt
     7021 ggatccaaga gttatgaaga gtgattttat aagcagaaat aggactgagt cctaatcaaa
     7081 tgagtcccga catttgctat gctagatttt aaattattat gcatcagtga ctcctttgta
     7141 attctcatgc ccctccctct tttgaacaag gatgtctata gtttgttctt tcgaatgttg
     7201 agtgtataag ggaaggaaat ctctagtatt gttaatttca caagccttca catggagaaa
     7261 aatgatactc aagaagctaa acttaaggaa cttcacctga tgagtctcac tcatacctgg
     7321 atgtgacaaa tttcggactt tgaactgaca ttgtaacgga atgagatttg gcagttggtg
     7381 tggattttgt atgtgggagg gacataaatc atttggggcc aaagattaga ctcttgtaaa
     7441 cagcttccta tatgctccca atgatccctg tttcttggaa tttaaccctt ttgatataat
     7501 caattacatt gtataagggt tgatcactgt gaccaagaga ataaggcaga agttatcgca
     7561 tatcactttt gaggctagat tataaaagac agtatgtctt tggcgttgcc ctttctcata
     7621 tcatctgatt tggtggaagc cagctacctt gtcgtgagca actcttttaa gcgttccatg
     7681 tggcaaagaa ctgaggcctc ctataaacag ctagcaagga actgcagcca tcttgtagac
     7741 agccttgtgc acgagcctcc ttggttcaac tcttcagcca gtgtcaagcc ttagaaaata
     7801 caacccaacc tacattttta ctgcaacctc atgagggatc ctgagctaga accacctagc
     7861 acagttgctc ttgatttctg acctcagaaa ctgtgaagtg aaatattttg ttgttttaag
     7921 cttacgagtt tgaggataat ttgttcttta tagtagttag ctgatacaat atgcttcatc
     7981 atcatgacct catgaataga gaacatttat ttatttattg agatggagtc tcactctgtc
     8041 acccaggctg gagtgcagtg gcacagtctt ggctcactgc aacctctgcc tcgctggttc
     8101 aagcgattct catgcctcag cctccccagt agctgggatt acaggcaccc accaccatgc
     8161 ctggctaatt tttgtatttt cagtagacat gaggttttgc catgttggcc aggctggtct
     8221 ccaactcctg gcctcaagtg atccacctgc ctcggcctcc tgaagtgctg ggattacagg
     8281 catgagccat tgtgtctggc caaatagagg acattttaga gcccaatagt aagctaggat
     8341 tatatttcct tctttgaggt tctattgtta taacccttat acaataaaaa acaactcttc
     8401 tgccagatta aaattttttg ttttttggtt tttttagttc tcaattatgt tgtataaccc
     8461 atgagtgtca ctttattctc attggaaata tcctcccaag agctcttacc cacctgctgt
     8521 tgtttggact ggcaccttac tagacctgct ccacaaactg ccgtcatgaa atttttcttc
     8581 actaattttc tcatttacac taaatacttc attgattaca gtttacctct tcatatattt
     8641 taattgagca aaaacacaat aaagaatacc tatcttaaat ttactcgtaa acatttaagc
     8701 tatgtctaca cttacacgat tactaccaga ttgcaataga gactacctac caccaccaag
     8761 actctcttgc tgtttgctaa ttgatactgt ctcccctgtt ccaagaaaac tgctactctg
     8821 atttctgaaa atataggttt atttagcctg ttctttaatt tcatataaat ggaagcttag
     8881 catgtatgat ctttgtggct tctgttgcta agcattacgt ctgtgagata catccatata
     8941 ttcgtgcagc agtagctcct cacttttatt gtcatgtaga attcataaga atgtatcaca
     9001 atttgcttat ttattctaat attgttcaac atttgagtca tttccacttt tcactattat
     9061 gagtaaaatt gctataaaca ttttaatata gctcttgtgg gacatgtggc ttcatatctt
     9121 ttgagtgtac gcctaggagt tgaatttcta agtcataagc tgtcatatat ttaggccctt
     9181 tagttcacgc tttaaaaact agtgataatt tattcataaa gcttatttat aatttcactg
     9241 gcagtttatg tgagtgttac tctgtattct tgacaataca tagtattatg aattatttta
     9301 gtctaaggac cttctggata ctatgcattt gcatacaatt gtacatttaa tttccatctt
     9361 ccaaatgaat aatgatgctt atccctcatc tttttttttc atttttatat ccccttctat
     9421 gtagtgcttg tttaagcttt tagccattat ttatttttaa cagcgctgtt gcagtataat
     9481 tgagatactt taagcatact ttatatgctt aaagtatgac atttgatgta tttccatatc
     9541 tatgcatctg tgaaaccatc acctcagcaa tatataaaac acctactaac ctcaaaagta
     9601 tcctttcccc tatgtataaa atacttcctc ttgctcctcc cctcacagat gaatattctg
     9661 ttactataga tttgcctttc tatgttttat atagatagaa tcatataata tgtacatctg
     9721 tgttctagat ttttcattca gcatcataat agtttttata ctcatctatg ttgatacatg
     9781 tatcaatagt taattccctt ttatttctta tttctttcct tttttttttt ttttgagact
     9841 gagtattgct ctgtcaccca gattagagtg cagtggtgtg atctcagctc actgcaacct
     9901 tcaccacctg ggttcaagtt attctcatgc ctcagcctcc ccagtagccg agattacaga
     9961 tgcccaccac cacgcccagc taatttttgt atttttagta gagacggggt ttcaccatgt
    10021 tgaccagtct tgtcttgaac tcctgacctc aactgctcca cctgccttga cctcccaaag
    10081 tgctggaatt acaggcgtga gccaccacat ccagccgatt cctttttact tctgagagtc
    10141 ttctgatcct tgagtaaagt atgtttcttg tacctcaata tgcttaattt tttccttctg
    10201 gctttcgttt taggttcagg gtatatatgt aggcttctta tatgagtaca ttgcatgttg
    10261 cagtggtttg gtgtacagat aattttgtca tcctggtaat cagcatagta cctgacaggc
    10321 agtttttcta tcctcatcct tctccctctc ccccccaagt aggccccagt gtctattgtt
    10381 tccttttttt gtgtgcctgt gtactccatg gttagctccc acttataagg gagaatatgt
    10441 ggtttttggt tttctgttct tccattgatt tgcttaggat aatggcctct agttctatcc
    10501 atgttcctgc aaaggacatg atttttttct tttttatgtc tgcatagtat tccatggtgt
    10561 atatgtacca cattttcttt acctagtcca ttgtctcaat atacttaagt tatactcagt
    10621 aatgttttgt agtttttaat attcaggcct tttatgtttt tatgagattt ccccaaagta
    10681 gtctattgtt tttaaagcta ttatacattt tattttctaa tttcaaatgt tttattttaa
    10741 aattgtaagt atatatgtat atgtgtgtgt gtgtatatat atatatatat atatatattc
    10801 atttacacag ttgattctaa gtgtatcttt tattgtttaa cctgcctaaa ttcacttatc
    10861 ctagcagcat ttctgtagat ttcattgggt tatctgcata gatgaataaa gacagttttt
    10921 acctctttct tttgaaaact gtgtgccttt aattcttttt atcaccttgt cacagtggcc
    10981 agaatattca acacaaagtt gaatacaagt ggtgagtaaa cacccttgtt ttgctattga
    11041 tcttagagca tgaatattca ctttttttac ctttatactt aattttagct gtaggatttt
    11101 cataaatgac ctttactagg ttgagaaagt tccctcctat tcctagtctg atgagaattt
    11161 ttataaggag tacatatgac atatgctttt attaaatgtt ttattctgcc tcgattgaaa
    11221 tcagatagtt tttatttccc agttataaac ctcagttgtt catgttatct tttttacgta
    11281 tctttgcaga tgctttgcta attttttaaa attttatttt attgaggtaa atacaacata
    11341 agatctatcc tcttaacaaa ttttcaagtc tacagtacag tattattaac aataggtaca
    11401 atgttgtata gtagatctct ataatttatt catcttgcat aattgaggct ttatgccctt
    11461 tgattaacga cgtcccattt tttcctctct ccattcctgg caaccaccat tctattctct
    11521 gattttataa gcttgaccac tttagatatt tcacgtaagt ggaatcatat agtatttatc
    11581 ctgtgacttg tttatttcat ttagcataat gtcctcaagt ttcatccaca ttgttacata
    11641 ttgcaggatt tcatttttaa ggctggataa tattctattg tatgtgtatg tacacattgg
    11701 ctactgtgac tagtatagca atggacagta gtatactaat atttctttga gattcttatt
    11761 tcaattcttt tgcataatta cccagaaagg ggattggtgg atcatatggt agttctattt
    11821 ttaatttttt gagaaatcac catcctgttt tccacagaag cagcacaatt tttcattccc
    11881 accaaagtgt tcaaggggtc taattacccc acgtacttct caacacttgt ctttcatttg
    11941 tttgataata gccatcctta taagtgagag atgatatttg gtggttataa tttgcatttc
    12001 cctgatgatt agtgatattg agcatcattt catatgccca ttgacccttt gtatgttttt
    12061 tatgaagaaa tgaccattca agtctttgat acatttttta attgggttac ttgtgttttt
    12121 tttaatattg agttgtagga gttctttata tgttttggat attgactcct tttctgatat
    12181 atgatttgca attattttct cccattctgt agatcatcct ttcattccat tggttatttc
    12241 ctttgtgaac cctgaaaatt tgagacaggt ctcagttaat ttagaaagtt tattttgcaa
    12301 aggttgagaa catatgccca taacacagcc tcacctcagg aggtcctgct gacatgtgcc
    12361 caaggtggtc agggcacagt ttggttttat acattttagg gagacatgag acatcaatca
    12421 acatatgtaa aatgaacagt ggtttggtct agaaaggtgg gacaattcaa agcagaagtg
    12481 aaacaactgg aagcaaggag ggggcttcca ggtcacaggt aagagacaaa tggttgcacc
    12541 tttttgtttc tgattagcct ttccaaagga ggcaatcaga tatgcattta tctcagtgag
    12601 caaagagatg actttgaata gaatgggggg ctcccaggtc acaggtaagg gacaaatggt
    12661 tgcatctttt tgtttctgat tagcctttcc aaaggaggca atcagatacg tatttatctc
    12721 agtgagcaaa gagatgactt tgaatagaat gggaggcagt tttgccctaa gcagttccca
    12781 gcttgaattt tcccttttgt tgagtgattt tgggggccca agatattttc ctttcacacc
    12841 tttgatgcga acaagctgtt tgtttgctat agtcctactt gtctattctt gcttttgttg
    12901 cctgtgcttt tggtgtcaga ttgatgatat cattgccaaa accaatgtca aaaggttttc
    12961 ctctatgttt tctttgaagg gctttacatt ttcagtactt acatttaggc ttttaatcca
    13021 tttgaaattt atttttgcat atggtgtaag ataagcaatt tctttgcaat atggatgttc
    13081 atttttcccg tcactgtttg ttgaagaaac tgtcatttcc ccttaaatag tcctgccacc
    13141 caaagaccgt ttaaccatat ttgcaaagtt tattcccaag ttctccaatc tgtttaattg
    13201 gtctatatgt tcatctttat gccagtgcca tattgtttca attattgtag ctttgtaata
    13261 tattttgata tcaggaagtt tgaggcctct ggccttctgt ttcttgctca agatttgttt
    13321 ggctattcag ggctttttgt ggttccatgt atattttagt atcattgttt tcctaattct
    13381 aaaatgccat tgaggtcttg ataggtattg cactaaatct gcagatcaca ttgtgaaata
    13441 caaatatttt aactatatga agtcttttaa taaatgaata taggaggatt tttgcatgtt
    13501 gattttgtac cctgcaactt tacttggttt taggaggctt ttttgtggat tctttagagc
    13561 atgccatagg caaacaggga ccattgtact tcttctttta caatctgtat gttgttaatt
    13621 tcttttcctt gcctaagagc tttaagtagg acaagggtta aatagaaatg gcaagtgcaa
    13681 acatccttgc catgtttctg atgtcagagg aaaagttcag ctttttccat agcatgatat
    13741 tagctatgca ctttacatat agggccttca aaatgttgaa atatttttct caaattctag
    13801 gttggcagga gttatcatca taaaatgggt attaaatttt gtgaaaactt tttttctgaa
    13861 tctattgaga tgcacaggtg acatttatcc ttcattctat taatgtggta tattacatta
    13921 attgattttg tatgttaggc tatccttgca ccccagggat aaatgccact tgcttatggc
    13981 atatactcct tttagtgtac tgttgaatta attttgctac tactttgttg aggatttttg
    14041 catctacgtt tactagacat attggcttat agttttcttg tggtatcttt gacaagcttt
    14101 ggtgtaatgg taatgctggc cacataaaat tagtttgaaa gtatttattc tttttaaatt
    14161 tttatataat agcttgggaa agatggccat taatttctcc ttaaatattt ggtggcttca
    14221 ccagaagagc catcttgtcc tgggaatttt tttgttgtaa gtttcttgat tactgattca
    14281 atcttcattc tagttataga tacgctcata ttttctattt cttcataatt cagtcttggt
    14341 aggtccttgt ctttgtgaat tttttcattt cttctaggtt atccaatttg ttggcctata
    14401 attgttctta gttgtctctt accatctttt atatttctgt ggcatcagtt gcaatgtctt
    14461 atttctgatt tcatttattt aaggcctctc ttctttttct tagtctagct aaaggtttgt
    14521 caagttattt atattttcca aaaactaact cttagttttg tttacttttt atatatcctt
    14581 tccattcact attttatttc tgaactaatc tttattattt tctttattct tctaaatttg
    14641 aactttgttt gttcttttct acatttctag ttgcttggga tatgtattag tccattttca
    14701 cactgttgat aaagacttaa ctgagagact gggtaatttg taaagaaaaa gaggtttaat
    14761 ggactcacag ttccacgtgg ctggggaggc ctcactatca tggcagaagg taaaacacat
    14821 gtctcacatg gcggcagaca agagagaatg aaagccaagc caaagggggt ttccccttat
    14881 aaaaccatct gatttcataa gactgattca ctaccatgag aacagtatgg gggaaaccac
    14941 ccccatgatt caattatctc ccactgggtc cctccaccaa catgggggaa ttatgggagc
    15001 tacaattcaa gatgagattt gggtggggac acagccaaac catatcaagg tataaagtgc
    15061 attgtttgag acctttcttt tttcttaatg cagatattca tcactataaa cttttctttt
    15121 agccctactt ttactacatc ccataagttt tgttagactt tatttttgtt ttcatttatt
    15181 ctaatgtgtt tttaaatttc ccttttgatt tattctttgc agattggttg ttcaaaaatg
    15241 tattgttaaa ttatcacata tttattagtt ttccttttgc aactgatttc tagtttcatt
    15301 cccttgatgc tgtaaaagat acttgatatg acttcaattt tcttaatttt cttaagactt
    15361 cttttatgac ctaacatatg atctatcctg cagaatgatc catgtgcact tgagaagaat
    15421 gtatactctg ctgctgttgg atggaatgtt ctgcacatgt ctgtaggtga cttgacttgc
    15481 agtgttgatc aggtcatctg ggtctttgtt gcctttatgt ttggttgttc tatccattat
    15541 taaaagtgag cactgaaatc tcc
//
