LOCUS       NM_013431                928 bp    mRNA    linear   PRI 02-JUN-2024
DEFINITION  Homo sapiens killer cell lectin like receptor C4 (KLRC4), mRNA.
ACCESSION   NM_013431
VERSION     NM_013431.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 928)
  AUTHORS   He,Y., Ma,P., Luo,Y., Gong,X., Gao,J., Sun,Y., Chen,P., Zhang,S.,
            Tian,Y., Shi,B. and Zhang,B.
  TITLE     Novel Association of KLRC4-KLRK1 Gene Polymorphisms with
            Susceptibility and Progression of Antithyroid Drug-Induced
            Agranulocytosis
  JOURNAL   Exp Clin Endocrinol Diabetes 132 (1), 17-22 (2024)
   PUBMED   38237612
  REMARK    GeneRIF: Novel Association of KLRC4-KLRK1 Gene Polymorphisms with
            Susceptibility and Progression of Antithyroid Drug-Induced
            Agranulocytosis.
REFERENCE   2  (bases 1 to 928)
  AUTHORS   Zhang,G., Li,J., Sun,H. and Yang,G.
  TITLE     Screening for the Biomarkers Associated with Myocardial Infarction
            by Bioinformatics Analysis
  JOURNAL   J Comput Biol 27 (5), 779-785 (2020)
   PUBMED   31502863
  REMARK    GeneRIF: Screening for the Biomarkers Associated with Myocardial
            Infarction by Bioinformatics Analysis.
REFERENCE   3  (bases 1 to 928)
  AUTHORS   Yang,Y., Tan,H., Deng,B., Yu,H., Su,G., Hu,J., Cao,Q., Yuan,G.,
            Kijlstra,A. and Yang,P.
  TITLE     Genetic polymorphisms of C-type lectin receptors in Behcet's
            disease in a Chinese Han population
  JOURNAL   Sci Rep 7 (1), 5348 (2017)
   PUBMED   28706259
  REMARK    GeneRIF: This study demonstrates that the MBL2/rs1800450 and
            KLRC4/rs2617170 are susceptibility factors for Behcet's disease in
            a Chinese Han population.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 928)
  AUTHORS   Sousa,I., Shahram,F., Francisco,D., Davatchi,F., Abdollahi,B.S.,
            Ghaderibarmi,F., Nadji,A., Mojarad Shafiee,N., Xavier,J.M. and
            Oliveira,S.A.
  TITLE     Brief report: association of CCR1, KLRC4, IL12A-AS1, STAT4, and
            ERAP1 With Behcet's disease in Iranians
  JOURNAL   Arthritis Rheumatol 67 (10), 2742-2748 (2015)
   PUBMED   26097239
  REMARK    GeneRIF: CCR1, KLRC4, IL12A-AS1, STAT4, and ERAP1 are bona fide
            susceptibility genes for Behcet's disease.
REFERENCE   5  (bases 1 to 928)
  AUTHORS   Kim,D.K., Kabat,J., Borrego,F., Sanni,T.B., You,C.H. and
            Coligan,J.E.
  TITLE     Human NKG2F is expressed and can associate with DAP12
  JOURNAL   Mol Immunol 41 (1), 53-62 (2004)
   PUBMED   15140575
  REMARK    GeneRIF: NKG2F is expressed in NK cells and can associate with
            DAP12.
REFERENCE   6  (bases 1 to 928)
  AUTHORS   Sobanov,Y., Glienke,J., Brostjan,C., Lehrach,H., Francis,F. and
            Hofer,E.
  TITLE     Linkage of the NKG2 and CD94 receptor genes to D12S77 in the human
            natural killer gene complex
  JOURNAL   Immunogenetics 49 (2), 99-105 (1999)
   PUBMED   9887346
REFERENCE   7  (bases 1 to 928)
  AUTHORS   Glienke,J., Sobanov,Y., Brostjan,C., Steffens,C., Nguyen,C.,
            Lehrach,H., Hofer,E. and Francis,F.
  TITLE     The genomic organization of NKG2C, E, F, and D receptor genes in
            the human natural killer gene complex
  JOURNAL   Immunogenetics 48 (3), 163-173 (1998)
   PUBMED   9683661
REFERENCE   8  (bases 1 to 928)
  AUTHORS   Plougastel,B. and Trowsdale,J.
  TITLE     Sequence analysis of a 62-kb region overlapping the human KLRC
            cluster of genes
  JOURNAL   Genomics 49 (2), 193-199 (1998)
   PUBMED   9598306
REFERENCE   9  (bases 1 to 928)
  AUTHORS   Plougastel,B. and Trowsdale,J.
  TITLE     Cloning of NKG2-F, a new member of the NKG2 family of human natural
            killer cell receptor genes
  JOURNAL   Eur J Immunol 27 (11), 2835-2839 (1997)
   PUBMED   9394807
REFERENCE   10 (bases 1 to 928)
  AUTHORS   Yabe,T., McSherry,C., Bach,F.H., Fisch,P., Schall,R.P., Sondel,P.M.
            and Houchins,J.P.
  TITLE     A multigene family on human chromosome 12 encodes natural
            killer-cell lectins
  JOURNAL   Immunogenetics 37 (6), 455-460 (1993)
   PUBMED   8436421
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AJ001683.1.
            
            On Jun 23, 2006 this sequence version replaced NM_013431.1.
            
            Summary: Natural killer (NK) cells are lymphocytes that can mediate
            lysis of certain tumor cells and virus-infected cells without
            previous activation. They can also regulate specific humoral and
            cell-mediated immunity. NK cells preferentially express several
            calcium-dependent (C-type) lectins, which have been implicated in
            the regulation of NK cell function. This gene is a member of the
            NKG2 group of genes that are expressed primarily in natural killer
            (NK) cells. These family members encode transmembrane proteins that
            are characterized by a type II membrane orientation (have an
            extracellular C-terminus) and the presence of a C-type lectin
            domain. This family member is located within the NK complex, a
            region that contains several C-type lectin genes preferentially
            expressed in NK cells. Read-through transcription exists between
            this gene and the downstream KLRK1 (killer cell lectin-like
            receptor subfamily K, member 1) family member. [provided by RefSeq,
            Dec 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ001683.1, U96845.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2150385 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000309384.3/ ENSP00000310216.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-928               AJ001683.1         1-928
FEATURES             Location/Qualifiers
     source          1..928
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.2"
     gene            1..928
                     /gene="KLRC4"
                     /gene_synonym="NKG2-F; NKG2F"
                     /note="killer cell lectin like receptor C4"
                     /db_xref="GeneID:8302"
                     /db_xref="HGNC:HGNC:6377"
                     /db_xref="MIM:602893"
     exon            1..369
                     /gene="KLRC4"
                     /gene_synonym="NKG2-F; NKG2F"
                     /inference="alignment:Splign:2.1.0"
     CDS             183..659
                     /gene="KLRC4"
                     /gene_synonym="NKG2-F; NKG2F"
                     /note="natual killer cell group 2-F; killer cell
                     lectin-like receptor subfamily C, member 4; NK cell
                     receptor F; NKG2-F-activating NK receptor"
                     /codon_start=1
                     /product="NKG2-F type II integral membrane protein"
                     /protein_id="NP_038459.1"
                     /db_xref="CCDS:CCDS8624.1"
                     /db_xref="GeneID:8302"
                     /db_xref="HGNC:HGNC:6377"
                     /db_xref="MIM:602893"
                     /translation="MNKQRGTYSEVSLAQDPKRQQRKLKGNKISISGTKQEIFQVELN
                     LQNASSDHQGNDKTYHCKGLLPPPEKLTAEVLGIICIVLMATVLKTIVLIPCIGVLEQ
                     NNFSLNRRMQKARHCGHCPEEWITYSNSCYYIGKERRTWEERVCWPVLRRTLICFL"
     exon            370..468
                     /gene="KLRC4"
                     /gene_synonym="NKG2-F; NKG2F"
                     /inference="alignment:Splign:2.1.0"
     exon            469..522
                     /gene="KLRC4"
                     /gene_synonym="NKG2-F; NKG2F"
                     /inference="alignment:Splign:2.1.0"
     exon            523..928
                     /gene="KLRC4"
                     /gene_synonym="NKG2-F; NKG2F"
                     /inference="alignment:Splign:2.1.0"
     regulatory      908..913
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLRC4"
                     /gene_synonym="NKG2-F; NKG2F"
     polyA_site      928
                     /gene="KLRC4"
                     /gene_synonym="NKG2-F; NKG2F"
ORIGIN      
        1 taaaacttta ggaaattagt accagacttt tatattggtc aacagcaaaa tgaacattac
       61 tactcagcct ccaacacatg cagtttgcct ataccaggga tcctgtcaaa atatacacca
      121 cttatagctt cttaagtgca gttatcatag agcacagtcc ctgacatcac acagctgcag
      181 agatgaataa acaaagagga acctactcag aagtgagtct ggcccaggac ccaaagaggc
      241 agcaaaggaa acttaagggc aataaaatct ccatttcagg aaccaaacag gaaatattcc
      301 aagtagaatt aaaccttcaa aatgcttctt cggatcatca agggaatgac aagacatatc
      361 actgcaaagg tttactgcca cctccagaga agctcactgc tgaggtccta ggaatcattt
      421 gcattgtcct gatggccact gtgttaaaaa caatagttct tattccttgt attggagtac
      481 tggagcagaa caatttttcc ctgaatagaa gaatgcagaa agcacgtcat tgtggccatt
      541 gtcctgagga gtggattaca tattccaaca gttgttatta cattggtaag gaaagaagaa
      601 cttgggaaga aagagtttgc tggcctgtgc ttcgaagaac tctgatctgc tttctataga
      661 taatgaggaa gaaatggtaa gacgtaaatg tttcaacact ttactaaaag cttatttctg
      721 tcaatatcat atttgtagaa atcatccata tgtttataca tatatttact tcatatattt
      781 ttaagtctgt gtagtattca actgacttca taatattttt atattcatat actgttaatg
      841 cacatttggt tatttccagt tttgcttttc atggaaaccc atgcttctat aaatgttttt
      901 atcacaaaat aaatataaag aaaactaa
//
