LOCUS       NM_001199805            1947 bp    mRNA    linear   PRI 03-JUN-2024
DEFINITION  Homo sapiens KLRC4-KLRK1 readthrough (KLRC4-KLRK1), mRNA.
ACCESSION   NM_001199805
VERSION     NM_001199805.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1947)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1947)
  AUTHORS   Zuo,J., Willcox,C.R., Mohammed,F., Davey,M., Hunter,S., Khan,K.,
            Antoun,A., Katakia,P., Croudace,J., Inman,C., Parry,H., Briggs,D.,
            Malladi,R., Willcox,B.E. and Moss,P.
  TITLE     A disease-linked ULBP6 polymorphism inhibits NKG2D-mediated target
            cell killing by enhancing the stability of NKG2D ligand binding
  JOURNAL   Sci Signal 10 (481) (2017)
   PUBMED   28559451
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1947)
  AUTHORS   Hosomi,S., Chen,Z., Baker,K., Chen,L., Huang,Y.H., Olszak,T.,
            Zeissig,S., Wang,J.H., Mandelboim,O., Beauchemin,N., Lanier,L.L.
            and Blumberg,R.S.
  TITLE     CEACAM1 on activated NK cells inhibits NKG2D-mediated cytolytic
            function and signaling
  JOURNAL   Eur J Immunol 43 (9), 2473-2483 (2013)
   PUBMED   23696226
REFERENCE   4  (bases 1 to 1947)
  AUTHORS   Kirino,Y., Bertsias,G., Ishigatsubo,Y., Mizuki,N., Tugal-Tutkun,I.,
            Seyahi,E., Ozyazgan,Y., Sacli,F.S., Erer,B., Inoko,H., Emrence,Z.,
            Cakar,A., Abaci,N., Ustek,D., Satorius,C., Ueda,A., Takeno,M.,
            Kim,Y., Wood,G.M., Ombrello,M.J., Meguro,A., Gul,A., Remmers,E.F.
            and Kastner,D.L.
  TITLE     Genome-wide association analysis identifies new susceptibility loci
            for Behcet's disease and epistasis between HLA-B*51 and ERAP1
  JOURNAL   Nat Genet 45 (2), 202-207 (2013)
   PUBMED   23291587
REFERENCE   5  (bases 1 to 1947)
  AUTHORS   Serrano-Pertierra,E., Cernuda-Morollon,E. and Lopez-Larrea,C.
  TITLE     Wiskott-Aldrich syndrome protein (WASp) and N-WASp are involved in
            the regulation of NK-cell migration upon NKG2D activation
  JOURNAL   Eur J Immunol 42 (8), 2142-2151 (2012)
   PUBMED   22585739
REFERENCE   6  (bases 1 to 1947)
  AUTHORS   Sobanov,Y., Glienke,J., Brostjan,C., Lehrach,H., Francis,F. and
            Hofer,E.
  TITLE     Linkage of the NKG2 and CD94 receptor genes to D12S77 in the human
            natural killer gene complex
  JOURNAL   Immunogenetics 49 (2), 99-105 (1999)
   PUBMED   9887346
REFERENCE   7  (bases 1 to 1947)
  AUTHORS   Glienke,J., Sobanov,Y., Brostjan,C., Steffens,C., Nguyen,C.,
            Lehrach,H., Hofer,E. and Francis,F.
  TITLE     The genomic organization of NKG2C, E, F, and D receptor genes in
            the human natural killer gene complex
  JOURNAL   Immunogenetics 48 (3), 163-173 (1998)
   PUBMED   9683661
REFERENCE   8  (bases 1 to 1947)
  AUTHORS   Plougastel,B. and Trowsdale,J.
  TITLE     Sequence analysis of a 62-kb region overlapping the human KLRC
            cluster of genes
  JOURNAL   Genomics 49 (2), 193-199 (1998)
   PUBMED   9598306
REFERENCE   9  (bases 1 to 1947)
  AUTHORS   Yabe,T., McSherry,C., Bach,F.H., Fisch,P., Schall,R.P., Sondel,P.M.
            and Houchins,J.P.
  TITLE     A multigene family on human chromosome 12 encodes natural
            killer-cell lectins
  JOURNAL   Immunogenetics 37 (6), 455-460 (1993)
   PUBMED   8436421
REFERENCE   10 (bases 1 to 1947)
  AUTHORS   Houchins,J.P., Yabe,T., McSherry,C. and Bach,F.H.
  TITLE     DNA sequence analysis of NKG2, a family of related cDNA clones
            encoding type II integral membrane proteins on human natural killer
            cells
  JOURNAL   J Exp Med 173 (4), 1017-1020 (1991)
   PUBMED   2007850
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF461811.1 and AC022075.29.
            
            Summary: This locus represents naturally occurring read-through
            transcription between the neighboring KLRC4 (killer cell
            lectin-like receptor subfamily C, member 4) and KLRK1 (killer cell
            lectin-like receptor subfamily K, member 1) genes on chromosome 12.
            The read-through transcript includes an alternate 5' exon and lacks
            a significant portion of the KLRC4 coding sequence, including the
            start codon, and it thus encodes the KLRK1 protein. [provided by
            RefSeq, Dec 2010].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF461811.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            readthrough transcript :: includes exons from GeneID 8302, 22914
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-171               AF461811.1         11-181
            172-172             AC022075.29        9466-9466
            173-276             AF461811.1         183-286
            277-277             AC022075.29        10110-10110
            278-387             AF461811.1         287-396
            388-388             AC022075.29        23989-23989
            389-748             AF461811.1         398-757
            749-749             AC022075.29        38097-38097
            750-1158            AF461811.1         759-1167
            1159-1947           AC022075.29        44683-45471
FEATURES             Location/Qualifiers
     source          1..1947
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.2"
     gene            1..1947
                     /gene="KLRC4-KLRK1"
                     /note="KLRC4-KLRK1 readthrough"
                     /db_xref="GeneID:100528032"
                     /db_xref="HGNC:HGNC:48357"
     exon            1..48
                     /gene="KLRC4-KLRK1"
                     /inference="alignment:Splign:2.1.0"
     exon            49..147
                     /gene="KLRC4-KLRK1"
                     /inference="alignment:Splign:2.1.0"
     exon            148..201
                     /gene="KLRC4-KLRK1"
                     /inference="alignment:Splign:2.1.0"
     exon            202..355
                     /gene="KLRC4-KLRK1"
                     /inference="alignment:Splign:2.1.0"
     exon            356..413
                     /gene="KLRC4-KLRK1"
                     /inference="alignment:Splign:2.1.0"
     exon            414..470
                     /gene="KLRC4-KLRK1"
                     /inference="alignment:Splign:2.1.0"
     exon            471..575
                     /gene="KLRC4-KLRK1"
                     /inference="alignment:Splign:2.1.0"
     CDS             536..1186
                     /gene="KLRC4-KLRK1"
                     /note="NK cell receptor D; NKG2-D-activating NK receptor;
                     killer cell lectin-like receptor subfamily K member 1"
                     /codon_start=1
                     /product="NKG2-D type II integral membrane protein"
                     /protein_id="NP_001186734.1"
                     /db_xref="GeneID:100528032"
                     /db_xref="HGNC:HGNC:48357"
                     /translation="MGWIRGRRSRHSWEMSEFHNYNLDLKKSDFSTRWQKQRCPVVKS
                     KCRENASPFFFCCFIAVAMGIRFIIMVTIWSAVFLNSLFNQEVQIPLTESYCGPCPKN
                     WICYKNNCYQFFDESKNWYESQASCMSQNASLLKVYSKEDQDLLKLVKSYHWMGLVHI
                     PTNGSWQWEDGSILSPNLLTIIEMQKGDCALYASSFKGYIENCSTPNTYICMQRTV"
     exon            576..683
                     /gene="KLRC4-KLRK1"
                     /inference="alignment:Splign:2.1.0"
     exon            684..776
                     /gene="KLRC4-KLRK1"
                     /inference="alignment:Splign:2.1.0"
     exon            777..812
                     /gene="KLRC4-KLRK1"
                     /inference="alignment:Splign:2.1.0"
     exon            813..964
                     /gene="KLRC4-KLRK1"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1068
                     /gene="KLRC4-KLRK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1947
                     /gene="KLRC4-KLRK1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1921..1926
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLRC4-KLRK1"
                     /note="hexamer: AATAAA"
     polyA_site      1947
                     /gene="KLRC4-KLRK1"
                     /note="major polyA site"
ORIGIN      
        1 agaataaaaa acatttgcca agacctcatg cccttttagt aaacgaatgt ttactgccac
       61 ctccagagaa gctcactgct gaggtcctag gaatcatttg cattgtcctg atggccactg
      121 tgttaaaaac aatagttctt attccttgta ttggagtact ggagcagaac aatttttccc
      181 tgaatagaag aatgcagaaa gcacgtcatt gtggccattg tcctgaggag tggattacat
      241 attccaacag ttgttattac attggtaagg aaagaagaac ttgggaagaa agagtttgct
      301 ggcctgtgct tcgaagaact ctgatctgct ttctatagat aatgaggaag aaatgctact
      361 ggggataaag gaaggagaaa taagtcaact aaaatttgag cacctgctaa taggtatgtg
      421 tggggacttc ccagttggct gtaagttgcc atttgaacta aacgaaatag gaatcctttg
      481 tgcattgaag actttagatt cctctctgcg gtagacgtgc acttataagt atttgatggg
      541 gtggattcgt ggtcggaggt ctcgacacag ctgggagatg agtgaatttc ataattataa
      601 cttggatctg aagaagagtg atttttcaac acgatggcaa aagcaaagat gtccagtagt
      661 caaaagcaaa tgtagagaaa atgcatctcc attttttttc tgctgcttca tcgctgtagc
      721 catgggaatc cgtttcatta ttatggtaac aatatggagt gctgtattcc taaactcatt
      781 attcaaccaa gaagttcaaa ttcccttgac cgaaagttac tgtggcccat gtcctaaaaa
      841 ctggatatgt tacaaaaata actgctacca attttttgat gagagtaaaa actggtatga
      901 gagccaggct tcttgtatgt ctcaaaatgc cagccttctg aaagtataca gcaaagagga
      961 ccaggattta cttaaactgg tgaagtcata tcattggatg ggactagtac acattccaac
     1021 aaatggatct tggcagtggg aagatggctc cattctctca cccaacctac taacaataat
     1081 tgaaatgcag aagggagact gtgcactcta tgcctcgagc tttaaaggct atatagaaaa
     1141 ctgttcaact ccaaatacgt acatctgcat gcaaaggact gtgtaaagat gatcaaccat
     1201 ctcaataaaa gccaggaaca gagaagagat tacaccagcg gtaacactgc caactgagac
     1261 taaaggaaac aaacaaaaac aggacaaaat gaccaaagac tgtcagattt cttagactcc
     1321 acaggaccaa accatagaac aatttcactg caaacatgca tgattctcca agacaaaaga
     1381 agagagatcc taaaggcaat tcagatatcc ccaaggctgc ctctcccacc acaagcccag
     1441 agtggatggg ctgggggagg ggtgctgttt taatttctaa aggtaggacc aacacccagg
     1501 ggatcagtga aggaagagaa ggccagcaga tcactgagag tgcaacccca ccctccacag
     1561 gaaattgcct catgggcagg gccacagcag agagacacag catgggcagt gccttccctg
     1621 cctgtggggg tcatgctgcc acttttaatg ggtcctccac ccaacggggt cagggaggtg
     1681 gtgctgcccc agtgggccat gattatctta aaggcattat tctccagcct taagtaagat
     1741 cttaggacgt ttcctttgct atgatttgta cttgcttgag tcccatgact gtttctcttc
     1801 ctctctttct tccttttgga atagtaatat ccatcctatg tttgtcccac tattgtattt
     1861 tggaagcaca taacttgttt ggtttcacag gttcacagtt aagaaggaat tttgcctctg
     1921 aataaataga atcttgagtc tcatgca
//
