LOCUS       NM_002261               1025 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens killer cell lectin like receptor C3 (KLRC3),
            transcript variant 1, mRNA.
ACCESSION   NM_002261
VERSION     NM_002261.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1025)
  AUTHORS   Chen,Y., Liu,J.J., Qu,M.Y., Ren,B.X., Wu,H.Y., Zhang,L., Zhou,Z.,
            Liu,L.X. and Shen,H.M.
  TITLE     DNA Methylation of KLRC1 and KLRC3 in Autoimmune Thyroiditis:
            Perspective of Different Water Iodine Exposure
  JOURNAL   Biomed Environ Sci 37 (9), 1044-1055 (2024)
   PUBMED   39401997
  REMARK    GeneRIF: DNA Methylation of KLRC1 and KLRC3 in Autoimmune
            Thyroiditis: Perspective of Different Water Iodine Exposure.
REFERENCE   2  (bases 1 to 1025)
  AUTHORS   Yang,X., Wang,X., Zou,Y., Zhang,S., Xia,M., Fu,L., Vollger,M.R.,
            Chen,N.C., Taylor,D.J., Harvey,W.T., Logsdon,G.A., Meng,D., Shi,J.,
            McCoy,R.C., Schatz,M.C., Li,W., Eichler,E.E., Lu,Q. and Mao,Y.
  TITLE     Characterization of large-scale genomic differences in the first
            complete human genome
  JOURNAL   Genome Biol 24 (1), 157 (2023)
   PUBMED   37403156
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1025)
  AUTHORS   Park,H., Ohshima,K., Nojima,S., Tahara,S., Kurashige,M., Hori,Y.,
            Okuzaki,D., Wada,N., Ikeda,J.I. and Morii,E.
  TITLE     Adenylosuccinate lyase enhances aggressiveness of endometrial
            cancer by increasing killer cell lectin-like receptor C3 expression
            by fumarate
  JOURNAL   Lab Invest 98 (4), 449-461 (2018)
   PUBMED   29467457
  REMARK    GeneRIF: ADSL is involved in endometrial cancer aggressiveness by
            regulating expression of killer cell lectin-like receptor C3.
REFERENCE   4  (bases 1 to 1025)
  AUTHORS   Dukovska,D., Fernandez-Soto,D., Vales-Gomez,M. and Reyburn,H.T.
  TITLE     NKG2H-Expressing T Cells Negatively Regulate Immune Responses
  JOURNAL   Front Immunol 9, 390 (2018)
   PUBMED   29545803
  REMARK    GeneRIF: These observations raise the intriguing possibility that
            NKG2H may be a novel marker for T cells able to negatively regulate
            T cell responses.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1025)
  AUTHORS   Cheray,M., Bessette,B., Lacroix,A., Melin,C., Jawhari,S., Pinet,S.,
            Deluche,E., Clavere,P., Durand,K., Sanchez-Prieto,R.,
            Jauberteau,M.O., Battu,S. and Lalloue,F.
  TITLE     KLRC3, a Natural Killer receptor gene, is a key factor involved in
            glioblastoma tumourigenesis and aggressiveness
  JOURNAL   J Cell Mol Med 21 (2), 244-253 (2017)
   PUBMED   27641066
  REMARK    GeneRIF: KLRC3 gene expression is linked to glioblastoma
            aggressiveness.
REFERENCE   6  (bases 1 to 1025)
  AUTHORS   Bellon,T., Heredia,A.B., Llano,M., Minguela,A., Rodriguez,A.,
            Lopez-Botet,M. and Aparicio,P.
  TITLE     Triggering of effector functions on a CD8+ T cell clone upon the
            aggregation of an activatory CD94/kp39 heterodimer
  JOURNAL   J Immunol 162 (7), 3996-4002 (1999)
   PUBMED   10201920
REFERENCE   7  (bases 1 to 1025)
  AUTHORS   Glienke,J., Sobanov,Y., Brostjan,C., Steffens,C., Nguyen,C.,
            Lehrach,H., Hofer,E. and Francis,F.
  TITLE     The genomic organization of NKG2C, E, F, and D receptor genes in
            the human natural killer gene complex
  JOURNAL   Immunogenetics 48 (3), 163-173 (1998)
   PUBMED   9683661
REFERENCE   8  (bases 1 to 1025)
  AUTHORS   Plougastel,B. and Trowsdale,J.
  TITLE     Sequence analysis of a 62-kb region overlapping the human KLRC
            cluster of genes
  JOURNAL   Genomics 49 (2), 193-199 (1998)
   PUBMED   9598306
REFERENCE   9  (bases 1 to 1025)
  AUTHORS   Lazetic,S., Chang,C., Houchins,J.P., Lanier,L.L. and Phillips,J.H.
  TITLE     Human natural killer cell receptors involved in MHC class I
            recognition are disulfide-linked heterodimers of CD94 and NKG2
            subunits
  JOURNAL   J Immunol 157 (11), 4741-4745 (1996)
   PUBMED   8943374
REFERENCE   10 (bases 1 to 1025)
  AUTHORS   Adamkiewicz,T.V., McSherry,C., Bach,F.H. and Houchins,J.P.
  TITLE     Natural killer lectin-like receptors have divergent
            carboxy-termini, distinct from C-type lectins
  JOURNAL   Immunogenetics 39 (3), 218 (1994)
   PUBMED   8276468
  REMARK    Erratum:[Immunogenetics 1994;40(4):318]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC068775.52, L14542.1 and
            AF461157.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 30, 2019 this sequence version replaced NM_002261.2.
            
            Summary: Natural killer (NK) cells are lymphocytes that can mediate
            lysis of certain tumor cells and virus-infected cells without
            previous activation. They can also regulate specific humoral and
            cell-mediated immunity. NK cells preferentially express several
            calcium-dependent (C-type) lectins, which have been implicated in
            the regulation of NK cell function. KLRC3 is a member of the NKG2
            group which are expressed primarily in natural killer (NK) cells
            and encodes a family of transmembrane proteins characterized by a
            type II membrane orientation (extracellular C terminus) and the
            presence of a C-type lectin domain. The NKG2 gene family is located
            within the NK complex, a region that contains several C-type lectin
            genes preferentially expressed on NK cells. Alternative splicing
            results in multiple transcript variants encoding different
            isoforms. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1), also known as NKG2-E,
            represents the longer transcript but encodes the shorter isoform
            (E).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L14542.1, AF350016.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000396439.7/ ENSP00000379716.3
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-232               AC068775.52        4549-4780           c
            233-331             AC068775.52        4051-4149           c
            332-376             AC068775.52        3229-3273           c
            377-531             AC068775.52        2529-2683           c
            532-896             L14542.1           532-896
            897-1025            AF461157.1         868-996
FEATURES             Location/Qualifiers
     source          1..1025
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.2"
     gene            1..1025
                     /gene="KLRC3"
                     /gene_synonym="NKG2-E; NKG2E"
                     /note="killer cell lectin like receptor C3"
                     /db_xref="GeneID:3823"
                     /db_xref="HGNC:HGNC:6376"
                     /db_xref="MIM:602892"
     exon            1..232
                     /gene="KLRC3"
                     /gene_synonym="NKG2-E; NKG2E"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..768
                     /gene="KLRC3"
                     /gene_synonym="NKG2-E; NKG2E"
                     /note="isoform E is encoded by transcript variant 1;
                     NKG2-E type II integral membrane protein; NK cell receptor
                     E; NKG2-E-activating NK receptor; killer cell lectin-like
                     receptor subfamily C, member 3"
                     /codon_start=1
                     /product="NKG2-E type II integral membrane protein isoform
                     E"
                     /protein_id="NP_002252.2"
                     /db_xref="CCDS:CCDS41755.1"
                     /db_xref="GeneID:3823"
                     /db_xref="HGNC:HGNC:6376"
                     /db_xref="MIM:602892"
                     /translation="MSKQRGTFSEVSLAQDPKWQQRKPKGNKSSISGTEQEIFQVELN
                     LQNASLNHQGIDKIYDCQGLLPPPEKLTAEVLGIICIVLMATVLKTIVLIPFLEQNNS
                     SPNARTQKARHCGHCPEEWITYSNSCYYIGKERRTWEESLQACASKNSSSLLCIDNEE
                     EMKFLASILPSSWIGVFRNSSHHPWVTINGLAFKHEIKDSDHAERNCAMLHVRGLISD
                     QCGSSRIIRRGFIMLTRLVLNS"
     exon            233..331
                     /gene="KLRC3"
                     /gene_synonym="NKG2-E; NKG2E"
                     /inference="alignment:Splign:2.1.0"
     exon            332..376
                     /gene="KLRC3"
                     /gene_synonym="NKG2-E; NKG2E"
                     /inference="alignment:Splign:2.1.0"
     exon            377..531
                     /gene="KLRC3"
                     /gene_synonym="NKG2-E; NKG2E"
                     /inference="alignment:Splign:2.1.0"
     exon            532..632
                     /gene="KLRC3"
                     /gene_synonym="NKG2-E; NKG2E"
                     /inference="alignment:Splign:2.1.0"
     exon            633..723
                     /gene="KLRC3"
                     /gene_synonym="NKG2-E; NKG2E"
                     /inference="alignment:Splign:2.1.0"
     exon            724..1025
                     /gene="KLRC3"
                     /gene_synonym="NKG2-E; NKG2E"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1007..1012
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLRC3"
                     /gene_synonym="NKG2-E; NKG2E"
                     /note="hexamer: AATAAA"
     polyA_site      1025
                     /gene="KLRC3"
                     /gene_synonym="NKG2-E; NKG2E"
                     /note="major polyA site"
ORIGIN      
        1 gcagttatca tagagcacag tccctcacat cacacagctg cagagatgag taaacaaaga
       61 ggaaccttct cagaagtgag tctggcccag gacccaaagt ggcagcaaag gaaacctaaa
      121 ggcaataaaa gctccatttc aggaaccgaa caggaaatat tccaagtaga attaaacctt
      181 caaaatgctt ctctgaatca tcaagggatt gataaaatat atgactgcca aggtttactg
      241 ccacctccag aaaagctcac tgccgaggtc ctaggaatca tttgcattgt cctgatggcc
      301 actgtgttaa aaacaatagt tcttattcct ttcctggagc agaacaattc ttccccgaat
      361 gcaagaaccc agaaagcacg tcattgtggc cattgtcctg aggagtggat tacatattcc
      421 aacagttgtt attacattgg taaggaaaga agaacttggg aagagagttt gcaggcctgt
      481 gcttcaaaga actcttctag tctgctttgt atagataatg aagaagaaat gaaatttctg
      541 gccagcattt taccttcctc atggattggt gtgtttcgta acagcagtca tcatccatgg
      601 gtgacaataa atggtttggc tttcaaacat gagataaaag actcagatca tgctgaacgt
      661 aactgtgcaa tgctacatgt acgtggactt atatcagacc agtgtggatc ttcaagaatc
      721 attagacggg gtttcatcat gttgaccagg ctggtcttga actcctgagc tcaagaaatc
      781 aacacatctt ggcctcccaa gttgctggga ttactgacac aagccaccgc ccctgagtgc
      841 tcatgtacca tttagcttgt gttttaaaaa tctacttttt ctgccctccc tatttttaac
      901 tagatgatgt tttaaaaatt acttttccct ctctatatag tttgatttaa gcattagtca
      961 tttacaacaa atattaatat taaaatgcag accgttatga ttggaaaata aatcaatgaa
     1021 caata
//
